PL3157577T3 - Automatyczna platforma technologii produkcji radiofarmaceutyków astatyna-211 [at-211] - Google Patents
Automatyczna platforma technologii produkcji radiofarmaceutyków astatyna-211 [at-211]Info
- Publication number
- PL3157577T3 PL3157577T3 PL15809093T PL15809093T PL3157577T3 PL 3157577 T3 PL3157577 T3 PL 3157577T3 PL 15809093 T PL15809093 T PL 15809093T PL 15809093 T PL15809093 T PL 15809093T PL 3157577 T3 PL3157577 T3 PL 3157577T3
- Authority
- PL
- Poland
- Prior art keywords
- astatine
- radiopharmaceuticals
- production
- automatic process
- process platform
- Prior art date
Links
- RYXHOMYVWAEKHL-OUBTZVSYSA-N astatine-211 Chemical compound [211At] RYXHOMYVWAEKHL-OUBTZVSYSA-N 0.000 title 1
- 229940121896 radiopharmaceutical Drugs 0.000 title 1
- 239000012217 radiopharmaceutical Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/008—Peptides; Proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
- A61K51/1051—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants the tumor cell being from breast, e.g. the antibody being herceptin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
- G21G1/001—Recovery of specific isotopes from irradiated targets
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
- G21G1/001—Recovery of specific isotopes from irradiated targets
- G21G2001/0094—Other isotopes not provided for in the groups listed above
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Physics & Mathematics (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Optics & Photonics (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cell Biology (AREA)
- General Engineering & Computer Science (AREA)
- Engineering & Computer Science (AREA)
- High Energy & Nuclear Physics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462013678P | 2014-06-18 | 2014-06-18 | |
| PCT/SE2015/050714 WO2015195042A1 (en) | 2014-06-18 | 2015-06-17 | AUTOMATIC PROCESS PLATFORM FOR THE PRODUCTION OF ASTATINE-211 [At-211]-RADIOPHARMACEUTICALS |
| EP15809093.6A EP3157577B8 (en) | 2014-06-18 | 2015-06-17 | AUTOMATIC PROCESS PLATFORM FOR THE PRODUCTION OF ASTATINE-211 [At-211]-RADIOPHARMACEUTICALS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3157577T3 true PL3157577T3 (pl) | 2021-04-19 |
Family
ID=54935878
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL15809093T PL3157577T3 (pl) | 2014-06-18 | 2015-06-17 | Automatyczna platforma technologii produkcji radiofarmaceutyków astatyna-211 [at-211] |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US10829423B2 (pl) |
| EP (1) | EP3157577B8 (pl) |
| JP (1) | JP6830435B2 (pl) |
| CN (1) | CN107073141B (pl) |
| DK (1) | DK3157577T3 (pl) |
| ES (1) | ES2843625T3 (pl) |
| PL (1) | PL3157577T3 (pl) |
| WO (1) | WO2015195042A1 (pl) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2552151A (en) | 2016-07-08 | 2018-01-17 | Univ Oslo | Cyclotron target |
| WO2019112034A1 (ja) * | 2017-12-07 | 2019-06-13 | 国立大学法人大阪大学 | アスタチンの製造方法 |
| US11684683B2 (en) | 2017-12-29 | 2023-06-27 | Osaka University | Astatine solution and method for producing same |
| AU2019233065A1 (en) * | 2018-03-15 | 2020-10-29 | Osaka University | Radionuclide preparation system, storage medium readable by computer storing radionuclide preparation program, radionuclide preparation method, and terminal device |
| US11776705B1 (en) * | 2020-01-16 | 2023-10-03 | Innosense Llc | High temperature and high beam current compatible targets and methods thereof for generating noble gas/radiohalogen generators for medical isotopes |
| CN114242299B (zh) * | 2021-11-10 | 2025-07-01 | 砹尔法纽克莱(宁波)医疗科技有限公司 | 用于制备靶向核素药的回旋加速器金属复合靶材 |
| CN114249301B (zh) * | 2021-11-10 | 2023-06-16 | 砹尔法纽克莱(宁波)医疗科技有限公司 | 一种洗脱溶液及用于靶向核素药的放射性核素砹-211的制备方法 |
