PL2970353T3 - Pochodne mannozy do leczenia infekcji bakteryjnych - Google Patents

Pochodne mannozy do leczenia infekcji bakteryjnych

Info

Publication number
PL2970353T3
PL2970353T3 PL14721598T PL14721598T PL2970353T3 PL 2970353 T3 PL2970353 T3 PL 2970353T3 PL 14721598 T PL14721598 T PL 14721598T PL 14721598 T PL14721598 T PL 14721598T PL 2970353 T3 PL2970353 T3 PL 2970353T3
Authority
PL
Poland
Prior art keywords
bacterial infections
treating bacterial
mannose derivatives
mannose
derivatives
Prior art date
Application number
PL14721598T
Other languages
English (en)
Inventor
Evelyne Dietrich
Carl Poisson
Michel Gallant
Stephanie Lessard
Bingcan Liu
Sanjoy Kumar Das
Yeeman Ramtohul
Thumkunta Jagadeeswar Reddy
Julien MARTEL
Frederic VALLEE
Jean-Francois Levesque
Original Assignee
Vertex Pharmaceuticals Incorporated
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharmaceuticals Incorporated filed Critical Vertex Pharmaceuticals Incorporated
Publication of PL2970353T3 publication Critical patent/PL2970353T3/pl

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D493/00Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10Spiro-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/02Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18Acyclic radicals, substituted by carbocyclic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20Carbocyclic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20Carbocyclic rings
    • C07H15/203Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20Carbocyclic rings
    • C07H15/207Cyclohexane rings not substituted by nitrogen atoms, e.g. kasugamycins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20Carbocyclic rings
    • C07H15/22Cyclohexane rings, substituted by nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26Acyclic or carbocyclic radicals, substituted by hetero rings
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
PL14721598T 2013-03-12 2014-03-12 Pochodne mannozy do leczenia infekcji bakteryjnych PL2970353T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361777398P 2013-03-12 2013-03-12
EP14721598.2A EP2970353B1 (en) 2013-03-12 2014-03-12 Mannose derivatives for treating bacterial infections
PCT/US2014/024411 WO2014165107A2 (en) 2013-03-12 2014-03-12 Mannose derivatives for treating bacterial infections

Publications (1)

Publication Number Publication Date
PL2970353T3 true PL2970353T3 (pl) 2018-10-31

Family

ID=50639929

Family Applications (1)

Application Number Title Priority Date Filing Date
PL14721598T PL2970353T3 (pl) 2013-03-12 2014-03-12 Pochodne mannozy do leczenia infekcji bakteryjnych

Country Status (16)

Country Link
US (1) US9890176B2 (pl)
EP (1) EP2970353B1 (pl)
JP (1) JP6373352B2 (pl)
KR (1) KR102249702B1 (pl)
CN (1) CN105164142B (pl)
AU (1) AU2014248717B2 (pl)
CA (1) CA2905019C (pl)
DK (1) DK2970353T3 (pl)
ES (1) ES2677115T3 (pl)
HK (1) HK1213268A1 (pl)
IL (1) IL241358B (pl)
MX (1) MX2015012472A (pl)
PL (1) PL2970353T3 (pl)
RU (1) RU2678327C2 (pl)
WO (1) WO2014165107A2 (pl)
ZA (1) ZA201507241B (pl)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3388441A1 (en) 2012-12-18 2018-10-17 Vertex Pharmaceuticals Incorporated Mannose derivatives for treating bacterial infections
JP2019508504A (ja) * 2016-03-11 2019-03-28 フィンブリオン セラピューティックス, インコーポレイテッドFimbrion Therapeutics, Inc. 疾病の処置に有用なc−グリコシド化合物
AU2017238392A1 (en) * 2016-03-23 2018-09-27 Fimbrion Therapeutics, Inc. Mannose-derived antagonists of FimH useful for treating disease
RS63712B1 (sr) 2018-07-10 2022-11-30 Glaxosmithkline Ip Dev Ltd Jedinjenja c-manozida korisna za tretman infekcija urinarnog trakta
CA3138394A1 (en) 2019-05-07 2020-11-12 Glaxosmithkline Intellectual Property Development Limited Novel compounds
WO2020254369A1 (en) 2019-06-19 2020-12-24 Glaxosmithkline Intellectual Property Development Limited Substituted biphenyl or phenylheteroaryl-mannosides as antagonists of fimh
WO2021197363A1 (zh) * 2020-03-31 2021-10-07 苏州大学 2-炔基甘露糖衍生物及其应用
CN115253144A (zh) * 2022-08-09 2022-11-01 青岛嘉智生物技术有限公司 针对戊二醛类消毒剂的中和剂及其制备方法
CN120004912B (zh) * 2024-12-24 2025-11-04 南华大学 一种三环前列腺素d2代谢物甲酯的制备方法

