PL2888228T3 - Inhibitory oddziaływania CD40-TRAF6 - Google Patents

Inhibitory oddziaływania CD40-TRAF6

Info

Publication number
PL2888228T3
PL2888228T3 PL13756096T PL13756096T PL2888228T3 PL 2888228 T3 PL2888228 T3 PL 2888228T3 PL 13756096 T PL13756096 T PL 13756096T PL 13756096 T PL13756096 T PL 13756096T PL 2888228 T3 PL2888228 T3 PL 2888228T3
Authority
PL
Poland
Prior art keywords
inhibitors
traf6 interaction
traf6
interaction
Prior art date
Application number
PL13756096T
Other languages
English (en)
Inventor
Esther Lutgens
Christian Weber
Gerry Nicolaes
Original Assignee
Univ Muenchen Ludwig Maximilians
Maastricht Univ
Acad Ziekenhuis Maastricht
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Muenchen Ludwig Maximilians, Maastricht Univ, Acad Ziekenhuis Maastricht filed Critical Univ Muenchen Ludwig Maximilians
Publication of PL2888228T3 publication Critical patent/PL2888228T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/02—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups
    • C07C251/24—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/02—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups
    • C07C251/26—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having nitrogen atoms of imino groups further bound to halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PL13756096T 2012-08-27 2013-08-27 Inhibitory oddziaływania CD40-TRAF6 PL2888228T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12181862.9A EP2703384A1 (en) 2012-08-27 2012-08-27 Inhibitors of CD40-TRAF6 interaction
PCT/EP2013/067714 WO2014033122A1 (en) 2012-08-27 2013-08-27 Inhibitors of cd40-traf6 interaction
EP13756096.7A EP2888228B1 (en) 2012-08-27 2013-08-27 Inhibitors of cd40-traf6 interaction

Publications (1)

Publication Number Publication Date
PL2888228T3 true PL2888228T3 (pl) 2019-10-31

Family

ID=46754331

Family Applications (1)

Application Number Title Priority Date Filing Date
PL13756096T PL2888228T3 (pl) 2012-08-27 2013-08-27 Inhibitory oddziaływania CD40-TRAF6

Country Status (8)

Country Link
US (2) US9408829B2 (pl)
EP (2) EP2703384A1 (pl)
AU (1) AU2013307369B2 (pl)
CA (1) CA2880374A1 (pl)
DK (1) DK2888228T3 (pl)
ES (1) ES2734286T3 (pl)
PL (1) PL2888228T3 (pl)
WO (1) WO2014033122A1 (pl)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017190145A1 (en) 2016-04-29 2017-11-02 Icahn School Of Medicine At Mount Sinai Targeting the innate immune system to induce long-term tolerance and to resolve macrophage accumulation in atherosclerosis
EP3464236A4 (en) 2016-05-26 2020-01-08 The Regents of the University of California CONNECTIONS AND METHOD FOR HEMATOPOIETIC REGENERATION
US20210188763A1 (en) * 2017-11-29 2021-06-24 The Regents Of The University Of California Compounds and methods for hematopoietic regeneration
CN118459539B (zh) 2021-03-19 2026-01-06 生物治疗探索股份有限公司 用于调节训练免疫的化合物及其使用方法
WO2023108488A1 (zh) * 2021-12-15 2023-06-22 深圳先进技术研究院 一种筛选抑制foxp3小分子药物的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2008345225A1 (en) * 2007-12-21 2009-07-09 University Of Rochester Method for altering the lifespan of eukaryotic organisms
US9486498B2 (en) * 2008-05-19 2016-11-08 Case Western Reserve University Method of treating CD40-mediated diseases
WO2011047129A1 (en) * 2009-10-15 2011-04-21 Southern Research Institute Treatment of neurodegenerative diseases, causation of memory enhancement, and assay for screening compounds for such

Also Published As

Publication number Publication date
AU2013307369A1 (en) 2015-02-19
US9408829B2 (en) 2016-08-09
CA2880374A1 (en) 2014-03-06
US20160228408A1 (en) 2016-08-11
EP2888228B1 (en) 2019-04-24
DK2888228T3 (da) 2019-07-15
US20150190370A1 (en) 2015-07-09
EP2888228A1 (en) 2015-07-01
ES2734286T3 (es) 2019-12-05
EP2703384A1 (en) 2014-03-05
US9750717B2 (en) 2017-09-05
AU2013307369B2 (en) 2018-01-04
WO2014033122A1 (en) 2014-03-06

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