PL2641897T3 - Sposób wytwarzania 6-(7-((1-aminocyklopropylo)metoksy)-6-metoksy-chinolin-4-yloksy)-n-metylo-1-naftamidu oraz jego syntetycznych produktów pośrednich - Google Patents
Sposób wytwarzania 6-(7-((1-aminocyklopropylo)metoksy)-6-metoksy-chinolin-4-yloksy)-n-metylo-1-naftamidu oraz jego syntetycznych produktów pośrednichInfo
- Publication number
- PL2641897T3 PL2641897T3 PL13172499T PL13172499T PL2641897T3 PL 2641897 T3 PL2641897 T3 PL 2641897T3 PL 13172499 T PL13172499 T PL 13172499T PL 13172499 T PL13172499 T PL 13172499T PL 2641897 T3 PL2641897 T3 PL 2641897T3
- Authority
- PL
- Poland
- Prior art keywords
- aminocyclopropyl
- naphthamide
- methoxyquinolin
- yloxy
- methoxy
- Prior art date
Links
- CUDVHEFYRIWYQD-UHFFFAOYSA-N E-3810 free base Chemical compound C=1C=C2C(C(=O)NC)=CC=CC2=CC=1OC(C1=CC=2OC)=CC=NC1=CC=2OCC1(N)CC1 CUDVHEFYRIWYQD-UHFFFAOYSA-N 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/44—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/04—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups from amines with formation of carbamate groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/24—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Quinoline Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI2009A000397A IT1393351B1 (it) | 2009-03-16 | 2009-03-16 | Procedimento per la preparazione della 6-(7-((1-amminociclopropil)metossi)-6-metossichinolin-4-ilossi)-n-metil-1-naftammide e suoi intermedi di sintesi |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2641897T3 true PL2641897T3 (pl) | 2017-01-31 |
Family
ID=41210541
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL13172499T PL2641897T3 (pl) | 2009-03-16 | 2010-03-11 | Sposób wytwarzania 6-(7-((1-aminocyklopropylo)metoksy)-6-metoksy-chinolin-4-yloksy)-n-metylo-1-naftamidu oraz jego syntetycznych produktów pośrednich |
| PL10712320T PL2408739T3 (pl) | 2009-03-16 | 2010-03-11 | Sposób wytwarzania 6-(7-((1-aminocyklopropylo)metoksy)-6-metoksychinolin-4-yloksy)-n-metylo-1-naftamidu oraz jego syntetycznych produktów pośrednich |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL10712320T PL2408739T3 (pl) | 2009-03-16 | 2010-03-11 | Sposób wytwarzania 6-(7-((1-aminocyklopropylo)metoksy)-6-metoksychinolin-4-yloksy)-n-metylo-1-naftamidu oraz jego syntetycznych produktów pośrednich |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US8642767B2 (pl) |
| EP (3) | EP2408739B1 (pl) |
| JP (2) | JP5817079B2 (pl) |
| CN (3) | CN104193676B (pl) |
| CY (2) | CY1114503T1 (pl) |
| DK (2) | DK2408739T3 (pl) |
| ES (2) | ES2585221T3 (pl) |
| HR (2) | HRP20130978T1 (pl) |
| HU (1) | HUE029528T2 (pl) |
| IT (1) | IT1393351B1 (pl) |
| PL (2) | PL2641897T3 (pl) |
| PT (2) | PT2641897T (pl) |
| SI (2) | SI2408739T1 (pl) |
| SM (1) | SMT201600356B (pl) |
| WO (1) | WO2010105761A1 (pl) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1393351B1 (it) | 2009-03-16 | 2012-04-20 | Eos Ethical Oncology Science Spa In Forma Abbreviata Eos Spa | Procedimento per la preparazione della 6-(7-((1-amminociclopropil)metossi)-6-metossichinolin-4-ilossi)-n-metil-1-naftammide e suoi intermedi di sintesi |
| JP2016506917A (ja) * | 2013-01-18 | 2016-03-07 | アドヴェンチェン ファーマスーティカルズ，エルエルシー | 抗腫瘍剤６−（７−（（１−アミノシクロプロピル）メトキシ）−６−メトキシキノリン−４−イルオキシ）−ｎ−メチル−１−ナフトアミドおよびその結晶を調製するプロセス |
