PL2784066T3 - Sposób syntezy pochodnych 7,8-dimetoksy-1,3-dihydro-2H-3-benzazepin-2-onu i jego zastosowanie do syntezy iwabradyny - Google Patents

Sposób syntezy pochodnych 7,8-dimetoksy-1,3-dihydro-2H-3-benzazepin-2-onu i jego zastosowanie do syntezy iwabradyny

Info

Publication number: PL2784066T3
Authority: PL; Poland
Prior art keywords: ivabradine; benzazepin; dimethoxy; dihydro; synthesis
Prior art date: 2013-03-26

Application number

PL14161388T

Other languages

English (en)

Inventor

Flohic Alexandre Le

Original Assignee

Servier Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2013-03-26

Filing date

2014-03-25

Publication date

2015-11-30

2014-03-25 Application filed by Servier Lab filed Critical Servier Lab

2015-11-30 Publication of PL2784066T3 publication Critical patent/PL2784066T3/pl

Links

CPNZASIAJKSBBH-UHFFFAOYSA-N 7,8-dimethoxy-1,3-dihydro-3-benzazepin-2-one Chemical class C1C(=O)NC=CC2=C1C=C(OC)C(OC)=C2 CPNZASIAJKSBBH-UHFFFAOYSA-N 0.000 title 1
230000015572 biosynthetic process Effects 0.000 title 1
ACRHBAYQBXXRTO-OAQYLSRUSA-N ivabradine Chemical compound C1CC2=CC(OC)=C(OC)C=C2CC(=O)N1CCCN(C)C[C@H]1CC2=C1C=C(OC)C(OC)=C2 ACRHBAYQBXXRTO-OAQYLSRUSA-N 0.000 title 1
229960003825 ivabradine Drugs 0.000 title 1
238000000034 method Methods 0.000 title 1
238000002360 preparation method Methods 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/06—One of the condensed rings being a six-membered aromatic ring the other ring being four-membered

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)

PL14161388T 2013-03-26 2014-03-25 Sposób syntezy pochodnych 7,8-dimetoksy-1,3-dihydro-2H-3-benzazepin-2-onu i jego zastosowanie do syntezy iwabradyny PL2784066T3 (pl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR1352741A FR3003859B1 (fr)	2013-03-26	2013-03-26	"procede de synthese de derives de la 7,8-dimethoxy-1,3-dihydro-2h-3-benzazepin-2-one et application a la synthese de l'ivabradine"
EP14161388.5A EP2784066B1 (fr)	2013-03-26	2014-03-25	Procédé de synthèse de dérivés de la 7,8-dimethoxy-1,3-dihydro-2H-3-benzazépin-2-one et application à la synthèse de l'ivabradine

Publications (1)

Publication Number	Publication Date
PL2784066T3 true PL2784066T3 (pl)	2015-11-30

Family

ID=48613923

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL14161388T PL2784066T3 (pl)	2013-03-26	2014-03-25	Sposób syntezy pochodnych 7,8-dimetoksy-1,3-dihydro-2H-3-benzazepin-2-onu i jego zastosowanie do syntezy iwabradyny

Country Status (37)

