PL2970333T3 - Makrocykliczne inhibitory kinazy LRRK2 - Google Patents
Makrocykliczne inhibitory kinazy LRRK2Info
- Publication number
- PL2970333T3 PL2970333T3 PL14709962T PL14709962T PL2970333T3 PL 2970333 T3 PL2970333 T3 PL 2970333T3 PL 14709962 T PL14709962 T PL 14709962T PL 14709962 T PL14709962 T PL 14709962T PL 2970333 T3 PL2970333 T3 PL 2970333T3
- Authority
- PL
- Poland
- Prior art keywords
- kinase inhibitors
- lrrk2 kinase
- macrocyclic
- macrocyclic lrrk2
- inhibitors
- Prior art date
Links
- 229940043355 kinase inhibitor Drugs 0.000 title 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epidemiology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13305314 | 2013-03-15 | ||
| EP13305311 | 2013-03-15 | ||
| PCT/EP2014/055049 WO2014140235A1 (en) | 2013-03-15 | 2014-03-14 | Macrocyclic lrrk2 kinase inhibitors |
| EP14709962.6A EP2970333B1 (en) | 2013-03-15 | 2014-03-14 | Macrocyclic lrrk2 kinase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2970333T3 true PL2970333T3 (pl) | 2017-12-29 |
Family
ID=50277239
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL14709962T PL2970333T3 (pl) | 2013-03-15 | 2014-03-14 | Makrocykliczne inhibitory kinazy LRRK2 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20160031905A1 (pl) |
| EP (1) | EP2970333B1 (pl) |
| JP (1) | JP2016510793A (pl) |
| KR (1) | KR20150129016A (pl) |
| CN (1) | CN105143232A (pl) |
| AU (1) | AU2014230485A1 (pl) |
| BR (1) | BR112015019873A2 (pl) |
| CA (1) | CA2904462A1 (pl) |
| DK (1) | DK2970333T3 (pl) |
| EA (1) | EA201591698A1 (pl) |
| ES (1) | ES2635021T3 (pl) |
| MX (1) | MX2015011359A (pl) |
| PL (1) | PL2970333T3 (pl) |
| PT (1) | PT2970333T (pl) |
| SG (1) | SG11201506357RA (pl) |
| TW (1) | TW201444850A (pl) |
| WO (1) | WO2014140235A1 (pl) |
| ZA (1) | ZA201506327B (pl) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014140299A1 (en) * | 2013-03-15 | 2014-09-18 | Oncodesign S.A | Macrocyclic rip2 kinase inhibitors |
| WO2016146651A1 (en) | 2015-03-16 | 2016-09-22 | Oncodesign Sa | Macrocyclic activin-like receptor kinase inhibitors |
| CN110386944B (zh) * | 2018-04-16 | 2021-10-29 | 深圳市塔吉瑞生物医药有限公司 | 用于抑制蛋白激酶活性的二(杂)芳基大环化合物 |
| CA3168814A1 (en) * | 2020-01-31 | 2021-08-05 | Oncodesign S.A. | Macrocyclic rip2-kinase inhibitors |
| CN115605267B (zh) * | 2020-03-21 | 2025-07-29 | 阿维纳斯企业公司 | 突变体lrrk2蛋白水解的选择性调节剂和相关使用方法 |
| MX2022013861A (es) | 2020-05-06 | 2023-02-22 | Servier Lab | Nuevos inhibidores macrociclicos de la quinasa de lrrk2. |
| WO2023073013A1 (en) * | 2021-10-27 | 2023-05-04 | H. Lundbeck A/S | Lrrk2 inhibitors |
| CN117425660A (zh) * | 2022-05-18 | 2024-01-19 | 上海翊石医药科技有限公司 | 一种芳杂环类化合物及其中间体、药物组合物和用途 |
| AU2023339247A1 (en) * | 2022-09-07 | 2025-03-27 | Suzhou Langrui Biopharmaceutical Co., Ltd. | Macrocyclic imidazo[1,2-b]pyridazine derivative, preparation method therefor, and use thereof |
| US11958865B1 (en) | 2022-09-15 | 2024-04-16 | H. Lundbeck A/S | Leucine-rich repeat kinase 2 (LRRK2) inhibitors |
| AR132486A1 (es) * | 2023-04-20 | 2025-07-02 | H Lundbeck As | Inhibidores de la cinasa con repeticiones ricas en leucina 2 (lrrk2) |
