PL2707380T3 - Dywersyfikacja oligosacharydów mleka kobiecego (hmo) lub ich prekursorów - Google Patents
Dywersyfikacja oligosacharydów mleka kobiecego (hmo) lub ich prekursorówInfo
- Publication number
- PL2707380T3 PL2707380T3 PL12785572T PL12785572T PL2707380T3 PL 2707380 T3 PL2707380 T3 PL 2707380T3 PL 12785572 T PL12785572 T PL 12785572T PL 12785572 T PL12785572 T PL 12785572T PL 2707380 T3 PL2707380 T3 PL 2707380T3
- Authority
- PL
- Poland
- Prior art keywords
- hmos
- diversification
- precursors
- human milk
- milk oligosaccharides
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/14—Preparation of compounds containing saccharide radicals produced by the action of a carbohydrase (EC 3.2.x), e.g. by alpha-amylase, e.g. by cellulase, hemicellulase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/12—Disaccharides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Nutrition Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Dairy Products (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11166137 | 2011-05-13 | ||
| PCT/IB2012/051314 WO2012127410A1 (en) | 2011-03-18 | 2012-03-19 | Synthesis of new fucose-containing carbohydrate derivatives |
| PCT/IB2012/052401 WO2012156898A1 (en) | 2011-05-13 | 2012-05-14 | DIVERSIFICATION OF HUMAN MILK OLIGOSACCHARIDES (HMOs) OR PRECURSORS THEREOF |
| EP12785572.4A EP2707380B1 (en) | 2011-05-13 | 2012-05-14 | DIVERSIFICATION OF HUMAN MILK OLIGOSACCHARIDES (HMOs) OR PRECURSORS THEREOF |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2707380T3 true PL2707380T3 (pl) | 2021-01-11 |
Family
ID=47176364
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL12785572T PL2707380T3 (pl) | 2011-05-13 | 2012-05-14 | Dywersyfikacja oligosacharydów mleka kobiecego (hmo) lub ich prekursorów |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US9382564B2 (pl) |
| EP (2) | EP2707380B1 (pl) |
| JP (1) | JP6106160B2 (pl) |
| KR (1) | KR20140036226A (pl) |
| CN (1) | CN103562214B9 (pl) |
| BR (1) | BR112013029203A2 (pl) |
| CA (1) | CA2835989A1 (pl) |
| DK (1) | DK2707380T3 (pl) |
| ES (1) | ES2820429T3 (pl) |
| IL (1) | IL229047A0 (pl) |
| MX (1) | MX349153B (pl) |
| PL (1) | PL2707380T3 (pl) |
| RU (1) | RU2013155453A (pl) |
| WO (1) | WO2012156898A1 (pl) |
Families Citing this family (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2805499A1 (en) | 2010-07-16 | 2012-01-19 | Glycom A/S | Derivatization of oligosaccharides |
| WO2013091660A1 (en) * | 2011-12-23 | 2013-06-27 | Glycom A/S | A method for obtaining crystalline lacto-n-tetraose and lacto-n-neotetraose precursors and mixtures thereof |
| US20150320780A1 (en) * | 2012-12-14 | 2015-11-12 | Glycom A/S | Mixture of fucosylate lactoses |
| GB201306689D0 (en) | 2013-04-12 | 2013-05-29 | Glycom As | Synthesis of sialylated/fucosylated human milk oligosaccharides |
| BR112015025951A2 (pt) * | 2013-04-12 | 2017-10-17 | Univ Danmarks Tekniske | sialidase mutante com atividade trans-sialidase, para uso em produção de glicanos sialilados |
| ES2891731T3 (es) | 2013-05-22 | 2022-01-31 | Glycom As | Mezcla sintética de oligosacáridos para el tratamiento de la microbiota de un mamífero |
| EP3041947A4 (en) | 2013-09-06 | 2017-07-26 | Glycom A/S | Fermentative production of oligosaccharides |
| EP2857410A1 (en) | 2013-10-04 | 2015-04-08 | Jennewein Biotechnologie GmbH | Process for purification of 2´-fucosyllactose using simulated moving bed chromatography |
| DK3209673T4 (da) | 2014-10-24 | 2023-10-02 | Glycom As | Mixtures of human milk oligosaccharides |
