PL2513119T3 - Pochodne 3,4,4a,10b-tetrahydro-1H-tiopirano-[4,3-c]izochinoliny - Google Patents

Pochodne 3,4,4a,10b-tetrahydro-1H-tiopirano-[4,3-c]izochinoliny

Info

Publication number: PL2513119T3
Authority: PL; Poland
Prior art keywords: thiopyrano; tetrahydro; isoquinoline derivatives; isoquinoline; derivatives
Prior art date: 2009-12-18

Application number

PL10790569T

Other languages

English (en)

Inventor

Dieter Flockerzi

Thomas Stengel

Alexander Mann

Harald Ohmer

Ulrich Kautz

Steffen Weinbrenner

Stefan Fischer

Christof Zitt

Armin Hatzelmann

Torsten Dunkern

Christian Hesslinger

Thomas Maier

Hermann Tenor

Clemens Braun

Raimund Külzer

Degenhard Marx

Original Assignee

Takeda Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-12-18

Filing date

2010-12-15

Publication date

2014-11-28

2010-12-15 Application filed by Takeda Gmbh filed Critical Takeda Gmbh

2014-11-28 Publication of PL2513119T3 publication Critical patent/PL2513119T3/pl

Links

ZQCSTHXMOLTGJA-UHFFFAOYSA-N 3,4,4a,10b-tetrahydro-1h-thiopyrano[4,3-c]isoquinoline Chemical class N1=CC2=CC=CC=C2C2C1CCSC2 ZQCSTHXMOLTGJA-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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Public Health (AREA)
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Pharmacology & Pharmacy (AREA)
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Chemical Kinetics & Catalysis (AREA)
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Dermatology (AREA)
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Orthopedic Medicine & Surgery (AREA)
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PL10790569T 2009-12-18 2010-12-15 Pochodne 3,4,4a,10b-tetrahydro-1H-tiopirano-[4,3-c]izochinoliny PL2513119T3 (pl)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
EP09179982		2009-12-18
US31555210P	2010-03-19	2010-03-19
PCT/EP2010/069704 WO2011073231A1 (en)	2009-12-18	2010-12-15	3,4,4A,10B-TETRAHYDRO-1H-THIOPYRANO-[4, 3-c] ISOQUINOLINE DERIVATIVES
EP10790569.7A EP2513119B1 (en)	2009-12-18	2010-12-15	3,4,4a,10b-tetrahydro-1h-thiopyrano-[4,3-c]isoquinoline derivatives

Publications (1)

Publication Number	Publication Date
PL2513119T3 true PL2513119T3 (pl)	2014-11-28

Family

ID=41718903

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL10790569T PL2513119T3 (pl)	2009-12-18	2010-12-15	Pochodne 3,4,4a,10b-tetrahydro-1H-tiopirano-[4,3-c]izochinoliny

Country Status (29)

