PL2440661T3 - Synteza hmo - Google Patents

Synteza hmo

Info

Publication number
PL2440661T3
PL2440661T3 PL09776698T PL09776698T PL2440661T3 PL 2440661 T3 PL2440661 T3 PL 2440661T3 PL 09776698 T PL09776698 T PL 09776698T PL 09776698 T PL09776698 T PL 09776698T PL 2440661 T3 PL2440661 T3 PL 2440661T3
Authority
PL
Poland
Prior art keywords
hmo
synthesis
hmo synthesis
Prior art date
Application number
PL09776698T
Other languages
English (en)
Inventor
Stefan Jennewein
Eric HÜFNER
Julia Parkot
Original Assignee
Jennewein Biotechnologie Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40941939&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2440661(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Jennewein Biotechnologie Gmbh filed Critical Jennewein Biotechnologie Gmbh
Publication of PL2440661T3 publication Critical patent/PL2440661T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
PL09776698T 2009-06-08 2009-06-08 Synteza hmo PL2440661T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/EP2009/004112 WO2010142305A1 (en) 2009-06-08 2009-06-08 Hmo synthesis
EP09776698.4A EP2440661B1 (en) 2009-06-08 2009-06-08 Hmo synthesis

Publications (1)

Publication Number Publication Date
PL2440661T3 true PL2440661T3 (pl) 2018-06-29

Family

ID=40941939

Family Applications (1)

Application Number Title Priority Date Filing Date
PL09776698T PL2440661T3 (pl) 2009-06-08 2009-06-08 Synteza hmo

Country Status (15)

Country Link
US (2) US8652808B2 (pl)
EP (1) EP2440661B1 (pl)
JP (1) JP5580408B2 (pl)
CN (2) CN106978382A (pl)
AU (1) AU2009347610B2 (pl)
BR (1) BRPI0924899B8 (pl)
DK (1) DK2440661T3 (pl)
ES (1) ES2660698T3 (pl)
MX (1) MX2011013231A (pl)
MY (1) MY182355A (pl)
NZ (1) NZ597129A (pl)
PL (1) PL2440661T3 (pl)
RU (1) RU2517602C2 (pl)
SG (1) SG176651A1 (pl)
WO (1) WO2010142305A1 (pl)

