PL310072A1 - Small-diameter microcapsules, method of making them and their applications - Google Patents

Small-diameter microcapsules, method of making them and their applications

Info

Publication number
PL310072A1
PL310072A1 PL31007294A PL31007294A PL310072A1 PL 310072 A1 PL310072 A1 PL 310072A1 PL 31007294 A PL31007294 A PL 31007294A PL 31007294 A PL31007294 A PL 31007294A PL 310072 A1 PL310072 A1 PL 310072A1
Authority
PL
Poland
Prior art keywords
cyanoacrylate
applications
making
small
mch3
Prior art date
Application number
PL31007294A
Inventor
Valery Alexandrovich Dyatlow
Georgy Arkadievich Katz
Original Assignee
Abacol Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abacol Ltd filed Critical Abacol Ltd
Publication of PL310072A1 publication Critical patent/PL310072A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5138—Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5161—Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicinal Preparation (AREA)

Abstract

Nanocapsules typically having a diameter in the range of 20-150 nm are provided and consist of a polymeric shell formed of a surface active poly(alkyl cyanoacrylate) material arranged in one or more layers. The polymeric shell can be composed of a surface active poly(alkyl 2-cyanoacrylate) having general formula (I), wherein R is -CH2-(-CH2-)-mCH3, -CH2-(-CH2-)-mCOOH, -CH2-(-CH2-)-mCOOR', or -CH2CH2-O-(-CH2CH2-O-)-mR'; R' is -CH3, -CH2-(-CH2-)-mCH3, -C-(-CH3-)-2-CH2-C(CH3)3, or -O-Ar; m has a value of from 0 to 20; and n has a value of from 1 to 20, formed by the interfacial polymerisation of self-arranged micelles of the cyanoacrylate monomers. The nanocapsules can be used to encapsulate a wide range of water soluble and water insoluble active agents in high yield for delivery to a target system or locus, for example, drugs for use in therapy or prophylaxis.
PL31007294A 1993-01-11 1994-01-10 Small-diameter microcapsules, method of making them and their applications PL310072A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU93001196 1993-01-11

Publications (1)

Publication Number Publication Date
PL310072A1 true PL310072A1 (en) 1995-11-27

Family

ID=20135403

Family Applications (1)

Application Number Title Priority Date Filing Date
PL31007294A PL310072A1 (en) 1993-01-11 1994-01-10 Small-diameter microcapsules, method of making them and their applications

Country Status (5)

Country Link
EP (1) EP0682513A1 (en)
AU (1) AU5714194A (en)
CA (1) CA2153343A1 (en)
PL (1) PL310072A1 (en)
WO (1) WO1994015590A1 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6395494B1 (en) 1993-05-13 2002-05-28 Neorx Corporation Method to determine TGF-β
CA2258744A1 (en) 1996-06-27 1997-12-31 G.D. Searle And Co. Particles comprising amphiphilic copolymers, having a cross-linked shell domain and an interior core domain, useful for pharmaceutical and other applications
JP3778575B2 (en) * 1997-06-13 2006-05-24 ナノデル テヒノロギーズ ゲーエムベーハー Drug targeting system, preparation method thereof and use thereof
EP1231905B1 (en) 1999-11-15 2009-04-08 BioCure, Inc. Responsive polymeric hollow particles
FR2806005B1 (en) * 2000-03-10 2002-06-14 Univ Claude Bernard Lyon PROCESS FOR THE PREPARATION OF COLLOIDAL PARTICLES IN THE FORM OF NANOCAPSULES
EP1272231A1 (en) 2000-04-06 2003-01-08 University Technology Corporation Compositions and methods for promoting wound healing
DE10111508A1 (en) * 2001-03-09 2002-09-26 Henkel Kgaa Modified cyanoacrylate esters, nano- or microcapsules made from them and their use in detergents or cleaning agents
US6613083B2 (en) 2001-05-02 2003-09-02 Eckhard Alt Stent device and method
FR2839517A1 (en) * 2002-05-07 2003-11-14 Centre Nat Rech Scient NOVEL BIODEGRADABLE SURFACTANTS OF THE AMPHIPHILIC COPOLYMER TYPE COMPRISING HYDROPHOBIC SEGMENTS AND OLIGO AND / OR POLYSACCHARIDES
CN1938040A (en) * 2003-03-05 2007-03-28 Pr药品有限公司 Oxytocin controlled release formulations and methods of using same
US7659423B1 (en) 2006-04-18 2010-02-09 Loctite (R&D) Limited Method of preparing electron deficient olefins in polar solvents
US7569719B1 (en) 2006-10-25 2009-08-04 Loctite (R&D) Limited Method of preparing electron deficient olefins
US7718821B1 (en) 2006-12-19 2010-05-18 Loctite (R&D) Limited Method of preparing electron deficient olefins
US8053589B1 (en) 2007-10-24 2011-11-08 Henkel Ireland Limited Imines and methods of preparing electron deficient olefins using such novel imines
JP5639892B2 (en) 2007-10-24 2014-12-10 ヘンケル アイルランド リミテッド Electron deficient olefin
US7973119B1 (en) 2007-10-24 2011-07-05 Loctite (R&D) Limited Adhesive systems using imines and salts thereof and precursurs to electron deficient olefins
ES2662644T3 (en) 2007-10-24 2018-04-09 Henkel IP & Holding GmbH Methylene reagents
US8399698B1 (en) 2008-10-24 2013-03-19 Henkel Ireland Limited Substituted activated methylene reagents and methods of using such reagents to form electron deficient olefins
US10196471B1 (en) 2008-10-24 2019-02-05 Henkel IP & Holding GmbH Curable composition having an electron deficient olefin
TWI664224B (en) 2014-12-12 2019-07-01 日商東亞合成股份有限公司 Two-liquid type hardening composition

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2646775A1 (en) * 1989-05-11 1990-11-16 Centre Nat Rech Scient USE OF CASEINOGLYCOPEPTIDE K, IN PARTICULAR COW MILK, FOR THE MANUFACTURE OF A COMPOSITION, IN PARTICULAR A MEDICINAL PRODUCT, FOR THE PREVENTION AND TREATMENT OF THROMBOSIS
FR2659554B1 (en) * 1990-03-16 1994-09-30 Oreal COMPOSITION FOR THE COSMETIC AND / OR PHARMACEUTICAL TREATMENT OF THE TOP LAYERS OF THE EPIDERMIS BY TOPICAL APPLICATION TO THE SKIN AND PREPARATION METHOD THEREOF.

Also Published As

Publication number Publication date
AU5714194A (en) 1994-08-15
CA2153343A1 (en) 1994-07-21
WO1994015590A1 (en) 1994-07-21
EP0682513A1 (en) 1995-11-22

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