PL2511262T3 - Process for producing 2-amino-2-[2-[4-(3-benzyloxyphenylthio)-2-chlorophenyl[ethyl]-1,3-propanediol hydrochloride - Google Patents
Process for producing 2-amino-2-[2-[4-(3-benzyloxyphenylthio)-2-chlorophenyl[ethyl]-1,3-propanediol hydrochlorideInfo
- Publication number
- PL2511262T3 PL2511262T3 PL12167175T PL12167175T PL2511262T3 PL 2511262 T3 PL2511262 T3 PL 2511262T3 PL 12167175 T PL12167175 T PL 12167175T PL 12167175 T PL12167175 T PL 12167175T PL 2511262 T3 PL2511262 T3 PL 2511262T3
- Authority
- PL
- Poland
- Prior art keywords
- phenylthio
- benzyloxy
- chlorophenyl
- ethyl
- amino
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
- C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/02—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols
- C07C319/12—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols by reactions not involving the formation of mercapto groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/01—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and halogen atoms, or nitro or nitroso groups bound to the same carbon skeleton
- C07C323/02—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and halogen atoms, or nitro or nitroso groups bound to the same carbon skeleton having sulfur atoms of thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/07—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and halogen atoms, or nitro or nitroso groups bound to the same carbon skeleton having sulfur atoms of thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/31—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/32—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to an acyclic carbon atom of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/56—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004297651 | 2004-10-12 | ||
| EP12167175.4A EP2511262B1 (en) | 2004-10-12 | 2005-10-07 | Process for producing 2-amino-2-[2-[4-(3-benzyloxy-phenylthio)-2-chlorophenyl[ethyl]-1,3-propanediol hydrochloride |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2511262T3 true PL2511262T3 (en) | 2017-08-31 |
Family
ID=36148313
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL05790615T PL1806338T3 (en) | 2004-10-12 | 2005-10-07 | Process for producing 2-amino-2-[2-[4-(3-benzyloxyphenylthio)-2-chlorophenyl[ethyl]-1,3-propanediol hydrochloride and hydrates thereof. and intermediates the production thereof |
| PL12167175T PL2511262T3 (en) | 2004-10-12 | 2005-10-07 | Process for producing 2-amino-2-[2-[4-(3-benzyloxyphenylthio)-2-chlorophenyl[ethyl]-1,3-propanediol hydrochloride |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL05790615T PL1806338T3 (en) | 2004-10-12 | 2005-10-07 | Process for producing 2-amino-2-[2-[4-(3-benzyloxyphenylthio)-2-chlorophenyl[ethyl]-1,3-propanediol hydrochloride and hydrates thereof. and intermediates the production thereof |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7795472B2 (en) |
| EP (2) | EP1806338B1 (en) |
| JP (1) | JP4792400B2 (en) |
