PL2426106T3 - Pochodne piperydynowe i piperazynowe do leczenia nowotworów - Google Patents

Pochodne piperydynowe i piperazynowe do leczenia nowotworów

Info

Publication number: PL2426106T3
Authority: PL; Poland
Prior art keywords: tumours; piperidine; treatment; piperazine derivatives; piperazine
Prior art date: 2007-10-05

Application number

PL11007349T

Other languages

English (en)

Inventor

Kai Schiemann

Melanie Schultz

Andree Blaukat

Ingo Kober

Original Assignee

Merck Patent Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-10-05

Filing date

2008-09-19

Publication date

2013-11-29

2008-09-19 Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh

2013-11-29 Publication of PL2426106T3 publication Critical patent/PL2426106T3/pl

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/26—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C07D249/18—Benzotriazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Hematology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Hydrogenated Pyridines (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

PL11007349T 2007-10-05 2008-09-19 Pochodne piperydynowe i piperazynowe do leczenia nowotworów PL2426106T3 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DE102007047737A DE102007047737A1 (de)	2007-10-05	2007-10-05	Piperidin- und Piperazinderivate
EP11007349.1A EP2426106B1 (de)	2007-10-05	2008-09-19	Piperidin- und Piperazinderivate zur Behandlung von Tumoren
EP08802402A EP2193118B1 (de)	2007-10-05	2008-09-19	Piperidin- und piperazinderivate zur behandlung von tumoren

Publications (1)

Publication Number	Publication Date
PL2426106T3 true PL2426106T3 (pl)	2013-11-29

Family

ID=40089983

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
PL11007349T PL2426106T3 (pl)	2007-10-05	2008-09-19	Pochodne piperydynowe i piperazynowe do leczenia nowotworów
PL08802402T PL2193118T3 (pl)	2007-10-05	2008-09-19	Pochodne piperydynowe i piperazynowe dla leczenia nowotworów

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
PL08802402T PL2193118T3 (pl)	2007-10-05	2008-09-19	Pochodne piperydynowe i piperazynowe dla leczenia nowotworów

Country Status (22)

Country	Link
US (2)	US8791111B2 (pl)
EP (2)	EP2426106B1 (pl)
JP (2)	JP5597538B2 (pl)
KR (1)	KR20100075601A (pl)
CN (1)	CN101808988A (pl)
AR (1)	AR068657A1 (pl)
AU (1)	AU2008310067B2 (pl)
BR (1)	BRPI0817644A2 (pl)
CA (1)	CA2701519C (pl)
CY (2)	CY1113757T1 (pl)
DE (1)	DE102007047737A1 (pl)
DK (2)	DK2193118T3 (pl)
EA (1)	EA017787B1 (pl)
ES (2)	ES2392475T3 (pl)
HR (2)	HRP20120802T1 (pl)
IL (1)	IL204562A0 (pl)
MX (1)	MX2010003366A (pl)
PL (2)	PL2426106T3 (pl)
PT (2)	PT2426106E (pl)
SI (2)	SI2193118T1 (pl)
WO (1)	WO2009046841A2 (pl)
ZA (1)	ZA201003124B (pl)

