PL2463368T3 - Humanizowane przeciwciało anty-oligomer amyloidu B - Google Patents

Humanizowane przeciwciało anty-oligomer amyloidu B

Info

Publication number
PL2463368T3
PL2463368T3 PL10806566T PL10806566T PL2463368T3 PL 2463368 T3 PL2463368 T3 PL 2463368T3 PL 10806566 T PL10806566 T PL 10806566T PL 10806566 T PL10806566 T PL 10806566T PL 2463368 T3 PL2463368 T3 PL 2463368T3
Authority
PL
Poland
Prior art keywords
amyloid
humanized anti
oligomer antibody
oligomer
antibody
Prior art date
Application number
PL10806566T
Other languages
English (en)
Inventor
Tsuguo Kubota
Nobuyuki Suzuki
Original Assignee
Kyowa Hakko Kirin Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kirin Co., Ltd. filed Critical Kyowa Hakko Kirin Co., Ltd.
Publication of PL2463368T3 publication Critical patent/PL2463368T3/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10Cells modified by introduction of foreign genetic material

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
PL10806566T 2009-08-07 2010-08-06 Humanizowane przeciwciało anty-oligomer amyloidu B PL2463368T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23203809P 2009-08-07 2009-08-07
EP10806566.5A EP2463368B1 (en) 2009-08-07 2010-08-06 Humanized anti-amyloid-b oligomer antibody
PCT/JP2010/063430 WO2011016567A1 (ja) 2009-08-07 2010-08-06 抗アミロイドβオリゴマーヒト化抗体

Publications (1)

Publication Number Publication Date
PL2463368T3 true PL2463368T3 (pl) 2018-07-31

Family

ID=43544461

Family Applications (1)

Application Number Title Priority Date Filing Date
PL10806566T PL2463368T3 (pl) 2009-08-07 2010-08-06 Humanizowane przeciwciało anty-oligomer amyloidu B

Country Status (16)

Country Link
US (2) US8333967B2 (pl)
EP (1) EP2463368B1 (pl)
JP (1) JP5051806B2 (pl)
KR (1) KR101787118B1 (pl)
CN (1) CN102597234B (pl)
AU (1) AU2010279892B8 (pl)
BR (1) BR112012002819B1 (pl)
CA (1) CA2769464C (pl)
DK (1) DK2463368T3 (pl)
ES (1) ES2661601T3 (pl)
HU (1) HUE036392T2 (pl)
MX (1) MX2012001708A (pl)
PL (1) PL2463368T3 (pl)
PT (1) PT2463368T (pl)
SG (1) SG177679A1 (pl)
WO (1) WO2011016567A1 (pl)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6683602B2 (ja) * 2014-04-16 2020-04-22 協和キリン株式会社 ヒトcsfの毒性を測定する方法
EP3404040B1 (en) * 2016-01-12 2022-03-02 National University Corporation Chiba University Anti-myl9 antibody
CN107118260B (zh) * 2017-05-12 2020-10-16 中国科学院过程工程研究所 一种多肽及其组成的疫苗和应用
JP7368856B2 (ja) 2017-07-25 2023-10-25 トゥルーバインディング,インコーポレイテッド Tim-3とそのリガンドとの相互作用の遮断によるがん治療
US12016885B2 (en) * 2018-11-06 2024-06-25 Alsatech, Inc. Method of solubilizing TDP-43 protein aggregates in amyotrophic lateral sclerosis using a microvascular endothelial cell expressing an anti-TDP-43 Fab
CN120058944A (zh) 2019-01-30 2025-05-30 真和制药有限公司 抗gal3抗体及其用途
CA3185040A1 (en) 2020-05-26 2021-12-02 Truebinding, Inc. Methods of treating inflammatory diseases by blocking galectin-3
TW202300517A (zh) 2021-03-12 2023-01-01 美商美國禮來大藥廠 抗類澱粉β抗體及其用途
WO2022251048A1 (en) 2021-05-24 2022-12-01 Eli Lilly And Company Anti-amyloid beta antibodies and uses thereof
CN117586388A (zh) * 2022-08-09 2024-02-23 深圳智源生物医药有限公司 改进的β淀粉样蛋白寡聚体特异性结合抗体

