PL2503993T3 - Chlorowodorek 4-[2-[[5-metylo-1-(2-naftalenylo)-1H-pirazol-3-ilo]oksy]etylo]morfoliny - Google Patents

Chlorowodorek 4-[2-[[5-metylo-1-(2-naftalenylo)-1H-pirazol-3-ilo]oksy]etylo]morfoliny

Info

Publication number: PL2503993T3
Authority: PL; Poland
Prior art keywords: naphthalenyl; pyrazol; morpholine; oxy; ethyl
Prior art date: 2009-11-25

Application number

PL10782303T

Other languages

English (en)

Inventor

MARíA ROSA CUBERES-ALTISENT

- Carandell Lluis Solà

- Couceiro Urko García

Original Assignee

Laboratorios Del. Dr. Esteve, S.A.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-11-25

Filing date

2010-11-25

Publication date

2017-09-29

2010-11-25 Application filed by Laboratorios Del. Dr. Esteve, S.A. filed Critical Laboratorios Del. Dr. Esteve, S.A.

2017-09-29 Publication of PL2503993T3 publication Critical patent/PL2503993T3/pl

Links

DGPGXHRHNRYVDH-UHFFFAOYSA-N 4-[2-(5-methyl-1-naphthalen-2-ylpyrazol-3-yl)oxyethyl]morpholine Chemical compound N=1N(C=2C=C3C=CC=CC3=CC=2)C(C)=CC=1OCCN1CCOCC1 DGPGXHRHNRYVDH-UHFFFAOYSA-N 0.000 title 1
QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4152—1,2-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. antipyrine, phenylbutazone, sulfinpyrazone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
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- A61K9/1605—Excipients; Inactive ingredients
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- A61K9/1682—Processes
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Bioinformatics & Cheminformatics (AREA)
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Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
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Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Immunology (AREA)
Addiction (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Rheumatology (AREA)
Hospice & Palliative Care (AREA)
Orthopedic Medicine & Surgery (AREA)
Psychology (AREA)
Vascular Medicine (AREA)
Inorganic Chemistry (AREA)
Urology & Nephrology (AREA)
Transplantation (AREA)
Child & Adolescent Psychology (AREA)
Physical Education & Sports Medicine (AREA)

PL10782303T 2009-11-25 2010-11-25 Chlorowodorek 4-[2-[[5-metylo-1-(2-naftalenylo)-1H-pirazol-3-ilo]oksy]etylo]morfoliny PL2503993T3 (pl)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP09382261A EP2335688A1 (en)	2009-11-25	2009-11-25	Pharmaceutical compositions comprising sigma receptor ligands

Publications (1)

Publication Number	Publication Date
PL2503993T3 true PL2503993T3 (pl)	2017-09-29

Family

ID=42077699

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
PL10787354T PL2503994T3 (pl)	2009-11-25	2010-11-25	Kompozycje farmaceutyczne zawierające ligandy receptora sigma
PL10782303T PL2503993T3 (pl)	2009-11-25	2010-11-25	Chlorowodorek 4-[2-[[5-metylo-1-(2-naftalenylo)-1H-pirazol-3-ilo]oksy]etylo]morfoliny

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
PL10787354T PL2503994T3 (pl)	2009-11-25	2010-11-25	Kompozycje farmaceutyczne zawierające ligandy receptora sigma

Country Status (35)

