PL2473048T3 - Pozytywne modulatory allosteryczne receptora M1 piranyloarylometylobenzochinazolinonowe - Google Patents
Pozytywne modulatory allosteryczne receptora M1 piranyloarylometylobenzochinazolinonoweInfo
- Publication number
- PL2473048T3 PL2473048T3 PL10812601T PL10812601T PL2473048T3 PL 2473048 T3 PL2473048 T3 PL 2473048T3 PL 10812601 T PL10812601 T PL 10812601T PL 10812601 T PL10812601 T PL 10812601T PL 2473048 T3 PL2473048 T3 PL 2473048T3
- Authority
- PL
- Poland
- Prior art keywords
- positive allosteric
- receptor positive
- allosteric modulators
- aryl methyl
- methyl benzoquinazolinone
- Prior art date
Links
- 230000003281 allosteric effect Effects 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23845709P | 2009-08-31 | 2009-08-31 | |
| EP10812601.2A EP2473048B1 (en) | 2009-08-31 | 2010-08-26 | Pyranyl aryl methyl benzoquinazolinone m1 receptor positive allosteric modulators |
| PCT/US2010/046733 WO2011025851A1 (en) | 2009-08-31 | 2010-08-26 | Pyranyl aryl methyl benzoquinazolinone m1 receptor positive allosteric modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2473048T3 true PL2473048T3 (pl) | 2015-08-31 |
Family
ID=43628378
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL10812601T PL2473048T3 (pl) | 2009-08-31 | 2010-08-26 | Pozytywne modulatory allosteryczne receptora M1 piranyloarylometylobenzochinazolinonowe |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US8846702B2 (pl) |
| EP (2) | EP2473048B1 (pl) |
| JP (1) | JP5658255B2 (pl) |
| KR (1) | KR101651312B1 (pl) |
| CN (1) | CN102480964B (pl) |
| AU (1) | AU2010286683B9 (pl) |
| BR (1) | BR112012003464B8 (pl) |
| CA (1) | CA2770480C (pl) |
| CO (1) | CO6501188A2 (pl) |
| CY (1) | CY1116452T1 (pl) |
| DK (1) | DK2473048T3 (pl) |
| ES (1) | ES2537979T3 (pl) |
| HK (1) | HK1208225A1 (pl) |
| HR (1) | HRP20150572T1 (pl) |
| HU (1) | HUE026296T2 (pl) |
| IL (1) | IL217638A (pl) |
| ME (1) | ME02151B (pl) |
| MX (1) | MX2012002583A (pl) |
| MY (1) | MY160075A (pl) |
| NZ (1) | NZ598462A (pl) |
| PL (1) | PL2473048T3 (pl) |
| PT (1) | PT2473048E (pl) |
| RS (1) | RS54051B1 (pl) |
| RU (1) | RU2507204C2 (pl) |
| SI (1) | SI2473048T1 (pl) |
| WO (1) | WO2011025851A1 (pl) |
| ZA (1) | ZA201201205B (pl) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG181719A1 (en) | 2009-12-17 | 2012-07-30 | Schering Corp | Quinoline amide m1 receptor positive allosteric modulators |
| WO2011159553A1 (en) | 2010-06-15 | 2011-12-22 | Merck Sharp & Dohme Corp. | Heterocyclic fused phenanthrolinone m1 receptor positive allosteric modulators |
| WO2011159554A1 (en) | 2010-06-15 | 2011-12-22 | Merck Sharp & Dohme Corp. | Tetrahydroquinoline amide m1 receptor positive allosteric modulators |
| EP2588104B1 (en) | 2010-07-01 | 2014-12-10 | Merck Sharp & Dohme Corp. | Isoindolone m1 receptor positive allosteric modulators |
| US9284312B2 (en) | 2011-05-17 | 2016-03-15 | Merck Sharp & Dohme Corp. | N-methyl tetrahydroquinoline M1 receptor positive allosteric modulators |
| WO2013129622A1 (ja) | 2012-03-02 | 2013-09-06 | 武田薬品工業株式会社 | 複素環化合物およびその用途 |
| JP6211530B2 (ja) | 2012-11-19 | 2017-10-11 | 武田薬品工業株式会社 | 含窒素複素環化合物 |
| GB201317363D0 (en) | 2013-10-01 | 2013-11-13 | Eisai Ltd | Novel compounds |
| KR20180019234A (ko) * | 2015-06-26 | 2018-02-23 | 다케다 야쿠힌 고교 가부시키가이샤 | 콜린성 무스카린 m1 수용체의 조절제로서의 2,3-디히드로-4h-1,3-벤족사진-4-온 유도체 |
| EA033826B1 (ru) * | 2015-09-10 | 2019-11-29 | Suven Life Sciences Ltd | Производные фториндола в качестве положительных аллостерических модуляторов мускаринового рецептора m1 |
