PL2755957T3 - Synteza związków triazolopirymidynowych - Google Patents
Synteza związków triazolopirymidynowychInfo
- Publication number
- PL2755957T3 PL2755957T3 PL12759136T PL12759136T PL2755957T3 PL 2755957 T3 PL2755957 T3 PL 2755957T3 PL 12759136 T PL12759136 T PL 12759136T PL 12759136 T PL12759136 T PL 12759136T PL 2755957 T3 PL2755957 T3 PL 2755957T3
- Authority
- PL
- Poland
- Prior art keywords
- synthesis
- triazolopyrimidine compounds
- triazolopyrimidine
- compounds
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- YWBFPKPWMSWWEA-UHFFFAOYSA-O triazolopyrimidine Chemical class BrC1=CC=CC(C=2N=C3N=CN[N+]3=C(NCC=3C=CN=CC=3)C=2)=C1 YWBFPKPWMSWWEA-UHFFFAOYSA-O 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/52—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups or amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/50—Three nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/69—Benzenesulfonamido-pyrimidines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11181280A EP2570405A1 (en) | 2011-09-14 | 2011-09-14 | Synthesis of Triazolopyrimidine Compounds |
| EP11188602 | 2011-11-10 | ||
| EP11195581 | 2011-12-23 | ||
| EP12759136.0A EP2755957B2 (en) | 2011-09-14 | 2012-09-14 | Synthesis of triazolopyrimidine compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL2755957T3 true PL2755957T3 (pl) | 2017-04-28 |
| PL2755957T4 PL2755957T4 (pl) | 2017-05-31 |
Family
ID=46851502
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL12759136T PL2755957T4 (pl) | 2011-09-14 | 2012-09-14 | Synteza związków triazolopirymidynowych |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US9221829B2 (pl) |
| EP (1) | EP2755957B2 (pl) |
| CN (1) | CN104024229B (pl) |
| CA (1) | CA2848621C (pl) |
| ES (1) | ES2620970T3 (pl) |
| HR (1) | HRP20170167T1 (pl) |
| HU (1) | HUE031673T2 (pl) |
| PL (1) | PL2755957T4 (pl) |
| WO (1) | WO2013037942A1 (pl) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IN2014KN01491A (pl) * | 2011-12-23 | 2015-10-23 | Lek Pharmaceuticals | |
| US9233966B2 (en) | 2012-04-05 | 2016-01-12 | Dr. Reddy's Laboratories Limited | Preparation of ticagrelor |
| ITMI20130487A1 (it) * | 2013-03-29 | 2014-09-30 | Chemo Res S L | Alchilazione selettiva di ciclopentilalcoli |
| WO2014206187A1 (zh) | 2013-06-24 | 2014-12-31 | 苏州明锐医药科技有限公司 | 替卡格雷及其中间体的制备方法 |
| CN103304545B (zh) * | 2013-06-26 | 2015-05-20 | 苏州明锐医药科技有限公司 | 5-氨基-1,4-二取代基-1,2,3-三氮唑及其制备方法 |
| CN103539773B (zh) * | 2013-09-25 | 2015-04-08 | 开原亨泰制药股份有限公司 | 一种制备替格瑞洛关键中间体的方法 |
| CN103524429B (zh) * | 2013-09-28 | 2015-08-19 | 银杏树药业(苏州)有限公司 | 一种替格瑞洛及其新的中间体的制备方法 |
| CN104710425B (zh) * | 2013-12-16 | 2019-06-14 | 石药集团中奇制药技术（石家庄）有限公司 | 一种替格瑞洛新结晶及其制备方法 |
| CN103787987B (zh) * | 2014-02-17 | 2015-04-08 | 苏州明锐医药科技有限公司 | 替格瑞洛中间体的制备方法 |
| US10011605B2 (en) | 2014-06-18 | 2018-07-03 | Flamma Spa | Process for the preparation of triazolo[4,5-D] pyrimidine cyclopentane compounds |
