PL2820006T3 - Pyrazol-1-yl benzene sulfonamides as ccr9 antagonists - Google Patents

Pyrazol-1-yl benzene sulfonamides as ccr9 antagonists

Info

Publication number
PL2820006T3
PL2820006T3 PL13708633T PL13708633T PL2820006T3 PL 2820006 T3 PL2820006 T3 PL 2820006T3 PL 13708633 T PL13708633 T PL 13708633T PL 13708633 T PL13708633 T PL 13708633T PL 2820006 T3 PL2820006 T3 PL 2820006T3
Authority
PL
Poland
Prior art keywords
pyrazol
benzene sulfonamides
ccr9 antagonists
ccr9
antagonists
Prior art date
Application number
PL13708633T
Other languages
Polish (pl)
Inventor
Xi Chen
Junfa Fan
Pingchen Fan
Antoni Krasinski
Lianfa Li
Rebecca M. Lui
Jeffrey P. Mcmahon
Jay P. Powers
Yibin Zeng
Penglie Zhang
Original Assignee
Chemocentryx, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemocentryx, Inc. filed Critical Chemocentryx, Inc.
Publication of PL2820006T3 publication Critical patent/PL2820006T3/en

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
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    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
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    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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PL13708633T 2012-02-29 2013-02-28 Pyrazol-1-yl benzene sulfonamides as ccr9 antagonists PL2820006T3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261604998P 2012-02-29 2012-02-29
EP13708633.6A EP2820006B1 (en) 2012-02-29 2013-02-28 Pyrazol-1-yl benzene sulfonamides as ccr9 antagonists
PCT/US2013/028328 WO2013130811A1 (en) 2012-02-29 2013-02-28 Pyrazol-1-yl benzene sulfonamides as ccr9 antagonists

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PL2820006T3 true PL2820006T3 (en) 2018-02-28

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PL13708633T PL2820006T3 (en) 2012-02-29 2013-02-28 Pyrazol-1-yl benzene sulfonamides as ccr9 antagonists
PL17184205T PL3263564T3 (en) 2012-02-29 2013-02-28 Aza-aryl 1h-pyrazol-1-yl benzene sulfonamides as ccr(9) antagonists

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US (5) US8916601B2 (en)
EP (3) EP3738958A1 (en)
JP (3) JP6249966B2 (en)
KR (1) KR102083693B1 (en)
CN (2) CN104520288B (en)
AU (3) AU2013225938B2 (en)
BR (1) BR112014021148B1 (en)
CA (1) CA2865714C (en)
DK (2) DK2820006T3 (en)
ES (2) ES2645617T3 (en)
HK (1) HK1206012A1 (en)
MX (2) MX372722B (en)
PL (2) PL2820006T3 (en)
PT (1) PT3263564T (en)
RU (1) RU2627268C2 (en)
SG (2) SG11201405241VA (en)
WO (1) WO2013130811A1 (en)
ZA (1) ZA201406432B (en)

Families Citing this family (23)