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* Cited by examiner, † Cited by third party
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PL2440661T3 (pl) * 2009-06-08 2018-06-29 Jennewein Biotechnologie Gmbh Synteza hmo
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CN102839157A (zh) * 2012-07-12 2012-12-26 扬州大学 稳定共表达hST3GalIV和β1-4GalT1的MDCK细胞系及构建方法和应用
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MY190346A (en) 2013-02-06 2022-04-15 Evolva Sa Methods for improved production of rebaudioside d and rebaudioside m
EP2954061B1 (en) 2013-02-11 2023-11-22 Evolva SA Efficient production of steviol glycosides in recombinant hosts
WO2014135167A1 (en) * 2013-03-08 2014-09-12 Glycom A/S Purification of oligosaccaharides by reversible derivatization
CN111172220B (zh) 2013-09-06 2023-08-04 格礼卡姆股份公司 寡糖的发酵生产
EP2845905B8 (en) * 2013-09-10 2021-07-14 Chr. Hansen HMO GmbH Production of oligosaccharides
EP2857410A1 (en) * 2013-10-04 2015-04-08 Jennewein Biotechnologie GmbH Process for purification of 2´-fucosyllactose using simulated moving bed chromatography
PL2896628T3 (pl) 2014-01-20 2019-03-29 Jennewein Biotechnologie Gmbh Sposób wydajnego oczyszczania obojętnych oligosacharydów ludzkiego mleka (HMO) z fermentacji mikrobiologicznej
EP2905341B1 (en) * 2014-02-07 2020-04-29 Jennewein Biotechnologie GmbH Methods for producing GDP-fucose using nucleotide sugar transporters and recombinant microorganism host cells used therefor
DK2927316T3 (en) 2014-03-31 2019-03-04 Jennewein Biotechnologie Gmbh Total fermentation of oligosaccharides
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CN108337892B (zh) 2015-01-30 2022-06-24 埃沃尔瓦公司 在重组宿主中生产甜菊醇糖苷
CN115851470B (zh) 2015-03-16 2025-09-02 帝斯曼知识产权资产管理有限公司 Udp-糖基转移酶
US10676723B2 (en) 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
WO2017025362A1 (en) * 2015-08-07 2017-02-16 Evolva Sa Production of steviol glycosides in recombinant hosts
EP3141610A1 (en) 2015-09-12 2017-03-15 Jennewein Biotechnologie GmbH Production of human milk oligosaccharides in microbial hosts with engineered import / export
US10982249B2 (en) 2016-04-13 2021-04-20 Evolva Sa Production of steviol glycosides in recombinant hosts
CN109312378A (zh) 2016-05-16 2019-02-05 埃沃尔瓦公司 在重组宿主中产生甜菊醇糖苷
CN106190937B9 (zh) * 2016-07-18 2020-12-01 南开大学 一种构建重组大肠杆菌生物合成2’-岩藻乳糖的方法
DK3315610T3 (da) 2016-10-29 2021-03-08 Jennewein Biotechnologie Gmbh Fremgangsmåde til fremstilling af fucosylerede oligosaccharider
EP3535406A1 (en) 2016-11-07 2019-09-11 Evolva SA Production of steviol glycosides in recombinant hosts
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
EP3604505A4 (en) * 2017-03-31 2020-02-19 Kaneka Corporation NOVEL MONOOXYGENASE AND USE THEREOF
EP3645545A4 (en) 2017-06-30 2021-05-05 Glycom A/S PURIFICATION OF OLIGOSACCHARIDES
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CN107805622B (zh) * 2017-11-08 2021-04-30 光明乳业股份有限公司 一种合成鸟苷二磷酸岩藻糖的重组枯草芽孢杆菌及其构建方法与应用
EP3486326A1 (en) 2017-11-21 2019-05-22 Jennewein Biotechnologie GmbH Method for the purification of n-acetylneuraminic acid from a fermentation broth
WO2019209241A1 (en) * 2018-04-23 2019-10-31 Dupont Nutrition Biosciences Aps Increasing export of 2' fucosyllactose from microbial cells through the expression of a heterologous nucleic acid
WO2019209245A1 (en) * 2018-04-23 2019-10-31 Dupont Nutrition Biosciences Aps Increasing activity of 2' fucosyllactose transporters endogenous to microbial cells
EP3569713A1 (en) * 2018-05-16 2019-11-20 Jennewein Biotechnologie GmbH Use of glycosidases in the production of oligosaccharides
CN109735479B (zh) * 2019-01-30 2022-04-01 光明乳业股份有限公司 一种合成2’-岩藻糖基乳糖的重组枯草芽孢杆菌及其构建方法与应用
EP3702468A1 (en) * 2019-03-01 2020-09-02 Jennewein Biotechnologie GmbH Fermentative production of carbohydrates by microbial cells utilizing a mixed feedstock
KR102254548B1 (ko) * 2019-04-26 2021-05-24 고려대학교 산학협력단 돌연변이 대장균을 이용한 콜라닉 산 생산
EP3751003A1 (en) 2019-06-12 2020-12-16 Jennewein Biotechnologie GmbH Production of fucosylated oligosaccharides in bacillus
KR20220035247A (ko) * 2019-07-19 2022-03-21 인바이오스 엔.브이. 숙주 세포에서 푸코실락토스의 제조
BR112022002584A2 (pt) * 2019-08-13 2022-08-09 Amyris Inc Célula de levedura, método para produzir um ou mais oligossacarídeos, composição de fermentação, método para recuperar um ou mais oligossacarídeos, método para modificar geneticamente uma célula de levedura
CN110396532A (zh) * 2019-08-23 2019-11-01 中国科学院合肥物质科学研究院 一种制备唾液酸乳糖的方法
KR20220080178A (ko) * 2019-10-14 2022-06-14 인바이오스 엔.브이. 숙주 세포에서 바이오산물의 생산
KR20220114632A (ko) * 2019-12-18 2022-08-17 인바이오스 엔.브이. 숙주 세포에서 시알릴화 올리고당의 생산
BR112022014367A2 (pt) 2020-01-23 2022-09-13 Glycom As Produção de hmo
AU2021209394A1 (en) 2020-01-23 2022-07-14 Glycom A/S HMO production
WO2021148610A1 (en) 2020-01-23 2021-07-29 Glycom A/S Hmo production
WO2021148620A1 (en) 2020-01-23 2021-07-29 Glycom A/S New major facilitator superfamily (mfs) protein (fred) in hmo production
EP4118089B1 (en) 2020-03-12 2026-02-25 Glycom A/S Crystallization of 2'-fl
EP3929300A1 (en) * 2020-06-26 2021-12-29 Chr. Hansen HMO GmbH Improved export of oligosaccharides from bacterial cells
DK180952B1 (en) 2020-12-22 2022-08-10 Glycom As A dfl-producing strain
JP2024505126A (ja) 2021-01-22 2024-02-05 グリコム・アクティーゼルスカブ シアル酸付加ｈｍｏの産生における新規の主要ファシリテータースーパーファミリー（ｍｆｓ）タンパク質（ｆｒｅｄ）
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DK181497B1 (en) 2021-05-17 2024-03-12 Dsm Ip Assets Bv ENHANCING FORMATION OF THE HMOS LNT AND/OR LNnT BY MODIFYING LACTOSE IMPORT IN THE CELL
DK181242B1 (en) 2021-05-17 2023-05-30 Dsm Ip Assets Bv GENETICALLY ENGINEERED CELLS COMPRISING A RECOMBINANT NUCLEIC ACID SEQUNCE ENCODING AN α-1,2-FUCOSYLTRANSFERASE CAPABLE OF PRODUCING LNFP-I, NUCLEIC ACID SEQUENCES ENCODING SAME AND METHODS FOR USE OF SAME
JP2024516207A (ja) 2021-05-17 2024-04-12 ディーエスエム アイピー アセッツ ビー．ブイ． インベルターゼ／スクロースヒドロラーゼを発現する微生物株
US20250051814A1 (en) 2021-12-21 2025-02-13 Kyowa Hakko Bio Co., Ltd. Method for producing sugar including lacto-n-triose ii as core trisaccharide and method for producing crystals of said sugar
CN115029371B (zh) * 2022-06-14 2024-01-02 大连工业大学 一种微生物生产的天然活性产物的高效分离方法
DK181765B1 (en) 2022-07-15 2024-12-04 Dsm Ip Assets Bv Cells expressing new fucosyltransferases for in vivo synthesis of lnfp-iii, and methods and uses of same
CN120018780A (zh) 2022-08-25 2025-05-16 帝斯曼知识产权资产管理有限公司 生产复杂hmo的混合方法
EP4623089A1 (en) 2022-11-25 2025-10-01 DSM IP Assets B.V. Two-strain system for producing oligosaccharides
WO2024175777A1 (en) 2023-02-24 2024-08-29 Dsm Ip Assets B.V. Product specific transporter for in vivo synthesis of human milk oligosaccharides
DK182227B1 (en) 2023-10-17 2025-12-18 Dsm Ip Assets Bv Genetically engineered cells comprising new fucosyltransferases for in vivo synthesis of complex fucosylated human milk oligosaccharides mixtures comprising lnfp-vi, methods using the same, and uses of new fucosyltransferases thereof.
WO2025190861A1 (en) 2024-03-11 2025-09-18 Dsm Ip Assets B.V. Fucosyltransferase mutants with low dfl formation
DK202430472A1 (en) 2024-08-19 2026-02-24 Dsm Ip Assets Bv Alpha-1,2 fucosyltransferase mutants with increased alpha 1,3-fucosyltransferase activity

