PL2479174T3 - Pochodne 6-aminochinazoliny lub 3-cyjanochinoliny, sposoby ich otrzymywania i farmaceutyczne zastosowanie - Google Patents
Pochodne 6-aminochinazoliny lub 3-cyjanochinoliny, sposoby ich otrzymywania i farmaceutyczne zastosowanieInfo
- Publication number
- PL2479174T3 PL2479174T3 PL10814867T PL10814867T PL2479174T3 PL 2479174 T3 PL2479174 T3 PL 2479174T3 PL 10814867 T PL10814867 T PL 10814867T PL 10814867 T PL10814867 T PL 10814867T PL 2479174 T3 PL2479174 T3 PL 2479174T3
- Authority
- PL
- Poland
- Prior art keywords
- preparation methods
- quinoline derivatives
- pharmaceutical uses
- amino quinazoline
- cyano quinoline
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title 1
- XFGPXURFKAUHQR-UHFFFAOYSA-N quinazolin-6-amine Chemical compound N1=CN=CC2=CC(N)=CC=C21 XFGPXURFKAUHQR-UHFFFAOYSA-N 0.000 title 1
- QZZYYBQGTSGDPP-UHFFFAOYSA-N quinoline-3-carbonitrile Chemical class C1=CC=CC2=CC(C#N)=CN=C21 QZZYYBQGTSGDPP-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/60—Quinoline or hydrogenated quinoline ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
- C07F9/65128—Six-membered rings having the nitrogen atoms in positions 1 and 3 condensed with carbocyclic rings or carbocyclic ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009101958233A CN102020639A (zh) | 2009-09-14 | 2009-09-14 | 6-氨基喹唑啉或3-氰基喹啉类衍生物、其制备方法及其在医药上的应用 |
| EP10814867.7A EP2479174B1 (en) | 2009-09-14 | 2010-08-26 | 6-amino quinazoline or 3-cyano quinoline derivatives, preparation methods and pharmaceutical uses thereof |
| PCT/CN2010/001293 WO2011029265A1 (zh) | 2009-09-14 | 2010-08-26 | 6-氨基喹唑啉或3-氰基喹啉类衍生物、其制备方法及其在医药上的应用 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2479174T3 true PL2479174T3 (pl) | 2018-02-28 |
Family
ID=43731939
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL10814867T PL2479174T3 (pl) | 2009-09-14 | 2010-08-26 | Pochodne 6-aminochinazoliny lub 3-cyjanochinoliny, sposoby ich otrzymywania i farmaceutyczne zastosowanie |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US8901140B2 (pl) |
| EP (1) | EP2479174B1 (pl) |
| JP (1) | JP5684811B2 (pl) |
| KR (1) | KR101738191B1 (pl) |
| CN (2) | CN102020639A (pl) |
| AU (1) | AU2010292790B2 (pl) |
| BR (1) | BR112012005760A2 (pl) |
| CA (1) | CA2774099C (pl) |
| DK (1) | DK2479174T3 (pl) |
| ES (1) | ES2647829T3 (pl) |
| HR (1) | HRP20171748T1 (pl) |
| HU (1) | HUE035873T2 (pl) |
| LT (1) | LT2479174T (pl) |
| MX (1) | MX2012002875A (pl) |
| NO (1) | NO2479174T3 (pl) |
| PL (1) | PL2479174T3 (pl) |
| PT (1) | PT2479174T (pl) |
| RU (1) | RU2536102C2 (pl) |
| SI (1) | SI2479174T1 (pl) |
| WO (1) | WO2011029265A1 (pl) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102020639A (zh) | 2009-09-14 | 2011-04-20 | 上海恒瑞医药有限公司 | 6-氨基喹唑啉或3-氰基喹啉类衍生物、其制备方法及其在医药上的应用 |
