PL2921166T3 - Biodegradowalne mikrokuleczki o zwiększonej adsorpcyjności leku przeciwrakowego, zawierające albuminę i siarczan dekstranu i sposób ich wytwarzania - Google Patents

Biodegradowalne mikrokuleczki o zwiększonej adsorpcyjności leku przeciwrakowego, zawierające albuminę i siarczan dekstranu i sposób ich wytwarzania

Info

Publication number
PL2921166T3
PL2921166T3 PL13854991T PL13854991T PL2921166T3 PL 2921166 T3 PL2921166 T3 PL 2921166T3 PL 13854991 T PL13854991 T PL 13854991T PL 13854991 T PL13854991 T PL 13854991T PL 2921166 T3 PL2921166 T3 PL 2921166T3
Authority
PL
Poland
Prior art keywords
production
adsorption capacity
dextran sulfate
cancer drug
biodegradable microspheres
Prior art date
Application number
PL13854991T
Other languages
English (en)
Inventor
Se Yoon Kim
Don Haeng Lee
Yixian Li
Original Assignee
Utah-Inha Dds & Advanced Therapeutics Research Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Utah-Inha Dds & Advanced Therapeutics Research Center filed Critical Utah-Inha Dds & Advanced Therapeutics Research Center
Publication of PL2921166T3 publication Critical patent/PL2921166T3/pl

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1658Proteins, e.g. albumin, gelatin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/136Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4738Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/38Albumins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40Cyclodextrins; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682Processes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1652Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
PL13854991T 2012-11-15 2013-11-15 Biodegradowalne mikrokuleczki o zwiększonej adsorpcyjności leku przeciwrakowego, zawierające albuminę i siarczan dekstranu i sposób ich wytwarzania PL2921166T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20120129722 2012-11-15
EP13854991.0A EP2921166B1 (en) 2012-11-15 2013-11-15 Biodegradable microbeads with improved anticancer drug adsorptivity, containing albumin and dextran sulfate, and preparation method therefor

Publications (1)

Publication Number Publication Date
PL2921166T3 true PL2921166T3 (pl) 2017-11-30

Family

ID=50731466

Family Applications (1)

Application Number Title Priority Date Filing Date
PL13854991T PL2921166T3 (pl) 2012-11-15 2013-11-15 Biodegradowalne mikrokuleczki o zwiększonej adsorpcyjności leku przeciwrakowego, zawierające albuminę i siarczan dekstranu i sposób ich wytwarzania

Country Status (17)

Country Link
US (2) US20150352050A1 (pl)
EP (1) EP2921166B1 (pl)
JP (1) JP6145513B2 (pl)
KR (1) KR101563968B1 (pl)
CN (1) CN104780912B (pl)
CY (1) CY1119337T1 (pl)
DK (1) DK2921166T3 (pl)
ES (1) ES2640363T3 (pl)
HR (1) HRP20171364T1 (pl)
HU (1) HUE036275T2 (pl)
LT (1) LT2921166T (pl)
PL (1) PL2921166T3 (pl)
PT (1) PT2921166T (pl)
RS (1) RS56295B1 (pl)
SI (1) SI2921166T1 (pl)
SM (1) SMT201700491T1 (pl)
WO (1) WO2014077629A1 (pl)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014084530A1 (ko) * 2012-11-27 2014-06-05 재단법인 유타 인하 디디에스 및 신의료기술개발공동연구소 음이온성 고분자를 포함하는 항암제 흡착능력이 향상된 생분해성 마이크로 비드 및 이의 제조방법
CN109010902A (zh) * 2018-05-04 2018-12-18 南京大学 一种具有抗肿瘤作用的肝素淀粉微球血管栓塞剂及制备方法
KR102097401B1 (ko) * 2018-10-10 2020-04-06 인제대학교 산학협력단 정전기적 결합을 통한 약물-고분자 복합체 및 이의 제조방법
ES2969226T3 (es) * 2018-11-30 2024-05-17 Nextbiomedical Co Ltd Partículas de hidrogel para quimioembolización que comprenden un polímero biodegradable
KR20200068574A (ko) * 2018-12-05 2020-06-15 주식회사 이노테라피 간동맥 화학색전술용 마이크로비드 및 그의 제조방법
KR102288833B1 (ko) * 2019-09-11 2021-08-13 주식회사 메피온 자가 팽창형 색전물질의 제조 방법
GB201918300D0 (en) * 2019-12-12 2020-01-29 Extruded Pharmaceuticals Ltd Chemotherapeutic drug implant
KR102641217B1 (ko) * 2019-12-24 2024-02-29 (주)아이엠지티 항암제가 코팅된 알부민 나노입자 및 이의 제조방법
KR102373590B1 (ko) 2020-09-22 2022-03-14 (주)아이엠지티 음이온성 고분자를 이용한 신규한 나노 입자, 이의 제조 방법 및 조성물