Country	Link
US (1)	US9241927B2 (pl)
EP (2)	EP2335688A1 (pl)
JP (1)	JP5827236B2 (pl)
KR (1)	KR101794579B1 (pl)
CN (2)	CN102711736A (pl)
AR (1)	AR079199A1 (pl)
AU (1)	AU2010323097B2 (pl)
BR (1)	BR112012012457A2 (pl)
CA (1)	CA2781726C (pl)
CO (1)	CO6501134A2 (pl)
CY (1)	CY1119357T1 (pl)
DK (1)	DK2503994T3 (pl)
EC (1)	ECSP12011958A (pl)
ES (1)	ES2641637T3 (pl)
HR (1)	HRP20171448T1 (pl)
HU (1)	HUE036377T2 (pl)
IL (1)	IL219996A (pl)
LT (1)	LT2503994T (pl)
MA (1)	MA33836B1 (pl)
ME (1)	ME02876B (pl)
MX (1)	MX351570B (pl)
NZ (1)	NZ600231A (pl)
PH (1)	PH12012501028A1 (pl)
PL (2)	PL2503994T3 (pl)
PT (1)	PT2503994T (pl)
RS (1)	RS56382B1 (pl)
RU (1)	RU2549882C2 (pl)
SG (1)	SG10201407504YA (pl)
SI (1)	SI2503994T1 (pl)
SM (1)	SMT201700429T1 (pl)
TN (1)	TN2012000246A1 (pl)
TW (1)	TWI526207B (pl)
UA (2)	UA109421C2 (pl)
WO (1)	WO2011064296A1 (pl)
ZA (1)	ZA201203774B (pl)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP2116539A1 (en)	2008-04-25	2009-11-11	Laboratorios Del. Dr. Esteve, S.A.	1-aryl-3-aminoalkoxy-pyrazoles as sigma ligands enhancing analgesic effects of opioids and attenuating the dependency thereof
RU2559325C2 (ru) *	2009-11-25	2015-08-10	Лабораторьос Дель Др. Эстеве, С.А.	Соли 4-[2-[[5-метил-1-(2-нафталинил)-1н-пиразол-3-ил]окси]этил]морфолина
EP2353591A1 (en)	2010-02-04	2011-08-10	Laboratorios Del. Dr. Esteve, S.A.	Sigma ligands for potentiating the analgesic effect of opioids and opiates in post-operative pain and attenuating the dependency thereof
EP2353598A1 (en)	2010-02-04	2011-08-10	Laboratorios Del. Dr. Esteve, S.A.	Sigma ligands for use in the prevention and/or treatment of postoperative pain
EP2388005A1 (en)	2010-05-21	2011-11-23	Laboratorios Del. Dr. Esteve, S.A.	Sigma ligands for the prevention and/or treatment of emesis induced by chemotherapy or radiotherapy
EP2415471A1 (en)	2010-08-03	2012-02-08	Laboratorios Del. Dr. Esteve, S.A.	Use of sigma ligands in opioid-induced hyperalgesia
EP2426111A1 (en) *	2010-08-09	2012-03-07	Laboratorios Del. Dr. Esteve, S.A.	4-[-2-[[5-methyl-1-(2-naphtalenyl)-1h-pyrazol-3-yl]oxy]ethyl]morpholine hydrochloride amorphous solid forms
EP2524694A1 (en)	2011-05-19	2012-11-21	Laboratorios Del. Dr. Esteve, S.A.	Use of sigma ligands in diabetes type-2 associated pain
CN105050708A (zh)	2012-11-14	2015-11-11	格雷斯公司	含有生物活性材料与无序无机氧化物的组合物
EP2792352A1 (en)	2013-04-16	2014-10-22	Laboratorios Del. Dr. Esteve, S.A.	Alpha-2 adrenoreceptor and sigma receptor ligand combinations
TW201607538A (zh)	2013-12-17	2016-03-01	以斯提夫博士實驗室股份有限公司	血清素－去甲腎上腺素再攝取抑制劑（ＳＮＲＩＳ）和σ受體配體組合物
CA2933057A1 (en)	2013-12-17	2015-06-25	Laboratorios Del Dr. Esteve, S.A.	Gabapentinoids and sigma receptor ligands combinations
EP2929883A1 (en) *	2014-04-08	2015-10-14	Institut Pasteur	Pyrazole derivatives as dihydroorotate dehydrogenase (DHODH) inhibitors
MA41177A (fr) *	2014-12-15	2017-10-24	Esteve Labor Dr	Utilisation de ligands des récepteurs sigma dans l'arthrose
EP3886854A4 (en)	2018-11-30	2022-07-06	Nuvation Bio Inc.	Pyrrole and pyrazole compounds and methods of use thereof
EP4124338A1 (en)	2021-07-30	2023-02-01	Université de Montpellier	Sigma-1 receptor activator for use in the treatment of a pathology associated with wfs1 mutation
WO2023070429A1 (zh) *	2021-10-28	2023-05-04	谛邈生物科技(北京)有限公司	牛奶外泌体在制备药物载体中的应用
EP4523686A1 (en)	2023-09-15	2025-03-19	Universite De Montpellier	A sigma-1 receptor positive modulator for its use in the prevention and the treatment of a pathology

