PL2714658T3 - Nowe inhibitory cholinoesteraz o strukturze hybrydowej - Google Patents

Nowe inhibitory cholinoesteraz o strukturze hybrydowej

Info

Publication number
PL2714658T3
PL2714658T3 PL12730282T PL12730282T PL2714658T3 PL 2714658 T3 PL2714658 T3 PL 2714658T3 PL 12730282 T PL12730282 T PL 12730282T PL 12730282 T PL12730282 T PL 12730282T PL 2714658 T3 PL2714658 T3 PL 2714658T3
Authority
PL
Poland
Prior art keywords
cholinesterase inhibitors
novel hybrid
hybrid
novel
cholinesterase
Prior art date
Application number
PL12730282T
Other languages
English (en)
Inventor
Anna Zawadzka
Zbigniew Czarnocki
Iwona Łozińska
Zuzanna Molęda
Mirosława Panasiewicz
Original Assignee
Univ Warszawski
Centrum Medyczne Ksztalcenia Podyplomowego
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PL395113A external-priority patent/PL219106B1/pl
Priority claimed from PL398731A external-priority patent/PL221154B1/pl
Application filed by Univ Warszawski, Centrum Medyczne Ksztalcenia Podyplomowego filed Critical Univ Warszawski
Publication of PL2714658T3 publication Critical patent/PL2714658T3/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16Tryptamines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PL12730282T 2011-06-03 2012-05-29 Nowe inhibitory cholinoesteraz o strukturze hybrydowej PL2714658T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
PL395113A PL219106B1 (pl) 2011-06-03 2011-06-03 Nowe inhibitory cholinoesteraz o strukturze hybrydowej
PL398731A PL221154B1 (pl) 2012-04-04 2012-04-04 Inhibitory cholinoesteraz o strukturze hybrydowej, sposób ich otrzymywania, ich zastosowanie oraz preparat farmaceutyczny je zawierający
EP20120730282 EP2714658B1 (en) 2011-06-03 2012-05-29 Novel hybrid cholinesterase inhibitors
PCT/PL2012/000038 WO2012165981A1 (en) 2011-06-03 2012-05-29 Novel hybrid cholinesterase inhibitors

Publications (1)

Publication Number Publication Date
PL2714658T3 true PL2714658T3 (pl) 2015-09-30

Family

ID=46395682

Family Applications (1)

Application Number Title Priority Date Filing Date
PL12730282T PL2714658T3 (pl) 2011-06-03 2012-05-29 Nowe inhibitory cholinoesteraz o strukturze hybrydowej

Country Status (5)

Country Link
US (1) US8841453B2 (pl)
EP (1) EP2714658B1 (pl)
ES (1) ES2539178T3 (pl)
PL (1) PL2714658T3 (pl)
WO (1) WO2012165981A1 (pl)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111727040A (zh) * 2018-02-19 2020-09-29 纳特雷恩公司 用于改善认知能力或认知功能的尿石素a和b的协同组合
CN108840864B (zh) * 2018-07-31 2021-07-27 中国医学科学院生物医学工程研究所 一种他克林-杂环轭联物的制备方法及用途
CN111592530B (zh) * 2020-05-18 2021-09-24 山东大学 含醛肟的他克林衍生物类选择性丁酰胆碱酯酶抑制剂及其制备方法和应用
CN113387867B (zh) * 2021-07-15 2023-03-14 南华大学 一种氨基甲酸酯类邻氨基苯甲酸色胺衍生物及其制备与应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0223494D0 (en) 2002-10-09 2002-11-13 Neuropharma Sa Dual binding site acetylcholinesterase inhibitors for the treatment of alzheimer's disease
GB0316094D0 (en) 2003-07-09 2003-08-13 Neuropharma Sa Acetylcholinesterase dual inhibitors

Also Published As

Publication number Publication date
EP2714658B1 (en) 2015-04-29
US8841453B2 (en) 2014-09-23
WO2012165981A1 (en) 2012-12-06
ES2539178T3 (es) 2015-06-26
US20140080860A1 (en) 2014-03-20
EP2714658A1 (en) 2014-04-09

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