PL2804865T3 - Heterocykliczne pochodne amidowe jako antagoniści receptora p2x7 - Google Patents

Heterocykliczne pochodne amidowe jako antagoniści receptora p2x7

Info

Publication number
PL2804865T3
PL2804865T3 PL13707053T PL13707053T PL2804865T3 PL 2804865 T3 PL2804865 T3 PL 2804865T3 PL 13707053 T PL13707053 T PL 13707053T PL 13707053 T PL13707053 T PL 13707053T PL 2804865 T3 PL2804865 T3 PL 2804865T3
Authority
PL
Poland
Prior art keywords
receptor antagonists
amide derivatives
heterocyclic amide
heterocyclic
derivatives
Prior art date
Application number
PL13707053T
Other languages
English (en)
Inventor
Kurt Hilpert
Francis Hubler
Thierry Kimmerlin
Dorte Renneberg
Simon Stamm
Original Assignee
Idorsia Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Idorsia Pharmaceuticals Ltd filed Critical Idorsia Pharmaceuticals Ltd
Publication of PL2804865T3 publication Critical patent/PL2804865T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
PL13707053T 2012-01-20 2013-01-18 Heterocykliczne pochodne amidowe jako antagoniści receptora p2x7 PL2804865T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IB2012050282 2012-01-20
PCT/IB2013/050479 WO2013108227A1 (en) 2012-01-20 2013-01-18 Heterocyclic amide derivatives as p2x7 receptor antagonists
EP13707053.8A EP2804865B1 (en) 2012-01-20 2013-01-18 Heterocyclic amide derivatives as p2x7 receptor antagonists

Publications (1)

Publication Number Publication Date
PL2804865T3 true PL2804865T3 (pl) 2016-06-30

Family

ID=47757670

Family Applications (1)

Application Number Title Priority Date Filing Date
PL13707053T PL2804865T3 (pl) 2012-01-20 2013-01-18 Heterocykliczne pochodne amidowe jako antagoniści receptora p2x7

Country Status (23)

Country Link
US (1) US9409917B2 (pl)
EP (1) EP2804865B1 (pl)
JP (1) JP6111268B2 (pl)
KR (1) KR102033190B1 (pl)
CN (1) CN104066737B (pl)
AR (1) AR089753A1 (pl)
AU (1) AU2013210682B2 (pl)
BR (1) BR112014017735B1 (pl)
CA (1) CA2863228C (pl)
CL (1) CL2014001772A1 (pl)
EA (1) EA024204B1 (pl)
ES (1) ES2563189T3 (pl)
HK (1) HK1203932A1 (pl)
IL (1) IL233662A0 (pl)
MA (1) MA35893B1 (pl)
MX (1) MX336247B (pl)
NZ (1) NZ628910A (pl)
PH (1) PH12014501415A1 (pl)
PL (1) PL2804865T3 (pl)
SG (1) SG11201403933UA (pl)
TW (1) TWI576347B (pl)
WO (1) WO2013108227A1 (pl)
ZA (1) ZA201406085B (pl)

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WO2014097140A1 (en) 2012-12-18 2014-06-26 Actelion Pharmaceuticals Ltd Indole carboxamide derivatives as p2x7 receptor antagonists
JP6282016B2 (ja) 2013-01-22 2018-02-21 イドーシア ファーマシューティカルズ リミテッドＩｄｏｒｓｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ Ｐ２ｘ７受容体アンタゴニストとしての複素環アミド誘導体
JP6282017B2 (ja) 2013-01-22 2018-02-21 イドーシア ファーマシューティカルズ リミテッドＩｄｏｒｓｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ Ｐ２ｘ７受容体アンタゴニストとしての複素環アミド誘導体
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CN122301820A (zh) * 2026-06-02 2026-06-30 辽宁龙田化工科技有限公司 一种高收率苯并呋喃-2,3-二酮3-(o-甲基肟)2-肟的合成方法

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JP6282017B2 (ja) 2013-01-22 2018-02-21 イドーシア ファーマシューティカルズ リミテッドＩｄｏｒｓｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ Ｐ２ｘ７受容体アンタゴニストとしての複素環アミド誘導体
JP6282016B2 (ja) 2013-01-22 2018-02-21 イドーシア ファーマシューティカルズ リミテッドＩｄｏｒｓｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ Ｐ２ｘ７受容体アンタゴニストとしての複素環アミド誘導体

Also Published As

Publication number Publication date
IL233662A0 (en) 2014-08-31
EP2804865B1 (en) 2015-12-23
ZA201406085B (en) 2016-05-25
AR089753A1 (es) 2014-09-17
EA024204B1 (ru) 2016-08-31
TWI576347B (zh) 2017-04-01
AU2013210682A1 (en) 2014-09-11
US9409917B2 (en) 2016-08-09
WO2013108227A1 (en) 2013-07-25
CA2863228A1 (en) 2013-07-25
EA201400822A1 (ru) 2014-12-30
JP6111268B2 (ja) 2017-04-05
MX336247B (es) 2016-01-13
KR102033190B1 (ko) 2019-10-16
BR112014017735A8 (pt) 2017-12-26
AU2013210682B2 (en) 2017-05-25
EP2804865A1 (en) 2014-11-26
HK1203932A1 (en) 2015-11-06
PH12014501415A1 (en) 2014-09-22
BR112014017735B1 (pt) 2022-06-28
ES2563189T3 (es) 2016-03-11
KR20140112567A (ko) 2014-09-23
SG11201403933UA (en) 2014-08-28
MA35893B1 (fr) 2014-12-01
NZ628910A (en) 2016-02-26
CN104066737A (zh) 2014-09-24
TW201333013A (zh) 2013-08-16
CL2014001772A1 (es) 2014-10-17
US20150025075A1 (en) 2015-01-22
BR112014017735A2 (pt) 2017-06-27
CA2863228C (en) 2020-07-21
MX2014008736A (es) 2014-08-29
CN104066737B (zh) 2016-06-08
JP2015504086A (ja) 2015-02-05

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