| KR (1) | KR101181090B1 (en) |
| CN (2) | CN101880250B (en) |
| AU (1) | AU2005292984B2 (en) |
| BR (1) | BRPI0516337A (en) |
| CA (1) | CA2583846C (en) |
| ES (2) | ES2615498T3 (en) |
| MX (1) | MX2007004319A (en) |
| PL (2) | PL1806338T3 (en) |
| PT (1) | PT2511262T (en) |
| RU (1) | RU2376285C2 (en) |
| WO (1) | WO2006041019A1 (en) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7781617B2 (en) | 2004-07-16 | 2010-08-24 | Kyorin Pharmaceutical Co., Ltd | Effective use method of medicaments and method of preventing expression of side effect |
| EP1806338B1 (en) | 2004-10-12 | 2016-01-20 | Kyorin Pharmaceutical Co., Ltd. | Process for producing 2-amino-2-[2-[4-(3-benzyloxy-phenylthio)-2-chlorophenyl[ethyl]-1,3-propanediol hydrochloride and hydrates thereof. and intermediates the production thereof |
| PL1932522T3 (en) * | 2005-10-07 | 2012-09-28 | Kyorin Seiyaku Kk | Therapeutic agent for liver disease containing 2-amino-1,3-propanediol derivative as active ingredient |
| TWI389683B (en) * | 2006-02-06 | 2013-03-21 | Kyorin Seiyaku Kk | A therapeutic agent for an inflammatory bowel disease or an inflammatory bowel disease treatment using a 2-amino-1,3-propanediol derivative as an active ingredient |
| JP5140593B2 (en) * | 2006-08-08 | 2013-02-06 | 杏林製薬株式会社 | Amino alcohol derivatives and immunosuppressants containing them as active ingredients |
| CA2659598A1 (en) * | 2006-08-08 | 2008-02-14 | Kyorin Pharmaceutical Co., Ltd. | Amino phosphate derivative and s1p receptor modulator having same as an active ingredient |
| WO2008078563A1 (en) * | 2006-12-22 | 2008-07-03 | Sumitomo Seika Chemicals Co., Ltd. | Process for production of 3-benzyloxybenzenethiol |
| TW200946105A (en) | 2008-02-07 | 2009-11-16 | Kyorin Seiyaku Kk | Therapeutic agent or preventive agent for inflammatory bowel disease containing amino alcohol derivative as active ingredient |
| CA2718987C (en) * | 2008-03-24 | 2016-03-08 | Kyorin Pharmaceutical Co., Ltd. | Method for crystallization of 2-amino-2-[2-[4-(3-benzyloxyphenylthio)-2-chlorophenyl]-ethyl]-1,3-propanediol hydrochloride |
| WO2009142194A1 (en) * | 2008-05-19 | 2009-11-26 | 杏林製薬株式会社 | Method for producing optically active aminoalcohol derivative |
| JP5330066B2 (en) * | 2009-04-13 | 2013-10-30 | 富士フイルム株式会社 | Method for producing triarylamine compound |
| WO2012073249A1 (en) | 2010-12-01 | 2012-06-07 | Arch Pharmalabs Limited | A novel process for the preparation of 3-(benzyloxy)- benzenethiol, a key intermediate for the preparation of pharmaceutical drugs. |
| WO2013157255A1 (en) | 2012-04-18 | 2013-10-24 | 杏林製薬株式会社 | 4-(3-benzyloxyphenylthio)-2-chloro-1-(3-nitropropyl)benzene crystal |
| CN102718662A (en) * | 2012-07-12 | 2012-10-10 | 杭州新博思生物医药有限公司 | Method for preparing cinacalcet hydrochloride |
| CN103113270A (en) * | 2012-11-26 | 2013-05-22 | 盛世泰科生物医药技术(苏州)有限公司 | Synthesis method of 4-(3-benzyloxy-phenylsulfanyl)-2-chloro-vinylbenzene |