| CN105311030B (zh) | 2014-06-06 | 2020-03-24 | 正大天晴药业集团股份有限公司 | 用于抗肿瘤的螺取代化合物 |
| CN105311029A (zh) | 2014-06-06 | 2016-02-10 | 正大天晴药业集团股份有限公司 | 抗肿瘤活性的喹啉衍生物 |
| AU2015290007B2 (en) | 2014-07-14 | 2019-11-21 | Advenchen Pharmaceuticals, Nanjing Ltd. | Fused quinoline compunds as pi3k, mTor inhibitors |
| US10307412B2 (en) | 2014-12-09 | 2019-06-04 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Quinoline derivative against non-small cell lung cancer |
| US9751859B2 (en) | 2015-05-04 | 2017-09-05 | Advenchen Pharmaceuticals, LLC | Process for preparing an anti-cancer agent, 1-((4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxyquinolin-7-yloxy)methyl)cyclopropanamine, its crystalline form and its salts |
| CN114805352B (zh) | 2015-07-11 | 2023-09-15 | 南京爱德程医药科技有限公司 | 作为pi3k/mtor抑制剂的吡咯并吡啶取代的稠合喹啉化合物 |
| JP6740354B2 (ja) | 2015-10-05 | 2020-08-12 | ザ トラスティーズ オブ コロンビア ユニバーシティー イン ザ シティー オブ ニューヨーク | オートファジーの流れ及びホスホリパーゼｄ及びタウを含むタンパク質凝集体のクリアランスの活性化剤ならびにタンパク質症の治療方法 |
| CN107296811B (zh) | 2016-04-15 | 2022-12-30 | 正大天晴药业集团股份有限公司 | 一种用于治疗胃癌的喹啉衍生物 |
| CN109748902B (zh) * | 2017-11-02 | 2020-11-06 | 杭州科巢生物科技有限公司 | 一种盐酸安罗替尼的制备方法 |
| CN115057815A (zh) | 2018-03-02 | 2022-09-16 | 正大天晴药业集团股份有限公司 | 作为c-Met激酶抑制剂的化合物的结晶及其制备方法和用途 |
| EP3762379A1 (en) | 2018-03-07 | 2021-01-13 | Bayer Aktiengesellschaft | Identification and use of erk5 inhibitors |
| CN110483392A (zh) * | 2018-05-14 | 2019-11-22 | 上海海和药物研究开发有限公司 | 合成n-保护的喹啉-7-基氧基甲基环丙基胺衍生物的方法及合成中间体 |
| CN110483393A (zh) * | 2018-05-14 | 2019-11-22 | 上海海和药物研究开发有限公司 | 德立替尼的晶型 |
| CN109705093A (zh) * | 2018-12-29 | 2019-05-03 | 正大天晴药业集团股份有限公司 | 喹啉衍生物及其制备方法和用途 |
| CN115160221B (zh) * | 2022-07-26 | 2024-10-18 | 恩祺生物科技(上海)有限公司 | 德立替尼晶型化合物和用途 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3282827B2 (ja) * | 1996-12-23 | 2002-05-20 | ヘキスト・マリオン・ルセル・インコーポレイテツド | ３−アリール−２−（１−置換−４−ピペリジニル）−１（１−ジ）オキソ−３ｈ−ベンゾ〔ｄ〕−イソチアゾール誘導体、その製造および神経伝達物質機能のモジュレーターとしてのその使用 |
| PT1154774E (pt) * | 1999-02-10 | 2005-10-31 | Astrazeneca Ab | Derivados de quinazolina como inibidores de angiogenese |
| WO2004018430A1 (ja) * | 2002-08-23 | 2004-03-04 | Kirin Beer Kabushiki Kaisha | ＴＧＦβ阻害活性を有する化合物およびそれを含んでなる医薬組成物 |
| AU2004309166B2 (en) * | 2003-12-23 | 2008-02-21 | Pfizer Inc. | Novel quinoline derivatives |
| US8163923B2 (en) | 2007-03-14 | 2012-04-24 | Advenchen Laboratories, Llc | Spiro substituted compounds as angiogenesis inhibitors |
| IT1393351B1 (it) | 2009-03-16 | 2012-04-20 | Eos Ethical Oncology Science Spa In Forma Abbreviata Eos Spa | Procedimento per la preparazione della 6-(7-((1-amminociclopropil)metossi)-6-metossichinolin-4-ilossi)-n-metil-1-naftammide e suoi intermedi di sintesi |
-
2009
- 2009-03-16 IT ITMI2009A000397A patent/IT1393351B1/it active
-
2010
- 2010-03-11 WO PCT/EP2010/001519 patent/WO2010105761A1/en not_active Ceased
- 2010-03-11 ES ES13172499.9T patent/ES2585221T3/es active Active
- 2010-03-11 US US13/256,722 patent/US8642767B2/en not_active Expired - Fee Related
- 2010-03-11 CN CN201410380387.8A patent/CN104193676B/zh not_active Expired - Fee Related
- 2010-03-11 SI SI201030383T patent/SI2408739T1/sl unknown
- 2010-03-11 ES ES10712320T patent/ES2431618T3/es active Active
- 2010-03-11 CN CN201610565855.8A patent/CN106187882A/zh active Pending
