PL2462118T3 - Sposób wytwarzania 1-benzylo-3-hydroksymetylo-1H-indazolu i jego pochodnych oraz potrzebnych magnezowych związków pośrednich - Google Patents

Sposób wytwarzania 1-benzylo-3-hydroksymetylo-1H-indazolu i jego pochodnych oraz potrzebnych magnezowych związków pośrednich

Info

Publication number: PL2462118T3
Authority: PL; Poland
Prior art keywords: indazole; hydroxymethyl; benzyl; derivatives; preparation
Prior art date: 2009-08-03

Application number

PL10735298T

Other languages

English (en)

Inventor

Torchiarolo Giuliano Caracciolo

Tommaso Iacoangeli

Guido Furlotti

Original Assignee

Acraf

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-08-03

Filing date

2010-07-28

Publication date

2014-10-31

2010-07-28 Application filed by Acraf filed Critical Acraf

2014-10-31 Publication of PL2462118T3 publication Critical patent/PL2462118T3/pl

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
- C07F3/02—Magnesium compounds

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Plural Heterocyclic Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

PL10735298T 2009-08-03 2010-07-28 Sposób wytwarzania 1-benzylo-3-hydroksymetylo-1H-indazolu i jego pochodnych oraz potrzebnych magnezowych związków pośrednich PL2462118T3 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP09425314		2009-08-03
PCT/EP2010/060941 WO2011015502A1 (en)	2009-08-03	2010-07-28	Process for the preparation of 1-benzyl-3-hydroxymethyl- 1h- indazole and its derivatives and required magnesium intermediates
EP10735298.1A EP2462118B1 (en)	2009-08-03	2010-07-28	Process for the preparation of 1-benzyl-3-hydroxymethyl-1H-indazole and its derivatives and required Magnesium intermediates

Publications (1)

Publication Number	Publication Date
PL2462118T3 true PL2462118T3 (pl)	2014-10-31

Family

ID=41353924

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
PL10739344T PL2462119T3 (pl)	2009-08-03	2010-07-28	Sposób wytwarzania 1-benzylo-3-hydroksymetylo-1H-indazolu i jego pochodnych oraz potrzebnych magnezowych związków pośrednich
PL10735298T PL2462118T3 (pl)	2009-08-03	2010-07-28	Sposób wytwarzania 1-benzylo-3-hydroksymetylo-1H-indazolu i jego pochodnych oraz potrzebnych magnezowych związków pośrednich

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
PL10739344T PL2462119T3 (pl)	2009-08-03	2010-07-28	Sposób wytwarzania 1-benzylo-3-hydroksymetylo-1H-indazolu i jego pochodnych oraz potrzebnych magnezowych związków pośrednich

Country Status (21)

Country	Link
US (2)	US8350052B2 (pl)
EP (2)	EP2462119B1 (pl)
JP (3)	JP5640086B2 (pl)
KR (2)	KR101736301B1 (pl)
CN (3)	CN102471281B (pl)
AR (2)	AR077667A1 (pl)
AU (1)	AU2010280828B2 (pl)
BR (2)	BR112012002130A2 (pl)
CA (2)	CA2765461C (pl)
DK (2)	DK2462119T3 (pl)
EA (2)	EA019060B1 (pl)
ES (2)	ES2480278T3 (pl)
GE (2)	GEP20135878B (pl)
IL (2)	IL216854A (pl)
MX (2)	MX2012001520A (pl)
PL (2)	PL2462119T3 (pl)
PT (2)	PT2462119E (pl)
SG (2)	SG176885A1 (pl)
SI (2)	SI2462118T1 (pl)
UA (2)	UA106988C2 (pl)
WO (2)	WO2011015501A1 (pl)

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MX2010009625A (es) *	2008-03-07	2010-09-28	Acraf	Derivados de 1-bencil-3-hidroximetilindazol y uso de los mismos en el tratamiento de enfermedades basadas en la expresion de mcp-1, cx3cr1 y p40.
JP2015521183A (ja)	2012-05-18	2015-07-27	サノフイ	ピリジン誘導体および病理学的血栓形成に関連する状態の治療へのその使用
DK2882715T3 (en)	2012-05-18	2017-02-13	Sanofi Sa	PYRAZOL DERIVATIVES AND USE THEREOF AS LPAR5 ANTAGONISTS
CN104876872B (zh) *	2015-04-24	2017-07-07	昆明理工大学	一种制备1‑叔丁氧基羰基‑3‑羟甲基吲唑的方法及应用
US20180221339A1 (en) *	2015-06-16	2018-08-09	Translatum Medicus, Inc.	Compositions and methods for treating and diagnosing ocular disorders
EP3990433B1 (en) *	2019-06-25	2026-05-20	Translatum Medicus Inc.	PROCESSES FOR THE MANUFACTURE OF 2-((1-BENZYL-1H-INDAZOL-3-YL)METHOXY)-2-METHYLPROPANOIC ACID AND ITS DERIVATIVES
CN113929627A (zh) *	2021-10-19	2022-01-14	吕梁学院	一种宾达利的合成方法

