PL2509950T3 - 5-Amino-4-hydroksypentoilo-amidy - Google Patents

5-Amino-4-hydroksypentoilo-amidy

Info

Publication number
PL2509950T3
PL2509950T3 PL10790938T PL10790938T PL2509950T3 PL 2509950 T3 PL2509950 T3 PL 2509950T3 PL 10790938 T PL10790938 T PL 10790938T PL 10790938 T PL10790938 T PL 10790938T PL 2509950 T3 PL2509950 T3 PL 2509950T3
Authority
PL
Poland
Prior art keywords
hydroxypentoyl
amides
amino
hydroxypentoyl amides
Prior art date
Application number
PL10790938T
Other languages
English (en)
Inventor
Genadiy Kalayanov
Bart Rudolf Romanie Kesteleyn
Kevin Parkes
Bengt Bertil Samuelsson
Wim Bert Griet Schepens
Johannes Wilhelmus J Thuring
Hans Kristian Wallberg
Jörg Kurt Wegner
Original Assignee
Medivir Ab
Janssen Sciences Ireland Uc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medivir Ab, Janssen Sciences Ireland Uc filed Critical Medivir Ab
Publication of PL2509950T3 publication Critical patent/PL2509950T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • AIDS & HIV (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
PL10790938T 2009-12-11 2010-12-10 5-Amino-4-hydroksypentoilo-amidy PL2509950T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP09178979 2009-12-11
EP10162370 2010-05-10
PCT/EP2010/069328 WO2011070131A1 (en) 2009-12-11 2010-12-10 5-amino- 4-hydroxypentoyl amides
EP10790938.4A EP2509950B1 (en) 2009-12-11 2010-12-10 5-Amino-4-hydroxypentoyl amides

Publications (1)

Publication Number Publication Date
PL2509950T3 true PL2509950T3 (pl) 2015-10-30

Family

ID=43534084

Family Applications (1)

Application Number Title Priority Date Filing Date
PL10790938T PL2509950T3 (pl) 2009-12-11 2010-12-10 5-Amino-4-hydroksypentoilo-amidy

Country Status (24)

Country Link
US (1) US8592429B2 (pl)
EP (1) EP2509950B1 (pl)
JP (1) JP5797662B2 (pl)
KR (1) KR101771698B1 (pl)
CN (1) CN102770413B (pl)
AP (1) AP3217A (pl)
AR (1) AR079354A1 (pl)
AU (1) AU2010329867B2 (pl)
BR (1) BR112012013493B1 (pl)
CA (1) CA2783929C (pl)
DK (1) DK2509950T3 (pl)
EA (1) EA020758B1 (pl)
ES (1) ES2536774T3 (pl)
IL (1) IL219272A (pl)
JO (1) JO3090B1 (pl)
MX (1) MX2012006613A (pl)
NZ (1) NZ599916A (pl)
PH (1) PH12012500805A1 (pl)
PL (1) PL2509950T3 (pl)
PT (1) PT2509950E (pl)
SG (1) SG181609A1 (pl)
TW (1) TWI485149B (pl)
UY (1) UY33098A (pl)
WO (1) WO2011070131A1 (pl)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018166493A1 (zh) 2017-03-16 2018-09-20 江苏恒瑞医药股份有限公司 杂芳基并[4,3-c]嘧啶-5-胺类衍生物、其制备方法及其在医药上的应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL89900A0 (en) * 1988-04-12 1989-12-15 Merck & Co Inc Hiv protease inhibitors useful for the treatment of aids and pharmaceutical compositions containing them
EP0534511A1 (en) * 1991-08-16 1993-03-31 Merck & Co. Inc. HIV protease inhibitors useful for the treatment of aids
CN1089269A (zh) * 1993-01-04 1994-07-13 希巴-盖吉股份公司 新颖的作为治疗剂的5-氨基-4-羟基己酸衍生物
US5733882A (en) * 1994-01-17 1998-03-31 Smithkline Beecham Corporation Retroviral protease inhibitors
PT708085E (pt) * 1994-10-19 2002-11-29 Novartis Ag Eteres antivirais de isosteros de substrato de aspartato protease
BR0207862A (pt) * 2001-02-14 2004-06-22 Tibotec Pharm Ltd Inibidores de protease de hiv 2-(amino-substituìda)-benzotiazol-sulfonamida de amplo espectro
AR037797A1 (es) * 2001-12-12 2004-12-01 Tibotec Pharm Ltd Combinacion de inhibidores de proteasa dependientes del citocromo p450
US7834043B2 (en) * 2003-12-11 2010-11-16 Abbott Laboratories HIV protease inhibiting compounds
ES2326041T3 (es) * 2005-02-10 2009-09-29 Medivir Ab Inhibidores de proteasas de vih.
CN101115713A (zh) * 2005-02-10 2008-01-30 美迪维尔公司 人类免疫缺陷性病毒蛋白酶抑制剂
WO2007048557A1 (en) * 2005-10-25 2007-05-03 Medivir Ab Protease inhibitors
JO2841B1 (en) * 2006-06-23 2014-09-15 تيبوتيك فارماسيوتيكالز ليمتد 2-(substituted-amino) -benzothiazole sulfonamide as protease inhibitors HIV (HIV)
AU2007275690B2 (en) * 2006-07-21 2013-01-17 Gilead Sciences, Inc. Antiviral protease inhibitors

Also Published As

Publication number Publication date
TWI485149B (zh) 2015-05-21
WO2011070131A1 (en) 2011-06-16
EP2509950B1 (en) 2015-02-25
KR101771698B1 (ko) 2017-08-25
ES2536774T3 (es) 2015-05-28
HK1177454A1 (en) 2013-08-23
BR112012013493A8 (pt) 2017-12-26
IL219272A0 (en) 2012-06-28
AU2010329867B2 (en) 2016-01-28
AU2010329867A1 (en) 2012-05-24
UY33098A (es) 2011-06-30
TW201130823A (en) 2011-09-16
EP2509950A1 (en) 2012-10-17
BR112012013493B1 (pt) 2020-12-08
AP3217A (en) 2015-04-30
CN102770413B (zh) 2015-08-26
BR112012013493A2 (pt) 2016-05-31
PH12012500805A1 (en) 2012-11-26
NZ599916A (en) 2013-10-25
SG181609A1 (en) 2012-07-30
CA2783929C (en) 2020-04-07
IL219272A (en) 2014-09-30
CN102770413A (zh) 2012-11-07
AR079354A1 (es) 2012-01-18
EA201290487A1 (ru) 2012-11-30
KR20120107104A (ko) 2012-09-28
JO3090B1 (ar) 2017-03-15
AP2012006228A0 (en) 2012-04-30
PT2509950E (pt) 2015-06-08
DK2509950T3 (en) 2015-05-18
EA020758B1 (ru) 2015-01-30
JP5797662B2 (ja) 2015-10-21
CA2783929A1 (en) 2011-06-16
US8592429B2 (en) 2013-11-26
JP2013513576A (ja) 2013-04-22
US20120295920A1 (en) 2012-11-22
MX2012006613A (es) 2012-07-10

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