PL2477967T3 - Proces przygotowania estru metylowego kwasu 3-[(4S)-8-bromo-1-metylo-6-(2-pirydynylo)-4 H-imidazo[1,2-a][1,4]benzodiazepin-4-ylo] propionowego lub jego soli benzenosulfonianowej i związki użyteczne w tym procesie - Google Patents
Proces przygotowania estru metylowego kwasu 3-[(4S)-8-bromo-1-metylo-6-(2-pirydynylo)-4 H-imidazo[1,2-a][1,4]benzodiazepin-4-ylo] propionowego lub jego soli benzenosulfonianowej i związki użyteczne w tym procesieInfo
- Publication number
- PL2477967T3 PL2477967T3 PL10760917T PL10760917T PL2477967T3 PL 2477967 T3 PL2477967 T3 PL 2477967T3 PL 10760917 T PL10760917 T PL 10760917T PL 10760917 T PL10760917 T PL 10760917T PL 2477967 T3 PL2477967 T3 PL 2477967T3
- Authority
- PL
- Poland
- Prior art keywords
- benzodiazepine
- imidazo
- pyridinyl
- bromo
- preparing
- Prior art date
Links
- SRSXLGNVWSONIS-UHFFFAOYSA-N benzenesulfonic acid Chemical class OS(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- CYHWMBVXXDIZNZ-KRWDZBQOSA-N methyl 3-[(4s)-8-bromo-1-methyl-6-pyridin-2-yl-4h-imidazo[1,2-a][1,4]benzodiazepin-4-yl]propanoate Chemical compound N([C@H](C1=NC=C(C)N1C1=CC=C(Br)C=C11)CCC(=O)OC)=C1C1=CC=CC=N1 CYHWMBVXXDIZNZ-KRWDZBQOSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/46—Oxygen atoms
- C07D213/50—Ketonic radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09011914A EP2305647A1 (en) | 2009-09-18 | 2009-09-18 | Process for preparing 3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4 H-imidazo[1,2-a][1,4]benzodiazepine-4-yl] propionic acid methyl ester or the benzene sulfonate salt thereof, and compounds useful in that process |
| PCT/EP2010/005668 WO2011032692A1 (en) | 2009-09-18 | 2010-09-15 | Process for preparing 3-[(4s)-8-bromo-1-methyl-6-(2-pyridinyl)-4h-imidazol[1,2-a][1,4]benzodiazepine-4-yl]propionic acid methyl ester or the benzene sulfonate salt thereof, and compounds useful in that process |
| EP10760917.4A EP2477967B1 (en) | 2009-09-18 | 2010-09-15 | Process for preparing 3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4 H-imidazo[1,2-a][1,4]benzodiazepine-4-yl] propionic acid methyl ester or the benzene sulfonate salt thereof, and compounds useful in that process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2477967T3 true PL2477967T3 (pl) | 2016-04-29 |
Family
ID=41467237
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL10760917T PL2477967T3 (pl) | 2009-09-18 | 2010-09-15 | Proces przygotowania estru metylowego kwasu 3-[(4S)-8-bromo-1-metylo-6-(2-pirydynylo)-4 H-imidazo[1,2-a][1,4]benzodiazepin-4-ylo] propionowego lub jego soli benzenosulfonianowej i związki użyteczne w tym procesie |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US9156842B2 (pl) |
| EP (2) | EP2305647A1 (pl) |
| JP (1) | JP5801309B2 (pl) |
| KR (1) | KR101801735B1 (pl) |
| CN (1) | CN102753525B (pl) |
| AU (1) | AU2010294873B2 (pl) |
| BR (1) | BR112012006053B1 (pl) |
| CA (1) | CA2774018C (pl) |
| DK (1) | DK2477967T3 (pl) |
| ES (1) | ES2555233T3 (pl) |
| HR (1) | HRP20151316T1 (pl) |
| HU (1) | HUE028298T2 (pl) |
| MX (2) | MX341093B (pl) |
| PL (1) | PL2477967T3 (pl) |
| PT (1) | PT2477967E (pl) |
| RU (1) | RU2551848C2 (pl) |
| WO (1) | WO2011032692A1 (pl) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0714886B8 (pt) | 2006-07-10 | 2021-05-25 | Paion Uk Ltd | sais de benzodiazepina, seus usos e seus processos de preparação, e composição farmacêutica |
