PL2426106T3 - Pochodne piperydynowe i piperazynowe do leczenia nowotworów - Google Patents

Pochodne piperydynowe i piperazynowe do leczenia nowotworów

Info

Publication number
PL2426106T3
PL2426106T3 PL11007349T PL11007349T PL2426106T3 PL 2426106 T3 PL2426106 T3 PL 2426106T3 PL 11007349 T PL11007349 T PL 11007349T PL 11007349 T PL11007349 T PL 11007349T PL 2426106 T3 PL2426106 T3 PL 2426106T3
Authority
PL
Poland
Prior art keywords
tumours
piperidine
treatment
piperazine derivatives
piperazine
Prior art date
Application number
PL11007349T
Other languages
English (en)
Inventor
Kai Schiemann
Melanie Schultz
Andree Blaukat
Ingo Kober
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of PL2426106T3 publication Critical patent/PL2426106T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C07D249/18—Benzotriazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Indole Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PL11007349T 2007-10-05 2008-09-19 Pochodne piperydynowe i piperazynowe do leczenia nowotworów PL2426106T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102007047737A DE102007047737A1 (de) 2007-10-05 2007-10-05 Piperidin- und Piperazinderivate
EP08802402A EP2193118B1 (de) 2007-10-05 2008-09-19 Piperidin- und piperazinderivate zur behandlung von tumoren
EP11007349.1A EP2426106B1 (de) 2007-10-05 2008-09-19 Piperidin- und Piperazinderivate zur Behandlung von Tumoren

Publications (1)

Publication Number Publication Date
PL2426106T3 true PL2426106T3 (pl) 2013-11-29

Family

ID=40089983

Family Applications (2)

Application Number Title Priority Date Filing Date
PL11007349T PL2426106T3 (pl) 2007-10-05 2008-09-19 Pochodne piperydynowe i piperazynowe do leczenia nowotworów
PL08802402T PL2193118T3 (pl) 2007-10-05 2008-09-19 Pochodne piperydynowe i piperazynowe dla leczenia nowotworów

Family Applications After (1)

Application Number Title Priority Date Filing Date
PL08802402T PL2193118T3 (pl) 2007-10-05 2008-09-19 Pochodne piperydynowe i piperazynowe dla leczenia nowotworów

Country Status (22)

Country Link
US (2) US8791111B2 (pl)
EP (2) EP2193118B1 (pl)
JP (2) JP5597538B2 (pl)
KR (1) KR20100075601A (pl)
CN (1) CN101808988A (pl)
AR (1) AR068657A1 (pl)
AU (1) AU2008310067B2 (pl)
BR (1) BRPI0817644A2 (pl)
CA (1) CA2701519C (pl)
CY (2) CY1113757T1 (pl)
DE (1) DE102007047737A1 (pl)
DK (2) DK2193118T3 (pl)
EA (1) EA017787B1 (pl)
ES (2) ES2392475T3 (pl)
HR (2) HRP20120802T1 (pl)
IL (1) IL204562A0 (pl)
MX (1) MX2010003366A (pl)
PL (2) PL2426106T3 (pl)
PT (2) PT2193118E (pl)
SI (2) SI2426106T1 (pl)
WO (1) WO2009046841A2 (pl)
ZA (1) ZA201003124B (pl)

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Also Published As

Publication number Publication date
EA017787B1 (ru) 2013-03-29
US8754097B2 (en) 2014-06-17
CY1114574T1 (el) 2016-10-05
CN101808988A (zh) 2010-08-18
PT2426106E (pt) 2013-11-07
JP2010540579A (ja) 2010-12-24
AR068657A1 (es) 2009-11-25
WO2009046841A2 (de) 2009-04-16
DK2426106T3 (da) 2013-11-04
AU2008310067B2 (en) 2013-09-26
PT2193118E (pt) 2012-11-02
US8791111B2 (en) 2014-07-29
PL2193118T3 (pl) 2013-01-31
JP2014129427A (ja) 2014-07-10
DE102007047737A1 (de) 2009-04-30
KR20100075601A (ko) 2010-07-02
ES2392475T3 (es) 2012-12-11
EP2193118A2 (de) 2010-06-09
ZA201003124B (en) 2011-04-28
AU2008310067A1 (en) 2009-04-16
US20120316162A1 (en) 2012-12-13
JP5597538B2 (ja) 2014-10-01
BRPI0817644A2 (pt) 2015-03-31
SI2193118T1 (sl) 2012-12-31
CA2701519C (en) 2017-07-11
HRP20120802T1 (hr) 2012-11-30
US20100222341A1 (en) 2010-09-02
CY1113757T1 (el) 2016-07-27
WO2009046841A3 (de) 2009-06-18
IL204562A0 (en) 2010-11-30
EP2426106B1 (de) 2013-07-31
JP5847226B2 (ja) 2016-01-20
CA2701519A1 (en) 2009-04-16
WO2009046841A8 (de) 2010-01-21
EA201000549A1 (ru) 2010-10-29
EP2193118B1 (de) 2012-08-22
HRP20130929T1 (hr) 2013-11-08
SI2426106T1 (sl) 2013-10-30
EP2426106A1 (de) 2012-03-07
DK2193118T3 (da) 2012-10-22
MX2010003366A (es) 2010-04-30
ES2429843T3 (es) 2013-11-18

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