PL308426A1 - Derivatives of pyrolopyrimidine, method of obtaining them and composition containing such derivatives - Google Patents

Derivatives of pyrolopyrimidine, method of obtaining them and composition containing such derivatives

Info

Publication number
PL308426A1
PL308426A1 PL95308426A PL30842695A PL308426A1 PL 308426 A1 PL308426 A1 PL 308426A1 PL 95308426 A PL95308426 A PL 95308426A PL 30842695 A PL30842695 A PL 30842695A PL 308426 A1 PL308426 A1 PL 308426A1
Authority
PL
Poland
Prior art keywords
derivatives
protein
alkyl
pyrolopyrimidine
obtaining
Prior art date
Application number
PL95308426A
Inventor
Peter Traxler
Pascal Furet
Wolfgang K-D Brill
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of PL308426A1 publication Critical patent/PL308426A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Use of pyrrolo(2,3-d)pyrimidine derivs. of formula (I) or their salts to prepare medicaments for treatment of tumours and other proliferative diseases, disorders of the immune system mediated by protein-tyrosine and/or protein-threonine kinases, and disorders of the central and peripheral nervous system involving signal transmission by protein-tyrosine and/or protein-threonine kinases, is new: n = 0-5; R = halo, alkyl, CF3 or alkoxy; and R1,R2 = H, alkyl, or phenyl opt. substd. by halo, CF3, alkyl or alkoxy; or R1+R2 = opt. alkyl-substd. 2-5C alkylene; provided that R1 and R2 are not both H.
PL95308426A 1994-05-03 1995-04-28 Derivatives of pyrolopyrimidine, method of obtaining them and composition containing such derivatives PL308426A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH138594 1994-05-03
CH24595 1995-01-30

Publications (1)

Publication Number Publication Date
PL308426A1 true PL308426A1 (en) 1995-11-13

Family

ID=25684008

Family Applications (1)

Application Number Title Priority Date Filing Date
PL95308426A PL308426A1 (en) 1994-05-03 1995-04-28 Derivatives of pyrolopyrimidine, method of obtaining them and composition containing such derivatives

Country Status (21)

Country Link
US (2) US5686457A (en)
EP (1) EP0682027B1 (en)
JP (1) JP3042760B2 (en)
KR (1) KR950031113A (en)
CN (1) CN1128263A (en)
AT (1) ATE159257T1 (en)
AU (1) AU695244B2 (en)
CA (1) CA2148324A1 (en)
CZ (1) CZ113195A3 (en)
DE (1) DE59500788D1 (en)
DK (1) DK0682027T3 (en)
ES (1) ES2109796T3 (en)
FI (1) FI952033A7 (en)
GR (1) GR3025158T3 (en)
HK (1) HK1002935A1 (en)
HU (1) HUT71818A (en)
IL (1) IL113531A0 (en)
NO (1) NO951684L (en)
NZ (1) NZ272031A (en)
PL (1) PL308426A1 (en)
SK (1) SK56195A3 (en)

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* Cited by examiner, † Cited by third party
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