PL2814502T3 - Warianty czynnika von Willebranda mające ulepszone powinowactwo do wiązania czynnika VIII - Google Patents
Warianty czynnika von Willebranda mające ulepszone powinowactwo do wiązania czynnika VIIIInfo
- Publication number
- PL2814502T3 PL2814502T3 PL13704770T PL13704770T PL2814502T3 PL 2814502 T3 PL2814502 T3 PL 2814502T3 PL 13704770 T PL13704770 T PL 13704770T PL 13704770 T PL13704770 T PL 13704770T PL 2814502 T3 PL2814502 T3 PL 2814502T3
- Authority
- PL
- Poland
- Prior art keywords
- binding affinity
- von willebrand
- variants
- improved
- viii binding
- Prior art date
Links
- 229960000301 factor viii Drugs 0.000 title 1
- 108010047303 von Willebrand Factor Proteins 0.000 title 1
- 102100036537 von Willebrand factor Human genes 0.000 title 1
- 229960001134 von willebrand factor Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12155509 | 2012-02-15 | ||
| PCT/EP2013/052948 WO2013120939A1 (en) | 2012-02-15 | 2013-02-14 | Von willebrand factor variants having improved factor viii binding affinity |
| EP13704770.0A EP2814502B1 (en) | 2012-02-15 | 2013-02-14 | Von willebrand factor variants having improved factor viii binding affinity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2814502T3 true PL2814502T3 (pl) | 2018-02-28 |
Family
ID=47722267
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL13704770T PL2814502T3 (pl) | 2012-02-15 | 2013-02-14 | Warianty czynnika von Willebranda mające ulepszone powinowactwo do wiązania czynnika VIII |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9458223B2 (pl) |
| EP (1) | EP2814502B1 (pl) |
| AU (1) | AU2013200843B2 (pl) |
| DK (1) | DK2814502T3 (pl) |
| ES (1) | ES2651523T3 (pl) |
| PL (1) | PL2814502T3 (pl) |
| WO (1) | WO2013120939A1 (pl) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2657291T3 (es) | 2013-04-22 | 2018-03-02 | Csl Ltd. | Un complejo covalente de factor de von Willebrand y factor VIII asociado por un puente disulfuro |
| US10114017B2 (en) | 2013-11-15 | 2018-10-30 | President And Fellows Of Harvard College | Methods and assays for factor VIII activity |
| EP3164150B1 (en) * | 2014-07-02 | 2020-11-04 | CSL Behring Lengnau AG | Modified von willebrand factor |
| BR112017023785A2 (pt) | 2015-05-22 | 2018-07-17 | Csl Behring Recombinant Facility Ag | polipeptídeos do fator de von willebrand truncados para tratar hemofilia |
| EP4089109A3 (en) | 2015-05-22 | 2023-03-01 | CSL Behring Lengnau AG | Methods for preparing modified von willebrand factor |
| KR20180031775A (ko) * | 2015-08-12 | 2018-03-28 | 셀 머신스, 인크. | 긴 반감기 응집 복합체와 관련된 방법 및 조성물 |
| EP3184149A1 (en) | 2015-12-23 | 2017-06-28 | Julius-Maximilians-Universität Würzburg | Soluble glycoprotein v for treating thrombotic diseases |
| DK3400238T3 (da) * | 2016-01-07 | 2021-07-26 | CSL Behring Lengnau AG | Muteret von willebrand faktor |
| RU2018128582A (ru) * | 2016-01-07 | 2020-02-11 | Цсл Беринг Ленгнау Аг | Мутированный укороченный фактор фон виллебранда |
| EP3458085B1 (en) * | 2016-05-20 | 2022-12-07 | Octapharma AG | Glycosylated vwf fusion proteins with improved pharmacokinetics |
| US11814421B2 (en) | 2016-11-11 | 2023-11-14 | CSL Behring Lengnau AG | Truncated von Willebrand Factor polypeptides for treating hemophilia |
| SG11201903954WA (en) | 2016-11-11 | 2019-05-30 | CSL Behring Lengnau AG | Truncated von willebrand factor polypeptides for extravascular administration in the treatment or prophylaxis of a blood coagulation disorder |
| WO2018102743A1 (en) | 2016-12-02 | 2018-06-07 | Bioverativ Therapeutics Inc. | Methods of treating hemophilic arthropathy using chimeric clotting factors |
