PL2825640T3 - Partie rekombinowanych adenowirusów o zmienionych końcach - Google Patents
Partie rekombinowanych adenowirusów o zmienionych końcachInfo
- Publication number
- PL2825640T3 PL2825640T3 PL13708445.5T PL13708445T PL2825640T3 PL 2825640 T3 PL2825640 T3 PL 2825640T3 PL 13708445 T PL13708445 T PL 13708445T PL 2825640 T3 PL2825640 T3 PL 2825640T3
- Authority
- PL
- Poland
- Prior art keywords
- batches
- terminal ends
- recombinant adenovirus
- altered terminal
- altered
- Prior art date
Links
- 241000701161 unidentified adenovirus Species 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C12N7/02—Recovery or purification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10351—Methods of production or purification of viral material
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261609678P | 2012-03-12 | 2012-03-12 | |
| EP12159009 | 2012-03-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2825640T3 true PL2825640T3 (pl) | 2016-10-31 |
Family
ID=49160272
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL13708445.5T PL2825640T3 (pl) | 2012-03-12 | 2013-03-11 | Partie rekombinowanych adenowirusów o zmienionych końcach |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP2825640B1 (pl) |
| JP (1) | JP5770952B2 (pl) |
| KR (1) | KR102044051B1 (pl) |
| CN (1) | CN104379733B (pl) |
| AR (1) | AR090318A1 (pl) |
| AU (1) | AU2013231423B2 (pl) |
| CA (1) | CA2864956C (pl) |
| DK (1) | DK2825640T3 (pl) |
| EA (1) | EA034284B1 (pl) |
| ES (1) | ES2582504T3 (pl) |
| HU (1) | HUE027839T2 (pl) |
| NZ (1) | NZ628385A (pl) |
| PL (1) | PL2825640T3 (pl) |
| SG (1) | SG11201405228VA (pl) |
| SI (1) | SI2825640T1 (pl) |
| TW (1) | TWI633188B (pl) |
| WO (1) | WO2013135615A1 (pl) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3115891A1 (en) | 2013-03-14 | 2014-09-25 | Salk Institute For Biological Studies | Oncolytic adenovirus compositions |
| PE20151867A1 (es) | 2013-04-25 | 2016-01-07 | Crucell Holland Bv | Polipeptidos f de prefusion del virus sincicial respiratorio (rsv )solubles y estabilizados |
| CA2914792C (en) | 2013-06-17 | 2024-02-27 | Crucell Holland B.V. | Stabilized soluble pre-fusion rsv f polypeptides |
| DK3198009T3 (da) | 2014-09-24 | 2021-11-22 | Salk Inst For Biological Studi | Onkolytiske tumorvira og anvendelsesfremgangsmåder |
| CN107847581B (zh) | 2015-07-07 | 2022-03-22 | 扬森疫苗与预防公司 | 稳定化的可溶性融合前rsv f多肽 |
| CA2991002C (en) | 2015-07-07 | 2023-11-28 | Janssen Vaccines & Prevention B.V. | Vaccine against rsv |
| GB201513010D0 (en) * | 2015-07-23 | 2015-09-09 | Glaxosmithkline Biolog Sa | Novel formulation |
| JP7054527B2 (ja) | 2016-02-23 | 2022-04-14 | ソーク インスティテュート フォー バイオロジカル スタディーズ | アデノウイルスの複製動態を測定するための高スループットアッセイ |
| EP3390645B1 (en) | 2016-02-23 | 2022-09-14 | Salk Institute for Biological Studies | Exogenous gene expression in therapeutic adenovirus for minimal impact on viral kinetics |
| MY193584A (en) | 2016-04-05 | 2022-10-19 | Janssen Vaccines & Prevention Bv | Vaccine against rsv |
| PT3439672T (pt) | 2016-04-05 | 2021-02-24 | Janssen Vaccines & Prevention Bv | Proteína f do rsv pré-fusão solúvel e estabilizada para uso na profilaxia de infeção por rsv |
| KR102573534B1 (ko) * | 2016-05-12 | 2023-08-31 | 얀센 백신스 앤드 프리벤션 비.브이. | 강력하고 균형 잡힌 양방향성 프로모터 |
| US10953087B2 (en) | 2016-05-30 | 2021-03-23 | Janssen Vaccines & Prevention B.V. | Stabilized pre-fusion RSV F proteins |
| WO2018011196A1 (en) | 2016-07-14 | 2018-01-18 | Janssen Vaccines & Prevention B.V. | Hpv vaccines |
| CN110062630A (zh) | 2016-12-12 | 2019-07-26 | 萨克生物研究学院 | 肿瘤靶向合成腺病毒及其用途 |
| US11229692B2 (en) | 2017-05-17 | 2022-01-25 | Janssen Vaccines & Prevention B.V. | Methods and compositions for inducing protective immunity against RSV infection |
