PL2872497T3 - Pochodne chromanylowe do leczenia choroby mitochondrialnej - Google Patents

Pochodne chromanylowe do leczenia choroby mitochondrialnej

Info

Publication number
PL2872497T3
PL2872497T3 PL13759838T PL13759838T PL2872497T3 PL 2872497 T3 PL2872497 T3 PL 2872497T3 PL 13759838 T PL13759838 T PL 13759838T PL 13759838 T PL13759838 T PL 13759838T PL 2872497 T3 PL2872497 T3 PL 2872497T3
Authority
PL
Poland
Prior art keywords
treatment
mitochondrial disease
chromanyl
derivatives
chromanyl derivatives
Prior art date
Application number
PL13759838T
Other languages
English (en)
Other versions
PL2872497T5 (pl
Inventor
Richard Hendrik Blaauw
Ruben Gerardus George Leenders
Geert Jan Sterk
Pedro Harold Han Hermkens
Original Assignee
Khondrion Ip B.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49916367&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2872497(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Khondrion Ip B.V. filed Critical Khondrion Ip B.V.
Publication of PL2872497T3 publication Critical patent/PL2872497T3/pl
Publication of PL2872497T5 publication Critical patent/PL2872497T5/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/66Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A61K8/498Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02Muscle relaxants, e.g. for tetanus or cramps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/16Otologicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/08Anti-ageing preparations

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Dermatology (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Diabetes (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PL13759838T 2012-07-12 2013-07-12 Pochodne chromanylowe do leczenia choroby mitochondrialnej PL2872497T5 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261670644P 2012-07-12 2012-07-12
EP12176128 2012-07-12
EP13759838.9A EP2872497B2 (en) 2012-07-12 2013-07-12 Chromanyl derivatives for treating mitochondrial disease
PCT/NL2013/050528 WO2014011047A1 (en) 2012-07-12 2013-07-12 Chromanyl derivatives for treating mitochondrial disease

Publications (2)

Publication Number Publication Date
PL2872497T3 true PL2872497T3 (pl) 2017-07-31
PL2872497T5 PL2872497T5 (pl) 2020-02-28

Family

ID=49916367

Family Applications (1)

Application Number Title Priority Date Filing Date
PL13759838T PL2872497T5 (pl) 2012-07-12 2013-07-12 Pochodne chromanylowe do leczenia choroby mitochondrialnej

Country Status (16)

Country Link
EP (1) EP2872497B2 (pl)
JP (1) JP6292721B2 (pl)
KR (1) KR102137450B1 (pl)
CN (1) CN104662011B (pl)
AU (1) AU2013287347B2 (pl)
CA (1) CA2878567C (pl)
DK (1) DK2872497T4 (pl)
ES (1) ES2622190T5 (pl)
HU (1) HUE033757T2 (pl)
LT (1) LT2872497T (pl)
PL (1) PL2872497T5 (pl)
PT (1) PT2872497T (pl)
RS (1) RS55813B2 (pl)
SI (1) SI2872497T2 (pl)
SM (1) SMT201700195T1 (pl)
WO (1) WO2014011047A1 (pl)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6779866B2 (ja) 2014-06-13 2020-11-04 チルドレンズ メディカル センター コーポレイション ミトコンドリアを単離するための製品および方法
US10676452B2 (en) * 2015-05-22 2020-06-09 Sulfateq B.V. Compound for the prophylaxis or treatment of organ damage
WO2016190852A1 (en) * 2015-05-26 2016-12-01 Stealth Peptides International, Inc. Therapeutic compositions including chromanyl compounds, variants and analogues thereof, and uses thereof
ES3033538T3 (en) 2015-10-08 2025-08-05 Khondrion Ip B V Novel compounds for treating mitochondrial disease
FI4272834T3 (fi) * 2016-01-15 2025-12-05 Childrens Medical Ct Corp Mitokondrioiden ja yhdistettyjen mitokondriaalisten aineiden terapeuttinen käyttö
KR101816277B1 (ko) 2016-10-06 2018-01-08 가천대학교 산학협력단 8-옥소-데옥시구아노신(8-oxo-2'-deoxyguanosine) 또는 이의 약학적으로 허용 가능한 염을 유효성분으로 함유하는 각막 손상 치료용 약학적 조성물
WO2018184706A1 (en) 2017-04-05 2018-10-11 Khondrion Ip B.V. Novel treatment of mitochondrial diseases
JP7754623B2 (ja) 2017-11-22 2025-10-15 コンドリオン アイピー ビー.ブイ. mPGES-1阻害剤としての化合物
EP3713563B1 (en) 2017-11-22 2025-02-19 Khondrion Ip B.V. Amide derivatives of chromanyl or chromanyl quinones for use in treating depression and migraine
EP3914239A1 (en) 2019-01-25 2021-12-01 Universitat Autònoma de Barcelona Cannabidiol and/or derivatives thereof for use in the treatment of mitochondrial diseases
US11584728B2 (en) * 2019-10-04 2023-02-21 Stealth Biotherapeutics Inc. Compositions and methods for the prevention and/or treatment of mitochondrial disease, including Friedreich's ataxia
NL2024431B1 (en) 2019-12-11 2021-09-07 Sulfateq Bv Compounds for treatment of alzheimer’s disease
CN121085756A (zh) 2020-04-03 2025-12-09 康德生物医疗有限公司 用于预防和/或治疗线粒体疾病的组合物和方法
NL2025730B1 (en) 2020-06-02 2022-01-20 Sulfateq Bv Compounds for treatment of sepsis
NL2026511B1 (en) 2020-09-21 2022-05-24 Sulfateq Bv Compounds for treatment of heart failure
NL2031091B1 (en) 2022-02-28 2023-09-07 Sulfateq Bv Chromanol compounds for treatment or prophylaxis of ageing and ageing-associated disorders
WO2025242849A1 (en) 2024-05-24 2025-11-27 Khondrion Ip B.V. Chromanyl derivatives for use in the treatment of bone disorders

