PL2841568T3 - Odporne na sprzężenie zwrotne syntazy alfa-izopropylojabłczanowe - Google Patents

Odporne na sprzężenie zwrotne syntazy alfa-izopropylojabłczanowe

Info

Publication number
PL2841568T3
PL2841568T3 PL13718528T PL13718528T PL2841568T3 PL 2841568 T3 PL2841568 T3 PL 2841568T3 PL 13718528 T PL13718528 T PL 13718528T PL 13718528 T PL13718528 T PL 13718528T PL 2841568 T3 PL2841568 T3 PL 2841568T3
Authority
PL
Poland
Prior art keywords
feedback
resistant alpha
isopropylmalate synthases
isopropylmalate
synthases
Prior art date
Application number
PL13718528T
Other languages
English (en)
Inventor
Robert Gerstmeir
Iris Wiegräbe
Original Assignee
Evonik Technochemie Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Evonik Technochemie Gmbh filed Critical Evonik Technochemie Gmbh
Publication of PL2841568T3 publication Critical patent/PL2841568T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/77—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Corynebacterium; for Brevibacterium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/06—Alanine; Leucine; Isoleucine; Serine; Homoserine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/03—Acyl groups converted into alkyl on transfer (2.3.3)
    • C12Y203/03013—2-Isopropylmalate synthase (2.3.3.13)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
PL13718528T 2012-04-27 2013-04-12 Odporne na sprzężenie zwrotne syntazy alfa-izopropylojabłczanowe PL2841568T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102012207097 2012-04-27
EP13718528.6A EP2841568B1 (en) 2012-04-27 2013-04-12 Feedback-resistant alpha-isopropylmalate synthases
PCT/EP2013/057660 WO2013160124A1 (en) 2012-04-27 2013-04-12 Feedback-resistant alpha-isopropylmalate synthases

Publications (1)

Publication Number Publication Date
PL2841568T3 true PL2841568T3 (pl) 2018-07-31

Family

ID=48184153

Family Applications (1)

Application Number Title Priority Date Filing Date
PL13718528T PL2841568T3 (pl) 2012-04-27 2013-04-12 Odporne na sprzężenie zwrotne syntazy alfa-izopropylojabłczanowe

Country Status (11)

Country Link
US (1) US9347048B2 (pl)
EP (1) EP2841568B1 (pl)
JP (1) JP6341907B2 (pl)
KR (1) KR102074841B1 (pl)
CN (1) CN104302765B (pl)
BR (1) BR112014021439B1 (pl)
CA (1) CA2869683C (pl)
DK (1) DK2841568T3 (pl)
ES (1) ES2666072T3 (pl)
PL (1) PL2841568T3 (pl)
WO (1) WO2013160124A1 (pl)

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* Cited by examiner, † Cited by third party
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ES2623161T3 (es) 2013-06-03 2017-07-10 Evonik Degussa Gmbh Procedimiento para la preparación de L-valina utilizando corinebacterias recombinantes que contienen el operón ilvBN inducible por propionato
CA3038660A1 (en) * 2016-09-30 2018-04-05 Dow Global Technologies Llc Processes to prepare elongated 2-ketoacids and c5-c10 compounds therefrom via genetic modifications to microbial metabolic pathways
WO2018124440A2 (ko) * 2016-12-28 2018-07-05 씨제이제일제당 (주) 신규한 이소프로필말레이트 신타제 변이체 및 이를 이용한 l-류신의 생산 방법
KR102075160B1 (ko) * 2018-12-13 2020-02-10 대상 주식회사 L-글루탐산 생산능이 향상된 변이 균주 및 이를 이용한 l-글루탐산의 제조 방법
CN110540976B (zh) * 2019-08-29 2020-07-24 天津科技大学 一种异丙基苹果酸合成酶及其应用
WO2021037190A1 (zh) 2019-08-29 2021-03-04 天津科技大学 一种2-异丙基苹果酸合成酶及其工程菌与应用
KR102360900B1 (ko) * 2020-05-20 2022-02-09 씨제이제일제당 (주) 신규한 폴리펩티드 및 이를 이용한 l-류신의 생산 방법
KR102527102B1 (ko) 2021-03-05 2023-04-28 씨제이제일제당 주식회사 이소프로필말레이트 신타제 변이체 및 이를 이용한 l-류신의 생산 방법
JP2024075803A (ja) * 2021-03-29 2024-06-05 GreenEarthInstitute株式会社 改変型α-イソプロピルマレートシンターゼ
KR102281370B1 (ko) * 2021-04-07 2021-07-22 씨제이제일제당 (주) 신규한 2-이소프로필말레이트합성효소 변이체 및 이를 이용한 l-발린 생산 방법
CN113683666B (zh) * 2021-08-23 2024-08-20 黑龙江伊品生物科技有限公司 Yh66-rs07020基因改造得到的工程菌及其在制备缬氨酸中的应用

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JPS579796B2 (pl) * 1974-03-15 1982-02-23
US5250434A (en) 1987-03-27 1993-10-05 Ajinomoto Co., Inc. Microorganisms for production of glutamic acid
US5976843A (en) 1992-04-22 1999-11-02 Ajinomoto Co., Inc. Bacterial strain of Escherichia coli BKIIM B-3996 as the producer of L-threonine
JP3023615B2 (ja) 1990-08-30 2000-03-21 協和醗酵工業株式会社 発酵法によるl―トリプトファンの製造法
DE4130867A1 (de) 1991-09-17 1993-03-18 Degussa Verfahren zur fermentativen herstellung von aminosaeuren
RU2188235C2 (ru) 1994-12-09 2002-08-27 Адзиномото Ко., Инк. Новый ген лизиндекарбоксилазы и способ получения l-лизина
GB2304718B (en) 1995-09-05 2000-01-19 Degussa The production of tryptophan by the bacterium escherichia coli
US5990350A (en) 1997-12-16 1999-11-23 Archer Midland Company Process for making granular L-lysine
RU2201454C2 (ru) * 1999-07-09 2003-03-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" Мутантная альфа-изопропилмалат синтаза (ipms), днк, кодирующая мутантную ipms, способ получения штамма escherichia coli, способ получения l-лейцина
JP4623825B2 (ja) 1999-12-16 2011-02-02 協和発酵バイオ株式会社 新規ポリヌクレオチド
US7160711B2 (en) 2001-08-06 2007-01-09 Degussa Ag Coryneform bacteria which produce chemical compounds I
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Also Published As

Publication number Publication date
US9347048B2 (en) 2016-05-24
KR102074841B1 (ko) 2020-02-07
BR112014021439A2 (pt) 2017-06-27
EP2841568A1 (en) 2015-03-04
EP2841568B1 (en) 2018-02-21
WO2013160124A1 (en) 2013-10-31
CA2869683A1 (en) 2013-10-31
DK2841568T3 (en) 2018-05-22
JP2015514431A (ja) 2015-05-21
US20150079641A1 (en) 2015-03-19
JP6341907B2 (ja) 2018-06-13
KR20150003752A (ko) 2015-01-09
ES2666072T3 (es) 2018-04-30
CN104302765B (zh) 2018-09-11
BR112014021439B1 (pt) 2021-12-21
CN104302765A (zh) 2015-01-21
CA2869683C (en) 2020-04-21

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