| CN111163800A (zh) | 2017-09-15 | 2020-05-15 | 扬森疫苗与预防公司 | 用于安全诱导针对rsv的免疫的方法 |
| CA3096099A1 (en) | 2018-04-09 | 2019-10-17 | Salk Institute For Biological Studies | Oncolytic adenovirus compositions with enhanced replication properties |
| EP3880243A1 (en) | 2018-11-13 | 2021-09-22 | Janssen Vaccines & Prevention B.V. | Stabilized pre-fusion rsv f proteins |
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| DE3584341D1 (de) | 1984-08-24 | 1991-11-14 | Upjohn Co | Rekombinante dna-verbindungen und expression von polypeptiden wie tpa. |
| US5168062A (en) | 1985-01-30 | 1992-12-01 | University Of Iowa Research Foundation | Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence |
| US5057540A (en) | 1987-05-29 | 1991-10-15 | Cambridge Biotech Corporation | Saponin adjuvant |
| NZ230747A (en) | 1988-09-30 | 1992-05-26 | Bror Morein | Immunomodulating matrix comprising a complex of at least one lipid and at least one saponin; certain glycosylated triterpenoid saponins derived from quillaja saponaria molina |
| JPH0832638B2 (ja) | 1989-05-25 | 1996-03-29 | カイロン コーポレイション | サブミクロン油滴乳剤を含んで成るアジュバント製剤 |
| FR2705686B1 (fr) | 1993-05-28 | 1995-08-18 | Transgene Sa | Nouveaux adénovirus défectifs et lignées de complémentation correspondantes. |
| US5851806A (en) | 1994-06-10 | 1998-12-22 | Genvec, Inc. | Complementary adenoviral systems and cell lines |
| DE69535178T2 (de) | 1994-06-10 | 2006-12-14 | Genvec, Inc. | Adenoviren-vektor systeme und zelllinien |
| US5559099A (en) | 1994-09-08 | 1996-09-24 | Genvec, Inc. | Penton base protein and methods of using same |
| US5965541A (en) | 1995-11-28 | 1999-10-12 | Genvec, Inc. | Vectors and methods for gene transfer to cells |
| US5846782A (en) | 1995-11-28 | 1998-12-08 | Genvec, Inc. | Targeting adenovirus with use of constrained peptide motifs |
| AUPM873294A0 (en) | 1994-10-12 | 1994-11-03 | Csl Limited | Saponin preparations and use thereof in iscoms |
| US5837520A (en) | 1995-03-07 | 1998-11-17 | Canji, Inc. | Method of purification of viral vectors |
| IL160406A0 (en) | 1995-06-15 | 2004-07-25 | Crucell Holland Bv | A cell harbouring nucleic acid encoding adenoritus e1a and e1b gene products |
| US5837511A (en) | 1995-10-02 | 1998-11-17 | Cornell Research Foundation, Inc. | Non-group C adenoviral vectors |
| US5891690A (en) | 1996-04-26 | 1999-04-06 | Massie; Bernard | Adenovirus E1-complementing cell lines |
| EP0944717A1 (fr) | 1996-07-01 | 1999-09-29 | Aventis Pharma S.A. | Procede de production d'adenovirus recombinants |
| FR2751343B1 (fr) | 1996-07-16 | 1998-12-18 | Transgene Sa | Procede de conservation de virus recombinants infectieux, suspension aqueuse virale et utilisation comme medicament |
| WO1998010087A1 (en) | 1996-09-06 | 1998-03-12 | Trustees Of The University Of Pennsylvania | Chimpanzee adenovirus vectors |
| BR9713368A (pt) | 1996-11-20 | 2001-09-18 | Introgen Therapeutics Inc | Processo melhorado para a produção e a purificação de vetores adenovirais |
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| US6261823B1 (en) | 1996-12-13 | 2001-07-17 | Schering Corporation | Methods for purifying viruses |
| CA2283253A1 (en) | 1997-03-04 | 1998-09-11 | Baxter International Inc. | Adenovirus e1-complementing cell lines |
| US6020191A (en) | 1997-04-14 | 2000-02-01 | Genzyme Corporation | Adenoviral vectors capable of facilitating increased persistence of transgene expression |
| US6210683B1 (en) | 1997-09-05 | 2001-04-03 | Merck & Co., Inc. | Stabilizers containing recombinant human serum albumin for live virus vaccines |