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Publication number Priority date Publication date Assignee Title
US10827315B2 (en) * 2006-04-07 2020-11-03 Groupon, Inc. Facilitating user interactions based on proximity
US9100454B2 (en) 2006-04-07 2015-08-04 Groupon, Inc. Method and system for enabling the creation and maintenance of proximity-related user groups
DK2820006T3 (en) * 2012-02-29 2017-11-06 Chemocentryx Inc PYRAZOL-1-YL BENZEN SULPHONAMIDES AS CCR9 ANTAGONISTS
UY35165A (en) 2012-12-04 2014-06-30 Takeda Pharmaceutical PROFILACTIC OR THERAPEUTIC METHOD FOR SJOGREN SYNDROME
GB201308978D0 (en) 2013-05-17 2013-07-03 Imp Innovations Ltd Method for producing polymers and block copolymers
CN105960237B (en) * 2013-12-02 2020-03-31 凯莫森特里克斯股份有限公司 CCR6 compound
JP2017501145A (en) * 2013-12-23 2017-01-12 ノージン ビーブイ Compounds useful as CCR9 modulators
MA40592A (en) 2014-10-06 2016-04-14 Chemocentryx Inc COMPOSITIONS AND METHODS FOR THE TREATMENT OF INFLAMMATORY DISEASE OF THE INTESTINE USING A POLYTHERAPY BASED ON SMALL MOLECULE INHIBITORS OF CHEMIOKINE C-C (CCR9) AND ANTIBODY BLOCKERS ALTIPHA4-INTEGRINE
GB201515350D0 (en) 2015-08-28 2015-10-14 Econic Technologies Ltd Method for preparing polyols
BR112018014666B1 (en) * 2016-01-20 2024-01-02 Chemocentryx, Inc 2-OXINDOL COMPOUNDS, THEIR USE AND PHARMACEUTICAL COMPOSITION
RU2768479C2 (en) * 2016-06-13 2022-03-24 Хемоцентрикс, Инк. Methods for treating pancreatic cancer
CN110636846B (en) * 2017-05-17 2023-05-16 艾库斯生物科学有限公司 Quinazoline pyrazole derivatives for the treatment of cancer-related diseases
AU2019312296B2 (en) * 2018-07-27 2025-05-29 Arcus Biosciences, Inc. Pyridone A2R antagonists
US20240281033A1 (en) * 2018-10-24 2024-08-22 Screen Skinz, Inc. Screen protector with engraved image
US20200319677A1 (en) * 2018-10-24 2020-10-08 Clay Canning Screen protector with engraved image
KR102890201B1 (en) 2019-07-10 2025-11-24 케모센트릭스, 인크. Indan as a PD-L1 inhibitor
EP3805206B1 (en) * 2019-10-08 2026-08-05 Novaled GmbH Compound and an organic semiconducting layer, an organic electronic device, a display device and a lighting device comprising the same
ES3068390T3 (en) * 2019-10-16 2026-05-29 Chemocentryx Inc Heteroaryl-biphenyl amides for the treatment of pd-l1 diseases
AU2020368392B2 (en) 2019-10-16 2026-01-08 Chemocentryx, Inc. Heteroaryl-biphenyl amines for the treatment of PD-L1 diseases
US10792360B1 (en) 2019-11-21 2020-10-06 Chemocentryx, Inc. Compositions and methods for treating inflammatory bowel disease using CCR9 inhibitor and anti-TNF-alpha blocking antibodies
TWI904146B (en) * 2020-03-31 2025-11-11 美商卡默森屈有限公司 Compositions and methods for treating inflammatory bowel disease using ccr9 inhibitor and anti-il-23 blocking antibodies
SMT202500447T1 (en) 2021-11-02 2026-01-12 Flare Therapeutics Inc Pparg inverse agonists and uses thereof
KR102584607B1 (en) 2023-01-19 2023-10-04 아주대학교산학협력단 Composition for Preventing or Treating Inflammatory Skin Diseases Comprising 1H-Pyrazole-3-Amide Compound Derivatives