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US6204431B1 (en) * 1994-03-09 2001-03-20 Abbott Laboratories Transgenic non-human mammals expressing heterologous glycosyltransferase DNA sequences produce oligosaccharides and glycoproteins in their milk
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RU2584599C2 (ru) 2008-12-19 2016-05-20 Дженневейн Биотехнологие Гмбх Синтез фукозилированных соединений
PL2440661T3 (pl) * 2009-06-08 2018-06-29 Jennewein Biotechnologie Gmbh Synteza hmo

Also Published As

Publication number Publication date
US20140120611A1 (en) 2014-05-01
ES2660698T3 (es) 2018-03-23
US8652808B2 (en) 2014-02-18
MY182355A (en) 2021-01-20
BRPI0924899A2 (pt) 2021-02-23
RU2011153792A (ru) 2013-07-20
US20120135467A1 (en) 2012-05-31
JP2012529274A (ja) 2012-11-22
BRPI0924899B1 (pt) 2022-03-22
EP2440661B1 (en) 2017-12-06
SG176651A1 (en) 2012-01-30
AU2009347610A1 (en) 2012-01-12
JP5580408B2 (ja) 2014-08-27
EP2440661A1 (en) 2012-04-18
RU2517602C2 (ru) 2014-05-27
WO2010142305A1 (en) 2010-12-16
NZ597129A (en) 2012-12-21
MX2011013231A (es) 2012-01-20
AU2009347610B2 (en) 2013-02-21
BRPI0924899B8 (pt) 2023-01-31
US9512433B2 (en) 2016-12-06
DK2440661T3 (en) 2018-03-12
CN106978382A (zh) 2017-07-25
CN102459605A (zh) 2012-05-16

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