| DE69936948T2 (de) | 1998-02-17 | 2008-05-15 | Schering Corporation | Virusenthaltende Zusammensetzungen und Methoden zur Konzentration von Viruspräparaten |
| US5981225A (en) | 1998-04-16 | 1999-11-09 | Baylor College Of Medicine | Gene transfer vector, recombinant adenovirus particles containing the same, method for producing the same and method of use of the same |
| US6670188B1 (en) | 1998-04-24 | 2003-12-30 | Crucell Holland B.V. | Packaging systems for human recombinant adenovirus to be used in gene therapy |
| US6113913A (en) | 1998-06-26 | 2000-09-05 | Genvec, Inc. | Recombinant adenovirus |
| AU1729600A (en) | 1998-11-16 | 2000-06-05 | Introgen Therapeutics, Inc. | Formulation of adenovirus for gene therapy |
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| ES2231103T5 (es) | 1999-05-17 | 2010-04-15 | Crucell Holland B.V. | Vehiculos de transferencia de genes derivados de adenovirus que comprenden al menos un elemento de adenovirus tipo 35. |
| US6492169B1 (en) | 1999-05-18 | 2002-12-10 | Crucell Holland, B.V. | Complementing cell lines |
| US6913922B1 (en) | 1999-05-18 | 2005-07-05 | Crucell Holland B.V. | Serotype of adenovirus and uses thereof |
| JP2003530307A (ja) | 1999-07-06 | 2003-10-14 | メルク・アンド・カンパニー・インコーポレーテッド | gag遺伝子保有アデノウイルスHIVワクチン |
| DE19955558C2 (de) | 1999-11-18 | 2003-03-20 | Stefan Kochanek | Permanente Amniozyten-Zelllinie, ihre Herstellung und Verwendung zur Herstellung von Gentransfervektoren |
| JP5118798B2 (ja) | 2000-03-07 | 2013-01-16 | メルク・シャープ・エンド・ドーム・コーポレイション | アデノウイルス製剤 |
| WO2002022080A2 (en) | 2000-09-15 | 2002-03-21 | Merck & Co., Inc. | Enhanced first generation adenovirus vaccines expressing codon optimized hiv1-gag, pol, nef and modifications |
| CA2469623C (en) | 2001-12-12 | 2012-05-29 | F H Faulding & Co Limited | Composition for the preservation of viruses |
| WO2003061708A1 (en) | 2002-01-18 | 2003-07-31 | Schering Aktiengesellschaft | Stabilized formulations of adenovirus |
| US20030180936A1 (en) | 2002-03-15 | 2003-09-25 | Memarzadeh Bahram Eric | Method for the purification, production and formulation of oncolytic adenoviruses |
| CA2478508C (en) | 2002-04-25 | 2013-07-02 | Crucell Holland B.V. | Stable adenoviral vectors and methods for propagation thereof |
| PT1497438E (pt) | 2002-04-25 | 2010-02-04 | Crucell Holland Bv | Meios e métodos para a produção de vectores de adenovírus |
| AU2003229060A1 (en) | 2002-05-14 | 2003-12-02 | Merck And Co., Inc. | Methods of adenovirus purification |
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| US20040106184A1 (en) | 2002-08-28 | 2004-06-03 | Introgen Therapeutics Inc. | Chromatographic methods for adenovirus purification |
| AU2003288273A1 (en) | 2002-10-23 | 2004-05-13 | Crucell Holland B.V. | New settings for recombinant adenoviral-based vaccines |
| EP2258850B1 (en) | 2002-12-17 | 2013-07-17 | Crucell Holland B.V. | Recominant viral-based malaria vaccins |
| SE0301998D0 (sv) | 2003-07-07 | 2003-07-07 | Isconova Ab | Quil A fraction with low toxicity and use thereof |
| ATE449105T1 (de) | 2004-01-23 | 2009-12-15 | Angeletti P Ist Richerche Bio | Impfstoffträger für schimpansen-adenovirus |
| AU2005214090B2 (en) | 2004-02-23 | 2008-09-11 | Crucell Holland B.V. | Virus purification methods |
| ATE491799T1 (de) * | 2004-05-26 | 2011-01-15 | Bayer Schering Pharma Ag | Chimäre adenoviren zur verwendung in der krebsbehandlung |
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| AU2006245920A1 (en) | 2005-05-12 | 2006-11-16 | Glaxo Group Limited | Vaccine composition |
| WO2007104792A2 (en) | 2006-03-16 | 2007-09-20 | Crucell Holland B.V. | Recombinant adenoviruses based on serotype 26 and 48, and use thereof |