| CN105503876B (zh) * | 2014-09-24 | 2017-09-05 | 海门慧聚药业有限公司 | 替卡格雷的制备方法 |
| CN107382953A (zh) * | 2017-07-25 | 2017-11-24 | 安徽诺全药业有限公司 | 一种制备多取代环戊烷衍生物的方法 |
| US11623927B2 (en) | 2018-03-02 | 2023-04-11 | The Trustees Of The University Of Pennsylvania | Substituted [1,2,4]triazolo[1,5-a]pyrimidines for stabilizing microtubules |
| CN113185485B (zh) | 2021-05-10 | 2022-03-04 | 合肥立方制药股份有限公司 | 一种二氢槲皮素的半合成方法 |
| CN113214210B (zh) * | 2021-05-10 | 2022-03-04 | 合肥立方制药股份有限公司 | 一种二氢槲皮素的制备方法 |
| CN113582947B (zh) * | 2021-09-07 | 2023-06-20 | 南开大学 | 一种脱除胺的磺酰基保护的方法 |
| CN116178375B (zh) * | 2023-02-24 | 2024-09-20 | 重庆文理学院 | 一种三唑并嘧啶化合物及其合成方法和应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI229674B (en) | 1998-12-04 | 2005-03-21 | Astra Pharma Prod | Novel triazolo[4,5-d]pyrimidine compounds, pharmaceutical composition containing the same, their process for preparation and uses |
| SE9903290D0 (sv) * | 1999-09-15 | 1999-09-15 | Astra Pharma Prod | Novel compounds |
| SE9904129D0 (sv) | 1999-11-15 | 1999-11-15 | Astra Pharma Prod | Novel compounds |
| GB0013488D0 (en) | 2000-06-02 | 2000-07-26 | Astrazeneca Ab | Chemical compound |
| SI2340252T1 (sl) | 2008-09-09 | 2016-02-29 | Astrazeneca Ab | Postopek priprave (1S-)1-alfa, 2-alfa, 3-beta(1S*,2R*)5-beta))-3-(7-(2-(3,4-difluorofenil)-ciklopropilamino)-5- (propiltio)-3H-1,2,3-triazolo(4,5-D)pirimidin-3-il)-5-(2-hidroksietoksi) ciklopentan-1,2-diola in njegovih vmesnih spojin |
| JP2013500347A (ja) | 2009-07-27 | 2013-01-07 | オースペックス ファーマシューティカルズ，インク． | Ｐ２ｙ１２受容体のシクロプロピルモジュレーター |
| EP2655341A2 (en) | 2010-12-20 | 2013-10-30 | Actavis Group Ptc Ehf | Novel processes for preparing triazolo[4,5-d]pyrimidine derivatives and intermediates thereof |
-
2012
- 2012-09-14 CN CN201280052377.0A patent/CN104024229B/zh not_active Expired - Fee Related
- 2012-09-14 EP EP12759136.0A patent/EP2755957B2/en active Active
- 2012-09-14 HU HUE12759136A patent/HUE031673T2/en unknown
- 2012-09-14 ES ES12759136.0T patent/ES2620970T3/es active Active
- 2012-09-14 HR HRP20170167TT patent/HRP20170167T1/hr unknown
- 2012-09-14 PL PL12759136T patent/PL2755957T4/pl unknown
- 2012-09-14 WO PCT/EP2012/068068 patent/WO2013037942A1/en not_active Ceased
- 2012-09-14 CA CA2848621A patent/CA2848621C/en not_active Expired - Fee Related
- 2012-09-14 US US14/344,960 patent/US9221829B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US9221829B2 (en) | 2015-12-29 |
| EP2755957B1 (en) | 2016-11-02 |
| CA2848621A1 (en) | 2013-03-21 |
| WO2013037942A1 (en) | 2013-03-21 |
| EP2755957A1 (en) | 2014-07-23 |
| HRP20170167T1 (hr) | 2017-08-25 |
| CN104024229A (zh) | 2014-09-03 |
| ES2620970T3 (es) | 2017-06-30 |
| US20150005498A1 (en) | 2015-01-01 |
| CA2848621C (en) | 2019-10-01 |
| EP2755957B2 (en) | 2019-05-15 |
| HUE031673T2 (en) | 2017-07-28 |
| PL2755957T4 (pl) | 2017-05-31 |
| CN104024229B (zh) | 2016-08-31 |
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