PL3155011T3 - Mutacje receptora hormonu glikoproteinowego - Google Patents
Mutacje receptora hormonu glikoproteinowegoInfo
- Publication number
- PL3155011T3 PL3155011T3 PL15738404T PL15738404T PL3155011T3 PL 3155011 T3 PL3155011 T3 PL 3155011T3 PL 15738404 T PL15738404 T PL 15738404T PL 15738404 T PL15738404 T PL 15738404T PL 3155011 T3 PL3155011 T3 PL 3155011T3
- Authority
- PL
- Poland
- Prior art keywords
- hormone receptor
- glycoprotein hormone
- receptor mutations
- mutations
- glycoprotein
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
- C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1796—Receptors; Cell surface antigens; Cell surface determinants for hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/535—Production of labelled immunochemicals with enzyme label or co-enzymes, co-factors, enzyme inhibitors or enzyme substrates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/577—Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
- G01N33/78—Thyroid gland hormones, e.g. T3, T4, TBH, TBG or their receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
- G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plant Pathology (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1410409.5A GB2527286A (en) | 2014-06-11 | 2014-06-11 | Glycoprotein hormone receptor mutations |
| PCT/GB2015/000171 WO2015189543A2 (en) | 2014-06-11 | 2015-06-11 | Glycoprotein hormone receptor mutations |
| EP15738404.1A EP3155011B1 (en) | 2014-06-11 | 2015-06-11 | Glycoprotein hormone receptor mutations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3155011T3 true PL3155011T3 (pl) | 2022-02-28 |
Family
ID=51267071
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL15738404T PL3155011T3 (pl) | 2014-06-11 | 2015-06-11 | Mutacje receptora hormonu glikoproteinowego |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US11732026B2 (pl) |
| EP (1) | EP3155011B1 (pl) |
| JP (2) | JP7223490B2 (pl) |
| CN (1) | CN106573968B (pl) |
| ES (1) | ES2901958T3 (pl) |
| GB (1) | GB2527286A (pl) |
| PL (1) | PL3155011T3 (pl) |
| WO (1) | WO2015189543A2 (pl) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2527286A (en) | 2014-06-11 | 2015-12-23 | Rsr Ltd | Glycoprotein hormone receptor mutations |
| US11865166B2 (en) * | 2016-08-29 | 2024-01-09 | The Trustees Of The University Of Pennsylvania | Nucleic acid encoding optimized immunogenic peptide that targets follicle stimulating hormone receptor |
| KR102676582B1 (ko) | 2018-07-25 | 2024-06-20 | 주식회사유한양행 | 갑상선 자극 호르몬 수용기(thyrotropin receptor, TSHR) 단편을 포함하는 융합 단백질 및 이의 용도 |
| CN116254253B (zh) * | 2022-11-11 | 2024-06-28 | 浙大宁波理工学院 | 一种通过dna合成改组组合突变获得的谷氨酸脱羧酶突变体及应用 |
| WO2026028159A1 (en) | 2024-07-31 | 2026-02-05 | Biohaven Therapeutics Ltd. | Bifunctional degraders for the treatment of graves' disease |
| CN118897090B (zh) * | 2024-09-30 | 2025-06-06 | 美康生物科技股份有限公司 | 一种刺激性促甲状腺激素受体抗体亚型检测试剂盒及其制备方法与应用 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9909661D0 (en) | 1998-06-06 | 1999-06-23 | Rsr Ltd | Assays for TSH receptor autoantibodies |
| US20040132101A1 (en) * | 2002-09-27 | 2004-07-08 | Xencor | Optimized Fc variants and methods for their generation |
| WO2004050708A2 (en) | 2002-11-29 | 2004-06-17 | Rsr Limited | Antibody for the thyrotropin receptor and uses thereof |
