PL29343B1 - A method of obtaining a blood pressure lowering agent from urine. - Google Patents
A method of obtaining a blood pressure lowering agent from urine. Download PDFInfo
- Publication number
- PL29343B1 PL29343B1 PL29343A PL2934337A PL29343B1 PL 29343 B1 PL29343 B1 PL 29343B1 PL 29343 A PL29343 A PL 29343A PL 2934337 A PL2934337 A PL 2934337A PL 29343 B1 PL29343 B1 PL 29343B1
- Authority
- PL
- Poland
- Prior art keywords
- urine
- blood pressure
- obtaining
- pressure lowering
- lowering agent
- Prior art date
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- 210000002700 urine Anatomy 0.000 title claims description 12
- 230000036772 blood pressure Effects 0.000 title claims description 4
- 238000000034 method Methods 0.000 title claims description 4
- 239000013543 active substance Substances 0.000 claims description 3
- 239000003795 chemical substances by application Substances 0.000 claims description 3
- 239000013049 sediment Substances 0.000 claims description 2
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 238000010438 heat treatment Methods 0.000 description 6
- 238000009835 boiling Methods 0.000 description 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- 239000002244 precipitate Substances 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 3
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 3
- 235000011130 ammonium sulphate Nutrition 0.000 description 3
- 238000000502 dialysis Methods 0.000 description 3
- 239000005556 hormone Substances 0.000 description 3
- 229940088597 hormone Drugs 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 238000000909 electrodialysis Methods 0.000 description 2
- 239000012467 final product Substances 0.000 description 2
- 238000005185 salting out Methods 0.000 description 2
- 239000005995 Aluminium silicate Substances 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 235000012211 aluminium silicate Nutrition 0.000 description 1
- WDIHJSXYQDMJHN-UHFFFAOYSA-L barium chloride Chemical compound [Cl-].[Cl-].[Ba+2] WDIHJSXYQDMJHN-UHFFFAOYSA-L 0.000 description 1
- 229910001626 barium chloride Inorganic materials 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000013067 intermediate product Substances 0.000 description 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Description
Jest rzecza znana otrzymywanie z ludz¬ kiego i zwierzecego moczu srodka obniza¬ jacego cisnienie krwi i odpornego na go¬ towanie, przy czym wszystkie nie wytrzy¬ mujace gotowania skladniki moczu zosta¬ ja zniszczone przez zagotowanie podczas jego przeróbki, majacej na celu otrzymy¬ wanie hormonów albo substancji podob¬ nych.Stwierdzono, ze mozna zniszczyc nie- wytrzymale na gotowanie skladniki nie tylko przez zagotowanie roztworu, ale równiez przez ogrzanie w dowolny inny sposób, o ile tylko to ogrzanie uskuteczni sie tak, aby wytrzymala na gotowanie sub¬ stancja czynna, obnizajaca cisnienie krwi, nie ulegla przy tym ujemnym zmianom.Mozna to uskutecznic przez ogrzewanie w prózni albo pod zwiekszonym cisnieniem produktów posrednich, zawierajacych hor¬ mony, i otrzymywanych podczas przerób¬ ki moczu osadów, zawierajacych te hor¬ mony, np. w suszarce do 100 — 150°C.Mozna np. osad, otrzymany z moczu przez zastosowanie znanych sposobów o- trzymywania hormonów, np. przez straca¬ nie z moczu naturalnego lub oczyszczone¬ go, np. przez, dialize lub wysalanie, albo ze stezonego moczu alkoholem metylowym albo siarczanem amonu lub tez przez stra¬ canie obydwoma tymi czynnikami, ogrze¬ wac w suszarce do 100 — 150°C, po czym plucze sie go najlepiej wielokrotnie alko¬ holem oraz eterem i suszy. Mozna takze ogrzewac suchy produkt ostateczny, a wiec bezposrednio przed opakowywaniem go al-bo przed wprowadzaniem do ampulek, co nadaje produktowi ostatecznemu znaczna trwalosc.Przez zakwaszanie moczu ludzkiego kwasem octowym i traktowanie roztworem chlorku baru, wzietym w nieznacznym nadmiarze