| WO2016063261A1 (en) * | 2014-10-24 | 2016-04-28 | Glycom A/S | Mutated fucosidase |
| EP3212198B1 (en) | 2014-10-29 | 2020-12-23 | Glycom A/S | Synthetic composition and method for promoting mucosal healing |
| WO2016066175A1 (en) | 2014-10-29 | 2016-05-06 | Glycom A/S | Synthetic composition and method for treating irritable bowel syndrome |
| US11040050B2 (en) | 2014-10-29 | 2021-06-22 | Glycom A/S | Composition comprising HMSs/HMOs and use thereof |
| US11040049B2 (en) | 2014-10-29 | 2021-06-22 | Glycom A/S | Composition comprising HMSs/HMOs and use thereof |
| US10835544B2 (en) | 2014-12-08 | 2020-11-17 | Glycom A/S | Synthetic composition for regulating satiety |
| US10881674B2 (en) | 2014-12-08 | 2021-01-05 | Glycom A/S | Synthetic composition for treating metabolic disorders |
| US10987368B2 (en) | 2014-12-08 | 2021-04-27 | Glycom A/S | Synthetic composition for preventing or treating CVD |
| CN115350200A (zh) | 2014-12-08 | 2022-11-18 | 格礼卡姆股份公司 | 用于治疗代谢障碍的合成组合物 |
| US10588917B2 (en) * | 2015-03-31 | 2020-03-17 | Glycom A/S | Mixtures of human milk oligosaccharides comprising 3 ′-O-sialyllactose |
| PL3307752T3 (pl) * | 2015-06-09 | 2021-11-02 | Glycom A/S | Mieszaniny trójskładnikowe 6’-sl, lnnt i lst c |
| ES2798373T3 (es) | 2015-06-09 | 2020-12-11 | Glycom As | Transsialidasas de photobacterium mutadas |
| WO2017021476A1 (en) | 2015-08-04 | 2017-02-09 | Nestec S.A. | Nutritional compositions with 2fl and lnnt for use in inducing a gut microbiota close to the one of breast fed infants |
| EP3349763B1 (en) | 2015-09-14 | 2021-08-11 | Glycom A/S | Composition for use in microbiota modulation |
| ES2950489T3 (es) | 2015-10-28 | 2023-10-10 | Glycom As | Composición sintética y método para modular los trastornos de la emoción y del ánimo |
| ES2927009T3 (es) * | 2015-10-28 | 2022-10-31 | Glycom As | Composición sintética y método para modular la función cerebral y la conducta |
| ES2975018T3 (es) | 2015-11-17 | 2024-07-02 | Glycom As | Oligosacáridos de la leche humana para el tratamiento de complicaciones asociadas a antibióticos |
| BR112018010505B1 (pt) | 2015-12-15 | 2021-11-16 | Société des Produits Nestlé S.A. | Composições para bebês e crianças pequenas, e uso de uma mistura sintética de hmos |
| WO2017144062A1 (en) | 2016-02-24 | 2017-08-31 | Glycom A/S | Synthetic composition for microbiota modulation |
| DK3452050T3 (da) | 2016-05-05 | 2023-02-20 | Glycom As | Composition comprising hmos for the treatment of noninfectious diarrhoea |
| DK3452051T3 (en) | 2016-05-05 | 2022-09-05 | Glycom As | COMPOSITION COMPRISING HMOs FOR USE IN THE TREATMENT OF MAST CELL MEDIATED VISCERAL HYPERSENSITIVITY AND/OR PAIN |
| US11224605B2 (en) | 2016-05-19 | 2022-01-18 | Glycom A/S | Synthetic composition |
| WO2017221208A1 (en) | 2016-06-24 | 2017-12-28 | Glycom A/S | Compositions comprising hmos, their production and use for the prevention and/or treatment of viral and/or bacterial infections |
| SG10202100843TA (en) | 2016-07-28 | 2021-03-30 | Fonterra Cooperative Group Ltd | Dairy product and process |
| US11278558B2 (en) | 2017-03-01 | 2022-03-22 | Glycom A/S | Synthetic composition for microbiota modulation |
| US11291677B2 (en) | 2017-05-09 | 2022-04-05 | Glycom A/S | Synthetic composition for microbiota modulation |
| WO2018215960A1 (en) | 2017-05-24 | 2018-11-29 | Glycom A/S | Synthetic composition comprising one or more human milk oligosaccharides (hmos) |
| US11541068B2 (en) | 2017-05-24 | 2023-01-03 | Glycom A/S | HMO compositions and methods for reducing autism spectrum disorder symptoms |