| CN102675287A (zh) * | 2011-03-11 | 2012-09-19 | 江苏恒瑞医药股份有限公司 | (e)-n-[4-[[3-氯-4-(2-吡啶基甲氧基)苯基]氨基]-3-氰基-7-乙氧基-6-喹啉基]-3-[(2r)-1-甲基吡咯烷-2-基]丙-2-烯酰胺的可药用的盐、其制备方法及其在医药上的应用 |
| CN103717590B (zh) * | 2011-05-17 | 2016-05-11 | 江苏康缘药业股份有限公司 | 喹唑啉-7-醚化合物及使用方法 |
| JP6437820B2 (ja) * | 2011-07-27 | 2018-12-12 | シャンハイ ファーマシューティカルズ ホールディング カンパニー，リミティド | キナゾリン誘導体、その製造方法、中間体、組成物及びその適用 |
| CN103987700B (zh) * | 2012-03-09 | 2016-08-31 | 江苏豪森药业集团有限公司 | 4-喹唑啉胺类衍生物及其用途 |
| CN103539783A (zh) | 2012-07-12 | 2014-01-29 | 江苏恒瑞医药股份有限公司 | 一种酪氨酸激酶抑制剂的二马来酸盐的i型结晶及制备方法 |
| CN103588755B (zh) * | 2012-08-17 | 2016-06-22 | 正大天晴药业集团股份有限公司 | Neratinib的制备方法 |
| CN103965120B (zh) * | 2013-01-25 | 2016-08-17 | 上海医药集团股份有限公司 | 喹啉及喹唑啉衍生物、制备方法、中间体、组合物及应用 |
| CN104119350B (zh) | 2013-04-28 | 2017-04-12 | 广东东阳光药业有限公司 | 氨基喹唑啉类衍生物及其盐和使用方法 |
| EP3081563B1 (en) | 2013-12-12 | 2018-09-19 | Tianjin Hemay Oncology Pharmaceutical Co., Ltd | Quinazoline derivative and salts thereof for use in the treatment of cancer |
| CN106068262B (zh) * | 2014-04-11 | 2019-10-29 | 海思科医药集团股份有限公司 | 喹唑啉衍生物及其制备方法和在医药上的应用 |
| SI3378479T1 (sl) | 2016-01-27 | 2020-10-30 | Jiangsu Hengrui Medicine Co., Ltd. | Postopek za pripravo farmacevtskega sestavka, ki obsega derivat kinolina ali njegovo sol |
| WO2017129087A1 (zh) | 2016-01-27 | 2017-08-03 | 江苏恒瑞医药股份有限公司 | 一种含有喹啉衍生物或其盐的药物组合物 |
| CN112426424A (zh) * | 2016-01-28 | 2021-03-02 | 江苏恒瑞医药股份有限公司 | 一种egfr/her2受体酪氨酸激酶抑制剂在制备治疗her2突变癌症药物中的用途 |
| CN105777604A (zh) * | 2016-04-14 | 2016-07-20 | 上海凯宝药业股份有限公司 | 一种n-甲基-反式-4-羟基-l-脯氨酸晶体化合物及其制备方法 |
| BR112018071617A2 (pt) * | 2016-04-28 | 2019-02-19 | Jiangsu Hengrui Medicine Co., Ltd. | método para preparar inibidor de tirosina quinase e derivado do mesmo |
| CN106008471B (zh) * | 2016-05-25 | 2019-09-03 | 江苏医诺万细胞诊疗有限公司 | 一种喹唑啉类化合物的合成方法 |
| CN107868059B (zh) * | 2016-09-23 | 2022-07-19 | 上海医药集团股份有限公司 | 一种喹唑啉衍生物的盐、其制备方法及应用 |
| TW201813644A (zh) * | 2016-09-23 | 2018-04-16 | 江蘇恆瑞醫藥股份有限公司 | 酪胺酸激酶抑制劑在製備治療癌症藥物中的用途 |
| CN106565692A (zh) * | 2016-11-03 | 2017-04-19 | 常茂生物化学工程股份有限公司 | 一种阿法替尼合成工艺的改进方法 |
| TW201827050A (zh) * | 2017-01-22 | 2018-08-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | Ｅｇｆｒ／ｈｅｒ２抑制劑聯合嘧啶類抗代謝藥物的用途 |
| CN109963846A (zh) * | 2017-08-07 | 2019-07-02 | 江苏恒瑞医药股份有限公司 | 一种酪氨酸激酶抑制剂的二马来酸盐的晶型及其制备方法 |
| US11578074B2 (en) | 2017-09-01 | 2023-02-14 | Shanghai Pharmaceuticals Holding Cd., Ltd. | Nitrogenous heterocyclic compound, preparation method, intermediate, composition, and application |
| AU2018351539A1 (en) * | 2017-10-18 | 2020-05-28 | Jiangsu Hengrui Medicine Co., Ltd. | Preparation method for tyrosine kinase inhibitor and intermediate thereof |
| US11701349B2 (en) | 2017-10-24 | 2023-07-18 | Jiangsu Hengrui Medicine Co., Ltd. | Pharmaceutical composition containing quinoline derivative |