| US10548899B2 (en) | 2015-10-20 | 2020-02-04 | Takeda Pharmaceutical Company Limited | Quinazolinone and benzotriazinone compounds with cholinergic muscarinin M1 receptor positive allosteric modulator activity |
| WO2017151449A1 (en) * | 2016-03-04 | 2017-09-08 | Merck Sharp & Dohme Corp. | M1 receptor positive allosteric modulator compounds and methods of use thereof |
| JP7145875B2 (ja) * | 2017-04-18 | 2022-10-03 | 武田薬品工業株式会社 | アセチルコリン受容体のモジュレーターとして有用な複素環化合物 |
| KR102811811B1 (ko) | 2018-09-28 | 2025-05-22 | 다케다 야쿠힌 고교 가부시키가이샤 | 헤테로시클릭 화합물 |
| WO2025104624A1 (en) * | 2023-11-14 | 2025-05-22 | Pfizer Inc. | Synthesis of 1,5-anhydro-3-({5-chloro-4-[4-fluoro-2-(2-hydroxypropan-2-yl)-1-(propan-2-yl)-1h-benzimidazol-6-yl]pyrimidin-2-yl}amino)-2,3-dideoxy-d-threo-pentitol |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8003A (en) * | 1851-03-25 | Improvement in scythe-tastenings | ||
| CA2220509C (en) | 1995-05-31 | 2005-07-05 | Eisai Co., Ltd. | Fused polycyclic heterocycle derivatives |
| CA2372173A1 (en) | 1999-04-30 | 2000-11-09 | Pfizer Products Inc. | Glucocorticoid receptor modulators |
| US20030176454A1 (en) * | 2000-05-15 | 2003-09-18 | Akira Yamada | N-coating heterocyclic compounds |
| US20060233843A1 (en) | 2003-02-19 | 2006-10-19 | Conn P J | Treatment of psychosis with a muscarinic m1 receptor ectopic activator |
| ATE530544T1 (de) * | 2006-06-28 | 2011-11-15 | Merck Sharp & Dohme | Benzyl-substituierte positive allosterische chinolon-m1-rezeptormodulatoren |
| WO2008011032A1 (en) * | 2006-07-17 | 2008-01-24 | Amgen Inc. | Quinazoline and pyridopyrimidine derivatives as p38 kinase inhibitors |
| KR101593242B1 (ko) * | 2007-09-26 | 2016-02-11 | 셀진 코포레이션 | ６-, ７- 또는 ８-치환된 퀴나졸리논 유도체, 및 그를 포함하는 조성물 및 그의 사용 방법 |
| BRPI0921924A2 (pt) * | 2008-11-20 | 2015-12-29 | Merck Sharp & Dohme | composto, composição farmacêutica, uso de uma composição farmacêutica, e de um composto, e, método de tratamento de uma doença ou distúrbio mediado pelo receptor m1 muscarínico |
| JP2012518640A (ja) * | 2009-02-23 | 2012-08-16 | メルク・シャープ・エンド・ドーム・コーポレイション | ピラゾロ［４，３−ｃ］シンノリン−３−オンＭ１受容体陽性アロステリックモジュレーター |
| US8293744B2 (en) | 2009-04-20 | 2012-10-23 | Merck Sharp & Dohme Corp. | Heterocyclic fused cinnoline M1 receptor positive allosteric modulators |
| WO2011041143A1 (en) | 2009-10-01 | 2011-04-07 | Merck Sharp & Dohme Corp. | HETEROCYCLIC-FUSED PYRAZOLO[4,3-c]PYRIDIN-3-ONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS |
| EP2490692B1 (en) | 2009-10-21 | 2016-11-16 | Merck Sharp & Dohme Corp. | Quinolinone-pyrazolone m1 receptor positive allosteric modulators |
| WO2011075371A1 (en) | 2009-12-14 | 2011-06-23 | Merck Sharp & Dohme Corp. | Pyridoquinazolinone m1 receptor positive allosteric modulators |
| GB0921949D0 (en) | 2009-12-16 | 2010-02-03 | Fujifilm Mfg Europe Bv | Curable compositions and membranes |
| US8507494B2 (en) | 2010-04-30 | 2013-08-13 | Merck Sharp & Dohme Corp. | Heterocyclic quinolizine derived M1 receptor positive allosteric modulators |
-
2010
- 2010-08-26 EP EP10812601.2A patent/EP2473048B1/en active Active
- 2010-08-26 NZ NZ598462A patent/NZ598462A/xx not_active IP Right Cessation
- 2010-08-26 KR KR1020127005167A patent/KR101651312B1/ko not_active Expired - Fee Related
- 2010-08-26 RS RS20150383A patent/RS54051B1/sr unknown
- 2010-08-26 SI SI201030940T patent/SI2473048T1/sl unknown