| CN108017928A (en) * | 2017-12-15 | 2018-05-11 | 淮海工学院 | A kind of Pegylation indole cyanine dyes for biomolecular labeling and preparation method thereof |
| IL280451B2 (en) | 2018-07-27 | 2025-10-01 | Priothera Ltd | Agent for inhibiting recurrence of hematological malignancy in patients who have undergone hematopoietic stem cell transplantation |
| AU2022214268A1 (en) | 2021-01-28 | 2023-07-27 | Priothera Limited | Methods of treatment with s1p receptor modulators |
| WO2022162409A1 (en) | 2021-01-28 | 2022-08-04 | Priothera Sas | Methods of treatment with s1p receptor modulators |
| KR20240149401A (en) | 2022-02-16 | 2024-10-14 | 프리오테라 에스에이에스 | Method of treatment using CAR cells in combination with S1P receptor modulators |
| EP4282407A1 (en) | 2022-05-27 | 2023-11-29 | Priothera SAS | Treatment of cancer with s1p receptor agonists |
| WO2025109119A1 (en) | 2023-11-22 | 2025-05-30 | Priothera Sas | Methods of treatment with multispecific antigen-binding proteins in combination with s1p receptor modulators |
Family Cites Families (86)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3997540A (en) * | 1975-07-21 | 1976-12-14 | Burroughs Wellcome Co. | O [(O-piperazinocarbonyl-phenyl)-thio]-benzoates |
| DE69321823T2 (en) * | 1992-10-21 | 1999-06-02 | Taito Co., Ltd., Tokio/Tokyo | 2-AMINO-1, 3-PROPANEDIOL COMPOUND AND IMMUNOSUPPRESSIUM |
| US5475138A (en) * | 1994-07-07 | 1995-12-12 | Pharm-Eco Laboratories Incorporated | Method preparing amino acid-derived diaminopropanols |
| US5948820A (en) * | 1994-08-22 | 1999-09-07 | Yoshitomi Pharmaceutical Industries, Ltd. | Benzene compound and pharmaceutical use thereof |
| US5447922A (en) * | 1994-08-24 | 1995-09-05 | Bristol-Myers Squibb Company | α-phosphonosulfinic squalene synthetase inhibitors |
| ES2240868T3 (en) * | 1997-04-04 | 2005-10-16 | Mitsubishi Pharma Corporation | COMPOSITE OF 2-AMINOPROPANE -1,3-DIOL, ITS PHARMACEUTICAL USE AND INTERMEDIATES IN ITS SYNTHESIS |
| JPH1180026A (en) * | 1997-09-02 | 1999-03-23 | Yoshitomi Pharmaceut Ind Ltd | Novel immunosuppressants, methods of use and methods of identification thereof |
| EP1092435B1 (en) * | 1998-07-02 | 2007-04-04 | Kyowa Hakko Kogyo Co., Ltd. | Remedies for diabetes |
| AU767241B2 (en) * | 1998-09-14 | 2003-11-06 | Qiang Xu | Immunosuppressive agents |
| US20020143034A1 (en) * | 1998-12-30 | 2002-10-03 | Fujisawa Pharmaceutical Co. Ltd. | Aminoalcohol derivatives and their use as beta 3 adrenergic agonists |
| WO2001098301A1 (en) | 2000-06-20 | 2001-12-27 | Japan Tobacco Inc. | Pyrazolopyridine compounds and use thereof as drugs |
| CN1328387C (en) * | 2000-07-13 | 2007-07-25 | 三共株式会社 | Amino alcohol derivatives |
| JP2002053575A (en) | 2000-08-09 | 2002-02-19 | Sankyo Co Ltd | Aminoalcohols |
| EP1315735A4 (en) * | 2000-08-31 | 2005-04-06 | Merck & Co Inc | PHOSPHATE DERIVATIVES AS IMMUNO-REGULATING AGENTS |
| JP2004529100A (en) * | 2001-01-30 | 2004-09-24 | ユニバーシティ オブ バージニア パテント ファウンデーション | Agonists and antagonists of sphingosine-1-phosphate receptor |
