PL2776442T3 - Pochodne [1,2,3]triazolo[4,5-d]pirymidyny jako agoniści receptora kanabinoidowego 2 - Google Patents

Pochodne [1,2,3]triazolo[4,5-d]pirymidyny jako agoniści receptora kanabinoidowego 2

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Publication number
PL2776442T3
PL2776442T3 PL12780208T PL12780208T PL2776442T3 PL 2776442 T3 PL2776442 T3 PL 2776442T3 PL 12780208 T PL12780208 T PL 12780208T PL 12780208 T PL12780208 T PL 12780208T PL 2776442 T3 PL2776442 T3 PL 2776442T3
Authority
PL
Poland
Prior art keywords
triazolo
agonists
pyrimidine derivatives
cannabinoid receptor
cannabinoid
Prior art date
Application number
PL12780208T
Other languages
English (en)
Inventor
Jean-Michel Adam
Caterina Bissantz
Uwe Grether
Atushi Kimbara
Matthias Nettekoven
Stephan Roever
Mark Rogers-Evans
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PL2776442T3 publication Critical patent/PL2776442T3/pl

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P27/02—Ophthalmic agents
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Ophthalmology & Optometry (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Emergency Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychiatry (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Transplantation (AREA)
PL12780208T 2011-11-08 2012-11-05 Pochodne [1,2,3]triazolo[4,5-d]pirymidyny jako agoniści receptora kanabinoidowego 2 PL2776442T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11188333 2011-11-08
PCT/EP2012/071788 WO2013068306A1 (en) 2011-11-08 2012-11-05 [1, 2, 3] triazolo [4, 5 -d] pyrimidine derivatives as agonists of the cannabinoid receptor 2
EP12780208.0A EP2776442B1 (en) 2011-11-08 2012-11-05 [1, 2, 3]triazolo [4, 5 -d]pyrimidine derivatives as agonists of the cannabinoid receptor 2

Publications (1)

Publication Number Publication Date
PL2776442T3 true PL2776442T3 (pl) 2016-04-29

Family

ID=47116003

Family Applications (1)

Application Number Title Priority Date Filing Date
PL12780208T PL2776442T3 (pl) 2011-11-08 2012-11-05 Pochodne [1,2,3]triazolo[4,5-d]pirymidyny jako agoniści receptora kanabinoidowego 2

Country Status (31)

Country Link
US (2) US8741906B2 (pl)
EP (1) EP2776442B1 (pl)
JP (1) JP6138141B2 (pl)
KR (1) KR102032337B1 (pl)
CN (1) CN103930426B (pl)
AR (1) AR088663A1 (pl)
AU (1) AU2012334173B2 (pl)
BR (1) BR112014011055B1 (pl)
CA (1) CA2850458C (pl)
CL (1) CL2014001174A1 (pl)
CO (1) CO6920295A2 (pl)
CY (1) CY1117147T1 (pl)
DK (1) DK2776442T3 (pl)
EA (1) EA023581B1 (pl)
ES (1) ES2553704T3 (pl)
HR (1) HRP20160052T1 (pl)
HU (1) HUE025543T2 (pl)
IL (1) IL231949A (pl)
MX (1) MX342309B (pl)
MY (1) MY170878A (pl)
PE (1) PE20141588A1 (pl)
PH (1) PH12014500813A1 (pl)
PL (1) PL2776442T3 (pl)
PT (1) PT2776442E (pl)
RS (1) RS54436B1 (pl)
SG (1) SG11201402197UA (pl)
SI (1) SI2776442T1 (pl)
TW (2) TWI704150B (pl)
UA (1) UA111640C2 (pl)
WO (1) WO2013068306A1 (pl)
ZA (1) ZA201402905B (pl)

