PL2657345T3 - Enzymatyczny sposób wytwarzania L-metioniny z prekursora i merkaptanu metylowego - Google Patents
Enzymatyczny sposób wytwarzania L-metioniny z prekursora i merkaptanu metylowegoInfo
- Publication number
- PL2657345T3 PL2657345T3 PL13178074T PL13178074T PL2657345T3 PL 2657345 T3 PL2657345 T3 PL 2657345T3 PL 13178074 T PL13178074 T PL 13178074T PL 13178074 T PL13178074 T PL 13178074T PL 2657345 T3 PL2657345 T3 PL 2657345T3
- Authority
- PL
- Poland
- Prior art keywords
- methylmercaptan
- methionine
- precursor
- producing
- enzymatic method
- Prior art date
Links
- LSDPWZHWYPCBBB-UHFFFAOYSA-N Methanethiol Chemical compound SC LSDPWZHWYPCBBB-UHFFFAOYSA-N 0.000 title 2
- FFEARJCKVFRZRR-UHFFFAOYSA-N L-Methionine Natural products CSCCC(N)C(O)=O FFEARJCKVFRZRR-UHFFFAOYSA-N 0.000 title 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 title 1
- 229930195722 L-methionine Natural products 0.000 title 1
- 238000006911 enzymatic reaction Methods 0.000 title 1
- 229960004452 methionine Drugs 0.000 title 1
- 239000002243 precursor Substances 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/12—Methionine; Cysteine; Cystine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
- C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/06—Alanine; Leucine; Isoleucine; Serine; Homoserine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/44—Polycarboxylic acids
- C12P7/46—Dicarboxylic acids having four or less carbon atoms, e.g. fumaric acid, maleic acid
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20060071581 | 2006-07-28 | ||
| KR1020070076045A KR100905381B1 (ko) | 2006-07-28 | 2007-07-27 | Ｌ-메치오닌 전구체 생산 균주 및 상기 ｌ-메치오닌전구체로부터의 ｌ-메치오닌 및 유기산의 생산방법 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2657345T3 true PL2657345T3 (pl) | 2017-01-31 |
Family
ID=39222930
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL07793305T PL2046968T3 (pl) | 2006-07-28 | 2007-07-30 | Mikroorganizm wytwarzający prekursor l-metioniny i sposób wytwarzania l-metioniny i kwasu organicznego z prekursora l-metioniny |
| PL13178074T PL2657345T3 (pl) | 2006-07-28 | 2007-07-30 | Enzymatyczny sposób wytwarzania L-metioniny z prekursora i merkaptanu metylowego |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL07793305T PL2046968T3 (pl) | 2006-07-28 | 2007-07-30 | Mikroorganizm wytwarzający prekursor l-metioniny i sposób wytwarzania l-metioniny i kwasu organicznego z prekursora l-metioniny |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US8426171B2 (pl) |
| EP (2) | EP2046968B1 (pl) |
| JP (2) | JP5078101B2 (pl) |
| KR (2) | KR100905381B1 (pl) |
| CN (3) | CN101356281B (pl) |
| BR (1) | BRPI0712399B1 (pl) |
| DK (1) | DK2657345T3 (pl) |
| ES (2) | ES2430274T3 (pl) |
| PL (2) | PL2046968T3 (pl) |
| WO (1) | WO2008013432A1 (pl) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100905381B1 (ko) | 2006-07-28 | 2009-06-30 | 씨제이제일제당 (주) | Ｌ-메치오닌 전구체 생산 균주 및 상기 ｌ-메치오닌전구체로부터의 ｌ-메치오닌 및 유기산의 생산방법 |