Country	Link
US (1)	US9018175B2 (pl)
EP (2)	EP2813509B1 (pl)
JP (1)	JP5645961B2 (pl)
KR (1)	KR20120123313A (pl)
CN (1)	CN102652136B (pl)
AR (1)	AR079451A1 (pl)
AU (1)	AU2010332955B8 (pl)
BR (1)	BR112012014058A8 (pl)
CA (1)	CA2784013A1 (pl)
CO (1)	CO6551705A2 (pl)
DK (1)	DK2513119T3 (pl)
EA (1)	EA023212B1 (pl)
ES (2)	ES2505290T3 (pl)
GE (1)	GEP20146105B (pl)
HR (1)	HRP20140893T1 (pl)
ME (1)	ME01914B (pl)
MX (1)	MX2012006696A (pl)
NZ (1)	NZ601115A (pl)
PH (1)	PH12012501125A1 (pl)
PL (1)	PL2513119T3 (pl)
PT (1)	PT2513119E (pl)
RS (1)	RS53544B1 (pl)
SG (2)	SG196785A1 (pl)
SI (1)	SI2513119T1 (pl)
SM (1)	SMT201400185B (pl)
TW (1)	TWI468411B (pl)
UA (1)	UA107689C2 (pl)
WO (1)	WO2011073231A1 (pl)
ZA (1)	ZA201204135B (pl)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP2577777B1 (en)	2010-06-07	2016-12-28	Sapurast Research LLC	Rechargeable, high-density electrochemical device
CN103501776A (zh) *	2011-02-17	2014-01-08	西普拉有限公司	甘罗铵与β2激动剂的组合物
EP2721036B1 (en)	2011-06-15	2015-07-22	Takeda GmbH	Novel 3,4,4a,10b-tetrahydro-1h-thiopyrano[4,3-c]isoquinoline compounds
WO2014016548A2 (en) *	2012-07-27	2014-01-30	Cipla Limited	Pharmaceutical composition
WO2014090990A1 (en) *	2012-12-13	2014-06-19	Ludwig Aigner	Leukotriene pathway antagonists for the treatment of dementia, cognitive deficits in parkinson's disease and/or learning and memory deficiencies in parkinson's disease
WO2014117947A1 (en)	2013-02-04	2014-08-07	Grünenthal GmbH	4-amino substituted condensed pyrimidine compounds as pde4 inhibitors
BR112015019276A2 (pt)	2013-02-19	2017-07-18	Pfizer	compostos de azabenzimidazol como inibidores de isoenzimas de pde4 para o tratamento de distúrbios do snc e outros distúrbios
WO2016012896A1 (en)	2014-07-24	2016-01-28	Pfizer Inc.	Pyrazolopyrimidine compounds
MD20170011A2 (ro)	2014-08-06	2017-08-31	Pfizer Inc.	Compuşi imidazopiridazinici
WO2017089347A1 (en)	2015-11-25	2017-06-01	Inserm (Institut National De La Sante Et De La Recherche Medicale)	Methods and pharmaceutical compositions for the treatment of braf inhibitor resistant melanomas
WO2022006470A1 (en)	2020-07-01	2022-01-06	Vanderbilt University	Methods of treatment for a kidney disease