- 2010-03-11 DK DK10712320.0T patent/DK2408739T3/da active
- 2010-03-11 HU HUE13172499A patent/HUE029528T2/en unknown
- 2010-03-11 PL PL13172499T patent/PL2641897T3/pl unknown
- 2010-03-11 PT PT131724999T patent/PT2641897T/pt unknown
- 2010-03-11 PT PT10712320T patent/PT2408739E/pt unknown
- 2010-03-11 PL PL10712320T patent/PL2408739T3/pl unknown
- 2010-03-11 EP EP10712320.0A patent/EP2408739B1/en active Active
- 2010-03-11 CN CN201080011948.7A patent/CN102356063B/zh not_active Expired - Fee Related
- 2010-03-11 HR HRP20130978AT patent/HRP20130978T1/hr unknown
- 2010-03-11 EP EP16171791.3A patent/EP3103792A1/en not_active Withdrawn
- 2010-03-11 SI SI201031256A patent/SI2641897T1/sl unknown
- 2010-03-11 EP EP13172499.9A patent/EP2641897B1/en active Active
- 2010-03-11 DK DK13172499.9T patent/DK2641897T3/en active
- 2010-03-11 JP JP2012500115A patent/JP5817079B2/ja not_active Expired - Fee Related
-
2013
- 2013-10-16 CY CY20131100907T patent/CY1114503T1/el unknown
- 2013-12-23 US US14/138,302 patent/US9012645B2/en not_active Expired - Fee Related
-
2015
- 2015-03-18 US US14/661,105 patent/US9340508B2/en not_active Expired - Fee Related
- 2015-05-22 JP JP2015104974A patent/JP6061158B2/ja not_active Expired - Fee Related
-
2016
- 2016-07-29 CY CY20161100749T patent/CY1117871T1/el unknown
- 2016-09-12 HR HRP20161163TT patent/HRP20161163T1/hr unknown
- 2016-10-06 SM SM201600356T patent/SMT201600356B/it unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PL2641897T3 (pl) | Sposób wytwarzania 6-(7-((1-aminocyklopropylo)metoksy)-6-metoksy-chinolin-4-yloksy)-n-metylo-1-naftamidu oraz jego syntetycznych produktów pośrednich | |
| IL237445A0 (en) | A method for the identification and production of (r)-specific omega-transaminases | |
| ZA201202504B (en) | Process for the preparation of calcobutrol | |
| ZA201202519B (en) | Method for manufacturing disposable wearing article | |
| IL221441A0 (en) | Process for preparing entecavir and its intermediates | |
| PL390042A1 (pl) | Sposób wytwarzania kwasu chlebowego | |
| PL388931A1 (pl) | Sposób otrzymywania fluorokarbofunkcyjnych silseskwioksanów | |
| IL220846A0 (en) | Process for the preparation of nebivolol | |
| IL226153A0 (en) | Process for preparing nabivolol | |
| IL218483A0 (en) | Process for the production of artemisinin intermediates | |
| GB0914589D0 (en) | Novel compounds and methods for their production | |
| GB0904540D0 (en) | Novel compounds and methods for their production | |
| EG27000A (en) | Process for the preparation of ibodutant (MEN15596) and related intermediates | |
| IL217460A0 (en) | Novel process for the preparation of 4-aminobut-2-enolides | |
| ZA201201657B (en) | Processes for the preparation of vardenafil | |
| GB0917816D0 (en) | Novel compounds and methods for their production | |
| GB0917817D0 (en) | Novel compounds and methods for their production | |
| PL388933A1 (pl) | Sposób otrzymywania fluorosilikonów | |
| PL392292A1 (pl) | Sposób otrzymywania nowych poliuretanowych proleków chinolonów | |
| GB0904542D0 (en) | Novel compounds and methods for their production | |
| IL220160A (en) | A process for the preparation of defrasirox | |
| PL389568A1 (pl) | Sposób otrzymywania 2-metyloglicydolu |