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CA1077842A (en) * 1975-10-09 1980-05-20 Minnesota Mining And Manufacturing Company Albumin medicament carrier system
US5041292A (en) * 1988-08-31 1991-08-20 Theratech, Inc. Biodegradable hydrogel matrices for the controlled release of pharmacologically active agents
JP3746293B2 (ja) * 1993-02-22 2006-02-15 アメリカン バイオサイエンス、インコーポレイテッド 生物製剤のインビボ送達の方法とそのための組成物
US6090925A (en) * 1993-03-09 2000-07-18 Epic Therapeutics, Inc. Macromolecular microparticles and methods of production and use
ES2215207T3 (es) * 1993-03-09 2004-10-01 Baxter International Inc. Microparticulas de macromoleculas y metodos de produccion.
AU693821B2 (en) * 1993-11-18 1998-07-09 Sirtex Medical Limited Controlled release preparation
ES2435944T3 (es) * 1997-06-27 2013-12-26 Abraxis Bioscience, Llc Nuevas formulaciones de agentes farmacológicos, métodos para su preparación y métodos para su uso
US20040161466A1 (en) * 2003-02-14 2004-08-19 Biocompatibles Uk Limited Chemoembolisation
CN101052378A (zh) * 2004-09-07 2007-10-10 生物相容英国有限公司 从栓塞剂送递药物
JP4654815B2 (ja) * 2005-07-26 2011-03-23 アイシン精機株式会社 車両用ヘッドレスト装置
US20070281031A1 (en) * 2006-06-01 2007-12-06 Guohan Yang Microparticles and methods for production thereof
WO2014084530A1 (ko) * 2012-11-27 2014-06-05 재단법인 유타 인하 디디에스 및 신의료기술개발공동연구소 음이온성 고분자를 포함하는 항암제 흡착능력이 향상된 생분해성 마이크로 비드 및 이의 제조방법
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Also Published As

Publication number Publication date
SMT201700491T1 (it) 2017-11-15
PT2921166T (pt) 2017-09-19
ES2640363T3 (es) 2017-11-02
RS56295B1 (sr) 2017-12-29
EP2921166A4 (en) 2016-04-20
HUE036275T2 (hu) 2018-06-28
US20190274957A1 (en) 2019-09-12
EP2921166A1 (en) 2015-09-23
KR101563968B1 (ko) 2015-10-29
DK2921166T3 (en) 2017-10-02
US20150352050A1 (en) 2015-12-10
SI2921166T1 (sl) 2017-10-30
HRP20171364T1 (hr) 2017-11-03
CN104780912A (zh) 2015-07-15
WO2014077629A1 (ko) 2014-05-22
JP2016505530A (ja) 2016-02-25
CY1119337T1 (el) 2018-02-14
EP2921166B1 (en) 2017-06-14
LT2921166T (lt) 2017-09-25
KR20140066099A (ko) 2014-05-30
JP6145513B2 (ja) 2017-06-14
CN104780912B (zh) 2018-03-30

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