PL2480523T3 - Sposób wytwarzania N-acylobifenyloalaniny - Google Patents

Sposób wytwarzania N-acylobifenyloalaniny

Info

Publication number
PL2480523T3
PL2480523T3 PL10818263T PL10818263T PL2480523T3 PL 2480523 T3 PL2480523 T3 PL 2480523T3 PL 10818263 T PL10818263 T PL 10818263T PL 10818263 T PL10818263 T PL 10818263T PL 2480523 T3 PL2480523 T3 PL 2480523T3
Authority
PL
Poland
Prior art keywords
acylbphenyl
alanine
manufacture
acylbphenyl alanine
Prior art date
Application number
PL10818263T
Other languages
English (en)
Inventor
Guoliang Zhu
Desong Shi
Junhui Wei
Fengfeng Tao
Original Assignee
Zhejiang Jiuzhou Pharmaceutical Co., Ltd.
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zhejiang Jiuzhou Pharmaceutical Co., Ltd., Novartis Ag filed Critical Zhejiang Jiuzhou Pharmaceutical Co., Ltd.
Publication of PL2480523T3 publication Critical patent/PL2480523T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/10—Preparation of carboxylic acid amides from compounds not provided for in groups C07C231/02 - C07C231/08
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/87—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/36—One oxygen atom
    • C07D263/42—One oxygen atom attached in position 5

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
PL10818263T 2008-09-24 2010-03-23 Sposób wytwarzania N-acylobifenyloalaniny PL2480523T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN200810200404.XA CN101684077B (zh) 2008-09-24 2008-09-24 N-酰基联苯丙氨酸的制备方法
PCT/CN2009/074125 WO2010034236A1 (en) 2008-09-24 2009-09-23 Process for the manufacture of n-acylbiphenyl alanine

Publications (1)

Publication Number Publication Date
PL2480523T3 true PL2480523T3 (pl) 2017-09-29

Family

ID=42047495

Family Applications (1)

Application Number Title Priority Date Filing Date
PL10818263T PL2480523T3 (pl) 2008-09-24 2010-03-23 Sposób wytwarzania N-acylobifenyloalaniny

Country Status (7)

Country Link
US (2) US20130172572A1 (pl)
CN (1) CN101684077B (pl)
ES (1) ES2627060T3 (pl)
MX (1) MX2012003488A (pl)
PL (1) PL2480523T3 (pl)
PT (1) PT2480523T (pl)
WO (1) WO2010034236A1 (pl)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101684077B (zh) 2008-09-24 2013-01-02 浙江九洲药业股份有限公司 N-酰基联苯丙氨酸的制备方法
BR112012006406A2 (pt) * 2009-09-23 2016-04-12 Novartis Ag "processo para a fabrição de n-acilbifenil alanina"
CN103764624B (zh) * 2011-08-19 2017-07-28 Dpx精细化学奥地利两合公司 R‑联苯丙氨醇的合成
CN104725279B (zh) * 2015-02-12 2018-03-02 威海迪素制药有限公司 一种N‑Boc‑联苯丙氨酸衍生物的制备方法
CN104892447A (zh) * 2015-06-26 2015-09-09 周治国 一种高纯度α–脱氢氨基酸类化合物的制备方法
CN105348209B (zh) 2015-12-09 2017-12-26 浙江天宇药业股份有限公司 一种抗心衰药lcz696的制备方法
RU2769445C2 (ru) * 2015-12-10 2022-03-31 Новартис Аг Новый способ и новые промежуточные соединения
EP3424899B1 (en) * 2016-02-29 2022-05-11 Sunshine Lake Pharma Co., Ltd. Sacubitril intermediate and preparation method thereof
CN105820064A (zh) * 2016-04-18 2016-08-03 浙江天宇药业股份有限公司 一种联苯基丙氨醇衍生物的合成方法及中间体

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60185752A (ja) 1984-03-05 1985-09-21 Mitsui Toatsu Chem Inc α−アセトアミド桂皮酸類の製造法
JPS60215657A (ja) 1984-04-10 1985-10-29 Mitsui Toatsu Chem Inc Ｎ−アシルフエニルアラニン類の製造法
CA1325222C (en) 1985-08-23 1993-12-14 Lederle (Japan), Ltd. Process for producing 4-biphenylylacetic acid
IL123986A (en) 1997-04-24 2011-10-31 Organon Nv Medicinal compounds
GB2354440A (en) 1999-07-20 2001-03-28 Merck & Co Inc Aryl amides as cell adhesion inhibitors
JP4270484B2 (ja) 2002-03-08 2009-06-03 第一ファインケミカル株式会社 光学活性フェニルアラニン誘導体の製造方法
US7041690B2 (en) * 2002-07-01 2006-05-09 Pharmacia & Upjohn Company, Llc Inhibitors of HCV NS5B polymerase
US20040180943A1 (en) 2002-07-23 2004-09-16 Augelli-Szafran Corinne Elizabeth Oxazolone analogs as amyloid aggregation inhibitors and for the treatment of alzheimer's disease and disorders related to amyloidosis
TW200838501A (en) * 2007-02-02 2008-10-01 Theravance Inc Dual-acting antihypertensive agents
CN101684077B (zh) 2008-09-24 2013-01-02 浙江九洲药业股份有限公司 N-酰基联苯丙氨酸的制备方法
CN101774941A (zh) 2009-01-13 2010-07-14 浙江九洲药业股份有限公司 2-酰基氨基-3-联苯基丙酸的制备及拆分方法
CN101555211B (zh) 2009-05-13 2012-01-25 浙江九洲药业股份有限公司 2-酰基氨基-3-联苯基丙酸的化学合成方法

Also Published As

Publication number Publication date
PT2480523T (pt) 2017-06-12
ES2627060T3 (es) 2017-07-26
US20140142320A1 (en) 2014-05-22
CN101684077A (zh) 2010-03-31
MX2012003488A (es) 2012-04-20
CN101684077B (zh) 2013-01-02
US20130172572A1 (en) 2013-07-04
US9242927B2 (en) 2016-01-26
WO2010034236A1 (en) 2010-04-01

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