PL310441A1 - Novel taxoides, method of obtaining them and pharmaceutical compositions containing such compounds - Google Patents
Novel taxoides, method of obtaining them and pharmaceutical compositions containing such compoundsInfo
- Publication number
- PL310441A1 PL310441A1 PL94310441A PL31044194A PL310441A1 PL 310441 A1 PL310441 A1 PL 310441A1 PL 94310441 A PL94310441 A PL 94310441A PL 31044194 A PL31044194 A PL 31044194A PL 310441 A1 PL310441 A1 PL 310441A1
- Authority
- PL
- Poland
- Prior art keywords
- radical
- pharmaceutical compositions
- taxoides
- novel
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
This invention relates to taxoids of general formula (I), their preparation and the pharmaceutical compositions which contain them. The products of general formula (I) have notable antitumoral properties. In the general formula (I), Ar represents an aryl radical, R represents a hydrogen atom or an acetyl or alkoxyacetyl radical, R1 represents a benzoyl radical or a radical R2-O-CO- in which R2 represents an alkyl, alkenyl, cycloalkyl, cycloalkenyl, bicycloalkyl, phenyl or heterocyclyl radical, and R3 represents an alkyl, alkenyl, cycloalkyl, cycloalkenyl, bicycloalkyl, optionally substituted aryl (with the exception of unsubstituted phenyl) or heterocyclyl radical. <IMAGE> (I)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9302370A FR2702212B1 (en) | 1993-03-02 | 1993-03-02 | New taxoids, their preparation and the pharmaceutical compositions containing them. |
| PCT/FR1994/000222 WO1994020484A1 (en) | 1993-03-02 | 1994-02-28 | Novel taxoids, preparation thereof and pharmaceutical compositions containing same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL310441A1 true PL310441A1 (en) | 1995-12-11 |
Family
ID=9444565
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL94310441A PL310441A1 (en) | 1993-03-02 | 1994-02-28 | Novel taxoides, method of obtaining them and pharmaceutical compositions containing such compounds |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US5556877A (en) |
| EP (1) | EP0687259B1 (en) |
| JP (1) | JP3782443B2 (en) |
| KR (1) | KR960701034A (en) |
| AT (1) | ATE151763T1 (en) |
| AU (1) | AU683449B2 (en) |
| CZ (1) | CZ223795A3 (en) |
| DE (1) | DE69402694T2 (en) |
| DK (1) | DK0687259T3 (en) |
| ES (1) | ES2101513T3 (en) |
| FI (1) | FI954111A7 (en) |
| FR (1) | FR2702212B1 (en) |
| GR (1) | GR3023162T3 (en) |
| NO (1) | NO953452L (en) |
| NZ (1) | NZ262137A (en) |
| PL (1) | PL310441A1 (en) |
| SK (1) | SK107295A3 (en) |
| WO (1) | WO1994020484A1 (en) |
| ZA (1) | ZA941387B (en) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6794523B2 (en) | 1991-09-23 | 2004-09-21 | Florida State University | Taxanes having t-butoxycarbonyl substituted side-chains and pharmaceutical compositions containing them |
| FR2698361B1 (en) * | 1992-11-20 | 1995-01-13 | Rhone Poulenc Rorer Sa | Process for the preparation of an oxazolidine-1,3 carboxylic-5 acid. |
| FR2706457B1 (en) * | 1993-06-16 | 1995-07-28 | Rhone Poulenc Rorer Sa | Process for the preparation of an oxazolidinecarboxylic acid useful for preparing therapeutically active taxoids. |
| US5760251A (en) * | 1995-08-11 | 1998-06-02 | Sepracor, Inc. | Taxol process and compounds |
| DE69734060T2 (en) | 1996-05-24 | 2006-06-29 | Angiotech Pharmaceuticals, Inc., Vancouver | PREPARATIONS AND METHODS FOR TREATING OR PREVENTING DISEASES OF THE BODY PASSAGE PATHS |
| FR2750989B1 (en) * | 1996-07-09 | 1998-09-25 | Rhone Poulenc Rorer Sa | PROCESS FOR MONOACYLATION OF HYDROXY TAXANES |
| KR100225535B1 (en) | 1996-08-27 | 1999-10-15 | 정지석 | Manufacturing method of paclitaxel |
| US6495579B1 (en) | 1996-12-02 | 2002-12-17 | Angiotech Pharmaceuticals, Inc. | Method for treating multiple sclerosis |
| US20030157187A1 (en) * | 1996-12-02 | 2003-08-21 | Angiotech Pharmaceuticals, Inc. | Compositions and methods for treating or preventing inflammatory diseases |
| US6515016B2 (en) | 1996-12-02 | 2003-02-04 | Angiotech Pharmaceuticals, Inc. | Composition and methods of paclitaxel for treating psoriasis |
| US7288665B1 (en) * | 1997-08-18 | 2007-10-30 | Florida State University | Process for selective derivatization of taxanes |
| HK1042302B (en) | 1999-05-17 | 2004-10-08 | Bristol-Myers Squibb Company | Novel reaction conditions for the cleavage of silyl ethers in the preparation of paclitaxel (taxol) and paclitaxel analogues |