| US7851180B2 (en) * | 2008-04-04 | 2010-12-14 | Cj Cheiljedang Corporation | Microorganism producing L-methionine precursor and the method of producing L-methionine precursor using the microorganism |
| US9005952B2 (en) * | 2008-04-04 | 2015-04-14 | Cj Cheiljedang Corporation | Microorganism producing L-methionine precursor and the method of producing L-methionine precursor using the microorganism |
| KR101164711B1 (ko) | 2009-02-27 | 2012-07-11 | 씨제이제일제당 (주) | 미네랄 첨가와 산처리를 이용하여 메치오닌의 용해도를 증가시키는 방법 |
| KR101048593B1 (ko) * | 2009-02-27 | 2011-07-12 | 씨제이제일제당 (주) | 메칠머캅탄과 디메칠설파이드의 혼합물을 사용하여 메치오닌 생산능을 증가시키는 방법 |
| US8283152B2 (en) * | 2009-08-28 | 2012-10-09 | Cj Cheiljedang Corporation | Microorganism producing O-acetyl-homoserine and the method of producing O-acetyl-homoserine using the microorganism |
| US8609396B2 (en) | 2009-08-28 | 2013-12-17 | Cj Cheiljedang Corporation | Microorganism producing O-acetyl-homoserine and the method of producing O-acetyl-homoserine using the microorganism |
| EP2519637A2 (en) * | 2009-12-30 | 2012-11-07 | Metabolic Explorer | Strains and method for the production of methionine |
| KR101381048B1 (ko) * | 2010-10-20 | 2014-04-14 | 씨제이제일제당 (주) | Ｏ-포스포세린 생산 균주 및 이로부터 생산된 ｏ-포스포세린으로부터 ｌ-시스테인 또는 이의 유도체의 생산방법 |
| KR101250651B1 (ko) * | 2010-12-21 | 2013-04-03 | 씨제이제일제당 (주) | 신규 ｏ-아세틸호모세린 설피드릴라제 또는 변이체 및 이를 이용한 메치오닌 전환 방법 |
| RU2673190C1 (ru) | 2010-12-29 | 2018-11-22 | СиДжей ЧеилДжеданг Корпорейшн | Способ получения L-метионина и органической кислоты |
| CN108342424A (zh) * | 2011-09-02 | 2018-07-31 | 阿克马法国公司 | L-甲硫氨酸的制备方法 |
| US9834491B2 (en) | 2013-03-20 | 2017-12-05 | Cj Cheiljedang Corporation | Method for producing bio-based homoserine lactone and bio-based organic acid from O-acyl homoserine produced by microorganisms |
| KR101555749B1 (ko) | 2013-10-23 | 2015-09-25 | 씨제이제일제당 (주) | O-숙시닐호모세린 생산 미생물 및 이를 이용한 o-숙시닐호모세린의 생산방법 |
| KR101565213B1 (ko) | 2013-10-23 | 2015-11-03 | 씨제이제일제당 (주) | Ｏ-숙시닐호모세린 생산 미생물 및 이를 이용한 ｏ-숙시닐호모세린의 생산방법 |
| KR101555750B1 (ko) * | 2013-10-23 | 2015-09-25 | 씨제이제일제당 (주) | O-숙시닐호모세린 생산 미생물 및 이를 이용한 o-숙시닐호모세린의 생산방법 |
| BR112016015573A2 (pt) * | 2014-01-02 | 2017-10-03 | Trelys Inc | Composições e métodos para produção biológica de aminoácidos em micro-organismos hidrogenotróficos |
| AU2014386892B2 (en) * | 2014-03-20 | 2017-11-23 | Cj Cheiljedang Corporation | Method for preparing biobased homoserine lactone hydrochloride and biobased organic acid from microorganism-derived O-acyl homoserine |
| KR101580785B1 (ko) * | 2014-04-10 | 2015-12-29 | 씨제이제일제당 주식회사 | O-숙시닐호모세린 생산 미생물 및 이를 이용한 o-숙시닐호모세린의 생산방법 |
| KR101547651B1 (ko) * | 2014-06-03 | 2015-08-26 | 씨제이제일제당 주식회사 | O-숙시닐호모세린 또는 숙신산의 생산능을 갖는 미생물 및 이를 이용한 숙신산 또는 o-숙시닐호모세린의 생산 방법 |
| KR101825777B1 (ko) * | 2014-06-05 | 2018-02-07 | 씨제이제일제당 (주) | O-아세틸-호모세린을 생산하는 미생물 및 이를 이용하여 o-아세틸-호모세린을 생산하는 방법 |
| KR101641770B1 (ko) * | 2014-06-23 | 2016-07-22 | 씨제이제일제당 (주) | O-아세틸 호모세린을 생산하는 미생물 및 상기 미생물을 이용하여 o-아세틸 호모세린을 생산하는 방법 |
| KR20160111285A (ko) | 2015-03-16 | 2016-09-26 | 씨제이제일제당 (주) | 사료 첨가제용 조성물 및 이를 포함하는 동물 사료 조성물 |