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DE102007047737A1 (de) *	2007-10-05	2009-04-30	Merck Patent Gmbh	Piperidin- und Piperazinderivate
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MA39792B1 (fr)	2014-03-26	2019-12-31	Hoffmann La Roche	Composés bicycliques en tant qu'inhibiteurs de production d'autotaxine (atx) et d'acide lysophosphatidique (lpa)
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CN104758286B (zh) *	2015-03-05	2016-09-14	南京工业大学	1-苄基-4-(2,4-二氯苯乙胺基)哌啶在制备抗肿瘤药物中的应用
MA41898A (fr)	2015-04-10	2018-02-13	Hoffmann La Roche	Dérivés de quinazolinone bicyclique
EA036337B1 (ru)	2015-05-27	2020-10-28	Сабре Терапьютикс Ллс	Ингибиторы аутотаксина и их применения
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CN107635995B (zh)	2015-09-24	2022-08-19	豪夫迈·罗氏有限公司	作为atx抑制剂的二环化合物
KR20180054634A (ko)	2015-09-24	2018-05-24	에프. 호프만-라 로슈 아게	이중 오토탁신(atx)/탄산 무수화효소(ca) 억제제로서 신규한 이환형 화합물
PE20180451A1 (es)	2015-09-24	2018-03-05	Hoffmann La Roche	Nuevos compuestos biciclicos como inhibidores de atx
WO2018106641A1 (en)	2016-12-06	2018-06-14	Vertex Pharmaceuticals Incorporated	Pyrazoles for the treatment of demyelinating diseases
WO2018106643A1 (en)	2016-12-06	2018-06-14	Vertex Pharmaceuticals Incorporated	Heterocyclic azoles for the treatment of demyelinating diseases
WO2018106646A1 (en)	2016-12-06	2018-06-14	Vertex Pharmaceuticals Incorporated	Aminotriazoles for the treatment of demyelinating diseases
CN110382484B (zh)	2017-03-16	2022-12-06	豪夫迈·罗氏有限公司	新的作为atx抑制剂的二环化合物
MA49879A (fr)	2017-03-16	2020-06-24	Hoffmann La Roche	Composés hétérocycliques utiles en tant qu'inhibiteurs doubles d'atx/ca
US10961242B2 (en)	2017-05-17	2021-03-30	Legochem Biosciences, Inc.	Compounds as autotaxin inhibitors and pharmaceutical compositions comprising the same
KR101798840B1 (ko)	2017-05-17	2017-11-17	주식회사 레고켐 바이오사이언스	신규 오토탁신 저해 화합물 및 이를 함유하는 약제학적 조성물
CN107266356B (zh) *	2017-07-25	2020-06-26	山西省生物研究院有限公司	一种作为自分泌运动因子抑制剂的咔唑类化合物及其制备方法和应用
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EP4405349A1 (en) *	2021-09-21	2024-07-31	Universität Münster	Autotaxin-inhibitors
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DE102007047737A1 (de) *	2007-10-05	2009-04-30	Merck Patent Gmbh	Piperidin- und Piperazinderivate

2007
- 2007-10-05 DE DE102007047737A patent/DE102007047737A1/de not_active Withdrawn
2008
- 2008-09-19 MX MX2010003366A patent/MX2010003366A/es not_active Application Discontinuation
- 2008-09-19 DK DK08802402.1T patent/DK2193118T3/da active
- 2008-09-19 EP EP11007349.1A patent/EP2426106B1/de not_active Not-in-force
- 2008-09-19 KR KR1020107009776A patent/KR20100075601A/ko not_active Ceased
- 2008-09-19 HR HRP20120802AT patent/HRP20120802T1/hr unknown
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- 2008-09-19 CN CN200880109583A patent/CN101808988A/zh active Pending
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- 2008-09-19 DK DK11007349.1T patent/DK2426106T3/da active
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- 2008-09-19 ES ES11007349T patent/ES2429843T3/es active Active
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2010
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2013
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Also Published As

Publication number	Publication date
EP2426106A1 (de)	2012-03-07
CN101808988A (zh)	2010-08-18
IL204562A0 (en)	2010-11-30
HRP20120802T1 (hr)	2012-11-30
DK2426106T3 (da)	2013-11-04
JP2014129427A (ja)	2014-07-10
US8791111B2 (en)	2014-07-29
WO2009046841A8 (de)	2010-01-21
SI2426106T1 (sl)	2013-10-30
PT2193118E (pt)	2012-11-02
WO2009046841A2 (de)	2009-04-16
JP5847226B2 (ja)	2016-01-20
EA017787B1 (ru)	2013-03-29
WO2009046841A3 (de)	2009-06-18
EP2426106B1 (de)	2013-07-31
AR068657A1 (es)	2009-11-25
ZA201003124B (en)	2011-04-28
DK2193118T3 (da)	2012-10-22
EA201000549A1 (ru)	2010-10-29
US8754097B2 (en)	2014-06-17
US20120316162A1 (en)	2012-12-13
EP2193118A2 (de)	2010-06-09
JP2010540579A (ja)	2010-12-24
JP5597538B2 (ja)	2014-10-01
CA2701519A1 (en)	2009-04-16
PL2193118T3 (pl)	2013-01-31
EP2193118B1 (de)	2012-08-22
KR20100075601A (ko)	2010-07-02
ES2392475T3 (es)	2012-12-11
MX2010003366A (es)	2010-04-30
CY1114574T1 (el)	2016-10-05
HRP20130929T1 (hr)	2013-11-08
AU2008310067A1 (en)	2009-04-16
DE102007047737A1 (de)	2009-04-30
CY1113757T1 (el)	2016-07-27
ES2429843T3 (es)	2013-11-18
BRPI0817644A2 (pt)	2015-03-31
AU2008310067B2 (en)	2013-09-26
CA2701519C (en)	2017-07-11
US20100222341A1 (en)	2010-09-02
SI2193118T1 (sl)	2012-12-31
PT2426106E (pt)	2013-11-07

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