| WO2002062389A1 (en) | 2001-02-08 | 2002-08-15 | Ono Pharmaceutical Co., Ltd. | Remedies for urinary diseases comprising lpa receptor controlling agents |
| JP4318921B2 (en) * | 2001-02-22 | 2009-08-26 | ノバルティス アクチエンゲゼルシャフト | Use of a lymphocyte homing promoter for the manufacture of a medicament for the treatment of delayed onset of graft function |
| CA2442178A1 (en) * | 2001-03-26 | 2002-10-03 | Novartis Ag | 2-amino-propanol derivatives |
| JP2002316985A (en) | 2001-04-20 | 2002-10-31 | Sankyo Co Ltd | Benzothiophene derivative |
| ES2316613T3 (en) * | 2001-05-10 | 2009-04-16 | Ono Pharmaceutical Co., Ltd. | DERIVATIVES OF CRBOXILIC ACID AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AS ACTIVE INGREDIENT. |
| US20040138462A1 (en) * | 2001-05-24 | 2004-07-15 | Minoru Sakurai | Aminoalcohol derivatives |
| EP1424078A4 (en) * | 2001-09-04 | 2009-03-25 | Ono Pharmaceutical Co | Remedies for respiratory diseases comprising sphingosine-1-phosphate receptor controller |
| CA2461212C (en) * | 2001-09-27 | 2010-08-17 | Kyorin Pharmaceutical Co., Ltd. | Diaryl sulfide derivatives, salts thereof and immunosuppressive agents using the same |
| DE60235900D1 (en) | 2001-09-27 | 2010-05-20 | Kyorin Seiyaku Kk | OSUPPRESSIVUM |
| JP4035759B2 (en) | 2001-11-06 | 2008-01-23 | 独立行政法人産業技術総合研究所 | Aminoalcohol phosphate compound, production method, and method of use thereof |
| DK1471054T3 (en) * | 2002-01-11 | 2009-11-09 | Daiichi Sankyo Co Ltd | Amino alcohol derivative or phosphonic acid derivative and medical composition containing them |
| JP2003267936A (en) | 2002-01-11 | 2003-09-25 | Sankyo Co Ltd | Benzene ring compound |
| ATE448193T1 (en) * | 2002-01-18 | 2009-11-15 | Merck & Co Inc | ßN-(BENZYL)AMINOALKYL CARBOXYLATE, PHOSPHINATES, PHOSPHONATES AND TETRAZOLES AS EDG RECEPTOR AGONISTSß |
| US20040058894A1 (en) | 2002-01-18 | 2004-03-25 | Doherty George A. | Selective S1P1/Edg1 receptor agonists |
| JP4430941B2 (en) | 2002-01-18 | 2010-03-10 | メルク エンド カムパニー インコーポレーテッド | Edg receptor agonist |
| JP2005531506A (en) * | 2002-03-01 | 2005-10-20 | メルク エンド カムパニー インコーポレーテッド | Aminoalkylphosphonates and related compounds as agonists of EDG receptors |
| WO2003074008A2 (en) | 2002-03-01 | 2003-09-12 | Merck & Co., Inc. | Aminoalkylphosphonates and related compounds as edg receptor agonists |
| AU2003213819C1 (en) * | 2002-03-11 | 2010-03-04 | Molecular Insight Pharmaceuticals, Inc. | Technetium-dipyridine complexes, and methods of use thereof |
| JP2005533058A (en) | 2002-06-17 | 2005-11-04 | メルク エンド カムパニー インコーポレーテッド | 1-((5-Aryl-1,2,4-oxadiazol-3-yl) benzyl) azetidine-3-carboxylate and 1-((5-aryl-1,2,4) as EDG receptor agonists -Oxadiazol-3-yl) benzyl) pyrrolidine-3-carboxylate |
| JPWO2004002531A1 (en) * | 2002-06-26 | 2005-10-27 | 小野薬品工業株式会社 | Treatment for diseases caused by contraction or dilation of blood vessels |
| US7241790B2 (en) | 2002-07-30 | 2007-07-10 | University Of Virginia Patent Foundation | Compounds active in spinigosine 1-phosphate signaling |