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3899494A (en)	1970-05-13	1975-08-12	Sandoz Ltd	Substituted 6-phenyl benzo-naphthyridines
DE2047465A1 (de)	1970-09-26	1972-03-30	Farbwerke Hoechst AG, vorm Meister Lucius & Bruning, 6000 Frankfurt	Neue Oxdiazole und Verfahren zu lh rer Herstellung
CN1003445B (zh)	1984-10-03	1989-03-01	武田药品工业株式会社	噻唑烷二酮衍生物，其制备方法和用途
JPH01213284A (ja)	1988-02-22	1989-08-28	Sankyo Co Ltd	チエノピリミジン−２，４−ジオン誘導体
GB8828477D0 (en)	1988-12-06	1989-01-05	Riker Laboratories Inc	Medical aerosol formulations
ATE111364T1 (de)	1989-05-31	1994-09-15	Fisons Plc	Medikament und inhalationsvorrichtung dafür.
GB8921222D0 (en)	1989-09-20	1989-11-08	Riker Laboratories Inc	Medicinal aerosol formulations
IL97065A (en)	1990-02-02	1994-01-25	Fisons Plc	Repellent preparations for aerosol
DE4003272A1 (de)	1990-02-03	1991-08-08	Boehringer Ingelheim Kg	Neue treibgasmischungen und ihre verwendung in arzneimittelzubereitungen
DE69131867T2 (de)	1990-03-23	2000-05-18	Minnesota Mining And Mfg. Co., Saint Paul	Anwendung von löslichen fluorhaltigen Tensiden zur Herstellung von Aerosol-Präparaten mit dosierter Abgabe
ATE114112T1 (de)	1990-10-18	1994-12-15	Minnesota Mining & Mfg	Aerosolzubereitung, die beclometason 17,21- dipropionat enthält.
AU650953B2 (en)	1991-03-21	1994-07-07	Novartis Ag	Inhaler
IL104068A (en)	1991-12-12	1998-10-30	Glaxo Group Ltd	Surfactant-free pharmaceutical aerosol formulation comprising 1,1,1,2-tetrafluoroethane or 1,1,1,2,3,3,3-heptafluoro-n- propane as propellant
GB9213874D0 (en)	1992-06-30	1992-08-12	Fisons Plc	Process to novel medicament form
GB9306703D0 (en)	1993-03-31	1993-05-26	Fisons Plc	Inhalation device
IL111194A (en)	1993-10-08	1998-02-08	Fisons Plc	Process for the production of medicament formulations
PL189641B1 (pl)	1996-11-11	2005-09-30	Altana Pharma Ag	Benzonaftyrydyny, środki farmaceutyczne je zawierające oraz zastosowanie benzonaftyrydyn
CA2288789C (en)	1997-05-08	2009-07-21	Merck Sharp & Dohme Limited	Substituted 1,2,4-triazolo[3,4-a]phthalazine derivatives as gaba alpha 5 ligands
ES2193539T3 (es)	1997-06-03	2003-11-01	Altana Pharma Ag	Benzonaftiridinas.
JP4672143B2 (ja)	1998-08-04	2011-04-20	ヤゴテックアーゲー	医薬用エーロゾル製剤
US6397838B1 (en)	1998-12-23	2002-06-04	Battelle Pulmonary Therapeutics, Inc.	Pulmonary aerosol delivery device and method
IL146034A0 (en)	1999-04-23	2002-07-25	Battelle Memorial Institute	High mass transfer electrosprayer
AU777167B2 (en)	1999-04-23	2004-10-07	Battelle Memorial Institute	Directionally controlled EHD aerosol sprayer
WO2001030757A1 (en)	1999-10-28	2001-05-03	Microcide Pharmaceuticals, Inc.	Drug discharge pump inhibitors
WO2001094350A1 (en)	2000-06-07	2001-12-13	Almirall Prodesfarma S.A.	6-phenylpyrrolopyrimidinedione derivatives
WO2002005616A1 (en)	2000-07-14	2002-01-24	Altana Pharma Ag	Novel 6-phenylphenanthridines
ES2260299T3 (es)	2000-10-09	2006-11-01	3M Innovative Properties Company	Formulaciones medicinales en aerosol.
AU2002331064B2 (en)	2001-08-10	2007-08-23	Palatin Technologies, Inc.	Peptidomimetics of biologically active metallopeptides
US20030216407A1 (en)	2002-01-31	2003-11-20	Pfizer Inc.	Use of PDE5 inhibitors in the treatment of scarring
GB0202254D0 (en)	2002-01-31	2002-03-20	Pfizer Ltd	Prevention of scarring
AU2003253165A1 (en)	2002-08-13	2004-02-25	Warner-Lambert Company Llc	Pyrimidine fused bicyclic metalloproteinase inhibitors
MXPA06012279A (es)	2004-04-23	2007-01-31	Celgene Corp	Metodos de uso y composiciones que comprenden moduladores de pde4 para el tratamiento y manejo de la hipertension pulmonar.
ATE508130T1 (de)	2004-09-08	2011-05-15	Nycomed Gmbh	3-oxa-10-aza-phenanthrene als pde4- oder pde3/4- inhibitoren
EP1791847A2 (en)	2004-09-08	2007-06-06	Altana Pharma AG	Novel 3-thia-10-aza-phenanthrene derivatives
CA2588768A1 (en)	2004-11-17	2006-05-26	Kissei Pharmaceutical Co., Ltd.	Aromatic amide derivatives, medicinal compositions containing the same, medical uses of both
CA2599368A1 (en)	2005-03-09	2006-09-14	Nycomed Gmbh	Amido-substituted 6-phenylphenanthridines
MX2009011089A (es)	2007-04-23	2009-10-30	Sanofi Aventis	Derivados de quinolina-carboxamida en calidad de antagonistas de p2y12.
EP2721036B1 (en) *	2011-06-15	2015-07-22	Takeda GmbH	Novel 3,4,4a,10b-tetrahydro-1h-thiopyrano[4,3-c]isoquinoline compounds