| JP2018516552A (ja) | 2015-05-06 | 2018-06-28 | トレリス， インコーポレイテッド | メチオニンの生物学的産生のための組成物及び方法 |
| US10400256B2 (en) | 2015-06-04 | 2019-09-03 | Cj Cheiljedang Corporation | Polypeptide having the activity of exporting O-acetyl-homoserine |
| WO2017009047A1 (en) * | 2015-07-13 | 2017-01-19 | Evonik Degussa Gmbh | Method for producing l-methionine |
| EP3331998B1 (en) | 2015-08-07 | 2020-06-24 | Evonik Operations GmbH | Protein thiocarboxylate-dependent l-methionine production by fermentation |
| FR3041659B1 (fr) * | 2015-09-30 | 2017-10-20 | Arkema France | Procede de production de l-methionine |
| FR3041658B1 (fr) * | 2015-09-30 | 2017-10-20 | Arkema France | Procede de production de l-methionine |
| US10378031B2 (en) | 2015-10-13 | 2019-08-13 | Cj Cheiljedang Corporation | O-acetylhomoserine sulfhydrylase variant and method for producing L-methionine using same |
| WO2017065567A1 (en) * | 2015-10-14 | 2017-04-20 | Cj Cheiljedang Corporation | Bio-based n-acetyl-l-methionine and use thereof |
| KR101821050B1 (ko) * | 2015-10-14 | 2018-03-09 | 씨제이제일제당 (주) | 바이오-기반 n-아세틸-l-메티오닌 및 이의 용도 |
| KR102771842B1 (ko) * | 2015-11-27 | 2025-02-21 | 에보닉 오퍼레이션스 게엠베하 | L-메티오닌을 제조하는 방법 |
| KR101851452B1 (ko) | 2016-07-18 | 2018-04-24 | 씨제이제일제당 (주) | O-아세틸-호모세린을 생산하는 미생물 및 이를 이용하여 o-아세틸-호모세린을 생산하는 방법 |
| CN106065411B (zh) * | 2016-08-10 | 2021-12-07 | 洛阳华荣生物技术有限公司 | 发酵法生产肌酸 |
| EP3330380A1 (en) | 2016-12-05 | 2018-06-06 | Evonik Degussa GmbH | Process for producing l-methionine from methional |
| FR3061494B1 (fr) | 2016-12-29 | 2020-07-03 | Arkema France | Procede de synthese de dithiocarbamates cycliques fonctionnalises |
| FR3061493B1 (fr) | 2016-12-29 | 2020-07-03 | Arkema France | Procede de synthese de polysulfures fonctionnalises |
| WO2019004780A2 (ko) | 2017-06-30 | 2019-01-03 | 씨제이제일제당 (주) | 신규한 o-숙시닐 호모세린 트랜스퍼라제 변이체 및 이를 이용한 o-숙시닐 호모세린의 제조방법 |
| JP6980819B2 (ja) | 2017-06-30 | 2021-12-15 | シージェイ チェイルジェダング コーポレイション | 新規なｏ−スクシニルホモセリントランスフェラーゼ変異体及びこれを用いたｏ−スクシニルホモセリンの製造方法 |
| CN107541531B (zh) * | 2017-09-26 | 2020-07-17 | 扬州工业职业技术学院 | 一种利用微生物代谢处理石油化工污水生产蛋氨酸的方法 |
| KR101866884B1 (ko) | 2018-01-29 | 2018-06-14 | 씨제이제일제당(주) | 사료 첨가제용 조성물 및 이를 포함하는 동물 사료 조성물 |
| KR102377500B1 (ko) | 2019-10-28 | 2022-03-23 | 씨제이제일제당 주식회사 | 외래 metZ 유전자에 의해 코딩되는 단백질이 도입된 L-메티오닌 생산 미생물 및 이를 이용한 L-메티오닌 생산방법 |
| KR102182497B1 (ko) | 2019-12-20 | 2020-11-24 | 씨제이제일제당 주식회사 | 내막 단백질의 변이체 및 이를 이용한 목적 산물 생산 방법 |
| KR102311391B1 (ko) * | 2020-05-21 | 2021-10-12 | 씨제이제일제당 주식회사 | L- 분지쇄 아미노산 생산능이 강화된 미생물 및 이를 이용하여 l-분지쇄 아미노산을 생산하는 방법 |
| US20230240332A1 (en) | 2020-06-26 | 2023-08-03 | Cj Cheiljedang Corporation | Method for preparing amino acid granule from fermentation broth |
| FR3112549A1 (fr) | 2020-07-20 | 2022-01-21 | Arkema France | Procede ameliore de synthese de mercaptans fonctionnalises |
| FR3117115B1 (fr) | 2020-12-04 | 2023-05-05 | Arkema France | Procede de synthese de mercaptans fonctionnalises sous pression d’h2s |
| KR102525074B1 (ko) | 2021-03-10 | 2023-04-24 | 씨제이제일제당 주식회사 | 신규한 시트레이트 신타아제 변이체 및 이를 이용한 o-아세틸-l-호모세린 또는 l-메티오닌 생산 방법 |
