PL3003412T3 - Degradowalna kompozycja hemostatyczna - Google Patents

Degradowalna kompozycja hemostatyczna

Info

Publication number
PL3003412T3
PL3003412T3 PL14736423T PL14736423T PL3003412T3 PL 3003412 T3 PL3003412 T3 PL 3003412T3 PL 14736423 T PL14736423 T PL 14736423T PL 14736423 T PL14736423 T PL 14736423T PL 3003412 T3 PL3003412 T3 PL 3003412T3
Authority
PL
Poland
Prior art keywords
haemostat composition
degradable
degradable haemostat
composition
haemostat
Prior art date
Application number
PL14736423T
Other languages
English (en)
Inventor
Craig Hardy
Andrew HOGGARTH
June Gladman
Original Assignee
Medtrade Products Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medtrade Products Limited filed Critical Medtrade Products Limited
Publication of PL3003412T3 publication Critical patent/PL3003412T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/08—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/64—Use of materials characterised by their function or physical properties specially adapted to be resorbable inside the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/722—Chitin, chitosan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/20—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing organic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/28—Polysaccharides or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0042—Materials resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/24—Naturally occurring macromolecular compounds, e.g. humic acids or their derivatives
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
    • B01J20/28023—Fibres or filaments
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
    • B01J20/28033—Membrane, sheet, cloth, pad, lamellar or mat
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
    • C08B37/0027—2-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
    • C08B37/003—Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
    • D01F9/00—Artificial filaments or the like of other substances; Manufacture thereof; Apparatus specially adapted for the manufacture of carbon filaments
    • D—TEXTILES; PAPER
    • D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
    • D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
    • D06M13/00—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment
    • D06M13/10—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment with compounds containing oxygen
    • D06M13/184—Carboxylic acids; Anhydrides, halides or salts thereof
    • D06M13/207—Substituted carboxylic acids, e.g. by hydroxy or keto groups; Anhydrides, halides or salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/04—Materials for stopping bleeding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2420/00—Materials or methods for coatings medical devices
    • A61L2420/02—Methods for coating medical devices
    • D—TEXTILES; PAPER
    • D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
    • D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
    • D06M2101/00—Chemical constitution of the fibres, threads, yarns, fabrics or fibrous goods made from such materials, to be treated
    • D06M2101/02—Natural fibres, other than mineral fibres
    • D06M2101/04—Vegetal fibres
    • D—TEXTILES; PAPER
    • D10—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
    • D10B—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
    • D10B2509/00—Medical; Hygiene
    • D10B2509/02—Bandages, dressings or absorbent pads

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Materials Engineering (AREA)
  • Surgery (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Textile Engineering (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Polymers & Plastics (AREA)
  • Biochemistry (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PL14736423T 2013-05-30 2014-05-28 Degradowalna kompozycja hemostatyczna PL3003412T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1309695.3A GB2514597A (en) 2013-05-30 2013-05-30 Degradable haemostat composition
PCT/GB2014/051625 WO2014191739A1 (en) 2013-05-30 2014-05-28 Degradable haemostat composition
EP14736423.6A EP3003412B1 (en) 2013-05-30 2014-05-28 Degradable haemostat composition

Publications (1)

Publication Number Publication Date
PL3003412T3 true PL3003412T3 (pl) 2020-04-30

Family

ID=48805504

Family Applications (1)

Application Number Title Priority Date Filing Date
PL14736423T PL3003412T3 (pl) 2013-05-30 2014-05-28 Degradowalna kompozycja hemostatyczna

Country Status (17)

