PL3119752T3 - Związki 3,4-diamino-6-chloropirazyno-2-karbokysamidowe do leczenia chorób mediowanych przez ENAC - Google Patents

Związki 3,4-diamino-6-chloropirazyno-2-karbokysamidowe do leczenia chorób mediowanych przez ENAC

Info

Publication number
PL3119752T3
PL3119752T3 PL15713339T PL15713339T PL3119752T3 PL 3119752 T3 PL3119752 T3 PL 3119752T3 PL 15713339 T PL15713339 T PL 15713339T PL 15713339 T PL15713339 T PL 15713339T PL 3119752 T3 PL3119752 T3 PL 3119752T3
Authority
PL
Poland
Prior art keywords
chloropyrazine
diamino
treatment
mediated diseases
carboxamide compounds
Prior art date
Application number
PL15713339T
Other languages
English (en)
Inventor
Susanne Elisabeth Berglund
Stephen Connolly
Martin Hemmerling
Nafizal Hossain
Anna Kristoffersson
Johan Rune Michael Lundkvist
Grigorios Nikitidis
Lena Elisabeth Ripa
Igor Shamovsky
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of PL3119752T3 publication Critical patent/PL3119752T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
    • C07D241/28—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms in which said hetero-bound carbon atoms have double bonds to oxygen, sulfur or nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
PL15713339T 2014-03-18 2015-03-17 Związki 3,4-diamino-6-chloropirazyno-2-karbokysamidowe do leczenia chorób mediowanych przez ENAC PL3119752T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461954674P 2014-03-18 2014-03-18
EP15713339.8A EP3119752B1 (en) 2014-03-18 2015-03-17 3,4-diamino-6-chloropyrazine-2-carboxamide compounds for the treatment of enac mediated diseases
PCT/GB2015/050765 WO2015140527A1 (en) 2014-03-18 2015-03-17 Chemical compounds

Publications (1)

Publication Number Publication Date
PL3119752T3 true PL3119752T3 (pl) 2018-09-28

Family

ID=52780553

Family Applications (1)

Application Number Title Priority Date Filing Date
PL15713339T PL3119752T3 (pl) 2014-03-18 2015-03-17 Związki 3,4-diamino-6-chloropirazyno-2-karbokysamidowe do leczenia chorób mediowanych przez ENAC

Country Status (39)

Country Link
US (3) US9873678B2 (pl)
EP (1) EP3119752B1 (pl)
JP (1) JP6502469B2 (pl)
KR (1) KR102296041B1 (pl)
CN (1) CN106103423B (pl)
AP (1) AP2016009447A0 (pl)
AR (1) AR099790A1 (pl)
AU (1) AU2015233195B2 (pl)
CA (1) CA2941807C (pl)
CL (1) CL2016002303A1 (pl)
CR (1) CR20160479A (pl)
CY (1) CY1120509T1 (pl)
DK (1) DK3119752T3 (pl)
DO (1) DOP2016000232A (pl)
EA (1) EA029952B1 (pl)
ES (1) ES2679618T3 (pl)
GT (1) GT201600190A (pl)
HR (1) HRP20181123T1 (pl)
HU (1) HUE039425T2 (pl)
IL (1) IL247610B (pl)
LT (1) LT3119752T (pl)
ME (1) ME03056B (pl)
MX (1) MX368577B (pl)
NI (1) NI201600134A (pl)
NZ (1) NZ724063A (pl)
PE (1) PE20170205A1 (pl)
PH (1) PH12016501808B1 (pl)
PL (1) PL3119752T3 (pl)
PT (1) PT3119752T (pl)
RS (1) RS57487B1 (pl)
SG (1) SG11201607751SA (pl)
SI (1) SI3119752T1 (pl)
SM (1) SMT201800378T1 (pl)
SV (1) SV2016005278A (pl)
TR (1) TR201810207T4 (pl)
TW (1) TWI687410B (pl)
UY (1) UY36034A (pl)
WO (1) WO2015140527A1 (pl)
ZA (1) ZA201607136B (pl)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7608847B2 (ja) * 2021-01-27 2025-01-07 三菱瓦斯化学株式会社 エポキシ樹脂硬化剤、エポキシ樹脂組成物、及び塗料
GB202406247D0 (en) 2024-05-03 2024-06-19 Enterprise Therapeutics Ltd Compounds and pharmaceutical compositions

