PL3008063T3 - Pochodne 4-amino-6-(2,6-dichlorofenylo)-2-(fenyloamino)pirydo(2,3- d)pirymidyn-7(8h)-onu, ich synteza oraz zastosowania - Google Patents

Pochodne 4-amino-6-(2,6-dichlorofenylo)-2-(fenyloamino)pirydo(2,3- d)pirymidyn-7(8h)-onu, ich synteza oraz zastosowania

Info

Publication number
PL3008063T3
PL3008063T3 PL14730889T PL14730889T PL3008063T3 PL 3008063 T3 PL3008063 T3 PL 3008063T3 PL 14730889 T PL14730889 T PL 14730889T PL 14730889 T PL14730889 T PL 14730889T PL 3008063 T3 PL3008063 T3 PL 3008063T3
Authority
PL
Poland
Prior art keywords
pyrido
phenylamino
pyrimidin
dichlorophenyl
synthesis
Prior art date
Application number
PL14730889T
Other languages
English (en)
Inventor
Bilbao José Ignacio Borrell
Closa Jordi Teixido
De La Bellacasa Cazorla Raimon Puig
Pujol Dolors Colomer
Gael Roue
Patricia Pérez-Galán
Original Assignee
Institut Químic de Sarriá CETS Fundació Privada
Hospital Clínic De Barcelona
Fundació Clinic Per A La Recerca Biomèdica (Fcrb)
Institut D'investigacions Biomèdiques August Pi I Sunyer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institut Químic de Sarriá CETS Fundació Privada, Hospital Clínic De Barcelona, Fundació Clinic Per A La Recerca Biomèdica (Fcrb), Institut D'investigacions Biomèdiques August Pi I Sunyer filed Critical Institut Químic de Sarriá CETS Fundació Privada
Publication of PL3008063T3 publication Critical patent/PL3008063T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PL14730889T 2013-06-14 2014-06-16 Pochodne 4-amino-6-(2,6-dichlorofenylo)-2-(fenyloamino)pirydo(2,3- d)pirymidyn-7(8h)-onu, ich synteza oraz zastosowania PL3008063T3 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP13382225.4A EP2813504A1 (en) 2013-06-14 2013-06-14 4-Amino-6-(2,6-dichlorophenyl)-2-(phenylamino)-pyrido[2,3-d]pyrimidin-7(8H)-one derivatives, synthesis and uses thereof

Publications (1)

Publication Number Publication Date
PL3008063T3 true PL3008063T3 (pl) 2017-09-29

Family

ID=48651953

Family Applications (1)

Application Number Title Priority Date Filing Date
PL14730889T PL3008063T3 (pl) 2013-06-14 2014-06-16 Pochodne 4-amino-6-(2,6-dichlorofenylo)-2-(fenyloamino)pirydo(2,3- d)pirymidyn-7(8h)-onu, ich synteza oraz zastosowania

Country Status (7)

Country Link
US (1) US9630962B2 (pl)
EP (2) EP2813504A1 (pl)
JP (1) JP2016523850A (pl)
ES (1) ES2628163T3 (pl)
PL (1) PL3008063T3 (pl)
PT (1) PT3008063T (pl)
WO (1) WO2014198960A1 (pl)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105294682B (zh) 2014-07-26 2017-07-07 广东东阳光药业有限公司 Cdk类小分子抑制剂的化合物及其用途
EP3120851A1 (en) * 2015-07-21 2017-01-25 Pangaea Biotech S.L. 4-amino-6-(2,6-dichlorophenyl)-8-methyl-2-(phenylamino)-pyrido[2,3-d]pyrimidin-7(8h)-one for treatment of solid cancers
US20240100172A1 (en) 2020-12-21 2024-03-28 Hangzhou Jijing Pharmaceutical Technology Limited Methods and compounds for targeted autophagy
WO2026082727A1 (en) 2024-10-15 2026-04-23 Institut Quimic De Sarria Cets Fundacio Privada Substituted 2-(phenylamino))pyrido[2,3-d]pyrimidin-7-one compounds for use in the treatment of pancreatic cancer