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0619317A1 (en) 1993-04-07 1994-10-12 Centre National De La Recherche Scientifique An expeditious synthesis of C-disaccharides using a temporary ketal connection
AU704114B2 (en) * 1993-11-18 1999-04-15 Siga Technologies, Inc. Compounds and pharmaceutical compositions for the treatment and prophylaxis of bacterial infections
AU6024998A (en) 1997-01-15 1998-08-07 Glycomed Incorporated Aryl c-glycoside compounds and sulfated esters thereof
AUPQ872300A0 (en) 2000-07-11 2000-08-03 Praxis Pharmaceuticals Pty Ltd Compounds and methods
EP1613261A4 (en) 2003-04-09 2011-01-26 Novo Nordisk As INTRA-CELLULAR FORMATION OF PEPTIDE CONJUGATES
EP1755619A2 (en) 2004-03-23 2007-02-28 VIB vzw Anti-adhesive compounds to prevent and treat bacterial infections
FR2876798A1 (fr) 2004-10-14 2006-04-21 Univ Clermont Auvergne Diagnostic et traitement de la maladie de crohn
US20090042949A1 (en) 2005-01-19 2009-02-12 Benjamin Pelcman Indoles Useful in the Treatment of Inflammation
CN101142185A (zh) 2005-01-19 2008-03-12 比奥里波克斯公司 用于炎症治疗的吲哚
EP1844013A1 (en) 2005-01-19 2007-10-17 Biolipox AB Indoles useful in the treatment of inflammation
JP2008527030A (ja) 2005-01-19 2008-07-24 バイオリポックス エービー 炎症の治療に有用なインドール類
US7572807B2 (en) 2005-06-09 2009-08-11 Bristol-Myers Squibb Company Heteroaryl 11-beta-hydroxysteroid dehydrogenase type I inhibitors
CN101379060B (zh) 2006-02-10 2012-05-23 转化技术制药公司 作为Aurora激酶抑制剂的苯并唑系衍生物、组合物和使用方法
WO2011050323A1 (en) * 2009-10-22 2011-04-28 The Washington University Compounds and methods for treating bacterial infections
NZ616764A (en) * 2009-12-14 2014-11-28 Univ Basel Mannose derivatives as antagonists of bacterial adhesion
EP2672820B1 (en) * 2011-02-07 2019-04-17 The Washington University Mannoside compounds and methods of use thereof
US8802078B2 (en) * 2011-03-11 2014-08-12 University Of Houston Compositions and methods for modifying a silicone surface for prolonged interference against pathogen colonization
US9315729B2 (en) 2011-05-27 2016-04-19 Merck Patent Gmbh Polymerizable compounds and their use in liquid crystal media and liquid crystal displays
WO2012164074A1 (en) * 2011-06-03 2012-12-06 University Of Basel Mannose phosphate derivatives as antagonists of bacterial adhesion
WO2013134415A1 (en) 2012-03-07 2013-09-12 Vertex Pharmaceuticals Incorporated Mannose derivatives for treating bacterial infections
WO2014055474A1 (en) 2012-10-04 2014-04-10 Vertex Pharmaceuticals Incorporated Mannose derivatives for treating bacterial infections
EP3388441A1 (en) * 2012-12-18 2018-10-17 Vertex Pharmaceuticals Incorporated Mannose derivatives for treating bacterial infections

Also Published As

Publication number Publication date
RU2015143165A (ru) 2017-04-17
MX2015012472A (es) 2016-02-10
RU2678327C2 (ru) 2019-01-28
EP2970353B1 (en) 2018-04-18
DK2970353T3 (en) 2018-07-09
WO2014165107A2 (en) 2014-10-09
AU2014248717B2 (en) 2018-03-29
CN105164142B (zh) 2019-03-08
ZA201507241B (en) 2018-12-19
CA2905019C (en) 2021-07-06
IL241358B (en) 2018-07-31
JP2016512538A (ja) 2016-04-28
US20140274930A1 (en) 2014-09-18
EP2970353A2 (en) 2016-01-20
NZ711932A (en) 2020-12-18
CA2905019A1 (en) 2014-10-09
ES2677115T3 (es) 2018-07-30
CN105164142A (zh) 2015-12-16
KR102249702B1 (ko) 2021-05-10
IL241358A0 (en) 2015-11-30
HK1213268A1 (zh) 2016-06-30
KR20150126692A (ko) 2015-11-12
US9890176B2 (en) 2018-02-13
WO2014165107A3 (en) 2015-02-26
AU2014248717A1 (en) 2015-09-24
JP6373352B2 (ja) 2018-08-15

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