PL2670751T3 - Metoda wytwarzania związku proleku inhibitora wiązania HIV i produktów pośrednich - Google Patents

Metoda wytwarzania związku proleku inhibitora wiązania HIV i produktów pośrednich

Info

Publication number
PL2670751T3
PL2670751T3 PL12704960T PL12704960T PL2670751T3 PL 2670751 T3 PL2670751 T3 PL 2670751T3 PL 12704960 T PL12704960 T PL 12704960T PL 12704960 T PL12704960 T PL 12704960T PL 2670751 T3 PL2670751 T3 PL 2670751T3
Authority
PL
Poland
Prior art keywords
intermediates
methods
prodrug compound
inhibitor prodrug
hiv attachment
Prior art date
Application number
PL12704960T
Other languages
English (en)
Inventor
Jonathan Clive Tripp
Dayne Dustan Fanfair
Mitchell J Schultz
Saravanababu Murugesan
Richard J Fox
Chung-Pin H Chen
Sabrina E Ivy
Joseph Francis Payack
Wendel W Doubleday
Original Assignee
Viiv Healthcare Uk No 4 Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Viiv Healthcare Uk No 4 Ltd filed Critical Viiv Healthcare Uk No 4 Ltd
Publication of PL2670751T3 publication Critical patent/PL2670751T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
PL12704960T 2011-01-31 2012-01-27 Metoda wytwarzania związku proleku inhibitora wiązania HIV i produktów pośrednich PL2670751T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161437821P 2011-01-31 2011-01-31
PCT/US2012/022851 WO2012106189A1 (en) 2011-01-31 2012-01-27 Methods of making hiv attachment inhibitor prodrug compound and intermediates
EP20120704960 EP2670751B1 (en) 2011-01-31 2012-01-27 Methods of making hiv attachment inhibitor prodrug compound and intermediates

Publications (1)

Publication Number Publication Date
PL2670751T3 true PL2670751T3 (pl) 2015-09-30

Family

ID=45688987

Family Applications (1)

Application Number Title Priority Date Filing Date
PL12704960T PL2670751T3 (pl) 2011-01-31 2012-01-27 Metoda wytwarzania związku proleku inhibitora wiązania HIV i produktów pośrednich

Country Status (25)

Country Link
US (1) US8436168B2 (pl)
EP (1) EP2670751B1 (pl)
JP (1) JP6006236B2 (pl)
KR (1) KR101848533B1 (pl)
CN (1) CN103339130B (pl)
AR (1) AR085052A1 (pl)
AU (1) AU2012212508B2 (pl)
BR (1) BR112013018159A2 (pl)
CA (1) CA2826260C (pl)
CY (1) CY1116505T1 (pl)
DK (1) DK2670751T3 (pl)
EA (1) EA021726B1 (pl)
ES (1) ES2539908T3 (pl)
HR (1) HRP20150616T1 (pl)
HU (1) HUE026880T2 (pl)
IL (1) IL227302A (pl)
MX (1) MX2013008371A (pl)
PL (1) PL2670751T3 (pl)
PT (1) PT2670751E (pl)
RS (1) RS54055B1 (pl)
SG (1) SG191841A1 (pl)
SI (1) SI2670751T1 (pl)
SM (1) SMT201500169B (pl)
TW (1) TW201309692A (pl)
WO (1) WO2012106189A1 (pl)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7745625B2 (en) * 2004-03-15 2010-06-29 Bristol-Myers Squibb Company Prodrugs of piperazine and substituted piperidine antiviral agents
US20100198192A1 (en) 2009-01-20 2010-08-05 Eugene Serina Anchor deployment devices and related methods
JP6114314B2 (ja) * 2012-02-08 2017-04-12 ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company Hiv付着阻害剤であるピペラジンプロドラッグ化合物の製造方法
WO2015200257A1 (en) * 2014-06-23 2015-12-30 Free Form Fibers, Llc An additive manufacturing technology for the fabrication and characterization of nuclear reactor fuel
EP3233853B1 (en) 2014-12-18 2019-03-06 Viiv Healthcare Uk (No. 4) Limited A process for preparing halogenated azaindole compounds using boroxine
CA2971096A1 (en) 2014-12-18 2016-06-23 ViiV Healthcare UK (No.4) Limited A process for preparing halogenated azaindole compounds using pybrop
EP3265004B1 (en) 2015-03-05 2023-06-28 Ancora Heart, Inc. Devices of visualizing and determining depth of penetration in cardiac tissue
JP6692542B2 (ja) * 2016-05-13 2020-05-13 学校法人早稲田大学 簡便、迅速、高精度な皮膚pHの測定法
EP3911651B1 (en) 2019-01-17 2024-01-10 ViiV Healthcare UK (No.4) Limited Process for preparing fostemsavir

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040110785A1 (en) 2001-02-02 2004-06-10 Tao Wang Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives
US7745625B2 (en) 2004-03-15 2010-06-29 Bristol-Myers Squibb Company Prodrugs of piperazine and substituted piperidine antiviral agents
US7776863B2 (en) 2004-03-24 2010-08-17 Bristol-Myers Squibb Company Methods of treating HIV infection
US7601715B2 (en) 2005-06-22 2009-10-13 Bristol-Myers Squibb Company Process for preparing triazole substituted azaindoleoxoacetic piperazine derivatives and novel salt forms produced therein
US7851476B2 (en) * 2005-12-14 2010-12-14 Bristol-Myers Squibb Company Crystalline forms of 1-benzoyl-4-[2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-YL)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-C]pyridin-3-YL]-1,2-dioxoethyl]-piperazine

Also Published As

Publication number Publication date
SG191841A1 (en) 2013-08-30
HRP20150616T1 (hr) 2015-07-03
EA021726B1 (ru) 2015-08-31
PT2670751E (pt) 2015-07-29
KR20140014154A (ko) 2014-02-05
ES2539908T3 (es) 2015-07-07
CA2826260C (en) 2018-09-04
AU2012212508B2 (en) 2016-01-14
JP6006236B2 (ja) 2016-10-12
SI2670751T1 (sl) 2015-07-31
JP2014503594A (ja) 2014-02-13
AU2012212508A1 (en) 2013-09-19
RS54055B1 (sr) 2015-10-30
TW201309692A (zh) 2013-03-01
HUE026880T2 (en) 2016-08-29
IL227302A (en) 2016-10-31
US8436168B2 (en) 2013-05-07
EA201391123A1 (ru) 2013-12-30
EP2670751A1 (en) 2013-12-11
CA2826260A1 (en) 2012-08-09
AR085052A1 (es) 2013-08-07
US20130030178A1 (en) 2013-01-31
EP2670751B1 (en) 2015-04-22
CN103339130B (zh) 2015-05-06
BR112013018159A2 (pt) 2018-09-11
CY1116505T1 (el) 2017-03-15
SMT201500169B (it) 2015-09-07
IL227302A0 (en) 2013-09-30
DK2670751T3 (en) 2015-07-20
WO2012106189A1 (en) 2012-08-09
CN103339130A (zh) 2013-10-02
KR101848533B1 (ko) 2018-04-12
MX2013008371A (es) 2013-08-12

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