| EP3645545A4 (en) | 2017-06-30 | 2021-05-05 | Glycom A/S | PURIFICATION OF OLIGOSACCHARIDES |
| EP3672600A4 (en) | 2017-08-21 | 2021-05-19 | Glycom A/S | SYNTHETIC COMPOSITION TO REDUCE ALLERGY SYMPTOMS |
| EP3450443A1 (en) * | 2017-08-29 | 2019-03-06 | Jennewein Biotechnologie GmbH | Process for purifying sialylated oligosaccharides |
| CA3081496A1 (en) | 2017-11-02 | 2019-05-09 | Glycom A/S | Mixture of hmos for reducing or preventing fatigue |
| JP7327724B2 (ja) | 2017-11-30 | 2023-08-16 | グリコム・アクティーゼルスカブ | 小麦過敏症を処置するためのｈｍｏの混合物 |
| CN111556755A (zh) | 2017-12-05 | 2020-08-18 | 格礼卡姆股份公司 | 用于治疗偏头痛的人乳寡糖 |
| US11566219B2 (en) * | 2017-12-08 | 2023-01-31 | Morinaga Milk Industry Co., Ltd. | Bifidobacterium bacteria and composition including novel bifidobacterium bacteria |
| WO2019123316A1 (en) | 2017-12-22 | 2019-06-27 | Glycom A/S | Composition comprising hmos for preventing or reducing nociception |
| EP3569713A1 (en) * | 2018-05-16 | 2019-11-20 | Jennewein Biotechnologie GmbH | Use of glycosidases in the production of oligosaccharides |
| BR112020022892A2 (pt) | 2018-05-31 | 2021-02-23 | Glycom A/S | mistura de hmos para tratamento de doenças autoi-munes |
| BR112021011071A2 (pt) | 2018-12-19 | 2021-08-31 | Glycom A/S | Composição e método para o tratamento de seres humanos utilizando dietas com baixo teor de fodmap |
| CN110016066B (zh) * | 2019-04-02 | 2021-11-02 | 江西师范大学 | 一种i型n-聚糖天线的合成方法 |
| BR112022010061A2 (pt) | 2019-11-29 | 2022-09-06 | Glycom As | Mistura de olhs para melhorar a microbiota das mulheres grávidas |
| CN112831510B (zh) * | 2019-12-13 | 2022-04-22 | 中国科学院天津工业生物技术研究所 | 一株高效表达几丁质酶重组菌的构建及高酶活突变体的筛选 |
| WO2022089707A1 (en) | 2020-10-30 | 2022-05-05 | Mille International Aps | A method of producing a human milk oligosaccharide (hmo) |
| CN112795583A (zh) * | 2020-11-16 | 2021-05-14 | 上海大学 | 重组唾液酸外切酶的制备方法、表达基因、重组表达载体及构建方法 |
| JP2023553548A (ja) | 2020-12-04 | 2023-12-22 | グリコム・アクティーゼルスカブ | 睡眠パターンの成熟又は改善の支援に使用するためのヒト母乳オリゴ糖 |
| WO2022223430A1 (en) | 2021-04-19 | 2022-10-27 | Dsm Ip Assets B.V. | A composition of enzymes and human milk oligosaccharides |
| DK181242B1 (en) * | 2021-05-17 | 2023-05-30 | Dsm Ip Assets Bv | GENETICALLY ENGINEERED CELLS COMPRISING A RECOMBINANT NUCLEIC ACID SEQUNCE ENCODING AN α-1,2-FUCOSYLTRANSFERASE CAPABLE OF PRODUCING LNFP-I, NUCLEIC ACID SEQUENCES ENCODING SAME AND METHODS FOR USE OF SAME |
| CN113960232B (zh) * | 2021-10-28 | 2024-02-20 | 苏州大学 | 一种基于唾液特异性岩藻糖基化结构糖谱及其检测方法和应用 |
| WO2023235555A1 (en) * | 2022-06-02 | 2023-12-07 | Bee-Io Honey Technologies Ltd. | Cultured buffalo milk production methods, systems, compositions and uses thereof |
| DK202200588A1 (en) | 2022-06-20 | 2024-02-23 | Dsm Ip Assets Bv | Mixture of fucosylated HMOs |
| CN120018780A (zh) | 2022-08-25 | 2025-05-16 | 帝斯曼知识产权资产管理有限公司 | 生产复杂hmo的混合方法 |
| EP4623089A1 (en) | 2022-11-25 | 2025-10-01 | DSM IP Assets B.V. | Two-strain system for producing oligosaccharides |
| DK182185B1 (en) | 2022-12-14 | 2025-10-29 | Dsm Ip Assets Bv | Mutated lacto-n-biosidase,method for making the same and method for synthesizing lacto-n-biose containing carbohydrates |
| DK182217B1 (en) * | 2024-04-11 | 2025-12-12 | Dsm Ip Assets Bv | Enzymatic n-acetyllactosaminylation of a terminal galactose in its 6-position |
| DK202430320A1 (en) | 2024-06-13 | 2026-01-07 | Dsm Ip Assets Bv | Synthesis of branched chain oligosaccharides |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0586687A4 (en) * | 1992-03-25 | 1996-04-17 | Univ New York | Trans-sialidase and methods of use and making thereof |