| WO2019080889A1 (zh) * | 2017-10-26 | 2019-05-02 | 江苏恒瑞医药股份有限公司 | 抗csf-1r抗体、其抗原结合片段及其医药用途 |
| CN108314639B (zh) * | 2018-05-09 | 2019-04-30 | 山东铂源药业有限公司 | 化合物（e）-3-（1-甲基吡咯烷-2-基）-丙烯酸盐酸盐及合成方法 |
| CN110840892A (zh) * | 2018-08-21 | 2020-02-28 | 江苏恒瑞医药股份有限公司 | 酪氨酸激酶抑制剂与cdk4/6抑制剂联合在制备预防或治疗肿瘤疾病的药物中的用途 |
| CN110960529A (zh) * | 2018-09-30 | 2020-04-07 | 江苏恒瑞医药股份有限公司 | 一种降低了毒性杂质含量的酪氨酸激酶抑制剂的原料药 |
| CN112566904A (zh) | 2018-10-22 | 2021-03-26 | 江苏恒瑞医药股份有限公司 | 一种酪氨酸激酶抑制剂的一马来酸盐的晶型及其制备方法 |
| US20220040324A1 (en) | 2018-12-21 | 2022-02-10 | Daiichi Sankyo Company, Limited | Combination of antibody-drug conjugate and kinase inhibitor |
| CN112279838B (zh) | 2020-10-29 | 2021-07-13 | 苏州富士莱医药股份有限公司 | 一种吡咯替尼的制备方法 |
| CN112694439B (zh) * | 2020-12-31 | 2022-08-30 | 河南省医药科学研究院 | 苯基丙烯酰胺基喹啉类衍生物及其制备方法和用途 |
| CN112625025B (zh) * | 2020-12-31 | 2022-03-29 | 河南省医药科学研究院 | 吡啶基取代的喹啉类衍生物及其制备方法和用途 |
| CN112759583B (zh) * | 2020-12-31 | 2022-10-11 | 河南省医药科学研究院 | 包含呋喃基的喹啉类衍生物及其制备方法和用途 |
| US20240246934A1 (en) * | 2021-03-19 | 2024-07-25 | Beijing Scitech-Mq Pharmaceuticals Limited | Quinazoline-based compound, composition, and application of quinazoline-based compound |
| WO2023061472A1 (zh) * | 2021-10-14 | 2023-04-20 | 江苏恒瑞医药股份有限公司 | 抗her2抗体药物偶联物和酪氨酸激酶抑制剂联合在制备治疗肿瘤的药物中的用途 |
| WO2024187321A1 (zh) * | 2023-03-10 | 2024-09-19 | 甫康（上海）健康科技有限责任公司 | 含有egfr抑制剂的药物组合物及其制备方法和应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA73073C2 (uk) * | 1997-04-03 | 2005-06-15 | Уайт Холдінгз Корпорейшн | Заміщені 3-ціанохіноліни, спосіб їх одержання та фармацевтична композиція |
| PL201475B1 (pl) | 1998-09-29 | 2009-04-30 | Wyeth Corp | Podstawione 3-cyjanochinoliny jako inhibitory białkowych kinaz tyrozynowych |
| WO2001077104A1 (de) * | 2000-04-08 | 2001-10-18 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Bicyclische heterocyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung |
| US7019012B2 (en) | 2000-12-20 | 2006-03-28 | Boehringer Ingelheim International Pharma Gmbh & Co. Kg | Quinazoline derivatives and pharmaceutical compositions containing them |
| DE10217689A1 (de) | 2002-04-19 | 2003-11-13 | Boehringer Ingelheim Pharma | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, ihre Verwendung und Verfahren zu ihrer Herstellung |
| US20040044014A1 (en) * | 2002-04-19 | 2004-03-04 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for the preparation thereof |
| DE10307165A1 (de) * | 2003-02-20 | 2004-09-02 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, ihre Verwendung und Verfahren zu ihrer Herstellung |
| US7399865B2 (en) | 2003-09-15 | 2008-07-15 | Wyeth | Protein tyrosine kinase enzyme inhibitors |
| KR100832594B1 (ko) | 2005-11-08 | 2008-05-27 | 한미약품 주식회사 | 다중저해제로서의 퀴나졸린 유도체 및 이의 제조방법 |
| CN101824029A (zh) * | 2009-03-05 | 2010-09-08 | 厦门艾德生物医药科技有限公司 | 酪氨酸激酶不可逆抑制剂、其药物组合物及其用途 |
