PL2607484T3 - Sposoby i środki do wydajnego pomijania eksonu 45 w pre-mRNA dystrofii mięśniowej Duchenne'a - Google Patents

Sposoby i środki do wydajnego pomijania eksonu 45 w pre-mRNA dystrofii mięśniowej Duchenne'a

Info

Publication number
PL2607484T3
PL2607484T3 PL13160338T PL13160338T PL2607484T3 PL 2607484 T3 PL2607484 T3 PL 2607484T3 PL 13160338 T PL13160338 T PL 13160338T PL 13160338 T PL13160338 T PL 13160338T PL 2607484 T3 PL2607484 T3 PL 2607484T3
Authority
PL
Poland
Prior art keywords
exon
mrna
methods
muscular dystrophy
duchenne muscular
Prior art date
Application number
PL13160338T
Other languages
English (en)
Inventor
Kimpe Josephus Johannes De
Gerardus Johannes Platenburg
Deutekom Judith Christina Theodora Van
Annemieke Aartsma-Rus
Ommen Garrit-Jan Boudewijn Van
Original Assignee
Biomarin Tech Bv
Academisch Ziekenhuis Leiden
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40873329&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2607484(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from PCT/NL2008/050673 external-priority patent/WO2009054725A2/en
Application filed by Biomarin Tech Bv, Academisch Ziekenhuis Leiden filed Critical Biomarin Tech Bv
Publication of PL2607484T3 publication Critical patent/PL2607484T3/pl

Links

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Neurology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Biotechnology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Psychiatry (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Hospice & Palliative Care (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
PL13160338T 2008-10-27 2009-01-13 Sposoby i środki do wydajnego pomijania eksonu 45 w pre-mRNA dystrofii mięśniowej Duchenne'a PL2607484T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/NL2008/050673 WO2009054725A2 (en) 2007-10-26 2008-10-27 Means and methods for counteracting muscle disorders
EP09788160.1A EP2344637B2 (en) 2008-10-27 2009-01-13 Methods and means for efficient skipping of exon 45 in duchenne muscular dystrophy pre-mrna
EP13160338.3A EP2607484B1 (en) 2008-10-27 2009-01-13 Methods and means for efficient skipping of exon 45 in Duchenne Muscular Dystrophy pre-mRNA

Publications (1)

Publication Number Publication Date
PL2607484T3 true PL2607484T3 (pl) 2016-06-30

Family

ID=40873329

Family Applications (1)

Application Number Title Priority Date Filing Date
PL13160338T PL2607484T3 (pl) 2008-10-27 2009-01-13 Sposoby i środki do wydajnego pomijania eksonu 45 w pre-mRNA dystrofii mięśniowej Duchenne'a

Country Status (14)

Country Link
EP (4) EP2344637B2 (pl)
JP (2) JP5786109B2 (pl)
AU (1) AU2009310557B2 (pl)
CA (3) CA2741629C (pl)
CY (1) CY1116305T1 (pl)
DK (2) DK2344637T4 (pl)
ES (2) ES2532634T5 (pl)
HR (1) HRP20160078T1 (pl)
IL (2) IL212508A (pl)
NZ (1) NZ592498A (pl)
PL (1) PL2607484T3 (pl)
PT (2) PT2607484E (pl)
SI (1) SI2607484T1 (pl)
WO (2) WO2010050801A1 (pl)

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Also Published As

Publication number Publication date
PT2344637E (pt) 2015-03-23
HK1160169A1 (en) 2012-08-10
JP2012506698A (ja) 2012-03-22
CA3017539A1 (en) 2010-05-06
ES2532634T5 (es) 2018-04-30
CA2741629C (en) 2022-07-05
JP5786109B2 (ja) 2015-09-30
ES2532634T3 (es) 2015-03-30
EP2344637B1 (en) 2014-12-24
AU2009310558A8 (en) 2015-01-22
CA2741793C (en) 2018-10-30
ES2562658T3 (es) 2016-03-07
CY1116305T1 (el) 2017-02-08
EP2349287A2 (en) 2011-08-03
JP2012506697A (ja) 2012-03-22
IL212508A0 (en) 2011-06-30
AU2009310557B2 (en) 2014-09-11
WO2010050802A2 (en) 2010-05-06
CA2741793A1 (en) 2010-05-06
PT2607484E (pt) 2016-03-09
EP2344637B2 (en) 2018-02-28
SI2607484T1 (sl) 2016-11-30
EP2607484B1 (en) 2016-01-06
EP3400948B1 (en) 2022-11-02
CA3017539C (en) 2025-10-07
DK2344637T4 (en) 2018-04-23
EP2349287B1 (en) 2018-08-15
IL212508A (en) 2013-11-28
HRP20160078T1 (hr) 2016-04-08
WO2010050802A3 (en) 2010-08-12
EP3400948A1 (en) 2018-11-14
CA2741629A1 (en) 2010-05-06
AU2009310557A8 (en) 2011-09-29
WO2010050801A1 (en) 2010-05-06
AU2009310558A1 (en) 2010-05-06
AU2009310557A1 (en) 2010-05-06
DK2607484T3 (en) 2016-03-07
NZ592498A (en) 2012-05-25
EP2344637A1 (en) 2011-07-20
DK2344637T3 (en) 2015-02-02
AU2009310558B2 (en) 2014-09-04
IL212509A (en) 2016-04-21
EP2607484A1 (en) 2013-06-26
JP5905260B2 (ja) 2016-04-20
IL212509A0 (en) 2011-06-30

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