| JP7728880B2 (ja) | 2021-04-01 | 2025-08-25 | エボニック オペレーションズ ゲーエムベーハー | Ｌ－グルホシネートおよびそのホスホエステルを産生するための酵素的方法 |
| CN113088503B (zh) * | 2021-04-27 | 2023-01-10 | 浙江工业大学 | 一种o-琥珀酰巯基转移酶突变体及其在l-甲硫氨酸合成中的应用 |
| KR102377745B1 (ko) | 2021-05-12 | 2022-03-23 | 씨제이제일제당 주식회사 | 신규 프로모터 및 이의 용도 |
| KR102685904B1 (ko) | 2021-05-20 | 2024-07-19 | 씨제이제일제당 주식회사 | 신규 프로모터 및 이의 용도 |
| TW202333581A (zh) | 2021-12-24 | 2023-09-01 | 南韓商Ｃｊ第一製糖股份有限公司 | 由發酵液製備含胺基酸製品之方法 |
| KR102966296B1 (ko) | 2022-03-28 | 2026-05-19 | 씨제이제일제당 주식회사 | O-아세틸 호모세린 생산 미생물 및 이를 이용한 o-아세틸 호모세린 또는 l-메치오닌 생산 방법 |
| KR102952497B1 (ko) | 2022-03-28 | 2026-04-15 | 씨제이제일제당 주식회사 | O-아세틸 호모세린 생산 미생물 및 이를 이용한 o-아세틸 호모세린 또는 l-메치오닌 생산 방법 |
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| JP2026508194A (ja) | 2023-03-01 | 2026-03-10 | フーナン リアー バイオテック カンパニー リミテッド | Ｌ－メチオニンをｌ－ホモセリンから直接調製するプロセス |
| KR20240139382A (ko) | 2023-03-14 | 2024-09-23 | 씨제이제일제당 (주) | 여과 유속이 개선된 아미노산의 제조방법 |
| KR102931070B1 (ko) | 2023-03-23 | 2026-02-26 | 씨제이제일제당 주식회사 | 변이형 트레오닌/호모세린 배출 단백질 및 이를 이용한 l-아미노산 생산 방법 |
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- 2007-07-27 KR KR1020070076045A patent/KR100905381B1/ko active Active
- 2007-07-30 ES ES07793305T patent/ES2430274T3/es active Active
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- 2007-07-30 CN CN200780001169.7A patent/CN101356281B/zh active Active
- 2007-07-30 PL PL13178074T patent/PL2657345T3/pl unknown
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- 2007-07-30 WO PCT/KR2007/003650 patent/WO2008013432A1/en not_active Ceased
- 2007-07-30 DK DK13178074.4T patent/DK2657345T3/en active
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- 2007-07-30 US US12/066,111 patent/US8426171B2/en active Active
- 2007-07-30 CN CN201210149909.4A patent/CN102943096B/zh active Active
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| US8426171B2 (en) | 2013-04-23 |
| BRPI0712399B1 (pt) | 2017-06-06 |
| PL2046968T3 (pl) | 2013-12-31 |
| KR20080102123A (ko) | 2008-11-24 |
| CN102943096B (zh) | 2014-08-27 |
| JP2009544309A (ja) | 2009-12-17 |
| DK2657345T3 (en) | 2016-10-24 |
| JP5078101B2 (ja) | 2012-11-21 |
| KR100905381B1 (ko) | 2009-06-30 |
| US20130231503A1 (en) | 2013-09-05 |
| JP2012213401A (ja) | 2012-11-08 |
| CN103397057A (zh) | 2013-11-20 |
| US20100184164A1 (en) | 2010-07-22 |
| US20150211034A1 (en) | 2015-07-30 |
| US9029105B2 (en) | 2015-05-12 |
| ES2595453T3 (es) | 2016-12-30 |
| KR100951766B1 (ko) | 2010-04-08 |
| EP2657345A1 (en) | 2013-10-30 |
| EP2046968A1 (en) | 2009-04-15 |
| CN102943096A (zh) | 2013-02-27 |
| KR20080011132A (ko) | 2008-01-31 |
| EP2046968A4 (en) | 2011-04-27 |
| WO2008013432A1 (en) | 2008-01-31 |
| JP5371073B2 (ja) | 2013-12-18 |
| CN101356281A (zh) | 2009-01-28 |
| CN103397057B (zh) | 2016-03-23 |
| ES2430274T3 (es) | 2013-11-19 |
| CN101356281B (zh) | 2015-08-19 |
| EP2046968B1 (en) | 2013-09-11 |
| EP2657345B1 (en) | 2016-09-07 |
| BRPI0712399A2 (pt) | 2012-10-16 |
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