| CN100516024C (en) * | 2002-09-13 | 2009-07-22 | 诺瓦提斯公司 | Amino-propanol derivatives |
| JP4571497B2 (en) * | 2002-09-19 | 2010-10-27 | 杏林製薬株式会社 | Amino alcohol derivatives and their addition salts and immunosuppressants |
| EP1575576A2 (en) * | 2002-09-24 | 2005-09-21 | Novartis AG | Organic compounds |
| US7820682B2 (en) | 2002-10-03 | 2010-10-26 | Ono Pharmaceutical Co., Ltd. | LPA receptor antagonist |
| JP4140698B2 (en) | 2002-10-18 | 2008-08-27 | 第一三共株式会社 | Phosphoric acid or phosphonic acid derivatives |
| DE60335827D1 (en) | 2002-12-20 | 2011-03-03 | Merck Sharp & Dohme | 1- (AMINO) INDANE AS EDG RECEPTOR AGONISTS |
| PL378134A1 (en) * | 2003-02-11 | 2006-03-06 | Irm Llc | Novel bicyclic compounds and compositions |
| BRPI0407658A (en) * | 2003-02-18 | 2006-02-21 | Kyorin Seiyaku Kk | aminophosphonic acid derivatives, their salts and hydrates that act as s1p receptor modulators and pharmaceutical agent |
| JP2004307441A (en) | 2003-04-10 | 2004-11-04 | Kyorin Pharmaceut Co Ltd | Benzene derivative, its addition salt and immunosuppressant |
| JP2004307440A (en) | 2003-04-10 | 2004-11-04 | Kyorin Pharmaceut Co Ltd | 2-amino-1,3-propanediol derivatives and their addition salts |
| JP2004307439A (en) | 2003-04-10 | 2004-11-04 | Kyorin Pharmaceut Co Ltd | Aminodiol derivative, its addition salt and immunosuppressant |
| JP2004307442A (en) | 2003-04-10 | 2004-11-04 | Kyorin Pharmaceut Co Ltd | Heterocyclic derivatives, their addition salts and immunosuppressants |
| CN1777575B (en) | 2003-04-30 | 2010-05-12 | 诺瓦提斯公司 | Amino-propanol derivatives as modulators of sphingosine-1-phosphate receptors |
| MXPA05011597A (en) | 2003-04-30 | 2005-12-15 | Novartis Ag | Aminopropanol derivatives as sphingosine-1-phosphate receptor modulators. |
| AU2004240586A1 (en) * | 2003-05-15 | 2004-12-02 | Merck & Co., Inc. | 3-(2-amino-1-azacyclyl)-5-aryl-1,2,4-oxadiazoles as S1P receptor agonists |
| MXPA05012459A (en) | 2003-05-19 | 2006-02-22 | Irm Llc | Immunosuppressant compounds and compositions. |
| GB0313612D0 (en) * | 2003-06-12 | 2003-07-16 | Novartis Ag | Organic compounds |
| JP2005047899A (en) | 2003-07-11 | 2005-02-24 | Sankyo Co Ltd | Amino alcohol compound |
| WO2005014603A1 (en) | 2003-08-12 | 2005-02-17 | Mitsubishi Pharma Corporation | Phosphinane compounds with immunomodulating activity |
| WO2005014525A2 (en) | 2003-08-12 | 2005-02-17 | Mitsubishi Pharma Corporation | Bi-aryl compound having immunosuppressive activity |
| ATE449069T1 (en) | 2003-08-28 | 2009-12-15 | Novartis Pharma Gmbh | AMINOPROPANOL DERIVATIVES |
| US7825109B2 (en) * | 2003-08-29 | 2010-11-02 | Ono Pharmaceutical Co., Ltd. | Compound capable of binding S1P receptor and pharmaceutical use thereof |
| US20070043014A1 (en) * | 2003-10-01 | 2007-02-22 | Merck & Co., Inc. | 3,5-Aryl, heteroaryl or cycloalkyl substituted-1,2,4-oxadiazoles as s1p receptor agonists |
| GB0324210D0 (en) | 2003-10-15 | 2003-11-19 | Novartis Ag | Organic compounds |