| KR20240141730A (ko) * | 2021-12-14 | 2024-09-27 | 더 텍사스 에이 & 엠 유니버시티 시스템 | 아스타틴의 자동화 분리 및 회수를 위한 시스템 및 방법 |
| JP2025541964A (ja) | 2022-11-05 | 2025-12-24 | アトレー ソリューションズ アクチボラグ | 放射性物質のための自動スクレーパ |
| WO2025134775A1 (ja) * | 2023-12-18 | 2025-06-26 | 住友重機械工業株式会社 | 乾式放射性同位元素精製装置 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4681727A (en) * | 1984-04-10 | 1987-07-21 | The United States Of America As Represented By The United States Department Of Energy | Process for producing astatine-211 for radiopharmaceutical use |
| EP0203764B1 (en) | 1985-05-17 | 1993-03-24 | Neorx Corporation | Radiohalogenated small molecules for protein labeling |
| US4826672A (en) * | 1985-06-07 | 1989-05-02 | President And Fellows Of Harvard College | Astatinated organic compounds |
| US5102651A (en) | 1989-12-29 | 1992-04-07 | Neorx Corporation | Process for isolation and radiolabeling of pharmaceuticals with isotopes of astatine |
| DE4239344A1 (en) * | 1991-12-20 | 1993-06-24 | Sulzer Ag | Robotic machining of workpieces using scraping process - involves manipulating workpiece so that features to be machined are drawn past scraper blade under controlled pressure |
| NO314537B1 (no) | 1999-12-06 | 2003-04-07 | Anticancer Therapeutic Inv Sa | Reseptorbindende konjugater |
| US6749830B2 (en) * | 2001-01-31 | 2004-06-15 | Centre For Addiction And Mental Health | Method for the synthesis of radiolabeled compounds |
| WO2003064678A2 (en) | 2002-01-31 | 2003-08-07 | Bioscan, Inc. | Apparatus for synthesis of radiolabeled compounds |
| WO2005003151A2 (en) | 2003-06-25 | 2005-01-13 | Peregrine Pharmaceuticals, Inc. | Method and apparatus for continuous large-scale radiolabeling of proteins |
| AU2003904201A0 (en) | 2003-08-11 | 2003-08-21 | Allen, Barry John Mr | Alpha-conjugate of C595 for therapy of pancreatic, prostate and other cancers |
| US8337810B2 (en) | 2005-12-22 | 2012-12-25 | Duke University | Stabilized compositions and methods for radiolabeling pharmaceuticals with alpha-particle emitters |
| US8951480B2 (en) | 2008-08-19 | 2015-02-10 | The Regents Of The University Of California | Modular radiochemistry synthesis system |
| US8273300B2 (en) | 2009-07-09 | 2012-09-25 | Siemens Medical Solutions Usa, Inc. | Modular system for radiosynthesis with multi-run capabilities and reduced risk of radiation exposure |
| US8435454B2 (en) * | 2009-07-09 | 2013-05-07 | Siemens Medical Solutions Usa, Inc. | Modular system for radiosynthesis with multi-run capabilities and reduced risk of radiation exposure |
-
2015
- 2015-06-17 PL PL15809093T patent/PL3157577T3/pl unknown
- 2015-06-17 DK DK15809093.6T patent/DK3157577T3/da active
- 2015-06-17 ES ES15809093T patent/ES2843625T3/es active Active
- 2015-06-17 CN CN201580032763.7A patent/CN107073141B/zh active Active
- 2015-06-17 EP EP15809093.6A patent/EP3157577B8/en active Active
- 2015-06-17 JP JP2017519443A patent/JP6830435B2/ja active Active
- 2015-06-17 US US15/530,265 patent/US10829423B2/en active Active
- 2015-06-17 WO PCT/SE2015/050714 patent/WO2015195042A1/en not_active Ceased
-
2020
- 2020-10-01 US US17/060,810 patent/US11851383B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN107073141B (zh) | 2021-06-29 |
| US11851383B2 (en) | 2023-12-26 |
| US10829423B2 (en) | 2020-11-10 |
| EP3157577B8 (en) | 2020-12-23 |
| EP3157577A1 (en) | 2017-04-26 |
| US20210139389A1 (en) | 2021-05-13 |
| DK3157577T3 (da) | 2021-01-18 |
| JP2017528512A (ja) | 2017-09-28 |
| EP3157577B1 (en) | 2020-10-28 |
| US20180215680A1 (en) | 2018-08-02 |
| JP6830435B2 (ja) | 2021-02-17 |
| ES2843625T3 (es) | 2021-07-19 |
| WO2015195042A1 (en) | 2015-12-23 |
| CN107073141A (zh) | 2017-08-18 |
| EP3157577A4 (en) | 2018-03-07 |
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