| GB0418181D0 (en) | 2004-08-13 | 2004-09-15 | Rsr Ltd | Thyrotrophin receptor preparations,thyrotrophin receptor epitopes,antibody and hormone interactions therewith,and uses thereof |
| EP1991679A2 (fr) | 2006-03-08 | 2008-11-19 | Biomethodes | Variants de l'interferon- gamma humain (ifngamma) |
| CN101595129B (zh) | 2006-08-30 | 2017-12-08 | Rsr有限公司 | Thsr受体的晶体结构 |
| US8097699B2 (en) * | 2006-08-30 | 2012-01-17 | Rsr Limited | Crystal structure of thyroid stimulating hormone receptor |
| PL2121758T3 (pl) | 2007-02-15 | 2015-02-27 | R S R Ltd | Ludzkie przeciwciała monoklonalne przeciwko receptorowi tyreotropiny, które działają jako antagoniści |
| GB2456236B8 (en) * | 2007-03-22 | 2009-12-09 | Heptares Therapeutics Ltd | Stable muscarinic receptor mutants |
| WO2008143910A2 (en) * | 2007-05-18 | 2008-11-27 | University Of Massachusetts | A strategy for cloning and expressing the extracellular domains of receptors as soluble proteins |
| GB0808402D0 (en) * | 2008-05-09 | 2008-06-18 | Asterion Ltd | Tsh |
| JP5784504B2 (ja) | 2008-12-24 | 2015-09-24 | アールエスアール リミテッド | ヒト抗tshr抗体 |
| US9782454B2 (en) * | 2010-04-22 | 2017-10-10 | Longevity Biotech, Inc. | Highly active polypeptides and methods of making and using the same |
| WO2012098413A1 (en) * | 2011-01-21 | 2012-07-26 | Heptares Therapeutics Limited | Mutant g-protein coupled receptor proteins and methods for producing them |
| AU2012220558A1 (en) | 2011-02-23 | 2013-08-22 | Massachusetts Institute Of Technology | Water soluble membrane proteins and methods for the preparation and use thereof |
| US9169309B2 (en) * | 2011-03-01 | 2015-10-27 | Humanzyme Inc. | Thermostable variants of fibroblast growth factors |
| CN102344966B (zh) * | 2011-10-21 | 2013-08-07 | 浙江省疾病预防控制中心 | 促甲状腺激素受体基因突变位点检测试剂盒、使用方法和应用 |
| GB2527286A (en) | 2014-06-11 | 2015-12-23 | Rsr Ltd | Glycoprotein hormone receptor mutations |
-
2014
- 2014-06-11 GB GB1410409.5A patent/GB2527286A/en not_active Withdrawn
-
2015
- 2015-06-11 WO PCT/GB2015/000171 patent/WO2015189543A2/en not_active Ceased
- 2015-06-11 PL PL15738404T patent/PL3155011T3/pl unknown
- 2015-06-11 JP JP2016572716A patent/JP7223490B2/ja active Active
- 2015-06-11 CN CN201580043074.6A patent/CN106573968B/zh active Active
- 2015-06-11 EP EP15738404.1A patent/EP3155011B1/en active Active
- 2015-06-11 US US15/317,687 patent/US11732026B2/en active Active
- 2015-06-11 ES ES15738404T patent/ES2901958T3/es active Active
-
2022
- 2022-02-10 JP JP2022019621A patent/JP2022078064A/ja active Pending
-
2023
- 2023-06-16 US US18/336,792 patent/US20240043498A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| GB201410409D0 (en) | 2014-07-23 |
| US20240043498A1 (en) | 2024-02-08 |
| CN106573968A (zh) | 2017-04-19 |
| EP3155011B1 (en) | 2021-11-10 |
| CN106573968B (zh) | 2021-12-21 |
| WO2015189543A2 (en) | 2015-12-17 |
| JP2022078064A (ja) | 2022-05-24 |
| US20170204159A1 (en) | 2017-07-20 |
| US11732026B2 (en) | 2023-08-22 |
| EP3155011A2 (en) | 2017-04-19 |
| GB2527286A (en) | 2015-12-23 |
| JP2017520246A (ja) | 2017-07-27 |
| ES2901958T3 (es) | 2022-03-24 |
| JP7223490B2 (ja) | 2023-02-16 |
| WO2015189543A3 (en) | 2016-02-25 |
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