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02257891A (ja) 1989-03-31 1990-10-18 Kyowa Hakko Kogyo Co Ltd 組換え動物細胞による蛋白質の製造
US6018032A (en) 1995-09-11 2000-01-25 Kyowa Hakko Kogyo Co., Ltd. Antibody against human interleukin-5-receptor α chain
US20030068316A1 (en) * 1997-02-05 2003-04-10 Klein William L. Anti-ADDL antibodies and uses thereof
US6218506B1 (en) 1997-02-05 2001-04-17 Northwestern University Amyloid β protein (globular assembly and uses thereof)
US6528624B1 (en) 1998-04-02 2003-03-04 Genentech, Inc. Polypeptide variants
US20050059591A1 (en) * 1998-04-07 2005-03-17 Neuralab Limited Prevention and treatment of amyloidogenic disease
US6737056B1 (en) 1999-01-15 2004-05-18 Genentech, Inc. Polypeptide variants with altered effector function
EP2264166B1 (en) 1999-04-09 2016-03-23 Kyowa Hakko Kirin Co., Ltd. Method for controlling the activity of immunologically functional molecule
HU231090B1 (hu) 2000-10-06 2020-07-28 Kyowa Kirin Co., Ltd. Antitest-kompozíciót termelő sejt
US7317091B2 (en) 2002-03-01 2008-01-08 Xencor, Inc. Optimized Fc variants
US20080241884A1 (en) 2003-10-08 2008-10-02 Kenya Shitara Fused Protein Composition
NZ579543A (en) * 2004-07-09 2011-07-29 Chugai Pharmaceutical Co Ltd Anti-glypican 3 antibody
JP3806883B2 (ja) 2004-09-28 2006-08-09 ダイキン工業株式会社 空気調和装置
BRPI0516962A (pt) 2004-10-25 2008-09-30 Univ Northwestern anticorpo isolado, ou fragmento do mesmo, composição farmacêutica, métodos para prevenir a ligação de ligantes difundìveis derivados de abeta a um neurÈnio, para inibir a constituição de ligantes difundìveis, para bloquear a fosforilação de proteìna, para tratar profilaticamente ou terapeuticamente uma doença, para identificar um agente terapêutico, para detectar ligantes difundìveis, e para diagnosticar uma doença, e, kit para detectar ligantes difundìveis
CN101137394A (zh) * 2004-10-25 2008-03-05 默克制药公司 抗addl抗体及其应用
WO2006075668A1 (ja) 2005-01-12 2006-07-20 Kirin Beer Kabushiki Kaisha 安定化されたヒトIgG2およびIgG3抗体
US7700099B2 (en) 2005-02-14 2010-04-20 Merck & Co., Inc. Non-immunostimulatory antibody and compositions containing the same
US7923538B2 (en) 2005-07-22 2011-04-12 Kyowa Hakko Kirin Co., Ltd Recombinant antibody composition
EP2210901A4 (en) * 2007-10-19 2012-04-25 Immunas Pharma Inc FOR THE SPECIFIC BINDING TO AN OLIGOMICALLY ABLE ANTIBODY AND ITS USE
PT2246427T (pt) * 2008-02-08 2017-03-03 Immunas Pharma Inc Anticorpos capazes de se ligar especificamente a oligómeros beta amilóides e a sua utilização
TWI629483B (zh) * 2010-06-11 2018-07-11 協和醱酵麒麟有限公司 anti-TIM-3 antibody

Also Published As

Publication number Publication date
KR101787118B1 (ko) 2017-10-18
SG177679A1 (en) 2012-02-28
US20130095526A1 (en) 2013-04-18
PT2463368T (pt) 2018-02-08
JPWO2011016567A1 (ja) 2013-01-17
CA2769464C (en) 2017-11-21
US8333967B2 (en) 2012-12-18
CN102597234A (zh) 2012-07-18
MX2012001708A (es) 2012-05-22
HUE036392T2 (hu) 2018-07-30
ES2661601T3 (es) 2018-04-02
DK2463368T3 (en) 2018-01-22
EP2463368A1 (en) 2012-06-13
EP2463368A9 (en) 2012-11-28
RU2012108610A (ru) 2013-09-20
BR112012002819B1 (pt) 2022-11-22
AU2010279892A8 (en) 2014-09-25
US20120009179A1 (en) 2012-01-12
CA2769464A1 (en) 2011-02-10
WO2011016567A1 (ja) 2011-02-10
EP2463368B1 (en) 2018-01-10
JP5051806B2 (ja) 2012-10-17
CN102597234B (zh) 2014-10-29
AU2010279892B8 (en) 2014-09-25
EP2463368A4 (en) 2013-09-18
AU2010279892B2 (en) 2014-05-22
US9181332B2 (en) 2015-11-10
AU2010279892A1 (en) 2012-02-09
BR112012002819A2 (pt) 2017-07-11
KR20120038474A (ko) 2012-04-23

Similar Documents

Publication Publication Date Title
ZA201104545B (en) Anti-siglec-15 antibody
IL217919A0 (en) Humanized anti-cdcp1 antibodies
ZA201106480B (en) Humanized anti-cd19 antibody formulations
IL220404A (en) Antiseptic antibodies
IL214996A0 (en) Anti-bcma antibodies
GB0920127D0 (en) Antibodies
GB0909906D0 (en) Antibodies
PL2581113T3 (pl) Przeciwciało anty-tim-3
PL2530091T3 (pl) Przeciwciało przeciwko dll3
PL2616489T3 (pl) Przeciwciało anty-huTNFR1
EP2463369A4 (en) HUMANIZED ANTIBODIES AGAINST AMYLOID B OLIGOMERS
EP2427496A4 (en) ANTI-VEGF-D ANTIBODIES
ZA201202227B (en) Monoclonal antibodies
PL2636736T3 (pl) Nowe przeciwciało anty-dr5
HUE036392T2 (hu) Humanizált anti-amiloid ß oligomer antitest
GB0920324D0 (en) Antibodies
GB0905972D0 (en) Antibodies against IL-17BR
EP2499256A4 (en) ANTI-C-MPL ANTIBODIES
GB2473934B (en) Anti-VEEV antibody
GB201007957D0 (en) Antibody
GB0911712D0 (en) Antibody
GB0804684D0 (en) Humanized antibody
GB0804686D0 (en) Humanized antibody
GB0804687D0 (en) Humanized antibody
GB0908945D0 (en) Antibodies