PL2542551T3 - Sposób stereoselektywnego otrzymywania 5-fluoro-1-(2R,SS)-[2-(hydroksymetylo)-1,3-oksatiolan--5-ylo]cytozyny - Google Patents
Sposób stereoselektywnego otrzymywania 5-fluoro-1-(2R,SS)-[2-(hydroksymetylo)-1,3-oksatiolan--5-ylo]cytozynyInfo
- Publication number
- PL2542551T3 PL2542551T3 PL11713057T PL11713057T PL2542551T3 PL 2542551 T3 PL2542551 T3 PL 2542551T3 PL 11713057 T PL11713057 T PL 11713057T PL 11713057 T PL11713057 T PL 11713057T PL 2542551 T3 PL2542551 T3 PL 2542551T3
- Authority
- PL
- Poland
- Prior art keywords
- oxathiolan
- cytosine
- hydroxymethyl
- fluoro
- stereoselective synthesis
- Prior art date
Links
- XQSPYNMVSIKCOC-NTSWFWBYSA-N Emtricitabine Chemical compound C1=C(F)C(N)=NC(=O)N1[C@H]1O[C@@H](CO)SC1 XQSPYNMVSIKCOC-NTSWFWBYSA-N 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 230000000707 stereoselective effect Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D411/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN489DE2010 | 2010-03-04 | ||
| PCT/IB2011/050824 WO2011107920A1 (en) | 2010-03-04 | 2011-02-25 | A process for stereoselective synthesis of 5-fluoro-1-(2r,5s)-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine |
| EP11713057.5A EP2542551B1 (en) | 2010-03-04 | 2011-02-25 | A process for stereoselective synthesis of 5-fluoro-1-(2r,5s)-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2542551T3 true PL2542551T3 (pl) | 2015-01-30 |
Family
ID=43904045
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL11713057T PL2542551T3 (pl) | 2010-03-04 | 2011-02-25 | Sposób stereoselektywnego otrzymywania 5-fluoro-1-(2R,SS)-[2-(hydroksymetylo)-1,3-oksatiolan--5-ylo]cytozyny |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8748604B2 (pl) |
| EP (1) | EP2542551B1 (pl) |
| AU (1) | AU2011222471B2 (pl) |
| CA (1) | CA2792044A1 (pl) |
| PL (1) | PL2542551T3 (pl) |
| WO (1) | WO2011107920A1 (pl) |
| ZA (1) | ZA201207419B (pl) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102516078B (zh) * | 2011-12-31 | 2014-06-04 | 浙江先锋科技有限公司 | 乙醛酸l-薄荷醇酯及其一水合物的制备方法 |
| CN105585564A (zh) * | 2014-11-18 | 2016-05-18 | 正大天晴药业集团股份有限公司 | 恩曲他滨的纯化方法 |
| CN105130972B (zh) * | 2015-08-04 | 2018-04-20 | 中孚药业股份有限公司 | 苯甲酸恩曲他滨盐、其制备方法以及用苯甲酸恩曲他滨盐制备恩曲他滨的方法 |
| GB201610327D0 (en) * | 2016-06-14 | 2016-07-27 | Univ Nelson Mandela Metropolitan | Process for producing Lamivudine and Entricitabine |
| CN106187988A (zh) * | 2016-07-28 | 2016-12-07 | 厦门市蔚嘉化学科技有限公司 | 一种制备恩曲他滨中间体的新工艺 |
| CN106478618A (zh) * | 2016-10-14 | 2017-03-08 | 上海礼泰医药科技有限公司 | 恩曲他滨氢卤酸盐的制备方法 |
| CN106496208A (zh) * | 2016-10-19 | 2017-03-15 | 上海博志研新药物技术有限公司 | 恩曲他滨的制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA923641B (en) | 1991-05-21 | 1993-02-24 | Iaf Biochem Int | Processes for the diastereoselective synthesis of nucleosides |
| IL113432A (en) * | 1994-04-23 | 2000-11-21 | Glaxo Group Ltd | Process for the diastereoselective synthesis of nucleoside analogues |
| ITMI20030578A1 (it) * | 2003-03-24 | 2004-09-25 | Clariant Lsm Italia Spa | Processo ed intermedi per la preparazione di emtricitabina |
| WO2007077505A2 (en) * | 2005-12-30 | 2007-07-12 | Ranbaxy Laboratories Limited | Crystalline l-menthyl (2r, 5s)-5-(4-amino-5-fluoro-2-oxo-2h-pyrimidin-1-yl)[1, 3]oxathiolan-2-carboxylate and process for preparation thereof |
| US8350030B2 (en) | 2007-12-07 | 2013-01-08 | Matrix Laboratories Limited | Process for producing 5-fluoro-1-(2R, 5S)-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine |
-
2011
- 2011-02-25 PL PL11713057T patent/PL2542551T3/pl unknown
- 2011-02-25 AU AU2011222471A patent/AU2011222471B2/en not_active Ceased
- 2011-02-25 CA CA2792044A patent/CA2792044A1/en not_active Abandoned
- 2011-02-25 EP EP11713057.5A patent/EP2542551B1/en not_active Not-in-force
- 2011-02-25 US US13/582,513 patent/US8748604B2/en not_active Expired - Fee Related
- 2011-02-25 WO PCT/IB2011/050824 patent/WO2011107920A1/en not_active Ceased
-
2012
- 2012-10-03 ZA ZA2012/07419A patent/ZA201207419B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2542551B1 (en) | 2014-08-27 |
| US8748604B2 (en) | 2014-06-10 |
| EP2542551A1 (en) | 2013-01-09 |
| WO2011107920A1 (en) | 2011-09-09 |
| CA2792044A1 (en) | 2011-09-09 |
| US20130072681A1 (en) | 2013-03-21 |
| ZA201207419B (en) | 2013-06-26 |
| AU2011222471B2 (en) | 2014-07-31 |
| AU2011222471A1 (en) | 2012-09-27 |
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