Country Link
US (3) US9867900B2 (pl)
EP (1) EP3003412B1 (pl)
JP (1) JP6608809B2 (pl)
KR (1) KR102342895B1 (pl)
CN (2) CN105431177A (pl)
AU (2) AU2014272869B2 (pl)
BR (1) BR112015029957B1 (pl)
CA (1) CA2913665C (pl)
DK (1) DK3003412T3 (pl)
ES (1) ES2763673T3 (pl)
GB (1) GB2514597A (pl)
MX (1) MX2015016381A (pl)
PL (1) PL3003412T3 (pl)
PT (1) PT3003412T (pl)
RU (1) RU2682336C2 (pl)
SA (1) SA515370211B1 (pl)
WO (1) WO2014191739A1 (pl)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2514597A (en) 2013-05-30 2014-12-03 Medtrade Products Ltd Degradable haemostat composition
WO2016053988A1 (en) 2014-09-29 2016-04-07 Board Of Regents Of The University Of Nebraska Nanofiber structures and methods of synthesis and use thereof
US11318224B2 (en) 2016-09-28 2022-05-03 Board Of Regents Of The University Of Nebraska Nanofiber structures and methods of use thereof
US11738116B2 (en) 2017-06-09 2023-08-29 Board Of Regents Of The University Of Nebraska Expanded nanofiber structures comprising electrospun nanofibers and a plurality of holes and methods of making and use thereof
WO2019060393A1 (en) 2017-09-19 2019-03-28 Board Of Regents Of The University Of Nebraska NANOFIBER STRUCTURES AND METHODS OF USE THEREOF
KR102073267B1 (ko) * 2017-12-20 2020-02-04 주식회사 테라시온 바이오메디칼 겔 타입 동물용 지혈제 조성물
US10517988B1 (en) 2018-11-19 2019-12-31 Endomedix, Inc. Methods and compositions for achieving hemostasis and stable blood clot formation
WO2020106703A1 (en) 2018-11-19 2020-05-28 Endomedix, Inc. Methods and compositions for achieving hemostasis and stable blood clot formation
KR102341718B1 (ko) * 2018-12-05 2021-12-22 주식회사 에이엔폴리 파이로갈롤기로 기능화한 다당류 기반의 지혈용 조직 접착제 및 조성물
CA3123236A1 (en) 2018-12-14 2020-06-18 Board Of Regents Of The University Of Nebraska Nanofiber structures and methods of manufacture and use thereof
KR102416012B1 (ko) * 2020-09-01 2022-07-05 정인선 지혈 및 분해 속도 조절형 의료용 소재의 제조방법 및 이에 따라 제조된 의료용 소재