tak, by uzyskac wysolenie, o- trzymuje sie osad, który odsacza sie, a po¬ zostaly roztwór, ewentualnie po dalszym oczyszczeniu, mogacym polegac na diali¬ zie, elektrodializie, wstrzasaniu ze srodka¬ mi adsorpcyjnymi, jak weglem zwierze¬ cym, kaolinem lub podobnymi srodkami, lub tez na powtórnym wysalaniu, zadaje sie pieciokrotna iloscia alkoholu metylowe¬ go albo okolo 0,4 kg siarczanu amonu na 1 litr moczu. Utworzony osad, zawieraja¬ cy substancje czynna, odsacza sie i ogrze¬ wa do temperatury 100 — 150°C w celu zniszczenia niewytrzymalych na cieplo substancji, po ewentualnym uprzednim przeplukaniu osadu alkoholem i eterem al¬ bo po usunieciu uzytego ewentualnie siar¬ czanu amonu przez dialize albo elektrodia- lize.Sposób wedlug wynalazku zapewnia znaczne korzysci, poniewaz mocz zawiera substancje czynna, obnizajaca cisnienie krwi, w bardzo nieznacznym stezeniu (po¬ nizej l°/o) i ogrzewanie malej ilosci sub¬ stancji stalej zamiast pierwotnego roztwo¬ ru daje znaczna oszczednosc, a mianowi¬ cie ze wzgledu na nieznaczna wielkosc apa¬ ratury, stosowanej do ogrzewania, a takze ze wzgledu na mala ilosc ciepla potrzebna do ogrzewania. PLIt is known to obtain from human and animal urine a blood pressure-lowering and boiling-resistant agent, all the non-boiling components of the urine having been destroyed by boiling during the processing thereof for the purpose of obtaining It has been found that the cooking-impervious ingredients can be destroyed not only by boiling the solution, but also by heating in any other way, as long as this heating is rendered resistant to boiling of the active ingredient. , which lowers blood pressure, did not change negatively. This can be achieved by heating in a vacuum or under increased pressure of intermediate products containing hormones and the sediments containing these hormones obtained during urine processing, e.g. in a dryer up to 100 - 150 ° C. One can, for example, a precipitate obtained from the urine by the use of known methods of hormone preservation, for example by incineration of the urine natural or purified, for example, by dialysis or salting out, or from concentrated urine with methyl alcohol or ammonium sulfate, or by losing both, heat in an oven to 100-150 ° C, then rinse it preferably repeatedly with alcohol and ether and dried. It is also possible to heat the dry final product, i.e. immediately before packaging it or before putting it into the ampoules, which gives the final product a significant stability. By acidifying human urine with acetic acid and treating with a solution of barium chloride, taken in a slight excess, so as to obtain salinity, a precipitate is retained, which is filtered off, and the residual solution is left, possibly after further purification, which may include dialysis, electrodialysis, shaking with adsorbing agents, such as animal carbon, kaolin or the like, or on the second salting out, 5 times the amount of methyl alcohol or about 0.4 kg of ammonium sulfate is added per liter of urine. The precipitate formed, containing the active substances, is filtered off and heated to a temperature of 100-150 ° C in order to destroy the heat-resistant substances, after any previous washing of the precipitate with alcohol and ether, or after removal of the possibly used ammonium sulfate by dialysis or electrodialysis. The method of the invention offers considerable advantages, since the urine contains the blood pressure lowering active substance in a very low concentration (less than 10%) and heating a small amount of solid instead of the original solution gives a considerable saving, namely due to the small size of the apparatus used for heating, and also due to the small amount of heat required for heating. PL
Claims (1)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL29343B1 true PL29343B1 (en) | 1940-11-30 |
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