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GB860303A (en)	1958-06-20	1961-02-01	Ici Ltd	Pharmaceutical compositions comprising ª‡-aryloxy-aliphatic carboxylic acids and/or ª
GB8707051D0 (en) *	1986-04-15	1987-04-29	Ici America Inc	Heterocyclic carboxamides
IT1230441B (it)	1989-02-07	1991-10-23	Acraf	Eteri della serie dell'indazolo
IT1253703B (it)	1991-04-22	1995-08-23	Angelini Francesco Ist Ricerca	Uso di acidi metossi alcanoici dell'indazolo per preparare un farmaco attivo nel trattamento di malattie autoimmunitarie
JP3159614B2 (ja) *	1994-11-28	2001-04-23	三井化学株式会社	クロロアルキルアミン塩酸塩の製造法
IT1276031B1 (it)	1995-10-31	1997-10-24	Angelini Ricerche Spa	Composizione farmaceutica per il trattamento delle malattie autoimmuni
IT1293795B1 (it)	1997-07-28	1999-03-10	Angelini Ricerche Spa	Farmaco attivo nel ridurre la produzione di proteina mcp-1
JP2001081080A (ja) *	1999-09-14	2001-03-27	Nissan Chem Ind Ltd	４（５）−クロロメチル−２−フェニル−１，２，３−トリアゾール誘導体の製造法
GB0028367D0 (en) *	2000-11-21	2001-01-03	Celltech Chiroscience Ltd	Chemical compounds
JP2006137718A (ja)	2004-11-12	2006-06-01	Astellas Pharma Inc	インドール若しくはインダゾール誘導体
US7777035B2 (en) *	2005-06-22	2010-08-17	Chemocentryx, Inc.	Azaindazole compounds and methods of use
US20070010523A1 (en) *	2005-06-22	2007-01-11	Chemocentryx, Inc.	Azaindazole compounds and methods of use
US7858645B2 (en) *	2006-11-01	2010-12-28	Hoffmann-La Roche Inc.	Indazole derivatives
ITMI20062254A1 (it)	2006-11-24	2008-05-25	Acraf	Uso di un acido metossi-alcanoico dell'indazolo per preparare una composizione farmaceutca
EP2134683A2 (en) *	2007-02-12	2009-12-23	Intermune, Inc.	Novel inhibitors hepatitis c virus replication
MX2009012525A (es) *	2007-05-25	2009-12-09	Elan Pharm Inc	Pirazol-pirrolidinas como inhibidores de gamma secretasa.
AR072657A1 (es) *	2008-02-29	2010-09-15	Genentech Inc	Compuestos inhibidores de raf y metodos para su uso
DK2254869T3 (en)	2008-03-07	2017-09-04	Acraf	1-BENZYL-3-HYDROXYMETHYL INDAZOLE DERIVATIVES AND USE THEREOF IN THE TREATMENT OF DISEASES BASED ON THE EXPRESSION OF CX3CR1 AND P40

2010
- 2010-07-28 BR BR112012002130A patent/BR112012002130A2/pt not_active Application Discontinuation
- 2010-07-28 KR KR1020127001575A patent/KR101736301B1/ko not_active Expired - Fee Related
- 2010-07-28 GE GEAP201012610A patent/GEP20135878B/en unknown
- 2010-07-28 JP JP2012523288A patent/JP5640086B2/ja not_active Expired - Fee Related
- 2010-07-28 CN CN201080034391.9A patent/CN102471281B/zh not_active Expired - Fee Related
- 2010-07-28 DK DK10739344.9T patent/DK2462119T3/da active
- 2010-07-28 WO PCT/EP2010/060937 patent/WO2011015501A1/en not_active Ceased
- 2010-07-28 ES ES10739344.9T patent/ES2480278T3/es active Active
- 2010-07-28 ES ES10735298.1T patent/ES2481393T3/es active Active
- 2010-07-28 US US13/381,137 patent/US8350052B2/en not_active Expired - Fee Related
- 2010-07-28 BR BRBR112012001731-4A patent/BR112012001731A2/pt not_active Application Discontinuation
- 2010-07-28 EP EP10739344.9A patent/EP2462119B1/en not_active Not-in-force
- 2010-07-28 MX MX2012001520A patent/MX2012001520A/es active IP Right Grant
- 2010-07-28 SG SG2011093309A patent/SG176885A1/en unknown
- 2010-07-28 PL PL10739344T patent/PL2462119T3/pl unknown
- 2010-07-28 PL PL10735298T patent/PL2462118T3/pl unknown
- 2010-07-28 CA CA2765461A patent/CA2765461C/en not_active Expired - Fee Related
- 2010-07-28 US US13/377,588 patent/US8354544B2/en not_active Expired - Fee Related
- 2010-07-28 WO PCT/EP2010/060941 patent/WO2011015502A1/en not_active Ceased
- 2010-07-28 CN CN2010800344095A patent/CN102471282A/zh active Pending
- 2010-07-28 EP EP10735298.1A patent/EP2462118B1/en not_active Not-in-force
- 2010-07-28 KR KR1020127002338A patent/KR101735577B1/ko not_active Expired - Fee Related
- 2010-07-28 SG SG2011095023A patent/SG176950A1/en unknown
- 2010-07-28 SI SI201030728T patent/SI2462118T1/sl unknown
- 2010-07-28 AU AU2010280828A patent/AU2010280828B2/en not_active Ceased
- 2010-07-28 UA UAA201115300A patent/UA106988C2/uk unknown
- 2010-07-28 CA CA2766235A patent/CA2766235C/en not_active Expired - Fee Related
- 2010-07-28 PT PT107393449T patent/PT2462119E/pt unknown
- 2010-07-28 PT PT107352981T patent/PT2462118E/pt unknown
- 2010-07-28 EA EA201270236A patent/EA019060B1/ru not_active IP Right Cessation
- 2010-07-28 DK DK10735298.1T patent/DK2462118T3/da active
- 2010-07-28 GE GEAP201012611A patent/GEP20135879B/en unknown
- 2010-07-28 CN CN201610870938.8A patent/CN106518769A/zh active Pending
- 2010-07-28 JP JP2012523289A patent/JP6200153B2/ja not_active Expired - Fee Related
- 2010-07-28 SI SI201030729T patent/SI2462119T1/sl unknown
- 2010-07-28 EA EA201270237A patent/EA019672B1/ru not_active IP Right Cessation
- 2010-07-28 UA UAA201115299A patent/UA106886C2/uk unknown
- 2010-07-28 MX MX2012001519A patent/MX2012001519A/es active IP Right Grant
- 2010-08-02 AR ARP100102815A patent/AR077667A1/es unknown
- 2010-08-02 AR ARP100102816A patent/AR077668A1/es unknown
2011
- 2011-12-08 IL IL216854A patent/IL216854A/en not_active IP Right Cessation
- 2011-12-20 IL IL217097A patent/IL217097A/en not_active IP Right Cessation
2015
- 2015-06-09 JP JP2015116951A patent/JP2015205900A/ja active Pending