- 2010-08-26 WO PCT/US2010/046733 patent/WO2011025851A1/en not_active Ceased
- 2010-08-26 AU AU2010286683A patent/AU2010286683B9/en not_active Ceased
- 2010-08-26 MX MX2012002583A patent/MX2012002583A/es active IP Right Grant
- 2010-08-26 BR BR112012003464A patent/BR112012003464B8/pt not_active IP Right Cessation
- 2010-08-26 RU RU2012112064/04A patent/RU2507204C2/ru active
- 2010-08-26 HU HUE10812601A patent/HUE026296T2/en unknown
- 2010-08-26 CN CN201080038600.7A patent/CN102480964B/zh not_active Expired - Fee Related
- 2010-08-26 US US13/392,647 patent/US8846702B2/en active Active
- 2010-08-26 JP JP2012526961A patent/JP5658255B2/ja not_active Expired - Fee Related
- 2010-08-26 CA CA2770480A patent/CA2770480C/en active Active
- 2010-08-26 EP EP15159929.7A patent/EP2915812A1/en not_active Withdrawn
- 2010-08-26 ES ES10812601.2T patent/ES2537979T3/es active Active
- 2010-08-26 HR HRP20150572TT patent/HRP20150572T1/hr unknown
- 2010-08-26 MY MYPI2012000722A patent/MY160075A/en unknown
- 2010-08-26 ME MEP-2015-86A patent/ME02151B/me unknown
- 2010-08-26 DK DK10812601.2T patent/DK2473048T3/en active
- 2010-08-26 PL PL10812601T patent/PL2473048T3/pl unknown
- 2010-08-26 PT PT108126012T patent/PT2473048E/pt unknown
-
2012
- 2012-01-19 IL IL217638A patent/IL217638A/en not_active IP Right Cessation
- 2012-02-17 ZA ZA2012/01205A patent/ZA201201205B/en unknown
- 2012-02-24 CO CO12033021A patent/CO6501188A2/es active IP Right Grant
-
2015
- 2015-06-19 CY CY20151100527T patent/CY1116452T1/el unknown
- 2015-09-11 HK HK15108922.9A patent/HK1208225A1/en unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ZA201201205B (en) | Pyranyl aryl methyl benzoquinazolinone m1 receptor positive allosteric modulators | |
| IL212573A0 (en) | Aryl methyl benzoquinazolinone m1 receptor positive allosteric modulators | |
| ZA201204313B (en) | Quinoline amide m1 receptor positive allosteric modulators | |
| EP2501231A4 (en) | POSITIVE ALLOSTERIC CHINOLIZIDINONE CARBOXAMIDE M1 RECEPTOR MODULATORS | |
| EP2490692A4 (en) | CHINOLINONE PYRAZOLON M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | |
| ZA201404270B (en) | Dosage regimen of an s1p receptor modulator | |
| HUE049460T2 (hu) | Heterociklusos vegyület és annak alkalmazása ampa receptor pozitív allosztérikus modulátorként | |
| EP2521515A4 (en) | ORAL ORTHOSIS | |
| GB201004739D0 (en) | Receptor modulators | |
| EP2624697A4 (en) | POSITIVE ALLOSTERIC DIHYDROBENZOCHINAZOLINONE M1 RECEPTOR MODULATORS | |
| ZA201108646B (en) | A novel formulation of indomethacin | |
| EP2512245A4 (en) | POSITIVE ALLOSTERIC PYRIDOCHINOLICIDIDINE M1 RECEPTOR MODULATORS | |
| SI2297100T1 (sl) | Tetrahidrociklopenta(b)indoli kot modulatorji androgenskega receptorja | |
| EP2543336A4 (en) | ARTICULATOR | |
| IL221287A0 (en) | Bidet apparatus | |
| IL231783A0 (en) | History of ethinyl as allosteric modulators of 5mglur | |
| EP2252151A4 (en) | POSITIVE ALLOSTERIC CHINOLIZIDINONE M1 RECEPTOR MODULATORS | |
| ZA201303950B (en) | Glucagon receptor modulators | |
| EP2340247A4 (en) | POSITIVE ALLOSTERIC MODULATORS OF THE CHINOLIZIDINONE M1 RECEPTOR | |
| GB0907445D0 (en) | Photoresponsive devices | |
| GB2474086B (en) | A fixing device for a cavity wall | |
| TWI370607B (en) | Vibrator | |
| GB201018035D0 (en) | Centrifuge concrete proforma | |
| PL384551A1 (pl) | Urządzenie do zalewania form | |
| HK1168031A (en) | Dosage regimen of an s1p receptor modulator |