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
RU2417987C2 (ru) *	2004-08-27	2011-05-10	Лабораторьос Дель Др.Эстеве, С.А.	Ингибиторы сигма-рецептора
EP1634872A1 (en) *	2004-08-27	2006-03-15	Laboratorios Del Dr. Esteve, S.A.	Pyrazole derivatives as sigma receptor inhibitors
EP1781618B1 (en)	2004-08-27	2012-10-03	Laboratorios Del Dr. Esteve, S.A.	Sigma receptor inhibitors
EP2116539A1 (en) *	2008-04-25	2009-11-11	Laboratorios Del. Dr. Esteve, S.A.	1-aryl-3-aminoalkoxy-pyrazoles as sigma ligands enhancing analgesic effects of opioids and attenuating the dependency thereof

2009
- 2009-11-25 EP EP09382261A patent/EP2335688A1/en not_active Withdrawn
2010
- 2010-11-25 SI SI201031545T patent/SI2503994T1/sl unknown
- 2010-11-25 ES ES10787354.9T patent/ES2641637T3/es active Active
- 2010-11-25 HU HUE10787354A patent/HUE036377T2/hu unknown
- 2010-11-25 AU AU2010323097A patent/AU2010323097B2/en not_active Ceased
- 2010-11-25 NZ NZ600231A patent/NZ600231A/xx not_active IP Right Cessation
- 2010-11-25 PL PL10787354T patent/PL2503994T3/pl unknown
- 2010-11-25 US US13/511,706 patent/US9241927B2/en not_active Expired - Fee Related
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Also Published As

Publication number	Publication date
US9241927B2 (en)	2016-01-26
JP2013512219A (ja)	2013-04-11
CA2781726A1 (en)	2011-06-03
HUE036377T2 (hu)	2018-07-30
CO6501134A2 (es)	2012-08-15
PH12012501028A1 (en)	2019-11-29
SI2503994T1 (sl)	2017-11-30
SMT201700429T1 (it)	2017-11-15
UA112055C2 (uk)	2016-07-25
IL219996A (en)	2017-10-31
EP2503994B1 (en)	2017-07-05
IL219996A0 (en)	2012-07-31
HRP20171448T1 (hr)	2017-11-03
CN105560250A (zh)	2016-05-11
MX351570B (es)	2017-10-19
NZ600231A (en)	2013-06-28
ZA201203774B (en)	2013-08-28
TN2012000246A1 (en)	2013-12-12
RU2549882C2 (ru)	2015-05-10
TW201127377A (en)	2011-08-16
PL2503994T3 (pl)	2017-11-30
UA109421C2 (uk)	2015-08-25
ME02876B (me)	2018-04-20
PT2503994T (pt)	2017-10-06
DK2503994T3 (en)	2017-10-02
US20120283262A1 (en)	2012-11-08
LT2503994T (lt)	2017-09-25
CY1119357T1 (el)	2018-02-14
AU2010323097A1 (en)	2012-06-14
AU2010323097B2 (en)	2016-03-24
WO2011064296A1 (en)	2011-06-03
CA2781726C (en)	2018-09-04
MA33836B1 (fr)	2012-12-03
KR101794579B1 (ko)	2017-12-01
TWI526207B (zh)	2016-03-21
ECSP12011958A (es)	2012-07-31
CN102711736A (zh)	2012-10-03
EP2335688A1 (en)	2011-06-22
BR112012012457A2 (pt)	2020-08-11
KR20120109522A (ko)	2012-10-08
AR079199A1 (es)	2012-01-04
RU2012126126A (ru)	2013-12-27
MX2012006106A (es)	2012-07-03
JP5827236B2 (ja)	2015-12-02
EP2503994A1 (en)	2012-10-03
RS56382B1 (sr)	2017-12-29
ES2641637T3 (es)	2017-11-10
SG10201407504YA (en)	2014-12-30
WO2011064296A9 (en)	2011-07-21

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ZA200908301B (en)	2010-08-25	Rnai inhibition of alpha-enac expression