PL2698372T3 - Nowy związek imidazooksazynowy lub jego sól - Google Patents
Nowy związek imidazooksazynowy lub jego sólInfo
- Publication number
- PL2698372T3 PL2698372T3 PL12768337T PL12768337T PL2698372T3 PL 2698372 T3 PL2698372 T3 PL 2698372T3 PL 12768337 T PL12768337 T PL 12768337T PL 12768337 T PL12768337 T PL 12768337T PL 2698372 T3 PL2698372 T3 PL 2698372T3
- Authority
- PL
- Poland
- Prior art keywords
- salt
- oxazine compound
- novel imidazo
- imidazo
- novel
- Prior art date
Links
- -1 imidazo-oxazine compound Chemical class 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2011084880 | 2011-04-06 | ||
| PCT/JP2012/059376 WO2012137870A1 (ja) | 2011-04-06 | 2012-04-05 | 新規イミダゾオキサジン化合物又はその塩 |
| EP12768337.3A EP2698372B1 (en) | 2011-04-06 | 2012-04-05 | Novel imidazo-oxazine compound or salt thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2698372T3 true PL2698372T3 (pl) | 2016-07-29 |
Family
ID=46969260
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL12768337T PL2698372T3 (pl) | 2011-04-06 | 2012-04-05 | Nowy związek imidazooksazynowy lub jego sól |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8772283B2 (pl) |
| EP (1) | EP2698372B1 (pl) |
| JP (1) | JP5599941B2 (pl) |
| KR (1) | KR101658274B1 (pl) |
| CN (1) | CN103459400B (pl) |
| AU (1) | AU2012239157B2 (pl) |
| BR (1) | BR112013025732B1 (pl) |
| CA (1) | CA2830367C (pl) |
| DK (1) | DK2698372T3 (pl) |
| ES (1) | ES2567605T3 (pl) |
| HU (1) | HUE027509T2 (pl) |
| MX (1) | MX342064B (pl) |
| MY (1) | MY163187A (pl) |
| PH (1) | PH12013501873A1 (pl) |
| PL (1) | PL2698372T3 (pl) |
| RU (1) | RU2578608C2 (pl) |
| SG (1) | SG193327A1 (pl) |
| TW (1) | TWI525097B (pl) |
| WO (1) | WO2012137870A1 (pl) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO2868660T3 (pl) * | 2012-07-02 | 2018-05-26 | ||
| US20140275504A1 (en) * | 2013-03-13 | 2014-09-18 | Dow Agrosciences Llc | Process for the preparation of certain triaryl rhamnose carbamates |
| HUE053322T2 (hu) * | 2013-06-20 | 2021-06-28 | Taiho Pharmaceutical Co Ltd | Eljárás PI3K/AKT/mTOR inhibitor terápiás hatékonyságának elõrejelzésére PHLDA1 vagy PIK3C2B expressziója alapján |
| KR101974254B1 (ko) | 2013-07-18 | 2019-04-30 | 다이호야쿠힌고교 가부시키가이샤 | Fgfr 저해제의 간헐 투여용 항종양제 |
| WO2015008844A1 (ja) | 2013-07-18 | 2015-01-22 | 大鵬薬品工業株式会社 | Ｆｇｆｒ阻害剤耐性癌の治療薬 |
| WO2016136928A1 (ja) * | 2015-02-27 | 2016-09-01 | 大鵬薬品工業株式会社 | イミダゾオキサジンの結晶、当該結晶を含む医薬組成物、及び当該結晶の製造方法 |
| MX373612B (es) | 2015-03-31 | 2020-05-07 | Taiho Pharmaceutical Co Ltd | Cristal del compuesto alquinil benceno 3,5-disustituido. |
| EP3424505A4 (en) * | 2016-03-04 | 2019-10-16 | Taiho Pharmaceutical Co., Ltd. | PREPARATION AND COMPOSITION FOR THE TREATMENT OF MALIGNANT TUMORS |
| US11883404B2 (en) | 2016-03-04 | 2024-01-30 | Taiho Pharmaceuticals Co., Ltd. | Preparation and composition for treatment of malignant tumors |