| EP2305647A1 (en) | 2009-09-18 | 2011-04-06 | PAION UK Limited | Process for preparing 3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4 H-imidazo[1,2-a][1,4]benzodiazepine-4-yl] propionic acid methyl ester or the benzene sulfonate salt thereof, and compounds useful in that process |
| EP2450039A1 (en) | 2010-11-08 | 2012-05-09 | PAION UK Ltd. | Dosing regimen for sedation with CNS 7056 (Remimazolam) |
| CN102964349A (zh) * | 2011-08-31 | 2013-03-13 | 江苏恒瑞医药股份有限公司 | 苯并二氮杂*衍生物的托西酸盐及其多晶型、它们的制备方法和用途 |
| AU2013309860B2 (en) | 2012-08-31 | 2017-12-21 | Paion Uk Limited | Method for administering hypnotic/sedative agent |
| AR094963A1 (es) | 2013-03-04 | 2015-09-09 | Ono Pharmaceutical Co | Reacción de oxidación excelente en el índice de conversión |
| CN103232454A (zh) * | 2013-05-05 | 2013-08-07 | 王元青 | 治疗精神疾病的药物 |
| CN103230595B (zh) * | 2013-05-05 | 2014-10-08 | 李友香 | 治疗精神疾病的组合物 |
| CN105726495B (zh) * | 2014-12-12 | 2019-03-29 | 宜昌人福药业有限责任公司 | 一种注射用短效苯并二氮杂卓盐药物组合物及其制备方法 |
| CN106892924B (zh) * | 2015-12-17 | 2021-01-08 | 四川科伦博泰生物医药股份有限公司 | 短效苯并二氮*衍生物、其制备方法及其用途 |
| CN107266452A (zh) * | 2016-04-08 | 2017-10-20 | 四川科伦药物研究院有限公司 | 苯并二氮杂*衍生物的盐及其晶体形式、制备方法和用途 |
| US20190175613A1 (en) | 2016-04-14 | 2019-06-13 | Paion Uk Limited | Orally inhaled and nasal benzodiazepines |
| CN108264499B (zh) * | 2017-01-04 | 2020-10-20 | 江苏恒瑞医药股份有限公司 | 一种苯并二氮杂*衍生物的制备方法 |
| WO2018148361A1 (en) | 2017-02-09 | 2018-08-16 | Watson Laboratories Inc. | Process for the preparation of remimazolam and solid state forms of remimazolam salts |
| ES2697918A1 (es) | 2017-07-28 | 2019-01-29 | Moehs Iberica Sl | Procedimiento para preparar ester metilico del acido 3-[(3s)-7-bromo-2-oxo-5-(piridin-2-il)-2,3-dihidro-1h-[1,4]-benzodiazepin-3-il] propionico, y compuestos utiles en ese procedimiento |
| ES2709298B2 (es) | 2017-10-13 | 2019-08-21 | Moehs Iberica Sl | Procedimiento para preparar metil ester de acido 3-[(4s)-8-bromo-1-metil-6-(piridin-2-il)-4h-imidazo[1,2-a][1,4]benzodiazepin-4-il]-propionico, y compuestos utiles en ese procedimiento |
| CN108033964B (zh) * | 2017-12-28 | 2021-02-09 | 杭州奥默医药股份有限公司 | 一种吡啶基咪唑并苯并二氮杂卓丙酸酯化合物及其合成和应用 |
| ES2827125A1 (es) * | 2019-11-19 | 2021-05-19 | Moehs Iberica Sl | Intermedio util en la preparacion de remimazolam, su procedimiento de obtencion, y su uso en la obtencion de remimazolam |
| KR102526590B1 (ko) * | 2020-06-19 | 2023-04-28 | 하나제약 주식회사 | 3-[(4S)-8-브로모-1-메틸-6-(2-피리디닐)-4H-이미다조[1,2-a][1,4]벤조디아제핀-4-일]프로피온산 메틸 에스테르의 제조방법 |
| CN112358483A (zh) * | 2020-11-09 | 2021-02-12 | 中国药科大学 | 一类新型苯并二氮*类化合物、其制备方法及其用途 |
| CN112321594B (zh) * | 2020-12-07 | 2022-05-20 | 扬子江药业集团有限公司 | 一种苯并二氮杂䓬类药物的制备方法 |
| CN114644612B (zh) * | 2020-12-17 | 2023-04-28 | 成都苑东生物制药股份有限公司 | 一种苯二氮杂类神经抑制剂中间体化合物的制备方法 |
| CN113717176B (zh) * | 2021-10-09 | 2022-07-05 | 上海再启生物技术有限公司 | 一种制备瑞马唑仑的方法 |
| CN116253761A (zh) * | 2021-12-10 | 2023-06-13 | 宜昌人福药业有限责任公司 | 一种制备瑞马唑仑o-磷酰化中间体的方法 |
| CN114014839A (zh) * | 2021-12-16 | 2022-02-08 | 上海再启生物技术有限公司 | 一种制备瑞马唑仑关键中间体的方法 |
| EP4504731A1 (en) | 2022-04-08 | 2025-02-12 | Fresenius Kabi Oncology Ltd | An improved process for the preparation of remimazolam |
| CN115385891A (zh) * | 2022-09-06 | 2022-11-25 | 上海药坦药物研究开发有限公司 | 一种瑞马唑仑中间体的制备方法 |