| JPH0686684A (ja) | 1992-05-26 | 1994-03-29 | Monsanto Co | シアロ抱合体の合成 |
| US5409817A (en) * | 1993-05-04 | 1995-04-25 | Cytel, Inc. | Use of trans-sialidase and sialyltransferase for synthesis of sialylα2→3βgalactosides |
| ES2180757T3 (es) | 1995-04-11 | 2003-02-16 | Neose Technologies Inc | Sintesis enzimatica mejorada de oligosacaridos. |
| US6323008B1 (en) * | 1997-08-14 | 2001-11-27 | Neose Technologies, Inc. | Methods for producing sialyloligosaccharides in a dairy source |
| AU2002330968B2 (en) | 2001-08-17 | 2007-03-22 | Neose Technologies, Inc. | Chemo-enzymatic synthesis of sialylated oligosaccharides |
| MXPA06006392A (es) * | 2003-12-05 | 2007-03-15 | Childrens Hosp Medical Center | Composiciones de oligosacaridos y uso de estas en el tratamiento de infecciones. |
| MX2007010094A (es) * | 2005-02-21 | 2007-09-25 | Nestec Sa | Mezcla de oligosacarido. |
| JP4937288B2 (ja) | 2009-03-02 | 2012-05-23 | シャープ株式会社 | 画像読取装置及び画像形成装置 |
| EP2536737B1 (en) * | 2010-02-19 | 2017-05-31 | Glycom A/S | A method for preparation of the tetrasaccharide lacto-n-neotetraose (lnnt) containing n-acetyllactosamine |
| CA2805499A1 (en) | 2010-07-16 | 2012-01-19 | Glycom A/S | Derivatization of oligosaccharides |
| RU2013146524A (ru) | 2011-03-18 | 2015-04-27 | Глюком А/С | Синтез новых фукозо-содержащих производных углеводородов |
-
2012
- 2012-05-14 PL PL12785572T patent/PL2707380T3/pl unknown
- 2012-05-14 JP JP2014510920A patent/JP6106160B2/ja not_active Expired - Fee Related
- 2012-05-14 US US14/117,332 patent/US9382564B2/en active Active
- 2012-05-14 CA CA2835989A patent/CA2835989A1/en not_active Abandoned
- 2012-05-14 EP EP12785572.4A patent/EP2707380B1/en active Active
- 2012-05-14 BR BR112013029203A patent/BR112013029203A2/pt not_active IP Right Cessation
- 2012-05-14 RU RU2013155453/04A patent/RU2013155453A/ru not_active Application Discontinuation
- 2012-05-14 EP EP20182361.4A patent/EP3744725B1/en active Active
- 2012-05-14 ES ES12785572T patent/ES2820429T3/es active Active
- 2012-05-14 KR KR1020137032961A patent/KR20140036226A/ko not_active Withdrawn
- 2012-05-14 MX MX2013013027A patent/MX349153B/es active IP Right Grant
- 2012-05-14 WO PCT/IB2012/052401 patent/WO2012156898A1/en not_active Ceased
- 2012-05-14 CN CN201280023818.4A patent/CN103562214B9/zh active Active
- 2012-05-14 DK DK12785572.4T patent/DK2707380T3/da active
-
2013
- 2013-10-24 IL IL229047A patent/IL229047A0/en unknown
-
2016
- 2016-05-23 US US15/161,887 patent/US9963729B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| MX349153B (es) | 2017-07-14 |
| EP3744725B1 (en) | 2025-09-17 |
| CA2835989A1 (en) | 2012-11-22 |
| CN103562214B (zh) | 2016-10-19 |
| US20140212930A1 (en) | 2014-07-31 |
| US9382564B2 (en) | 2016-07-05 |
| EP2707380A4 (en) | 2014-10-08 |
| KR20140036226A (ko) | 2014-03-25 |
| CN103562214B9 (zh) | 2016-12-14 |
| EP3744725C0 (en) | 2025-09-17 |
| BR112013029203A2 (pt) | 2016-08-09 |
| US9963729B2 (en) | 2018-05-08 |
| JP6106160B2 (ja) | 2017-03-29 |
| EP3744725A1 (en) | 2020-12-02 |
| WO2012156898A1 (en) | 2012-11-22 |
| US20160289721A1 (en) | 2016-10-06 |
| EP2707380A1 (en) | 2014-03-19 |
| RU2013155453A (ru) | 2015-06-20 |
| EP2707380B1 (en) | 2020-07-08 |
| JP2014513986A (ja) | 2014-06-19 |
| DK2707380T3 (da) | 2020-10-12 |
| ES2820429T3 (es) | 2021-04-21 |
| MX2013013027A (es) | 2013-12-02 |
| CN103562214A (zh) | 2014-02-05 |
| IL229047A0 (en) | 2013-12-31 |
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