Family Cites Families (23)

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CA1338012C (en) * 1987-04-27 1996-01-30 John Michael Mccall Pharmaceutically active amines
JPH02250831A (ja) * 1989-03-23 1990-10-08 Kuraray Co Ltd 3,4―ジヒドロ―2h―ベンゾピラン誘導体及びそれを有効成分とする抗消化性潰瘍剤
FR2676056B1 (fr) 1991-05-03 1993-07-16 Adir Nouveaux derives du benzopyranne leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
JP3093170B2 (ja) * 1996-09-19 2000-10-03 株式会社ジャパンエナジー ヒドロキノン誘導体及びその医薬用途
FR2761066B1 (fr) * 1997-03-24 2000-11-24 Sod Conseils Rech Applic Nouveaux derives du 2-(iminomethyl)amino-phenyle, leur preparation, leur application a titre de medicaments et les compositions pharmaceutiques les contenant
FR2764889B1 (fr) * 1997-06-20 2000-09-01 Sod Conseils Rech Applic Nouveaux derives du 2-(iminomethyl)amino-phenyle, leur preparation, leur application a titre de medicaments et les compositions pharmaceutiques les contenant
JPH11106371A (ja) * 1997-07-04 1999-04-20 Nisshin Flour Milling Co Ltd アシルヒドラゾン誘導体
AR019190A1 (es) * 1998-07-08 2001-12-26 Sod Conseils Rech Applic Derivados de 2-aminopiridinas, productos intermedios para su preparacion, medicamentos y composiciones farmaceuticas que los contienen y su uso para preparar medicamentos
KR20010072080A (ko) * 1998-07-31 2001-07-31 쓰끼하시 다미까따 페닐아졸 화합물, 그의 제조 방법 및 고지혈증용 약제
FR2783519B1 (fr) * 1998-09-23 2003-01-24 Sod Conseils Rech Applic Nouveaux derives d'amidines, leur preparation, leur application a titre de medicaments et les compositions pharmaceutiques les contenant
WO2001081324A1 (de) * 2000-04-25 2001-11-01 Schering Aktiengesellschaft Benzoxazin- und benzothiazin-derivate mit nos-inhibitorischen und antioxidativen eigenschaften
GR1003725B (el) 2000-07-12 2001-11-27 Νεες ενωσεις με συνδυασμενη αντιοξειδωτικη και αντιαρρυθμικη δραση
JP2002047272A (ja) * 2000-07-26 2002-02-12 Dai Ichi Seiyaku Co Ltd ポリアミンアミド誘導体
NZ513547A (en) 2001-08-13 2002-09-27 Antipodean Biotechnology Ltd Synthesis of triphenylphosphonium quinols (e.g. mitoquinol) and/or quinones (e.g. mitoquinone)
JP2003212872A (ja) * 2002-01-23 2003-07-30 Japan Energy Corp 新規クロマン誘導体及びその医薬用途
GB0204232D0 (en) 2002-02-22 2002-04-10 Isis Innovation Assay
JP4377881B2 (ja) * 2003-08-01 2009-12-02 日本曹達株式会社 フェニルアゾール化合物、製造法および抗酸化薬
US20050065099A1 (en) 2003-09-19 2005-03-24 Gail Walkinshaw Treatment of mitochondrial diseases
JP2008019188A (ja) * 2006-07-11 2008-01-31 Hamari Chemicals Ltd 新規カルノシン誘導体及び組成物
EP3456707B1 (en) * 2007-11-06 2020-04-15 PTC Therapeutics, Inc. 4- (p-quinonyl)-2-hydroxybutanamide derivatives for treatment of mitochondrial diseases
EP2601168A4 (en) 2010-08-06 2013-12-04 Ampere Life Sciences Inc TREATMENT OF MITOCHONDRIAL DISEASES BY VITAMIN K
SG187744A1 (en) 2010-08-06 2013-03-28 Edison Pharmaceuticals Inc Treatment of mitochondrial diseases with naphthoquinones
NL2010010C2 (en) 2012-12-19 2014-06-23 Sulfateq B V Compounds for protection of cells.

Also Published As

Publication number Publication date
PL2872497T5 (pl) 2020-02-28
JP2015522067A (ja) 2015-08-03
LT2872497T (lt) 2017-04-25
RS55813B1 (sr) 2017-08-31
SI2872497T2 (sl) 2019-12-31
ES2622190T5 (es) 2020-04-23
CN104662011B (zh) 2017-09-29
KR20150036035A (ko) 2015-04-07
KR102137450B1 (ko) 2020-07-27
PT2872497T (pt) 2017-04-24
EP2872497B1 (en) 2017-03-08
AU2013287347A1 (en) 2015-01-22
SMT201700195T1 (it) 2017-05-08
HUE033757T2 (en) 2017-12-28
DK2872497T4 (da) 2019-11-25
RS55813B2 (sr) 2019-12-31
CA2878567A1 (en) 2014-01-16
JP6292721B2 (ja) 2018-03-14
EP2872497B2 (en) 2019-10-09
EP2872497A1 (en) 2015-05-20
ES2622190T3 (es) 2017-07-05
AU2013287347B2 (en) 2017-11-30
CN104662011A (zh) 2015-05-27
WO2014011047A1 (en) 2014-01-16
CA2878567C (en) 2021-02-23
SI2872497T1 (sl) 2017-08-31
DK2872497T3 (en) 2017-04-24

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