| EP4470621A3 (en) | 2018-03-19 | 2025-05-07 | Taiho Pharmaceutical Co., Ltd. | Use of sodium alkyl sulfate |
| WO2020078865A1 (en) | 2018-10-16 | 2020-04-23 | F. Hoffmann-La Roche Ag | Use of akt inhibitors in ophthalmology |
| US20220354858A1 (en) * | 2019-06-21 | 2022-11-10 | Taiho Pharmaceutical Co., Ltd. | Method for treating malignant tumor |
| WO2021055728A1 (en) | 2019-09-18 | 2021-03-25 | Merck Sharp & Dohme Corp. | Small molecule inhibitors of kras g12c mutant |
| CA3158793A1 (en) | 2019-10-28 | 2021-05-06 | Merck Sharp & Dohme Corp. | Small molecule inhibitors of kras g12c mutant |
| JP2023515235A (ja) | 2019-10-31 | 2023-04-12 | 大鵬薬品工業株式会社 | ４－アミノブタ－２－エンアミド誘導体及びその塩 |
| WO2021106231A1 (en) | 2019-11-29 | 2021-06-03 | Taiho Pharmaceutical Co., Ltd. | A compound having inhibitory activity against kras g12d mutation |
| US20230174518A1 (en) | 2020-04-24 | 2023-06-08 | Taiho Pharmaceutical Co., Ltd. | Kras g12d protein inhibitors |
| WO2021215545A1 (en) | 2020-04-24 | 2021-10-28 | Taiho Pharmaceutical Co., Ltd. | Anticancer combination therapy with n-(1-acryloyl-azetidin-3-yl)-2-((1h-indazol-3-yl)amino)methyl)-1h-imidazole-5-carboxamide inhibitor of kras-g12c |
| JP7373664B2 (ja) | 2020-07-15 | 2023-11-02 | 大鵬薬品工業株式会社 | 腫瘍の治療に使用されるピリミジン化合物を含む組み合わせ |
| JP2024505252A (ja) * | 2021-02-01 | 2024-02-05 | 大鵬薬品工業株式会社 | Ｐｔｅｎ不活性化突然変異を有する患者における癌の治療 |
| WO2022250170A1 (en) | 2021-05-28 | 2022-12-01 | Taiho Pharmaceutical Co., Ltd. | Small molecule inhibitors of kras mutated proteins |
| WO2025043187A1 (en) | 2023-08-24 | 2025-02-27 | Otsuka Pharmaceutical Co., Ltd. | Fixed dose combinations of cedazuridine and azacitidine |
| US11970475B1 (en) | 2023-09-05 | 2024-04-30 | King Faisal University | 4-(1-(2-Hydroxypropyl)-4,5-diphenyl-1H-imidazol-2-yl)pyridin-3-ol as an antimicrobial compound |
| WO2025085748A1 (en) | 2023-10-20 | 2025-04-24 | Merck Sharp & Dohme Llc | Small molecule inhibitors of kras proteins |
| WO2025128834A1 (en) * | 2023-12-15 | 2025-06-19 | Alterome Therapeutics, Inc. | Akt1 modulators |
| CN119912475B (zh) * | 2025-03-06 | 2026-01-06 | 复旦大学 | 用作tlr2拮抗剂的化合物或其衍生物及其制备方法和应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57212188A (en) * | 1981-06-25 | 1982-12-27 | Sankyo Co Ltd | Imidazobenzoxazine derivative and its preparation |
| US5985871A (en) * | 1997-12-24 | 1999-11-16 | Cortex Pharmaceuticals, Inc. | Benzoxazine compounds for enhancing synaptic response |
| EP1737843B1 (en) * | 2004-04-09 | 2011-02-23 | Merck Sharp & Dohme Corp. | Inhibitors of akt activity |
| AR064010A1 (es) | 2006-12-06 | 2009-03-04 | Merck & Co Inc | Inhibidores de la actividad de la akt |
| DE602008005894D1 (de) | 2007-08-14 | 2011-05-12 | Bayer Schering Pharma Ag | Kondensierte imidazole zur krebsbehandlung |
| US9451809B2 (en) | 2008-05-29 | 2016-09-27 | Nike, Inc. | Article of footwear with a marking system |
| AU2009255358A1 (en) | 2008-06-03 | 2009-12-10 | Msd K.K. | Inhibitors of Akt activity |
