PL250076B1 - Application of the peptide derivative of the phosphonic analogue of arginine Cbz-Ile-Ala-ArgP(OPh)2 as an antibacterial agent - Google Patents

Application of the peptide derivative of the phosphonic analogue of arginine Cbz-Ile-Ala-ArgP(OPh)2 as an antibacterial agent

Info

Publication number
PL250076B1
PL250076B1 PL445144A PL44514423A PL250076B1 PL 250076 B1 PL250076 B1 PL 250076B1 PL 445144 A PL445144 A PL 445144A PL 44514423 A PL44514423 A PL 44514423A PL 250076 B1 PL250076 B1 PL 250076B1
Authority
PL
Poland
Prior art keywords
argp
oph
cbz
phosphonic
ile
Prior art date
Application number
PL445144A
Other languages
Polish (pl)
Other versions
PL445144A1 (en
Inventor
Ewa Burchacka
Original Assignee
Politechnika Wrocławska
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Politechnika Wrocławska filed Critical Politechnika Wrocławska
Priority to PL445144A priority Critical patent/PL250076B1/en
Publication of PL445144A1 publication Critical patent/PL445144A1/en
Publication of PL250076B1 publication Critical patent/PL250076B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Przedmiotem zgłoszenia jest zastosowanie peptydowej pochodnej fosfonowego analogu argininy Cbz-Ile-Ala-ArgP(OPh)2 o wzorze 1 jako środka o aktywności przeciwbakteryjnej do eliminowania bakterii chorobotwórczych wybranych z grupy: Finegoldia magna, Escherichia coli, Staphylococcus aureus, Serratia marcescens.The subject of the application is the use of a peptide derivative of the phosphonic analogue of arginine Cbz-Ile-Ala-ArgP(OPh)2 of formula 1 as an agent with antibacterial activity for eliminating pathogenic bacteria selected from the group: Finegoldia magna, Escherichia coli, Staphylococcus aureus, Serratia marcescens.

PL445144A 2023-06-06 2023-06-06 Application of the peptide derivative of the phosphonic analogue of arginine Cbz-Ile-Ala-ArgP(OPh)2 as an antibacterial agent PL250076B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL445144A PL250076B1 (en) 2023-06-06 2023-06-06 Application of the peptide derivative of the phosphonic analogue of arginine Cbz-Ile-Ala-ArgP(OPh)2 as an antibacterial agent

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL445144A PL250076B1 (en) 2023-06-06 2023-06-06 Application of the peptide derivative of the phosphonic analogue of arginine Cbz-Ile-Ala-ArgP(OPh)2 as an antibacterial agent

Publications (2)

Publication Number Publication Date
PL445144A1 PL445144A1 (en) 2024-12-09
PL250076B1 true PL250076B1 (en) 2026-08-10

Family

ID=93799835

Family Applications (1)

Application Number Title Priority Date Filing Date
PL445144A PL250076B1 (en) 2023-06-06 2023-06-06 Application of the peptide derivative of the phosphonic analogue of arginine Cbz-Ile-Ala-ArgP(OPh)2 as an antibacterial agent

Country Status (1)

Country Link
PL (1) PL250076B1 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL212735B1 (en) * 2006-02-28 2012-11-30 Politechnika Wroclawska Method for the manufacture of the phosphonic analogues of pseudopeptides and their application as inhibitors of the proteolytic enzymes as well as compounds with bactericidal activity

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL212735B1 (en) * 2006-02-28 2012-11-30 Politechnika Wroclawska Method for the manufacture of the phosphonic analogues of pseudopeptides and their application as inhibitors of the proteolytic enzymes as well as compounds with bactericidal activity

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BURCHACKA E. ET AL., (2014),: "Biochimie, Volume 103, 08.2014., pp 137-143.", „SUBSTRATE PROFILING OF FINEGOLDIA MAGNA SUFA PROTEASE, INHIBITOR SCREENING AND APPLICATION TO PREVENT HUMAN FIBRINOGEN DEGRADATION AND BACTERIA GROWTH IN VITRO", *
SEPAHI M, JALAL R, MASHREGHI M.: "Iran J Microbiol. 2017 Apr;9(2):103-111.", ANTIBACTERIAL ACTIVITY OF POLY-L-ARGININE UNDER DIFFERENT CONDITIONS. *
SKOREŃSKI M, MILEWSKA A, PYRĆ K, SIEŃCZYK M, OLEKSYSZYN J.: "J Enzyme Inhib Med Chem. 2019 Dec;34(1):8-14.", PHOSPHONATE INHIBITORS OF WEST NILE VIRUS NS2B/NS3 PROTEASE. *

Also Published As

Publication number Publication date
PL445144A1 (en) 2024-12-09