Country	Link
US (1)	US8927708B2 (pl)
EP (1)	EP2784066B1 (pl)
JP (1)	JP5732159B2 (pl)
KR (1)	KR101616434B1 (pl)
CN (1)	CN104072420B (pl)
AR (1)	AR095722A1 (pl)
AU (1)	AU2014201355B2 (pl)
BR (1)	BR102014007079A2 (pl)
CA (1)	CA2846917C (pl)
CY (1)	CY1116535T1 (pl)
DK (1)	DK2784066T3 (pl)
EA (1)	EA025516B1 (pl)
ES (1)	ES2548713T3 (pl)
FR (1)	FR3003859B1 (pl)
GE (1)	GEP201706731B (pl)
HK (1)	HK1202532A1 (pl)
HR (1)	HRP20150924T1 (pl)
HU (1)	HUE025550T2 (pl)
IN (1)	IN2014DE00793A (pl)
JO (1)	JO3132B1 (pl)
MA (1)	MA35509B1 (pl)
MD (1)	MD4461C1 (pl)
ME (1)	ME02213B (pl)
MX (1)	MX346640B (pl)
MY (1)	MY189537A (pl)
NZ (1)	NZ622915A (pl)
PL (1)	PL2784066T3 (pl)
PT (1)	PT2784066E (pl)
RS (1)	RS54186B1 (pl)
SA (1)	SA114350383B1 (pl)
SG (1)	SG10201400610SA (pl)
SI (1)	SI2784066T1 (pl)
TW (1)	TWI511957B (pl)
UA (1)	UA116527C2 (pl)
UY (1)	UY35503A (pl)
WO (1)	WO2014154994A1 (pl)
ZA (1)	ZA201402072B (pl)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN104610146A (zh) *	2015-01-23	2015-05-13	常州大学	一种3-氮杂二环[5,1,0]-7-醛及合成方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3119874A1 (de) *	1981-05-19	1982-12-09	Dr. Karl Thomae Gmbh, 7950 Biberach	"benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel"
US4490369A (en) *	1981-05-19	1984-12-25	Dr. Karl Thomae Gesellschaft Mit Beschrankter Haftung	Benzazepine derivatives, their pharmaceutical compositions and method of use
DE3343801A1 (de) *	1983-12-03	1985-06-13	Dr. Karl Thomae Gmbh, 7950 Biberach	Neue indolderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE3418270A1 (de) *	1984-05-17	1985-11-21	Dr. Karl Thomae Gmbh, 7950 Biberach	Neue aminotetralinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
EP0204349A3 (de) *	1985-06-01	1990-01-03	Dr. Karl Thomae GmbH	Neue heteroaromatische Aminderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
DE3519735A1 (de) *	1985-06-01	1986-12-04	Dr. Karl Thomae Gmbh, 7950 Biberach	Neue heteroaromatische aminderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
FR2681862B1 (fr) *	1991-09-27	1993-11-12	Adir Cie	Nouvelles (benzocycloalkyl)alkylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent.
FR2868775B1 (fr) *	2004-04-13	2008-04-11	Servier Lab	Nouveau procede de synthese de derives de la 1,3,4,5- tetrahydro-2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2870537A1 (fr) *	2004-05-19	2005-11-25	Servier Lab	Nouveau procede de synthese du (1s)-4,5-dimethoxy-1-(methyl aminomethyl-)-benzocyclobutane et de ses sels d'addition, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
GB0412314D0 (en) *	2004-06-02	2004-07-07	Glaxo Group Ltd	Compounds
US8312771B2 (en)	2006-11-10	2012-11-20	Siemens Medical Solutions Usa, Inc.	Transducer array imaging system
EP2097383B1 (en) *	2006-11-30	2012-02-08	Cadila Healthcare Limited	Process for preparation of ivabradine hydrochloride
FR2920773B1 (fr) *	2007-09-11	2009-10-23	Servier Lab	Derives de 1,2,4,5-tetrahydro-3h-benzazepines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CN101343249A (zh) *	2008-06-10	2009-01-14	上海医药工业研究院	3－(3－氯丙基)－7,8－二甲氧基－1,3－二氢－2h－3－苯并氮杂－2－酮的制备方法
FR2932800B1 (fr) *	2008-06-20	2015-02-20	Servier Lab	Nouveau procede de synthese de la 7,8-dimethoxy-1,3-dihydro- 2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2941695B1 (fr) *	2009-02-04	2011-02-18	Servier Lab	Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable

2013
- 2013-03-26 FR FR1352741A patent/FR3003859B1/fr not_active Expired - Fee Related
2014
- 2014-03-11 MY MYPI2014700574A patent/MY189537A/en unknown
- 2014-03-11 AU AU2014201355A patent/AU2014201355B2/en not_active Ceased
- 2014-03-13 MA MA36830A patent/MA35509B1/fr unknown
- 2014-03-13 SG SG10201400610SA patent/SG10201400610SA/en unknown
- 2014-03-16 JO JOP/2014/0112A patent/JO3132B1/ar active
- 2014-03-18 IN IN793DE2014 patent/IN2014DE00793A/en unknown
- 2014-03-19 MX MX2014003347A patent/MX346640B/es active IP Right Grant
- 2014-03-19 CA CA2846917A patent/CA2846917C/fr not_active Expired - Fee Related
- 2014-03-20 MD MDA20140028A patent/MD4461C1/ro not_active IP Right Cessation
- 2014-03-20 ZA ZA2014/02072A patent/ZA201402072B/en unknown
- 2014-03-21 GE GEAP201413425A patent/GEP201706731B/en unknown
- 2014-03-24 US US14/223,143 patent/US8927708B2/en not_active Expired - Fee Related
- 2014-03-24 UA UAA201402995A patent/UA116527C2/uk unknown
- 2014-03-24 TW TW103110914A patent/TWI511957B/zh not_active IP Right Cessation
- 2014-03-24 UY UY0001035503A patent/UY35503A/es unknown
- 2014-03-25 PL PL14161388T patent/PL2784066T3/pl unknown
- 2014-03-25 NZ NZ622915A patent/NZ622915A/en not_active IP Right Cessation
- 2014-03-25 ES ES14161388.5T patent/ES2548713T3/es active Active
- 2014-03-25 SI SI201430005T patent/SI2784066T1/sl unknown
- 2014-03-25 AR ARP140101337A patent/AR095722A1/es unknown
- 2014-03-25 KR KR1020140034869A patent/KR101616434B1/ko not_active Expired - Fee Related
- 2014-03-25 BR BR102014007079A patent/BR102014007079A2/pt not_active Application Discontinuation
- 2014-03-25 PT PT141613885T patent/PT2784066E/pt unknown
- 2014-03-25 EA EA201400269A patent/EA025516B1/ru not_active IP Right Cessation
- 2014-03-25 ME MEP-2015-152A patent/ME02213B/me unknown
- 2014-03-25 SA SA114350383A patent/SA114350383B1/ar unknown
- 2014-03-25 WO PCT/FR2014/050690 patent/WO2014154994A1/fr not_active Ceased
- 2014-03-25 HU HUE14161388A patent/HUE025550T2/en unknown
- 2014-03-25 JP JP2014061183A patent/JP5732159B2/ja active Active
- 2014-03-25 RS RS20150527A patent/RS54186B1/sr unknown
- 2014-03-25 EP EP14161388.5A patent/EP2784066B1/fr active Active
- 2014-03-25 DK DK14161388.5T patent/DK2784066T3/en active
- 2014-03-26 CN CN201410130182.4A patent/CN104072420B/zh not_active Expired - Fee Related
2015
- 2015-03-23 HK HK15102942.8A patent/HK1202532A1/xx unknown
- 2015-07-23 CY CY20151100650T patent/CY1116535T1/el unknown
- 2015-09-03 HR HRP20150924TT patent/HRP20150924T1/hr unknown

Also Published As

Publication number	Publication date
EP2784066B1 (fr)	2015-07-01
KR101616434B1 (ko)	2016-04-28
MD20140028A2 (ro)	2014-09-30
FR3003859B1 (fr)	2015-03-13
ME02213B (me)	2016-02-20
UY35503A (es)	2014-10-31
TWI511957B (zh)	2015-12-11
TW201522313A (zh)	2015-06-16
HK1198366A1 (en)	2015-04-10
AU2014201355B2 (en)	2017-08-24
HK1202532A1 (en)	2015-10-02
MX2014003347A (es)	2014-09-25
JO3132B1 (ar)	2017-09-20
JP2014196299A (ja)	2014-10-16
US20140296512A1 (en)	2014-10-02
WO2014154994A1 (fr)	2014-10-02
NZ622915A (en)	2015-05-29
PT2784066E (pt)	2015-08-31
MY189537A (en)	2022-02-16
IN2014DE00793A (pl)	2015-06-12
UA116527C2 (uk)	2018-04-10
ES2548713T3 (es)	2015-10-20
SI2784066T1 (sl)	2015-10-30
ZA201402072B (en)	2015-03-25
KR20140117298A (ko)	2014-10-07
EP2784066A1 (fr)	2014-10-01
CN104072420B (zh)	2016-09-28
MA35509B1 (fr)	2014-10-02
CA2846917A1 (fr)	2014-09-26
MX346640B (es)	2017-03-27
EA025516B1 (ru)	2016-12-30
CN104072420A (zh)	2014-10-01
CA2846917C (fr)	2016-02-09
SG10201400610SA (en)	2014-10-30
RS54186B1 (sr)	2015-12-31
US8927708B2 (en)	2015-01-06
JP5732159B2 (ja)	2015-06-10
MD4461B1 (ro)	2017-01-31
SA114350383B1 (ar)	2015-10-08
BR102014007079A2 (pt)	2015-10-20
HRP20150924T1 (hr)	2015-10-09
DK2784066T3 (en)	2015-10-05
GEP201706731B (en)	2017-09-11
FR3003859A1 (fr)	2014-10-03
EA201400269A1 (ru)	2014-09-30
AR095722A1 (es)	2015-11-04
MD4461C1 (ro)	2017-08-31
AU2014201355A1 (en)	2014-10-16
HUE025550T2 (en)	2016-02-29
CY1116535T1 (el)	2017-03-15

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