Also Published As

Publication number	Publication date
JP6200153B2 (ja)	2017-09-20
SI2462119T1 (sl)	2014-10-30
CA2766235A1 (en)	2011-02-10
AU2010280827A8 (en)	2016-04-07
MX2012001520A (es)	2012-06-01
GEP20135878B (en)	2013-07-10
UA106886C2 (uk)	2014-10-27
GEP20135879B (en)	2013-07-10
BR112012002130A2 (pt)	2015-09-15
PT2462118E (pt)	2014-07-25
KR101736301B1 (ko)	2017-05-29
SG176950A1 (en)	2012-02-28
KR20120071380A (ko)	2012-07-02
SI2462118T1 (sl)	2014-10-30
US20120184752A1 (en)	2012-07-19
JP2013501019A (ja)	2013-01-10
SG176885A1 (en)	2012-01-30
IL216854A (en)	2016-02-29
IL216854A0 (en)	2012-02-29
DK2462118T3 (da)	2014-08-25
AU2010280828A1 (en)	2012-01-19
DK2462119T3 (da)	2014-09-01
CA2766235C (en)	2017-04-04
KR101735577B1 (ko)	2017-05-15
AR077667A1 (es)	2011-09-14
EP2462118A1 (en)	2012-06-13
JP5640086B2 (ja)	2014-12-10
AU2010280828B2 (en)	2016-02-25
UA106988C2 (uk)	2014-11-10
EA019672B1 (ru)	2014-05-30
CA2765461C (en)	2017-04-11
MX2012001519A (es)	2012-06-01
WO2011015501A1 (en)	2011-02-10
CN102471281B (zh)	2014-10-15
PL2462119T3 (pl)	2014-10-31
CN106518769A (zh)	2017-03-22
US20120149912A1 (en)	2012-06-14
IL217097A (en)	2014-02-27
JP2015205900A (ja)	2015-11-19
US8350052B2 (en)	2013-01-08
EA201270236A1 (ru)	2012-09-28
CN102471282A (zh)	2012-05-23
EP2462119B1 (en)	2014-06-11
AU2010280827B2 (en)	2016-02-25
CA2765461A1 (en)	2011-02-10
EA019060B1 (ru)	2013-12-30
ES2480278T3 (es)	2014-07-25
EP2462118B1 (en)	2014-06-11
EP2462119A1 (en)	2012-06-13
HK1165408A1 (en)	2012-10-05
CN102471281A (zh)	2012-05-23
BR112012001731A2 (pt)	2015-09-01
PT2462119E (pt)	2014-07-25
WO2011015502A1 (en)	2011-02-10
ES2481393T3 (es)	2014-07-30
EA201270237A1 (ru)	2012-12-28
IL217097A0 (en)	2012-02-29
HK1165409A1 (en)	2012-10-05
US8354544B2 (en)	2013-01-15
AU2010280827A1 (en)	2012-01-12
JP2013501020A (ja)	2013-01-10
KR20120042871A (ko)	2012-05-03
AR077668A1 (es)	2011-09-14

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