| CN115974835B (zh) * | 2022-12-16 | 2025-02-28 | 湖南复瑞生物医药技术有限责任公司 | 一种瑞吗唑仑关键中间体的合成方法 |
| KR102728217B1 (ko) * | 2023-05-23 | 2024-11-12 | 하나제약 주식회사 | 고효율의 레미마졸람 베실산염 제조방법 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6440959B1 (en) | 1999-04-21 | 2002-08-27 | Hoffman-La Roche Inc. | Pyrazolobenzodiazepines |
| GB9911152D0 (en) | 1999-05-14 | 1999-07-14 | Glaxo Group Ltd | Short-acting benzodiazepines |
| BRPI0517418A (pt) * | 2004-10-13 | 2008-10-07 | Merck & Co Inc | composto, composição farmacêutica, e, métodos para antagonismo de atividade do receptor de cgrp em um mamìfero, para tratar, controlar, melhorar ou reduzir o risco de dor de cabeça, enxaqueca ou cefalgia, e de tratamento ou prevenção de dores de cabeça de enxaqueca, cefalgias, e dores de cabeça |
| JP2008526984A (ja) | 2005-01-18 | 2008-07-24 | メルク エンド カムパニー インコーポレーテッド | Ｃｇｒｐ受容体拮抗薬 |
| GB0613692D0 (en) * | 2006-07-10 | 2006-08-16 | Cenes Ltd | Benzodiazepine salts |
| BRPI0714886B8 (pt) | 2006-07-10 | 2021-05-25 | Paion Uk Ltd | sais de benzodiazepina, seus usos e seus processos de preparação, e composição farmacêutica |
| GB0613693D0 (en) | 2006-07-10 | 2006-08-16 | Cenes Ltd | Benzodiazepine salts (3) |
| HUE032273T2 (en) * | 2007-05-22 | 2017-09-28 | Chemocentryx Inc | 3-Imidazolyl-pyrazolo [3,4-b] pyridines |
| WO2009145323A1 (ja) | 2008-05-30 | 2009-12-03 | 日産化学工業株式会社 | 多環式化合物を用いるアルコールの酸化方法 |
| EP2346506A1 (en) | 2008-10-16 | 2011-07-27 | Paion UK Limited | Administration scheme of polar opioid metabolites for post-operative pain management |
| JP4669584B2 (ja) | 2009-03-30 | 2011-04-13 | 日本製紙株式会社 | Ｎ−オキシル化合物の回収・再利用方法 |
| EP2305647A1 (en) | 2009-09-18 | 2011-04-06 | PAION UK Limited | Process for preparing 3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4 H-imidazo[1,2-a][1,4]benzodiazepine-4-yl] propionic acid methyl ester or the benzene sulfonate salt thereof, and compounds useful in that process |
| JP5635275B2 (ja) | 2010-01-28 | 2014-12-03 | 日清紡ホールディングス株式会社 | アルコールの酸化方法 |
| EP2450039A1 (en) | 2010-11-08 | 2012-05-09 | PAION UK Ltd. | Dosing regimen for sedation with CNS 7056 (Remimazolam) |
| PE20150683A1 (es) | 2012-05-22 | 2015-06-03 | Paion Uk Ltd | Composiciones que comprenden benzodiazepinas de accion corta |
| AU2013309860B2 (en) | 2012-08-31 | 2017-12-21 | Paion Uk Limited | Method for administering hypnotic/sedative agent |
| AR094963A1 (es) | 2013-03-04 | 2015-09-09 | Ono Pharmaceutical Co | Reacción de oxidación excelente en el índice de conversión |
-
2009
- 2009-09-18 EP EP09011914A patent/EP2305647A1/en not_active Withdrawn
-
2010
- 2010-09-15 PT PT107609174T patent/PT2477967E/pt unknown
- 2010-09-15 US US13/496,742 patent/US9156842B2/en active Active
- 2010-09-15 WO PCT/EP2010/005668 patent/WO2011032692A1/en not_active Ceased
- 2010-09-15 HU HUE10760917A patent/HUE028298T2/en unknown
- 2010-09-15 JP JP2012529154A patent/JP5801309B2/ja active Active
- 2010-09-15 MX MX2015018057A patent/MX341093B/es unknown
- 2010-09-15 DK DK10760917.4T patent/DK2477967T3/en active
- 2010-09-15 AU AU2010294873A patent/AU2010294873B2/en not_active Ceased
- 2010-09-15 CN CN201080049975.3A patent/CN102753525B/zh active Active
- 2010-09-15 MX MX2012003183A patent/MX337683B/es active IP Right Grant