| US7638637B2 (en) * | 2003-11-03 | 2009-12-29 | University Of Virginia Patent Foundation | Orally available sphingosine 1-phosphate receptor agonists and antagonists |
| EP1697333A4 (en) | 2003-12-17 | 2009-07-08 | Merck & Co Inc | 3,4-DISUSBSTITUTED PROPANOIC CARBOXYLATES AS S1P RECEPTOR AGONISTS (EDG) |
| TW200526548A (en) | 2003-12-25 | 2005-08-16 | Sankyo Co | Ether derivatives |
| GB0401332D0 (en) | 2004-01-21 | 2004-02-25 | Novartis Ag | Organic compounds |
| US7718704B2 (en) | 2004-02-24 | 2010-05-18 | Irm Llc | Immunosuppressant compounds and compositions |
| TW200538433A (en) | 2004-02-24 | 2005-12-01 | Irm Llc | Immunosuppressant compounds and compositiions |
| NZ549162A (en) * | 2004-02-24 | 2009-12-24 | Sankyo Co | Amino-pyrrol alcohol compounds |
| JP2005247691A (en) | 2004-03-01 | 2005-09-15 | Toa Eiyo Ltd | S1P3 receptor antagonist |
| GB0405289D0 (en) | 2004-03-09 | 2004-04-21 | Novartis Ag | Organic compounds |
| GB0411929D0 (en) * | 2004-05-27 | 2004-06-30 | Novartis Ag | Organic compounds |
| JP5315611B2 (en) * | 2004-06-23 | 2013-10-16 | 小野薬品工業株式会社 | Compound having S1P receptor binding ability and use thereof |
| US7781617B2 (en) | 2004-07-16 | 2010-08-24 | Kyorin Pharmaceutical Co., Ltd | Effective use method of medicaments and method of preventing expression of side effect |
| TW200611687A (en) | 2004-07-29 | 2006-04-16 | Sankyo Co | Pharmaceutical compositions used for immunosuppressant |
| MX2007001661A (en) | 2004-08-13 | 2007-04-23 | Praecis Pharm Inc | Methods and compositions for modulating sphingosine-1-phosphate (s1p) receptor activity. |
| EP1806338B1 (en) | 2004-10-12 | 2016-01-20 | Kyorin Pharmaceutical Co., Ltd. | Process for producing 2-amino-2-[2-[4-(3-benzyloxy-phenylthio)-2-chlorophenyl[ethyl]-1,3-propanediol hydrochloride and hydrates thereof. and intermediates the production thereof |
| WO2006041015A1 (en) | 2004-10-12 | 2006-04-20 | Kyorin Pharmaceutical Co., Ltd. | Amino alcohol derivative, addition salt thereof and immunosuppressive agent |
| WO2006063033A2 (en) | 2004-12-06 | 2006-06-15 | University Of Virginia Patent Foundation | Aryl amide sphingosine 1-phosphate analogs |
| TW200702326A (en) | 2005-05-31 | 2007-01-16 | Mitsubishi Pharma Corp | 2-aminobutanol compound and its pharmaceutical use |
| TWI418350B (en) | 2005-06-24 | 2013-12-11 | Sankyo Co | Use of pharmaceutical compositions comprising ppar modulator |
| ES2529724T3 (en) | 2005-09-09 | 2015-02-25 | Novartis Ag | Treatment of autoimmune diseases |
| PL1932522T3 (en) | 2005-10-07 | 2012-09-28 | Kyorin Seiyaku Kk | Therapeutic agent for liver disease containing 2-amino-1,3-propanediol derivative as active ingredient |
| US8546452B2 (en) | 2005-10-12 | 2013-10-01 | Toa Eiyo Ltd. | S1P3 receptor antagonist |
| TWI389683B (en) | 2006-02-06 | 2013-03-21 | Kyorin Seiyaku Kk | A therapeutic agent for an inflammatory bowel disease or an inflammatory bowel disease treatment using a 2-amino-1,3-propanediol derivative as an active ingredient |