| WO2024218296A1 (en) * | 2023-04-20 | 2024-10-24 | H. Lundbeck A/S | Combination treatments comprising administration of leucine-rich repeat kinase 2 (lrrk2) inhibitors |
| AR132487A1 (es) * | 2023-04-20 | 2025-07-02 | H Lundbeck As | Inhibidores de la cinasa con repeticiones ricas en leucina 2 (lrrk2) |
| WO2025256640A1 (zh) * | 2024-06-14 | 2025-12-18 | 北京康辰药业股份有限公司 | 大环化合物及其药物组合物和应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201008134D0 (en) * | 2010-05-14 | 2010-06-30 | Medical Res Council Technology | Compounds |
| GB201015949D0 (en) * | 2010-09-22 | 2010-11-03 | Medical Res Council Technology | Compounds |
| TWI557121B (zh) * | 2011-04-21 | 2016-11-11 | 原真股份有限公司 | 新穎激酶抑制劑 |
| WO2013001310A1 (en) * | 2011-06-30 | 2013-01-03 | Centro Nacional De Investigaciones Oncológicas (Cnio) | Macrocyclic compounds and their use as cdk8 inhibitors |
| MX347765B (es) * | 2011-09-30 | 2017-05-12 | Oncodesign Sa | Inhibidores macrociclicos de la quinasa flt3. |
| PT2760453T (pt) * | 2011-09-30 | 2016-08-02 | Ipsen Pharma Sas | Inibidores macrocíclicos da cinase lrrk2 |
-
2014
- 2014-03-14 PL PL14709962T patent/PL2970333T3/pl unknown
- 2014-03-14 CN CN201480014168.6A patent/CN105143232A/zh active Pending
- 2014-03-14 PT PT147099626T patent/PT2970333T/pt unknown
- 2014-03-14 US US14/777,495 patent/US20160031905A1/en not_active Abandoned
- 2014-03-14 WO PCT/EP2014/055049 patent/WO2014140235A1/en not_active Ceased
- 2014-03-14 AU AU2014230485A patent/AU2014230485A1/en not_active Abandoned
- 2014-03-14 EA EA201591698A patent/EA201591698A1/ru unknown
- 2014-03-14 KR KR1020157029380A patent/KR20150129016A/ko not_active Withdrawn
- 2014-03-14 JP JP2015562173A patent/JP2016510793A/ja not_active Abandoned
- 2014-03-14 DK DK14709962.6T patent/DK2970333T3/en active
- 2014-03-14 BR BR112015019873A patent/BR112015019873A2/pt not_active IP Right Cessation
- 2014-03-14 EP EP14709962.6A patent/EP2970333B1/en not_active Not-in-force
- 2014-03-14 MX MX2015011359A patent/MX2015011359A/es unknown
- 2014-03-14 SG SG11201506357RA patent/SG11201506357RA/en unknown
- 2014-03-14 ES ES14709962.6T patent/ES2635021T3/es active Active
- 2014-03-14 TW TW103109451A patent/TW201444850A/zh unknown
- 2014-03-14 CA CA2904462A patent/CA2904462A1/en not_active Abandoned
-
2015
- 2015-08-28 ZA ZA2015/06327A patent/ZA201506327B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2970333B1 (en) | 2017-05-03 |
| DK2970333T3 (en) | 2017-08-21 |
| ES2635021T3 (es) | 2017-10-02 |
| CN105143232A (zh) | 2015-12-09 |
| WO2014140235A1 (en) | 2014-09-18 |
| AU2014230485A1 (en) | 2015-09-24 |
| BR112015019873A2 (pt) | 2017-07-18 |
| HK1219481A1 (en) | 2017-04-07 |
| ZA201506327B (en) | 2017-02-22 |
| US20160031905A1 (en) | 2016-02-04 |
| MX2015011359A (es) | 2015-12-16 |
| TW201444850A (zh) | 2014-12-01 |
| EA201591698A1 (ru) | 2016-02-29 |
| JP2016510793A (ja) | 2016-04-11 |
| SG11201506357RA (en) | 2015-09-29 |
| KR20150129016A (ko) | 2015-11-18 |
| PT2970333T (pt) | 2017-08-01 |
| CA2904462A1 (en) | 2014-09-18 |
| EP2970333A1 (en) | 2016-01-20 |
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