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| EP2094284A2 (en) * | 2006-12-22 | 2009-09-02 | Bayer Schering Pharma AG | Generation of oncolytic adenoviruses and uses thereof |
| WO2009026183A1 (en) | 2007-08-17 | 2009-02-26 | The Government Of The U.S.A., As Represented By The Secretary, Department Of Health & Human Services | Use of chimeric hiv/siv gag proteins to optimize vaccine-induced t cell responses against hiv gag |
| WO2009117134A2 (en) | 2008-03-21 | 2009-09-24 | National Institutes Of Health | Aerosolized genetic vaccines and methods of use |
| US10041049B2 (en) | 2008-11-03 | 2018-08-07 | Janssen Vaccines & Prevention B.V. | Method for the production of adenoviral vectors |
| KR101761425B1 (ko) | 2009-02-02 | 2017-07-26 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 시미안 아데노바이러스 핵산- 및 아미노산-서열, 이를 포함하는 벡터 및 이의 용도 |
| WO2010085984A1 (en) | 2009-02-02 | 2010-08-05 | Okairos Ag | Simian adenovirus nucleic acid- and amino acid-sequences, vectors containing same, and uses thereof |
| WO2010096561A1 (en) | 2009-02-18 | 2010-08-26 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Synthetic hiv/siv gag proteins and uses thereof |
| CA2777116C (en) | 2009-10-15 | 2020-09-01 | Crucell Holland B.V. | Process for adenovirus purification from high cell density cultures |
| EA028623B1 (ru) | 2009-10-15 | 2017-12-29 | Янссен Вэксинс Энд Превеншн Б.В. | Способ очистки аденовирусных частиц |
| KR101820980B1 (ko) | 2010-02-15 | 2018-01-22 | 얀센 백신스 앤드 프리벤션 비.브이. | Ad 26 아데노바이러스 벡터를 제조하는 방법 |
-
2013
- 2013-03-11 PL PL13708445.5T patent/PL2825640T3/pl unknown
- 2013-03-11 EP EP13708445.5A patent/EP2825640B1/en active Active
- 2013-03-11 JP JP2014561393A patent/JP5770952B2/ja active Active
- 2013-03-11 SG SG11201405228VA patent/SG11201405228VA/en unknown
- 2013-03-11 DK DK13708445.5T patent/DK2825640T3/en active
- 2013-03-11 EA EA201491676A patent/EA034284B1/ru not_active IP Right Cessation
- 2013-03-11 AU AU2013231423A patent/AU2013231423B2/en not_active Ceased
- 2013-03-11 HU HUE13708445A patent/HUE027839T2/en unknown
- 2013-03-11 WO PCT/EP2013/054846 patent/WO2013135615A1/en not_active Ceased
- 2013-03-11 CA CA2864956A patent/CA2864956C/en active Active
- 2013-03-11 NZ NZ628385A patent/NZ628385A/en not_active IP Right Cessation
- 2013-03-11 ES ES13708445.5T patent/ES2582504T3/es active Active
- 2013-03-11 KR KR1020147026543A patent/KR102044051B1/ko not_active Expired - Fee Related
- 2013-03-11 SI SI201330239A patent/SI2825640T1/sl unknown
- 2013-03-11 CN CN201380013551.5A patent/CN104379733B/zh active Active
- 2013-03-12 AR ARP130100798A patent/AR090318A1/es active IP Right Grant
- 2013-03-12 TW TW102108773A patent/TWI633188B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| TW201336993A (zh) | 2013-09-16 |
| EP2825640A1 (en) | 2015-01-21 |
| EA201491676A1 (ru) | 2014-12-30 |
| KR20140139509A (ko) | 2014-12-05 |
| WO2013135615A1 (en) | 2013-09-19 |
| CA2864956A1 (en) | 2013-09-19 |
| SI2825640T1 (sl) | 2016-08-31 |
| HUE027839T2 (en) | 2016-11-28 |
| CN104379733A (zh) | 2015-02-25 |
| ES2582504T3 (es) | 2016-09-13 |
| EP2825640B1 (en) | 2016-04-27 |
| JP5770952B2 (ja) | 2015-08-26 |
| CN104379733B (zh) | 2016-01-20 |
| CA2864956C (en) | 2021-11-09 |
| KR102044051B1 (ko) | 2019-11-12 |
| EA034284B1 (ru) | 2020-01-24 |
| NZ628385A (en) | 2016-09-30 |
| SG11201405228VA (en) | 2014-11-27 |
| TWI633188B (zh) | 2018-08-21 |
| DK2825640T3 (en) | 2016-08-01 |
| AU2013231423B2 (en) | 2018-10-04 |
| AU2013231423A1 (en) | 2014-08-28 |
| AR090318A1 (es) | 2014-11-05 |
| JP2015511597A (ja) | 2015-04-20 |
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