| US20070264403A1 (en) * | 2006-05-11 | 2007-11-15 | Nehmer Warren L | Sparkling agglomerated sweetener, and method of making it |
| ZA200900316B (en) | 2006-07-25 | 2010-05-26 | Alcon Res Ltd | Antagonists of endothelial differentiation gene subfamily 3 (EDG-3, S1P3) receptors for prevention and treatment of ocular disorders |
| US7877152B2 (en) * | 2006-07-31 | 2011-01-25 | JusJas LLC | Bipolar stimulation/recording device with widely spaced electrodes |
-
2005
- 2005-10-07 EP EP05790615.8A patent/EP1806338B1/en not_active Expired - Lifetime
- 2005-10-07 ES ES12167175.4T patent/ES2615498T3/en not_active Expired - Lifetime
- 2005-10-07 BR BRPI0516337-4A patent/BRPI0516337A/en not_active IP Right Cessation
- 2005-10-07 CA CA2583846A patent/CA2583846C/en not_active Expired - Lifetime
- 2005-10-07 MX MX2007004319A patent/MX2007004319A/en active IP Right Grant
- 2005-10-07 EP EP12167175.4A patent/EP2511262B1/en not_active Expired - Lifetime
- 2005-10-07 WO PCT/JP2005/018602 patent/WO2006041019A1/en not_active Ceased
- 2005-10-07 PL PL05790615T patent/PL1806338T3/en unknown
- 2005-10-07 CN CN2010101975227A patent/CN101880250B/en not_active Expired - Fee Related
- 2005-10-07 RU RU2007117372/04A patent/RU2376285C2/en not_active IP Right Cessation
- 2005-10-07 ES ES05790615.8T patent/ES2563034T3/en not_active Expired - Lifetime
- 2005-10-07 AU AU2005292984A patent/AU2005292984B2/en not_active Ceased
- 2005-10-07 PT PT121671754T patent/PT2511262T/en unknown
- 2005-10-07 PL PL12167175T patent/PL2511262T3/en unknown
- 2005-10-07 JP JP2006540913A patent/JP4792400B2/en not_active Expired - Fee Related
- 2005-10-07 US US11/665,058 patent/US7795472B2/en not_active Expired - Fee Related
- 2005-10-07 KR KR1020077010572A patent/KR101181090B1/en not_active Expired - Fee Related
- 2005-10-07 CN CN2005800417574A patent/CN101072752B/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN101072752A (en) | 2007-11-14 |
| KR20070073895A (en) | 2007-07-10 |
| JP4792400B2 (en) | 2011-10-12 |
| ES2615498T3 (en) | 2017-06-07 |
| CA2583846C (en) | 2013-10-01 |
| CN101880250B (en) | 2013-04-03 |
| JPWO2006041019A1 (en) | 2008-05-15 |
| PL1806338T3 (en) | 2016-07-29 |
| KR101181090B1 (en) | 2012-09-07 |
| EP1806338A1 (en) | 2007-07-11 |
| BRPI0516337A (en) | 2008-04-29 |
| EP1806338A4 (en) | 2009-12-16 |
| EP1806338B1 (en) | 2016-01-20 |
| ES2563034T3 (en) | 2016-03-10 |
| EP2511262A1 (en) | 2012-10-17 |
| CN101880250A (en) | 2010-11-10 |
| EP2511262B1 (en) | 2017-02-01 |
| RU2007117372A (en) | 2008-11-20 |
| RU2376285C2 (en) | 2009-12-20 |
| US7795472B2 (en) | 2010-09-14 |
| CN101072752B (en) | 2010-12-08 |
| PT2511262T (en) | 2017-03-30 |
| MX2007004319A (en) | 2007-06-15 |
| WO2006041019A1 (en) | 2006-04-20 |
| CA2583846A1 (en) | 2006-04-20 |
| AU2005292984B2 (en) | 2011-01-20 |
| AU2005292984A1 (en) | 2006-04-20 |
| US20080207941A1 (en) | 2008-08-28 |
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