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US3573306A (en) 1969-03-05 1971-03-30 Merck & Co Inc Process for preparation of n-substituted 3,5-diamino-6-halopyrazinamides
IE52345B1 (en) 1981-02-02 1987-09-16 Ici Plc Alkanolamine derivatives
DE3361244D1 (de) 1982-01-29 1986-01-02 Ici Plc Alkanolamine derivatives
GB8810933D0 (en) 1987-05-26 1988-06-15 Ici America Inc Heterocyclic compounds
GB8810934D0 (en) 1987-05-26 1988-06-15 Ici America Inc Amides
US4803206A (en) 1988-03-07 1989-02-07 Schering Corporation Antihypertensive acylpyrazines
GB8812343D0 (en) 1988-05-25 1988-06-29 Ici America Inc Amino compounds
GB8812342D0 (en) 1988-05-25 1988-06-29 Ici America Inc Bicyclic compounds
SK112899A3 (en) 1997-02-26 2001-05-10 Pfizer Heteroaryl-hexanoic acid amide derivatives, their preparation and their use as selective inhibitors of mip-1-alpha binding to its ccr1 receptor
GB9930557D0 (en) 1999-12-23 2000-02-16 Rolic Ag Optically active materials
CA2408408C (en) 2000-05-12 2013-07-09 Genzyme Corporation Modulators of tnf- alpha signaling
AR039555A1 (es) 2001-11-08 2005-02-23 Upjohn Co Derivados n,n'-sustituidos de 1,3-diamino-2-hidroxipropano
US6858615B2 (en) 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenyl guanidine sodium channel blockers
US7154002B1 (en) 2002-10-08 2006-12-26 Takeda San Diego, Inc. Histone deacetylase inhibitors
US20040087571A1 (en) 2002-10-30 2004-05-06 Pfizer Inc Methods of using CCR1 antagonists as immunomodulatory agents
EP1581499A1 (en) 2002-12-20 2005-10-05 Pfizer Products Inc. Microsomal triglyceride transfer protein inhibitors
US6903105B2 (en) 2003-02-19 2005-06-07 Parion Sciences, Inc. Sodium channel blockers
MX2007004536A (es) 2004-10-13 2007-07-17 Univ Connecticut Ligandos de lipido canabinergico.
GB0511065D0 (en) 2005-05-31 2005-07-06 Novartis Ag Organic compounds
GB0526244D0 (en) 2005-12-22 2006-02-01 Novartis Ag Organic compounds
GB0526240D0 (en) 2005-12-22 2006-02-01 Novartis Ag Organic compounds
CN101679266B (zh) 2007-03-01 2015-05-06 诺华股份有限公司 Pim激酶抑制剂及其应用方法
EP2332933A1 (en) 2007-05-07 2011-06-15 Novartis AG Epithelial sodium channel (ENaC) inhibitors
BRPI0820669A2 (pt) 2007-12-10 2020-08-04 Novartis Ag compostos orgânicos
AU2008345225A1 (en) 2007-12-21 2009-07-09 University Of Rochester Method for altering the lifespan of eukaryotic organisms
MX2010012441A (es) 2008-05-13 2010-12-06 Novartis Ag Derivados de acido 3,5-diamino-6-cloro-pirazin-2-carboxilico y su uso como bloqueadores del canal de sodio epitelial para el tratamiento de enfermedades de las vias respiratorias.
US9315449B2 (en) 2008-05-15 2016-04-19 Duke University Substituted pyrazoles as heat shock transcription factor activators
KR20110040818A (ko) 2008-06-10 2011-04-20 노파르티스 아게 상피 나트륨 채널 차단제로서의 피라진 유도체
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Also Published As

Publication number Publication date
US20180162838A1 (en) 2018-06-14
NZ724063A (en) 2018-02-23
NI201600134A (es) 2017-03-13
TWI687410B (zh) 2020-03-11
SMT201800378T1 (it) 2018-09-13
IL247610A0 (en) 2016-11-30
CL2016002303A1 (es) 2017-01-13
PH12016501808A1 (en) 2017-01-09
CY1120509T1 (el) 2019-07-10
CA2941807A1 (en) 2015-09-24
SI3119752T1 (en) 2018-08-31
DOP2016000232A (es) 2016-10-16
GT201600190A (es) 2019-07-29
EP3119752A1 (en) 2017-01-25
WO2015140527A1 (en) 2015-09-24
US20170107195A1 (en) 2017-04-20
JP2017512830A (ja) 2017-05-25
AU2015233195B2 (en) 2017-04-20
CA2941807C (en) 2023-03-07
LT3119752T (lt) 2018-08-10
UY36034A (es) 2015-09-30
EA201691641A1 (ru) 2017-02-28
TW201620880A (zh) 2016-06-16
ZA201607136B (en) 2018-04-25
HRP20181123T1 (hr) 2018-09-21
TR201810207T4 (tr) 2018-08-27
CR20160479A (es) 2017-02-24
ES2679618T3 (es) 2018-08-29
PT3119752T (pt) 2018-07-24
US20190330187A1 (en) 2019-10-31
PE20170205A1 (es) 2017-04-06
US10954211B2 (en) 2021-03-23
AU2015233195A1 (en) 2016-09-22
SG11201607751SA (en) 2016-10-28
US9873678B2 (en) 2018-01-23
CN106103423A (zh) 2016-11-09
ME03056B (me) 2018-10-20
HUE039425T2 (hu) 2018-12-28
JP6502469B2 (ja) 2019-04-17
KR20160127135A (ko) 2016-11-02
US10336725B2 (en) 2019-07-02
MX368577B (es) 2019-10-08
AR099790A1 (es) 2016-08-17
CN106103423B (zh) 2019-12-06
DK3119752T3 (en) 2018-07-30
AP2016009447A0 (en) 2016-09-30
EA029952B1 (ru) 2018-06-29
RS57487B1 (sr) 2018-10-31
EP3119752B1 (en) 2018-05-16
SV2016005278A (es) 2016-11-30
IL247610B (en) 2019-05-30
KR102296041B1 (ko) 2021-08-30
PH12016501808B1 (en) 2017-01-09
MX2016011681A (es) 2016-10-28

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