| JP2003522171A (en) | 2000-02-02 | 2003-07-22 | フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド | C10 carbonate substituted taxanes as antitumor agents |
| US6649632B2 (en) | 2000-02-02 | 2003-11-18 | Fsu Research Foundation, Inc. | C10 ester substituted taxanes |
| NZ514406A (en) | 2000-02-02 | 2005-01-28 | Univ Florida State Res Found | C10 heterosubstituted acetate taxanes as antitumor agents |
| US20040132991A1 (en) * | 2002-10-09 | 2004-07-08 | Phytogen Life Sciences Inc. | Novel taxanes and methods related to use and preparation thereof |
| US7202370B2 (en) * | 2003-10-27 | 2007-04-10 | Conor Medsystems, Inc. | Semi-synthesis of taxane intermediates from 9-dihydro-13-acetylbaccatin III |
| HN2005000054A (en) | 2004-02-13 | 2009-02-18 | Florida State University Foundation Inc | REPLACED TAXANS WITH CYCLOPENTILO ESTERS IN C10 |
| JP2011517455A (en) | 2008-03-31 | 2011-06-09 | フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド | C (10) ethyl ester and C (10) cyclopropyl ester substituted taxanes |
| CN102408397B (en) * | 2011-10-19 | 2014-08-20 | 上海贝美医药科技有限公司 | New taxane derivative and preparation method thereof |
| EP3316880B1 (en) | 2015-07-01 | 2021-09-01 | The Research Foundation for The State University of New York | Third generation taxoids and use thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2601675B1 (en) * | 1986-07-17 | 1988-09-23 | Rhone Poulenc Sante | TAXOL DERIVATIVES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
| US5430160A (en) * | 1991-09-23 | 1995-07-04 | Florida State University | Preparation of substituted isoserine esters using β-lactams and metal or ammonium alkoxides |
| US5254703A (en) * | 1992-04-06 | 1993-10-19 | Florida State University | Semi-synthesis of taxane derivatives using metal alkoxides and oxazinones |
| CA2130578A1 (en) * | 1992-04-17 | 1993-10-28 | Geewananda P. Gunawardana | Taxol derivatives |
| IL108444A0 (en) * | 1993-01-29 | 1994-04-12 | Univ Florida State | C2 taxane derivatives and pharmaceutical compositions containing them |
-
1993
- 1993-03-02 FR FR9302370A patent/FR2702212B1/en not_active Expired - Fee Related
-
1994
- 1994-02-28 FI FI954111A patent/FI954111A7/en not_active Application Discontinuation
- 1994-02-28 ES ES94908385T patent/ES2101513T3/en not_active Expired - Lifetime
- 1994-02-28 AT AT94908385T patent/ATE151763T1/en active
- 1994-02-28 SK SK1072-95A patent/SK107295A3/en unknown
- 1994-02-28 JP JP51965294A patent/JP3782443B2/en not_active Expired - Lifetime
- 1994-02-28 CZ CZ952237A patent/CZ223795A3/en unknown
- 1994-02-28 WO PCT/FR1994/000222 patent/WO1994020484A1/en not_active Ceased
- 1994-02-28 DK DK94908385.1T patent/DK0687259T3/en active
- 1994-02-28 KR KR1019950703730A patent/KR960701034A/en not_active Withdrawn
- 1994-02-28 NZ NZ262137A patent/NZ262137A/en unknown
- 1994-02-28 EP EP94908385A patent/EP0687259B1/en not_active Expired - Lifetime
- 1994-02-28 PL PL94310441A patent/PL310441A1/en unknown
- 1994-02-28 AU AU61446/94A patent/AU683449B2/en not_active Expired - Fee Related
- 1994-02-28 DE DE69402694T patent/DE69402694T2/en not_active Expired - Lifetime
- 1994-02-28 ZA ZA941387A patent/ZA941387B/en unknown
- 1994-03-02 US US08/204,128 patent/US5556877A/en not_active Expired - Lifetime
-
1995
- 1995-09-01 NO NO953452A patent/NO953452L/en unknown
-
1996
- 1996-02-27 US US08/607,854 patent/US5654449A/en not_active Expired - Lifetime
-
1997
- 1997-04-17 GR GR960402947T patent/GR3023162T3/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FR2702212B1 (en) | 1995-04-07 |
| FR2702212A1 (en) | 1994-09-09 |
| DK0687259T3 (en) | 1997-05-26 |
| JP3782443B2 (en) | 2006-06-07 |
| ES2101513T3 (en) | 1997-07-01 |
| AU683449B2 (en) | 1997-11-13 |
| AU6144694A (en) | 1994-09-26 |
| KR960701034A (en) | 1996-02-24 |
| SK107295A3 (en) | 1996-06-05 |
| NO953452D0 (en) | 1995-09-01 |
| ZA941387B (en) | 1994-09-29 |
| US5556877A (en) | 1996-09-17 |
| DE69402694T2 (en) | 1997-10-16 |
| FI954111L (en) | 1995-09-01 |
| FI954111A0 (en) | 1995-09-01 |
| EP0687259A1 (en) | 1995-12-20 |
| DE69402694D1 (en) | 1997-05-22 |
| WO1994020484A1 (en) | 1994-09-15 |
| NZ262137A (en) | 1997-11-24 |
| GR3023162T3 (en) | 1997-07-30 |
| FI954111A7 (en) | 1995-09-01 |
| JPH08509959A (en) | 1996-10-22 |
| NO953452L (en) | 1995-09-01 |
| EP0687259B1 (en) | 1997-04-16 |
| CZ223795A3 (en) | 1995-12-13 |
| ATE151763T1 (en) | 1997-05-15 |
| US5654449A (en) | 1997-08-05 |
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