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL154598B (en) 1970-11-10 1977-09-15 Organon Nv PROCEDURE FOR DETERMINING AND DETERMINING LOW MOLECULAR COMPOUNDS AND PROTEINS THAT CAN SPECIFICALLY BIND THESE COMPOUNDS AND TEST PACKAGING.
US3817837A (en) 1971-05-14 1974-06-18 Syva Corp Enzyme amplification assay
US3939350A (en) 1974-04-29 1976-02-17 Board Of Trustees Of The Leland Stanford Junior University Fluorescent immunoassay employing total reflection for activation
US3996345A (en) 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4166452A (en) 1976-05-03 1979-09-04 Generales Constantine D J Jr Apparatus for testing human responses to stimuli
US4256108A (en) 1977-04-07 1981-03-17 Alza Corporation Microporous-semipermeable laminated osmotic system
US4275149A (en) 1978-11-24 1981-06-23 Syva Company Macromolecular environment control in specific receptor assays
US4277437A (en) 1978-04-05 1981-07-07 Syva Company Kit for carrying out chemically induced fluorescence immunoassay
US4265874A (en) 1980-04-25 1981-05-05 Alza Corporation Method of delivering drug with aid of effervescent activity generated in environment of use
US4366241A (en) 1980-08-07 1982-12-28 Syva Company Concentrating zone method in heterogeneous immunoassays
US5120643A (en) 1987-07-13 1992-06-09 Abbott Laboratories Process for immunochromatography with colloidal particles
US6159686A (en) 1992-09-14 2000-12-12 Sri International Up-converting reporters for biological and other assays
US5514555A (en) 1993-03-12 1996-05-07 Center For Blood Research, Inc. Assays and therapeutic methods based on lymphocyte chemoattractants
US6322901B1 (en) 1997-11-13 2001-11-27 Massachusetts Institute Of Technology Highly luminescent color-selective nano-crystalline materials
US6207392B1 (en) 1997-11-25 2001-03-27 The Regents Of The University Of California Semiconductor nanocrystal probes for biological applications and process for making and using such probes
US5990479A (en) 1997-11-25 1999-11-23 Regents Of The University Of California Organo Luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes
US6326144B1 (en) 1998-09-18 2001-12-04 Massachusetts Institute Of Technology Biological applications of quantum dots
US6306610B1 (en) 1998-09-18 2001-10-23 Massachusetts Institute Of Technology Biological applications of quantum dots
US6251303B1 (en) 1998-09-18 2001-06-26 Massachusetts Institute Of Technology Water-soluble fluorescent nanocrystals
US6294192B1 (en) 1999-02-26 2001-09-25 Lipocine, Inc. Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents
AU2001273040A1 (en) 2000-06-27 2002-01-08 Du Pont Pharmaceuticals Company Factor xa inhibitors
AU2003248549B2 (en) * 2002-05-24 2010-04-08 Millennium Pharmaceuticals, Inc. CCR9 inhibitors and methods of use thereof
AU2003298661B2 (en) * 2002-11-18 2007-05-10 Chemocentryx, Inc. Aryl sulfonamides
TW200510311A (en) * 2002-12-23 2005-03-16 Millennium Pharm Inc CCr8 inhibitors
SE0301653D0 (en) * 2003-06-05 2003-06-05 Astrazeneca Ab Novel compounds
JP2007537275A (en) * 2004-05-12 2007-12-20 ケモセントリックス， インコーポレイテッド Arylsulfonamide
SE0402635D0 (en) 2004-10-29 2004-10-29 Astrazeneca Ab Chemical compounds
PL2046762T3 (en) * 2006-07-14 2011-07-29 Chemocentryx Inc Triazolyl phenyl benzenesulfonamides
US20100234364A1 (en) * 2006-07-14 2010-09-16 Arindrajit Basak Ccr2 inhibitors and methods of use thereof
MX2009008425A (en) 2007-02-06 2009-08-17 Novartis Ag 1-benzenesulfonyl-1h-indole derivatives as inhibitors of ccr9 activity.
US7776877B2 (en) * 2007-06-22 2010-08-17 Chemocentryx, Inc. N-(2-(hetaryl)aryl) arylsulfonamides and N-(2-(hetaryl) hetaryl arylsulfonamides
US9315449B2 (en) 2008-05-15 2016-04-19 Duke University Substituted pyrazoles as heat shock transcription factor activators
DK2820006T3 (en) * 2012-02-29 2017-11-06 Chemocentryx Inc PYRAZOL-1-YL BENZEN SULPHONAMIDES AS CCR9 ANTAGONISTS
MA40592A (en) * 2014-10-06 2016-04-14 Chemocentryx Inc COMPOSITIONS AND METHODS FOR THE TREATMENT OF INFLAMMATORY DISEASE OF THE INTESTINE USING A POLYTHERAPY BASED ON SMALL MOLECULE INHIBITORS OF CHEMIOKINE C-C (CCR9) AND ANTIBODY BLOCKERS ALTIPHA4-INTEGRINE
US9715915B2 (en) 2014-10-30 2017-07-25 Samsung Electronics Co., Ltd. Magneto-resistive devices including a free layer having different magnetic properties during operations

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