| WO2018234518A1 (en) | 2017-06-22 | 2018-12-27 | CSL Behring Lengnau AG | Modulation of fviii immunogenicity by truncated vwf |
| AU2018338608B2 (en) | 2017-09-27 | 2025-09-11 | Sigilon Therapeutics, Inc. | Methods, compositions, and implantable elements comprising active cells |
| CA3081106A1 (en) * | 2017-11-01 | 2019-05-09 | Queen's University At Kingston | Von willebrand factor proteins for treating bleeding disorders |
| MX2020010369A (es) | 2018-04-04 | 2020-10-22 | Sigilon Therapeutics Inc | Particulas implantables y metodos relacionados. |
| WO2019195056A1 (en) | 2018-04-04 | 2019-10-10 | Sigilon Therapeutics, Inc. | Methods, compositions, and implantable elements comprising stem cells |
| JP7763589B2 (ja) | 2018-05-18 | 2025-11-04 | バイオベラティブ セラピューティクス インコーポレイテッド | 血友病ａを処置する方法 |
| UY38389A (es) | 2018-09-27 | 2020-04-30 | Sigilon Therapeutics Inc | Dispositivos implantables para terapia celular y métodos relacionados |
| US20220211808A1 (en) | 2019-05-17 | 2022-07-07 | Universitaet Zuerich | Haptoglobin for use in treating an adverse secondary neurological outcome following a haemorrhagic stroke |
| KR20220029733A (ko) | 2019-07-04 | 2022-03-08 | 체에스엘 베링 렝나우 아게 | 응고 인자 viii의 시험관내 안정성을 증가시키기 위한 절단된 폰 빌레브란트 인자 (vwf) |
| WO2021094344A1 (en) | 2019-11-11 | 2021-05-20 | CSL Behring Lengnau AG | Polypeptides for inducing tolerance to factor viii |
| KR20230142569A (ko) | 2021-02-01 | 2023-10-11 | 체에스엘 베링 아게 | 출혈성 뇌졸중 후의 이차 신경학적 이상 반응을 치료 또는 예방하는 방법 |
| CN117321074A (zh) | 2021-05-07 | 2023-12-29 | 瑞士杰特贝林生物制品有限公司 | 用于产生重组触珠蛋白(Hp)β链的表达系统 |
| KR20250058762A (ko) | 2022-09-02 | 2025-04-30 | 체에스엘 베링 아게 | 과도한 발기 반응 또는 발기 부전을 치료하거나 예방하는 데 사용하기 위한 합토글로빈 |
| WO2025257801A1 (en) | 2024-06-13 | 2025-12-18 | CSL Innovation Pty Ltd | Heme-binding protein for the treatment of ischemia-reperfusion injury (iri) |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4970300A (en) | 1985-02-01 | 1990-11-13 | New York University | Modified factor VIII |
| FR2673632A1 (fr) | 1991-03-08 | 1992-09-11 | Lille Transfusion Sanguine | Procede de preparation de concentre de facteur von willebrand humain de tres haute purete, approprie a un usage therapeutique. |
| US5179385A (en) | 1992-01-02 | 1993-01-12 | International Marine Industries, Inc. | Visual navigation aid with point of interest feature |
| AU6029594A (en) | 1993-01-15 | 1994-08-15 | Enzon, Inc. | Factor viii - polymeric conjugates |
| DE4435485C1 (de) | 1994-10-04 | 1996-03-21 | Immuno Ag | Verfahren zur Gewinnung von hochreinem von Willebrand-Faktor |
| EP0793504B1 (en) | 1994-12-12 | 2005-06-08 | Beth Israel Deaconess Medical Center, Inc. | Chimeric cytokines and uses thereof |
| AU6455896A (en) | 1995-07-11 | 1997-02-10 | Chiron Corporation | Novel factor viii:c polypeptide analogs with altered metal-binding properties |
| SE9503380D0 (sv) | 1995-09-29 | 1995-09-29 | Pharmacia Ab | Protein derivatives |
| EP0910628B1 (en) | 1996-04-24 | 2006-03-08 | The Regents of The University of Michigan | Inactivation resistant factor viii |
| US20040092442A1 (en) | 1996-04-24 | 2004-05-13 | University Of Michigan | Inactivation resistant factor VIII |
| DE69922189T2 (de) | 1998-04-27 | 2005-11-10 | Opperbas Holding B.V. | Pharmazeutische zusammensetzungen enthaltend faktor viii und neutrale liposomen |
| US6660843B1 (en) | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
| JP2003530838A (ja) * | 2000-04-12 | 2003-10-21 | ヒューマン ゲノム サイエンシズ インコーポレイテッド | アルブミン融合タンパク質 |
| EP1351986A2 (en) | 2001-01-12 | 2003-10-15 | The American National Red Cross | Methods and compositions for reducing heparan sulfate proteoglycan-mediated clearance of factor viii |