- 2010-09-15 HR HRP20151316TT patent/HRP20151316T1/hr unknown
- 2010-09-15 RU RU2012115456/04A patent/RU2551848C2/ru active
- 2010-09-15 PL PL10760917T patent/PL2477967T3/pl unknown
- 2010-09-15 CA CA2774018A patent/CA2774018C/en active Active
- 2010-09-15 ES ES10760917.4T patent/ES2555233T3/es active Active
- 2010-09-15 EP EP10760917.4A patent/EP2477967B1/en active Active
- 2010-09-15 KR KR1020127009891A patent/KR101801735B1/ko active Active
- 2010-09-15 BR BR112012006053-8A patent/BR112012006053B1/pt active IP Right Grant
-
2015
- 2015-09-01 US US14/841,899 patent/US9512078B2/en active Active
-
2016
- 2016-10-27 US US15/336,143 patent/US10000464B2/en active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PT2477967E (pt) | Processo para a preparação de éster metílico do ácido 3-[(4s)-8-bromo-1-metil-6-(2-piridinil)-4h-imidazo[1,2-a][1,4]benzodiazepina-4-il]propiónico ou seu o sal sulfonato de benzeno, e compostos úteis nesse processo | |
| IL192907A0 (en) | Heterocycles as nicotinic acid receptor agonists for the treatment of dyslipidemia | |
| ZA200903646B (en) | Carboxylic acid derivatives | |
| IL210246A0 (en) | Carboxylic acid compounds and pharmaceutical containing the same | |
| IL197852A0 (en) | Methods, compounds, compositions and vehicles for delivering 3-amino-1-propanesulfonic acid | |
| ZA200902912B (en) | Process for preparing 2-amino-5-cyanobenzoic acid derivatives | |
| PL2124944T3 (pl) | Pochodne pirazolo[3,4-b]pirydyny jako inhibitory fosfodiesterazy | |
| IL210835A0 (en) | Processes for the preparation of 4-oxo-octahydro-indole-1-carboxylic acid methyl ester and derivatives thereof | |
| ZA201106628B (en) | Process for the preparation of propionic acid derivatives | |
| EP2124891A4 (en) | CILOSTAZOL-CONTAINING PREPARATION WITH CONTROLLED RELEASE AND METHOD FOR THE PRODUCTION THEREOF | |
| EG25838A (en) | Process for the preparation of amino acid methyl esters | |
| ZA201003507B (en) | Novel naphthyridine derivative monohydrate and method for producing the same | |
| IL184592A0 (en) | Process for the preparation of boronic acids and derivatives thereof | |
| GB2464854B (en) | Process for the preparation of risperidone | |
| PL2132161T3 (pl) | Sposób nitrowania podstawionych benzenów w obecności kwasu propionowego | |
| GB0600712D0 (en) | Process for the manufacture of substituted propionic acids | |
| IL220015A0 (en) | Process for the preparation of propionic acid derivatives | |
| ZA200709777B (en) | Heterocycles as nicotinic acid receptor agonists for the treatment of dyslipidemia | |
| HK1123299A (en) | Heterocycles as nicotinic acid receptor agonists for the treatment of dyyslipidemia | |
| AU2007905798A0 (en) | alpha-Cyclopropyl-alpha-Amino Carboxylic Acid Compounds and Methods for their Preparation | |
| HK1114386A (en) | Heterocycles as nicotinic acid receptor agonists for the treatment of dyslipidemia | |
| GB0714815D0 (en) | Pyrazolo[3,4-b]pyridine compounds, and their use as PDE4 inhibitors | |
| AU2008903868A0 (en) | Process for Controlled Homogeneous Acid Leaching | |
| GB0817909D0 (en) | Process for the preparation of ortho amino-substituted aromatic carboxylic acids | |
| HK1144902A (en) | Antibody-containing formulation for the use for treating cardiovascular diseases associated with atherosclerosis |