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UA111640C2 (uk) * 2011-11-08 2016-05-25 Ф. Хоффманн-Ля Рош Аг ПОХІДНІ [1,2,3]ТРИАЗОЛО[4,5-d]ПІРИМІДИНУ ЯК АГОНІСТИ КАНАБІНОЇДНОГО РЕЦЕПТОРА 2
US9067943B2 (en) * 2011-11-25 2015-06-30 Hoffmann-La Roche Inc. [1,2,3]triazolo[4,5-D]pyrimidine derivatives
EA027935B1 (ru) 2013-03-07 2017-09-29 Ф. Хоффманн-Ля Рош Аг Новые производные пиразола
PE20151559A1 (es) 2013-03-26 2015-11-05 Hoffmann La Roche Nuevos derivados de piridina
CN105209466B (zh) 2013-05-02 2018-05-18 豪夫迈·罗氏有限公司 作为cb2受体激动剂的嘌呤衍生物
HUE035333T2 (en) 2013-05-02 2018-05-02 Hoffmann La Roche Pyrrolo [2,3-d] pyrimidine derivatives as CB2 receptor agonists
PL3041843T3 (pl) * 2013-09-06 2019-06-28 F. Hoffmann-La Roche Ag Pochodne triazolo[4,5-d]pirymidyny jako antagoniści receptora cb2
CR20170077A (es) 2014-08-04 2017-06-26 Nuevolution As Derivados de heterociclilo opcionalmente condensados de pirimidina útiles para el tratamiento de enfermedades inflamatorias, metabólicas, oncológicas y autoinmunitarias
AU2015341811A1 (en) * 2014-11-07 2017-03-30 F. Hoffmann-La Roche Ag Triazolo[4,5-d]pyrimidines as agonists of the cannabinoid receptor 2
CN107743491B (zh) * 2015-05-08 2020-08-21 豪夫迈·罗氏有限公司 用于治疗和预防病毒感染的新的氧硫杂环戊烷甲酸及其衍生物
CN105541738B (zh) * 2016-01-21 2018-04-06 西北师范大学 一种三氮唑取代的苯乙酮类化合物的制备方法
WO2017220516A1 (en) 2016-06-23 2017-12-28 F. Hoffmann-La Roche Ag Novel [1,2,3]triazolo[4,5-d]pyrimidine derivatives
WO2017220544A1 (en) 2016-06-23 2017-12-28 F. Hoffmann-La Roche Ag Novel[1,2,3]triazolo[4,5-d]pyrimidine derivatives
CN109311886B (zh) 2016-06-23 2021-11-09 豪夫迈·罗氏有限公司 [1,2,3]三唑并[4,5-d]嘧啶衍生物
MA45442A (fr) 2016-06-23 2019-05-01 Hoffmann La Roche Dérivés de [1,2,3]triazolo[4,5-d]pyrimidine ayant une affinité pour le récepteur cannabinoïde de type 2
JP2021535203A (ja) 2018-08-20 2021-12-16 ベッソール ファルマ、エルエルシー 既知および新規カンナビノイドの適用
WO2020231723A1 (en) 2019-05-13 2020-11-19 Ecolab Usa Inc. 1,2,4-triazolo[1,5-a] pyrimidine derivative as copper corrosion inhibitor
UY38994A (es) 2019-12-20 2021-07-30 Nuevolution As Compuestos activos frente a receptores nucleares
MX2022007265A (es) 2019-12-20 2022-09-09 Nuevolution As Compuestos activos frente a receptores nucleares.
AU2021245397A1 (en) 2020-03-31 2022-10-20 Nuevolution A/S Compounds active towards nuclear receptors
WO2021198956A1 (en) 2020-03-31 2021-10-07 Nuevolution A/S Compounds active towards nuclear receptors
US20230279006A1 (en) * 2020-07-08 2023-09-07 Klotho Therapeutics, Inc. Novel compounds and methods for increasing klotho gene expression
MX2023005713A (es) * 2020-11-23 2023-05-30 Hoffmann La Roche Nuevo proceso para la elaboracion de derivados de tetrazol.
AR127456A1 (es) 2021-10-28 2024-01-24 Hoffmann La Roche Sintesis de [1,2,3]triazol[4,5-d]pirimidinas
CN119325477A (zh) 2022-06-07 2025-01-17 豪夫迈·罗氏有限公司 用于制备1-[5-叔丁基-3-[(1-甲基四唑-5-基)甲基]三唑并[4,5-d]嘧啶-7-基]吡咯烷-3-醇的方法
JP2025530036A (ja) * 2022-09-01 2025-09-10 エフ． ホフマン－ラ ロシュ アーゲー ビカシナビンの投与レジメン
JP2025531720A (ja) 2022-09-01 2025-09-25 エフ． ホフマン－ラ ロシュ アーゲー 抗ｃｂ２抗体及び細胞表面ｃｂ２発現を測定するためのフローサイトメトリーアッセイにおけるそれらの使用

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UA111640C2 (uk) * 2011-11-08 2016-05-25 Ф. Хоффманн-Ля Рош Аг ПОХІДНІ [1,2,3]ТРИАЗОЛО[4,5-d]ПІРИМІДИНУ ЯК АГОНІСТИ КАНАБІНОЇДНОГО РЕЦЕПТОРА 2
US9067943B2 (en) * 2011-11-25 2015-06-30 Hoffmann-La Roche Inc. [1,2,3]triazolo[4,5-D]pyrimidine derivatives

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AU2012334173B2 (en) 2017-06-08
HRP20160052T1 (hr) 2016-02-12
CN103930426A (zh) 2014-07-16
DK2776442T3 (en) 2015-11-09
TW201333011A (zh) 2013-08-16
CL2014001174A1 (es) 2014-09-12
US20140288046A1 (en) 2014-09-25
CY1117147T1 (el) 2017-04-05
EP2776442A1 (en) 2014-09-17
US9056866B2 (en) 2015-06-16
AU2012334173A1 (en) 2014-04-03
EP2776442B1 (en) 2015-10-21
TW201825496A (zh) 2018-07-16
US8741906B2 (en) 2014-06-03
PE20141588A1 (es) 2014-10-25
US20130116236A1 (en) 2013-05-09
AU2012334173A8 (en) 2014-04-10
HUE025543T2 (en) 2016-03-29
BR112014011055A2 (pt) 2017-05-02
WO2013068306A1 (en) 2013-05-16
PH12014500813A1 (en) 2016-06-17
HK1194732A1 (zh) 2014-10-24
SG11201402197UA (en) 2014-09-26
IL231949A (en) 2016-02-29
CA2850458A1 (en) 2013-05-16
IL231949A0 (en) 2014-05-28
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