| WO2002103024A2 (en) | 2001-06-14 | 2002-12-27 | The Scripps Research Institute | Stabilized proteins with engineered disulfide bonds |
| US20080108560A1 (en) | 2002-03-05 | 2008-05-08 | Eli Lilly And Company | Heterologous G-Csf Fusion Proteins |
| JP2005535588A (ja) | 2002-04-29 | 2005-11-24 | バクスター・インターナショナル・インコーポレイテッド | 第ｖｉｉｉ因子と低密度リポタンパク質レセプター関連タンパク質との相互作用のアンタゴニスト |
| CA2788505C (en) | 2003-02-26 | 2018-09-04 | Nektar Therapeutics | Polymer-factor viii moiety conjugates |
| TWI353991B (en) | 2003-05-06 | 2011-12-11 | Syntonix Pharmaceuticals Inc | Immunoglobulin chimeric monomer-dimer hybrids |
| PT1624891E (pt) | 2003-05-06 | 2010-01-05 | Syntonix Pharmaceuticals Inc | Proteínas quiméricas de factor de coagulação-fc destinadas ao tratamento da hemofilia |
| EA008831B1 (ru) | 2003-06-12 | 2007-08-31 | Эли Лилли Энд Компани | Слитые белки аналогов glp-1 |
| WO2005063808A1 (en) | 2003-12-31 | 2005-07-14 | Merck Patent Gmbh | Fc-ERYTHROPOIETIN FUSION PROTEIN WITH IMPROVED PHARMACOKINETICS |
| US7670595B2 (en) | 2004-06-28 | 2010-03-02 | Merck Patent Gmbh | Fc-interferon-beta fusion proteins |
| JP2006101790A (ja) * | 2004-10-06 | 2006-04-20 | Japan Health Science Foundation | 高血圧症のリスクの評価方法 |
| US7632921B2 (en) | 2004-11-12 | 2009-12-15 | Bayer Healthcare Llc | Site-directed modification of FVIII |
| DK1835938T3 (da) | 2004-12-27 | 2013-11-04 | Baxter Int | Polymer-von Willebrand-faktor-konjugater |
| US20110124565A1 (en) | 2005-04-14 | 2011-05-26 | Hans-Peter Hauser | Modified Coagulation Factor VIII With Enhanced Stability and Its Derivatives |
| EP1816201A1 (en) | 2006-02-06 | 2007-08-08 | CSL Behring GmbH | Modified coagulation factor VIIa with extended half-life |
| EP2010222A1 (en) | 2006-03-31 | 2009-01-07 | Baxter International Inc. | Pegylated factor viii |
| PL2032607T5 (pl) | 2006-06-14 | 2017-10-31 | Csl Behring Gmbh | Rozszczepialne proteolitycznie białko fuzyjne obejmujące czynnik krzepnięcia krwi |
| WO2008005290A2 (en) * | 2006-06-29 | 2008-01-10 | The Trustees Of Columbia University In The City Of New York | Methods for testing anti-thrombotic agents |
| US8754194B2 (en) | 2006-12-22 | 2014-06-17 | Csl Behring Gmbh | Modified coagulation factors with prolonged in vivo half-life |
| KR100981092B1 (ko) * | 2008-02-29 | 2010-09-08 | 고려대학교 산학협력단 | 제8 혈액응고 인자와 폰 빌리 블란트 인자 변이체의 재조합발현 벡터 시스템 |
| DK2865760T3 (en) | 2008-06-24 | 2018-01-15 | Csl Behring Gmbh | Factor VIII, Von Willebrand Factor or complexes thereof with extended in vivo half-life |
| AU2010284977A1 (en) * | 2009-08-20 | 2012-03-29 | Csl Behring Gmbh | Albumin fused coagulation factors for non-intravenous administration in the therapy and prophylactic treatment of bleeding disorders |
-
2013
- 2013-02-14 PL PL13704770T patent/PL2814502T3/pl unknown
- 2013-02-14 DK DK13704770.0T patent/DK2814502T3/en active
- 2013-02-14 ES ES13704770.0T patent/ES2651523T3/es active Active
- 2013-02-14 EP EP13704770.0A patent/EP2814502B1/en active Active
- 2013-02-14 US US14/378,446 patent/US9458223B2/en active Active
- 2013-02-14 WO PCT/EP2013/052948 patent/WO2013120939A1/en not_active Ceased
- 2013-02-15 AU AU2013200843A patent/AU2013200843B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20140357564A1 (en) | 2014-12-04 |
| WO2013120939A1 (en) | 2013-08-22 |
| EP2814502B1 (en) | 2017-09-13 |
| AU2013200843A1 (en) | 2013-08-29 |
| US9458223B2 (en) | 2016-10-04 |
| ES2651523T3 (es) | 2018-01-26 |
| DK2814502T3 (en) | 2017-12-18 |
| EP2814502A1 (en) | 2014-12-24 |
| AU2013200843B2 (en) | 2015-09-17 |
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