2010
- 2010-12-14 AR ARP100104617A patent/AR079451A1/es unknown
- 2010-12-15 EP EP14164018.5A patent/EP2813509B1/en active Active
- 2010-12-15 ME MEP-2014-114A patent/ME01914B/me unknown
- 2010-12-15 RS RSP20140499 patent/RS53544B1/sr unknown
- 2010-12-15 SG SG2014000335A patent/SG196785A1/en unknown
- 2010-12-15 WO PCT/EP2010/069704 patent/WO2011073231A1/en not_active Ceased
- 2010-12-15 SG SG2012034732A patent/SG180824A1/en unknown
- 2010-12-15 ES ES10790569.7T patent/ES2505290T3/es active Active
- 2010-12-15 CA CA2784013A patent/CA2784013A1/en not_active Abandoned
- 2010-12-15 CN CN201080057293.7A patent/CN102652136B/zh not_active Expired - Fee Related
- 2010-12-15 PL PL10790569T patent/PL2513119T3/pl unknown
- 2010-12-15 DK DK10790569.7T patent/DK2513119T3/da active
- 2010-12-15 PH PH1/2012/501125A patent/PH12012501125A1/en unknown
- 2010-12-15 UA UAA201208482A patent/UA107689C2/ru unknown
- 2010-12-15 SI SI201030746T patent/SI2513119T1/sl unknown
- 2010-12-15 ES ES14164018.5T patent/ES2621291T3/es active Active
- 2010-12-15 NZ NZ601115A patent/NZ601115A/en not_active IP Right Cessation
- 2010-12-15 GE GEAP201012783A patent/GEP20146105B/en unknown
- 2010-12-15 MX MX2012006696A patent/MX2012006696A/es active IP Right Grant
- 2010-12-15 US US13/515,214 patent/US9018175B2/en not_active Expired - Fee Related
- 2010-12-15 EA EA201200891A patent/EA023212B1/ru not_active IP Right Cessation
- 2010-12-15 BR BR112012014058A patent/BR112012014058A8/pt not_active IP Right Cessation
- 2010-12-15 PT PT107905697T patent/PT2513119E/pt unknown
- 2010-12-15 JP JP2012543701A patent/JP5645961B2/ja not_active Expired - Fee Related
- 2010-12-15 KR KR1020127017957A patent/KR20120123313A/ko not_active Withdrawn
- 2010-12-15 AU AU2010332955A patent/AU2010332955B8/en not_active Ceased
- 2010-12-15 EP EP10790569.7A patent/EP2513119B1/en active Active
- 2010-12-15 HR HRP20140893AT patent/HRP20140893T1/hr unknown
- 2010-12-17 TW TW99144591A patent/TWI468411B/zh not_active IP Right Cessation
2012
- 2012-05-24 CO CO12085785A patent/CO6551705A2/es active IP Right Grant
- 2012-06-06 ZA ZA2012/04135A patent/ZA201204135B/en unknown
2014
- 2014-12-11 SM SM201400185T patent/SMT201400185B/xx unknown

Also Published As

Publication number	Publication date
RS53544B1 (sr)	2015-02-27
SMT201400185B (it)	2015-01-15
TWI468411B (zh)	2015-01-11
ZA201204135B (en)	2013-03-27
EP2813509A1 (en)	2014-12-17
JP5645961B2 (ja)	2014-12-24
JP2013514308A (ja)	2013-04-25
PH12012501125A1 (en)	2012-10-29
ME01914B (me)	2015-05-20
ES2505290T3 (es)	2014-10-09
MX2012006696A (es)	2012-07-17
BR112012014058A8 (pt)	2018-02-06
AU2010332955B2 (en)	2015-01-22
BR112012014058A2 (pt)	2017-10-24
EP2513119A1 (en)	2012-10-24
US20120289474A1 (en)	2012-11-15
SG196785A1 (en)	2014-02-13
CO6551705A2 (es)	2012-10-31
PT2513119E (pt)	2014-09-05
AU2010332955A1 (en)	2012-08-02
EA023212B1 (ru)	2016-05-31
HK1174326A1 (en)	2013-06-07
UA107689C2 (xx)	2015-02-10
EA201200891A1 (ru)	2013-01-30
SG180824A1 (en)	2012-07-30
SI2513119T1 (sl)	2014-10-30
US9018175B2 (en)	2015-04-28
CN102652136A (zh)	2012-08-29
AU2010332955B8 (en)	2015-05-21
ES2621291T3 (es)	2017-07-03
EP2513119B1 (en)	2014-06-25
CA2784013A1 (en)	2011-06-23
AR079451A1 (es)	2012-01-25
WO2011073231A1 (en)	2011-06-23
GEP20146105B (en)	2014-05-27
NZ601115A (en)	2014-05-30
TW201130851A (en)	2011-09-16
KR20120123313A (ko)	2012-11-08
EP2813509B1 (en)	2017-02-01
HRP20140893T1 (hr)	2014-11-07
AU2010332955A8 (en)	2015-05-28
CN102652136B (zh)	2014-11-26
DK2513119T3 (da)	2014-10-06

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