| WO2010088177A1 (en) | 2009-02-02 | 2010-08-05 | Merck Sharp & Dohme Corp. | Inhibitors of akt activity |
| WO2010104933A1 (en) | 2009-03-11 | 2010-09-16 | Merck Sharp & Dohme Corp. | Inhibitors of akt activity |
| WO2010114780A1 (en) | 2009-04-01 | 2010-10-07 | Merck Sharp & Dohme Corp. | Inhibitors of akt activity |
| JP5830094B2 (ja) * | 2010-07-12 | 2015-12-09 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ | 置換イミダゾ［１，２−ａ］ピリミジンおよび−ピリジン |
-
2012
- 2012-04-05 ES ES12768337.3T patent/ES2567605T3/es active Active
- 2012-04-05 KR KR1020137029041A patent/KR101658274B1/ko active Active
- 2012-04-05 TW TW101112057A patent/TWI525097B/zh active
- 2012-04-05 BR BR112013025732-6A patent/BR112013025732B1/pt active IP Right Grant
- 2012-04-05 JP JP2013508918A patent/JP5599941B2/ja active Active
- 2012-04-05 AU AU2012239157A patent/AU2012239157B2/en active Active
- 2012-04-05 WO PCT/JP2012/059376 patent/WO2012137870A1/ja not_active Ceased
- 2012-04-05 DK DK12768337.3T patent/DK2698372T3/en active
- 2012-04-05 SG SG2013066949A patent/SG193327A1/en unknown
- 2012-04-05 RU RU2013149174/04A patent/RU2578608C2/ru active
- 2012-04-05 US US14/004,446 patent/US8772283B2/en active Active
- 2012-04-05 CN CN201280017414.4A patent/CN103459400B/zh active Active
- 2012-04-05 CA CA2830367A patent/CA2830367C/en active Active
- 2012-04-05 PL PL12768337T patent/PL2698372T3/pl unknown
- 2012-04-05 MX MX2013011429A patent/MX342064B/es active IP Right Grant
- 2012-04-05 MY MYPI2013701632A patent/MY163187A/en unknown
- 2012-04-05 PH PH1/2013/501873A patent/PH12013501873A1/en unknown
- 2012-04-05 EP EP12768337.3A patent/EP2698372B1/en active Active
- 2012-04-05 HU HUE12768337A patent/HUE027509T2/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SG193327A1 (en) | 2013-10-30 |
| HK1188451A1 (zh) | 2014-05-02 |
| KR20140039186A (ko) | 2014-04-01 |
| CA2830367A1 (en) | 2012-10-11 |
| CA2830367C (en) | 2016-08-30 |
| RU2013149174A (ru) | 2015-05-20 |
| TW201247679A (en) | 2012-12-01 |
| MX342064B (es) | 2016-09-12 |
| EP2698372B1 (en) | 2016-02-03 |
| US8772283B2 (en) | 2014-07-08 |
| PH12013501873A1 (en) | 2013-10-14 |
| CN103459400B (zh) | 2016-05-18 |
| EP2698372A4 (en) | 2014-09-10 |
| DK2698372T3 (en) | 2016-03-21 |
| ES2567605T3 (es) | 2016-04-25 |
| BR112013025732B1 (pt) | 2022-02-22 |
| HUE027509T2 (en) | 2016-10-28 |
| AU2012239157B2 (en) | 2015-11-05 |
| CN103459400A (zh) | 2013-12-18 |
| MX2013011429A (es) | 2013-12-09 |
| BR112013025732A2 (pt) | 2016-12-13 |
| KR101658274B1 (ko) | 2016-09-22 |
| MY163187A (en) | 2017-08-15 |
| JP5599941B2 (ja) | 2014-10-01 |
| TWI525097B (zh) | 2016-03-11 |
| RU2578608C2 (ru) | 2016-03-27 |
| WO2012137870A1 (ja) | 2012-10-11 |
| AU2012239157A1 (en) | 2013-09-26 |
| US20140005185A1 (en) | 2014-01-02 |
| EP2698372A1 (en) | 2014-02-19 |
| JPWO2012137870A1 (ja) | 2014-07-28 |
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