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3702889A (en) 1970-10-19 1972-11-14 Pfizer Process for making activated manganese dioxide
WO2004063195A1 (en) * 2003-01-03 2004-07-29 Sloan-Kettering Institute For Cancer Research Pyridopyrimidine kinase inhibitors
CN102746298A (zh) * 2005-10-07 2012-10-24 埃克塞里艾克西斯公司 PI3Kα的吡啶并嘧啶酮抑制剂
MX2008014618A (es) * 2006-05-15 2008-11-28 Irm Llc Composiciones y metodos para inhibidores de cinasas del receptor fgf.
JP2010510222A (ja) * 2006-11-17 2010-04-02 シェーリング コーポレイション 増殖性障害に対する併用療法
ES2377610B1 (es) * 2010-09-01 2013-02-05 Institut Químic de Sarriá CETS Fundació Privada Preparación de compuestos pirido[2,3-d]pirimidin-7(8h)-ona sustituidos.
WO2012035131A1 (en) * 2010-09-16 2012-03-22 University Of Zurich Treatment of abl overexpressing b-cell lymphoma
MX2014005285A (es) * 2011-11-03 2014-05-30 Hoffmann La Roche Compuestos biciclicos de piperazina.

Also Published As

Publication number Publication date
WO2014198960A1 (en) 2014-12-18
EP3008063A1 (en) 2016-04-20
EP3008063B1 (en) 2017-04-19
JP2016523850A (ja) 2016-08-12
ES2628163T3 (es) 2017-08-01
US9630962B2 (en) 2017-04-25
US20160176866A1 (en) 2016-06-23
PT3008063T (pt) 2017-07-05
EP2813504A1 (en) 2014-12-17

Similar Documents

Publication Publication Date Title
HUS2300040I1 (hu) Pirrolo[2,3-d]pirimidinil-, pirrolo[2,3-b]pirazinil- és pirrolo[2,3-d]-piridinil- akrilamidok
ZA201506570B (en) 2-phenylimidazo[1,2-a]pyrimidines as imaging agents
SI2914594T1 (sl) Amino substituirani imidazo(1,2-A)piridinkarboksamidi in njihova uporaba
IL240010B (en) Sulfonyl-2-(1h-pyrrolo[2,3-b]pyridine-5-yloxy)benzamide compounds for the treatment of cancer and autoimmune diseases
SI2968294T1 (sl) 7-benzil-10-(2-metilbenzil)-2,6,7,8,9,10-heksahidroimidazo(1,2-A)pirido (4,3-D)pirimidin-5(3H)-on za uporabo pri zdravljenju raka
ZA201603893B (en) 2-amino-6-fluoro-n-[5-fluoro-pyridin-3-yl]pyrazolo[1,5-a]pyrimidin-3-carboxamide compound useful as atr kinase inhibitor, its preparation, different solid forms and radiolabelled derivatives thereof
IL243092B (en) New triazolo[d–4,5]pyrimidine histories
ZA201507151B (en) Antiviral indolo[2,3-b]quinoxaline
PL3008063T3 (pl) Pochodne 4-amino-6-(2,6-dichlorofenylo)-2-(fenyloamino)pirydo(2,3- d)pirymidyn-7(8h)-onu, ich synteza oraz zastosowania
PT2989105T (pt) Compostos de pirazino[1,2-a]indole, sua preparação e utilização em medicamentos
ZA201508613B (en) Pyrazino[1,2-a]indole compounds, their preparation and use in medicaments
TH1601003263A (th) ไพร์โรโล[2,3-d]ไพริมิดินิล, ไพร์โรโล[2,3-b]ไพราซินิล และ ไพร์โรโล[2,3-d] ไพริดินิล เอคริลเอไมด์