| CN102020639A (zh) | 2009-09-14 | 2011-04-20 | 上海恒瑞医药有限公司 | 6-氨基喹唑啉或3-氰基喹啉类衍生物、其制备方法及其在医药上的应用 |
-
2009
- 2009-09-14 CN CN2009101958233A patent/CN102020639A/zh active Pending
-
2010
- 2010-08-26 NO NO10814867A patent/NO2479174T3/no unknown
- 2010-08-26 MX MX2012002875A patent/MX2012002875A/es active IP Right Grant
- 2010-08-26 EP EP10814867.7A patent/EP2479174B1/en active Active
- 2010-08-26 WO PCT/CN2010/001293 patent/WO2011029265A1/zh not_active Ceased
- 2010-08-26 SI SI201031574T patent/SI2479174T1/sl unknown
- 2010-08-26 AU AU2010292790A patent/AU2010292790B2/en active Active
- 2010-08-26 ES ES10814867.7T patent/ES2647829T3/es active Active
- 2010-08-26 PL PL10814867T patent/PL2479174T3/pl unknown
- 2010-08-26 KR KR1020127009554A patent/KR101738191B1/ko active Active
- 2010-08-26 JP JP2012528211A patent/JP5684811B2/ja active Active
- 2010-08-26 CA CA2774099A patent/CA2774099C/en active Active
- 2010-08-26 DK DK10814867.7T patent/DK2479174T3/da active
- 2010-08-26 BR BR112012005760A patent/BR112012005760A2/pt not_active Application Discontinuation
- 2010-08-26 RU RU2012110882/04A patent/RU2536102C2/ru active
- 2010-08-26 CN CN201080030048.7A patent/CN102471312B/zh active Active
- 2010-08-26 US US13/395,892 patent/US8901140B2/en active Active
- 2010-08-26 PT PT108148677T patent/PT2479174T/pt unknown
- 2010-08-26 LT LTEP10814867.7T patent/LT2479174T/lt unknown
- 2010-08-26 HU HUE10814867A patent/HUE035873T2/en unknown
- 2010-08-26 HR HRP20171748TT patent/HRP20171748T1/hr unknown
-
2014
- 2014-12-01 US US14/556,792 patent/US9358227B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| BR112012005760A2 (pt) | 2016-02-16 |
| CA2774099C (en) | 2017-07-04 |
| JP2013504521A (ja) | 2013-02-07 |
| RU2536102C2 (ru) | 2014-12-20 |
| DK2479174T3 (da) | 2017-11-27 |
| CN102471312A (zh) | 2012-05-23 |
| CN102471312B (zh) | 2014-06-18 |
| EP2479174A4 (en) | 2013-04-17 |
| US20120165352A1 (en) | 2012-06-28 |
| KR101738191B1 (ko) | 2017-05-19 |
| AU2010292790B2 (en) | 2015-03-26 |
| HUE035873T2 (en) | 2018-05-28 |
| HK1163081A1 (en) | 2012-09-07 |
| US9358227B2 (en) | 2016-06-07 |
| US8901140B2 (en) | 2014-12-02 |
| RU2012110882A (ru) | 2013-11-10 |
| MX2012002875A (es) | 2012-04-20 |
| PT2479174T (pt) | 2017-11-20 |
| NO2479174T3 (pl) | 2018-03-17 |
| EP2479174B1 (en) | 2017-10-18 |
| CA2774099A1 (en) | 2011-03-17 |
| KR20120081142A (ko) | 2012-07-18 |
| LT2479174T (lt) | 2017-11-27 |
| JP5684811B2 (ja) | 2015-03-18 |
| EP2479174A1 (en) | 2012-07-25 |
| SI2479174T1 (sl) | 2017-12-29 |
| US20150126550A1 (en) | 2015-05-07 |
| HRP20171748T1 (hr) | 2017-12-29 |
| WO2011029265A1 (zh) | 2011-03-17 |
| CN102020639A (zh) | 2011-04-20 |
| AU2010292790A1 (en) | 2012-05-10 |
| ES2647829T3 (es) | 2017-12-26 |
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