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US2463523A (en) * 1946-06-13 1949-03-08 Bucyrus Erie Co Apron for wheeled scrapers
JP3569927B2 (ja) * 1993-03-15 2004-09-29 栗田工業株式会社 エンドトキシンの除去方法
DK1401352T3 (da) * 2001-06-14 2012-06-25 Kenton W Gregory Fremgangsmåde til fremstilling af en chitosansårforbinding
US8269058B2 (en) * 2002-06-14 2012-09-18 Hemcon Medical Technologies, Inc. Absorbable tissue dressing assemblies, systems, and methods formed from hydrophilic polymer sponge structures such as chitosan
US20050118238A1 (en) * 2003-06-16 2005-06-02 Zhu Yong H. Deployable hemostatic agent
US7125967B2 (en) 2003-10-08 2006-10-24 Adjuvant Pharmaceuticals, Llc Water-soluble chitosan having low endotoxin concentration and methods for making and using the same
EP1718147B1 (en) * 2004-02-23 2012-03-28 Loma Linda University Medical Center Hemostatic agent for topical and internal use
JP2009505685A (ja) * 2005-07-13 2009-02-12 ヘムコン， インコーポレイテッド キトサンのような親水性ポリマーフォームから形成された粒状止血薬を使用する、止血の組成、アセンブリ、システムおよび方法
US20070104769A1 (en) * 2005-11-04 2007-05-10 Lifescience Plus, Inc. Bioabsorbable hemostatic gauze
GB0526503D0 (en) 2005-12-29 2006-02-08 Medtrade Products Ltd Hemostatic material
WO2008063503A2 (en) 2006-11-13 2008-05-29 Hawaii Chitopure, Inc. Methods of making a chitosan product having an ultra-low endotoxin concentration and the ultra-low endotoxin chitosan product derived therefrom and method of accurately determining inflammatory and anti-inflammatory cellular response to such materials.
WO2009011858A1 (en) * 2007-07-16 2009-01-22 Hemcon Medical Technologies, Inc. Absorbable tissue dressing assemblies, systems, and methods formed from a hydrophilic chitosan sponge structure and including a flexible absorbable backing layer of poly-4-hydroxy butyrate
CZ2007716A3 (cs) 2007-10-15 2009-04-29 Elmarco S. R. O. Zpusob výroby nanovláken
JP5725862B2 (ja) * 2007-10-30 2015-05-27 ヴィスコゲル アーベーＶｉｓｃｏｇｅｌ Ａｂ キトサン組成物
GB2461019B (en) * 2008-04-25 2013-06-05 Medtrade Products Ltd Haemostatic material
GB2463523B (en) * 2008-09-17 2013-05-01 Medtrade Products Ltd Wound care device
WO2010107794A2 (en) * 2009-03-16 2010-09-23 University Of Memphis Research Foundation Compositions and methods for delivering an agent to a wound
RU2468129C2 (ru) 2010-12-30 2012-11-27 Государственное образовательное учреждение высшего профессионального образования "Саратовский государственный университет им. Н.Г. Чернышевского" Биополимерное волокно, состав формовочного раствора для его получения, способ приготовления формовочного раствора, полотно биомедицинского назначения, способ его модификации, биологическая повязка и способ лечения ран
GB201104175D0 (en) 2011-03-11 2011-04-27 Medtrade Products Ltd Haemostatic material
CN102727925B (zh) * 2011-04-02 2014-09-17 佛山市优特医疗科技有限公司 酰化壳聚糖伤口敷料、其制备方法及其应用
CN102737684A (zh) * 2011-04-08 2012-10-17 腾讯科技（深圳）有限公司 视频广告编辑方法、播放方法、编辑装置及播放装置
GB201205174D0 (en) * 2012-03-23 2012-05-09 Medtrade Products Ltd Process for producing low endotoxin chitosan
GB2514597A (en) 2013-05-30 2014-12-03 Medtrade Products Ltd Degradable haemostat composition

Also Published As

Publication number Publication date
RU2682336C2 (ru) 2019-03-19
PT3003412T (pt) 2020-01-08
JP6608809B2 (ja) 2019-11-20
AU2018201124A1 (en) 2018-03-08
CN112295012A (zh) 2021-02-02
WO2014191739A1 (en) 2014-12-04
CA2913665A1 (en) 2014-12-04
CN105431177A (zh) 2016-03-23
GB2514597A (en) 2014-12-03
AU2014272869B2 (en) 2018-03-01
RU2015155734A (ru) 2017-07-06
RU2015155734A3 (pl) 2018-04-25
GB201309695D0 (en) 2013-07-17
ES2763673T3 (es) 2020-05-29
US20170202994A1 (en) 2017-07-20
US20160121020A1 (en) 2016-05-05
SA515370211B1 (ar) 2018-10-04
US20170202997A1 (en) 2017-07-20
BR112015029957A2 (pt) 2017-07-25
EP3003412B1 (en) 2019-09-25
EP3003412A1 (en) 2016-04-13
US9867900B2 (en) 2018-01-16
CA2913665C (en) 2024-01-09
DK3003412T3 (da) 2020-01-13
KR20160034256A (ko) 2016-03-29
MX2015016381A (es) 2016-09-29
JP2016521595A (ja) 2016-07-25
BR112015029957B1 (pt) 2020-07-14
US10300166B2 (en) 2019-05-28
KR102342895B1 (ko) 2021-12-22
US10434212B2 (en) 2019-10-08
AU2014272869A1 (en) 2016-01-21

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