PL3152193T3 - Pochodne tetrahydroizochinolinonu i ich zastosowanie do hamowania białka hsp70 - Google Patents
Pochodne tetrahydroizochinolinonu i ich zastosowanie do hamowania białka hsp70Info
- Publication number
- PL3152193T3 PL3152193T3 PL14728177T PL14728177T PL3152193T3 PL 3152193 T3 PL3152193 T3 PL 3152193T3 PL 14728177 T PL14728177 T PL 14728177T PL 14728177 T PL14728177 T PL 14728177T PL 3152193 T3 PL3152193 T3 PL 3152193T3
- Authority
- PL
- Poland
- Prior art keywords
- inhibition
- hsp70 protein
- tetrahydroisoquinolinone
- derivatives
- tetrahydroisoquinolinone derivatives
- Prior art date
Links
- NTNKZGHUNBWBBV-UHFFFAOYSA-N 3,4,4a,5-tetrahydro-2h-isoquinolin-1-one Chemical class C1C=CC=C2C(=O)NCCC21 NTNKZGHUNBWBBV-UHFFFAOYSA-N 0.000 title 1
- 101100125027 Dictyostelium discoideum mhsp70 gene Proteins 0.000 title 1
- 101150031823 HSP70 gene Proteins 0.000 title 1
- 101150052825 dnaK gene Proteins 0.000 title 1
- 230000005764 inhibitory process Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2014/061495 WO2015185114A1 (en) | 2014-06-03 | 2014-06-03 | Tetrahydroisoquinolinone derivatives and their use in the inhibition of the hsp70 protein |
| EP14728177.8A EP3152193B1 (en) | 2014-06-03 | 2014-06-03 | Tetrahydroisoquinolinone derivatives and their use in the inhibition of the hsp70 protein |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3152193T3 true PL3152193T3 (pl) | 2018-10-31 |
Family
ID=50884916
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL14728177T PL3152193T3 (pl) | 2014-06-03 | 2014-06-03 | Pochodne tetrahydroizochinolinonu i ich zastosowanie do hamowania białka hsp70 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US9975853B2 (pl) |
| EP (1) | EP3152193B1 (pl) |
| DK (1) | DK3152193T3 (pl) |
| ES (1) | ES2674845T3 (pl) |
| HR (1) | HRP20180935T1 (pl) |
| HU (1) | HUE039216T2 (pl) |
| LT (1) | LT3152193T (pl) |
| PL (1) | PL3152193T3 (pl) |
| PT (1) | PT3152193T (pl) |
| RS (1) | RS57398B1 (pl) |
| SI (1) | SI3152193T1 (pl) |
| TR (1) | TR201808915T4 (pl) |
| WO (1) | WO2015185114A1 (pl) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5916899A (en) * | 1996-10-18 | 1999-06-29 | Trega Biosciences, Inc. | Isoquinoline derivatives and isoquinoline combinatorial libraries |
| US20050124614A1 (en) * | 2002-07-03 | 2005-06-09 | Axys Pharmaceuticals, Inc. | 3,4-Dihydroisoquinolin-1-one derivatives as inducers of apoptosis |
-
2014
- 2014-06-03 ES ES14728177.8T patent/ES2674845T3/es active Active
- 2014-06-03 DK DK14728177.8T patent/DK3152193T3/en active
- 2014-06-03 SI SI201430769T patent/SI3152193T1/en unknown
- 2014-06-03 HU HUE14728177A patent/HUE039216T2/hu unknown
- 2014-06-03 LT LTEP14728177.8T patent/LT3152193T/lt unknown
- 2014-06-03 RS RS20180687A patent/RS57398B1/sr unknown
- 2014-06-03 PL PL14728177T patent/PL3152193T3/pl unknown
- 2014-06-03 EP EP14728177.8A patent/EP3152193B1/en active Active
- 2014-06-03 HR HRP20180935TT patent/HRP20180935T1/hr unknown
- 2014-06-03 TR TR2018/08915T patent/TR201808915T4/tr unknown
- 2014-06-03 PT PT147281778T patent/PT3152193T/pt unknown
- 2014-06-03 US US15/316,279 patent/US9975853B2/en active Active
- 2014-06-03 WO PCT/EP2014/061495 patent/WO2015185114A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| SI3152193T1 (en) | 2018-08-31 |
| US20170152229A1 (en) | 2017-06-01 |
| US9975853B2 (en) | 2018-05-22 |
| EP3152193A1 (en) | 2017-04-12 |
| HRP20180935T1 (hr) | 2018-08-10 |
| ES2674845T3 (es) | 2018-07-04 |
| PT3152193T (pt) | 2018-06-28 |
| LT3152193T (lt) | 2018-08-10 |
| HUE039216T2 (hu) | 2018-12-28 |
| WO2015185114A1 (en) | 2015-12-10 |
| RS57398B1 (sr) | 2018-09-28 |
| DK3152193T3 (en) | 2018-07-16 |
| EP3152193B1 (en) | 2018-03-28 |
| TR201808915T4 (tr) | 2018-07-23 |
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