PL3157577T3 - Automatyczna platforma technologii produkcji radiofarmaceutyków astatyna-211 [at-211] - Google Patents

Automatyczna platforma technologii produkcji radiofarmaceutyków astatyna-211 [at-211]

Info

Publication number
PL3157577T3
PL3157577T3 PL15809093T PL15809093T PL3157577T3 PL 3157577 T3 PL3157577 T3 PL 3157577T3 PL 15809093 T PL15809093 T PL 15809093T PL 15809093 T PL15809093 T PL 15809093T PL 3157577 T3 PL3157577 T3 PL 3157577T3
Authority
PL
Poland
Prior art keywords
astatine
radiopharmaceuticals
production
automatic process
process platform
Prior art date
Application number
PL15809093T
Other languages
English (en)
Inventor
Sture LINDEGREN
Emma ANEHEIM
Original Assignee
Alpha Therapy Solutions Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alpha Therapy Solutions Ab filed Critical Alpha Therapy Solutions Ab
Publication of PL3157577T3 publication Critical patent/PL3157577T3/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/008Peptides; Proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/08Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1045Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
    • A61K51/1051Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants the tumor cell being from breast, e.g. the antibody being herceptin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/08Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1045Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • GPHYSICS
    • G21NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21GCONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
    • G21G1/00Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
    • G21G1/001Recovery of specific isotopes from irradiated targets
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05Isotopically modified compounds, e.g. labelled
    • GPHYSICS
    • G21NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21GCONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
    • G21G1/00Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
    • G21G1/001Recovery of specific isotopes from irradiated targets
    • G21G2001/0094Other isotopes not provided for in the groups listed above

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Engineering & Computer Science (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
PL15809093T 2014-06-18 2015-06-17 Automatyczna platforma technologii produkcji radiofarmaceutyków astatyna-211 [at-211] PL3157577T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462013678P 2014-06-18 2014-06-18
PCT/SE2015/050714 WO2015195042A1 (en) 2014-06-18 2015-06-17 AUTOMATIC PROCESS PLATFORM FOR THE PRODUCTION OF ASTATINE-211 [At-211]-RADIOPHARMACEUTICALS
EP15809093.6A EP3157577B8 (en) 2014-06-18 2015-06-17 AUTOMATIC PROCESS PLATFORM FOR THE PRODUCTION OF ASTATINE-211 [At-211]-RADIOPHARMACEUTICALS

Publications (1)

Publication Number Publication Date
PL3157577T3 true PL3157577T3 (pl) 2021-04-19

Family

ID=54935878

Family Applications (1)

Application Number Title Priority Date Filing Date
PL15809093T PL3157577T3 (pl) 2014-06-18 2015-06-17 Automatyczna platforma technologii produkcji radiofarmaceutyków astatyna-211 [at-211]

Country Status (8)

Country Link
US (2) US10829423B2 (pl)
EP (1) EP3157577B8 (pl)
JP (1) JP6830435B2 (pl)
CN (1) CN107073141B (pl)
DK (1) DK3157577T3 (pl)
ES (1) ES2843625T3 (pl)
PL (1) PL3157577T3 (pl)
WO (1) WO2015195042A1 (pl)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2552151A (en) 2016-07-08 2018-01-17 Univ Oslo Cyclotron target
WO2019112034A1 (ja) * 2017-12-07 2019-06-13 国立大学法人大阪大学 アスタチンの製造方法
US11684683B2 (en) 2017-12-29 2023-06-27 Osaka University Astatine solution and method for producing same
AU2019233065A1 (en) * 2018-03-15 2020-10-29 Osaka University Radionuclide preparation system, storage medium readable by computer storing radionuclide preparation program, radionuclide preparation method, and terminal device
US11776705B1 (en) * 2020-01-16 2023-10-03 Innosense Llc High temperature and high beam current compatible targets and methods thereof for generating noble gas/radiohalogen generators for medical isotopes
CN114242299B (zh) * 2021-11-10 2025-07-01 砹尔法纽克莱(宁波)医疗科技有限公司 用于制备靶向核素药的回旋加速器金属复合靶材
CN114249301B (zh) * 2021-11-10 2023-06-16 砹尔法纽克莱(宁波)医疗科技有限公司 一种洗脱溶液及用于靶向核素药的放射性核素砹-211的制备方法
KR20240141730A (ko) * 2021-12-14 2024-09-27 더 텍사스 에이 & 엠 유니버시티 시스템 아스타틴의 자동화 분리 및 회수를 위한 시스템 및 방법
JP2025541964A (ja) 2022-11-05 2025-12-24 アトレー ソリューションズ アクチボラグ 放射性物質のための自動スクレーパ
WO2025134775A1 (ja) * 2023-12-18 2025-06-26 住友重機械工業株式会社 乾式放射性同位元素精製装置

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4681727A (en) * 1984-04-10 1987-07-21 The United States Of America As Represented By The United States Department Of Energy Process for producing astatine-211 for radiopharmaceutical use
EP0203764B1 (en) 1985-05-17 1993-03-24 Neorx Corporation Radiohalogenated small molecules for protein labeling
US4826672A (en) * 1985-06-07 1989-05-02 President And Fellows Of Harvard College Astatinated organic compounds
US5102651A (en) 1989-12-29 1992-04-07 Neorx Corporation Process for isolation and radiolabeling of pharmaceuticals with isotopes of astatine
DE4239344A1 (en) * 1991-12-20 1993-06-24 Sulzer Ag Robotic machining of workpieces using scraping process - involves manipulating workpiece so that features to be machined are drawn past scraper blade under controlled pressure
NO314537B1 (no) 1999-12-06 2003-04-07 Anticancer Therapeutic Inv Sa Reseptorbindende konjugater
US6749830B2 (en) * 2001-01-31 2004-06-15 Centre For Addiction And Mental Health Method for the synthesis of radiolabeled compounds
WO2003064678A2 (en) 2002-01-31 2003-08-07 Bioscan, Inc. Apparatus for synthesis of radiolabeled compounds
WO2005003151A2 (en) 2003-06-25 2005-01-13 Peregrine Pharmaceuticals, Inc. Method and apparatus for continuous large-scale radiolabeling of proteins
AU2003904201A0 (en) 2003-08-11 2003-08-21 Allen, Barry John Mr Alpha-conjugate of C595 for therapy of pancreatic, prostate and other cancers
US8337810B2 (en) 2005-12-22 2012-12-25 Duke University Stabilized compositions and methods for radiolabeling pharmaceuticals with alpha-particle emitters
US8951480B2 (en) 2008-08-19 2015-02-10 The Regents Of The University Of California Modular radiochemistry synthesis system
US8273300B2 (en) 2009-07-09 2012-09-25 Siemens Medical Solutions Usa, Inc. Modular system for radiosynthesis with multi-run capabilities and reduced risk of radiation exposure
US8435454B2 (en) * 2009-07-09 2013-05-07 Siemens Medical Solutions Usa, Inc. Modular system for radiosynthesis with multi-run capabilities and reduced risk of radiation exposure

Also Published As

Publication number Publication date
CN107073141B (zh) 2021-06-29
US11851383B2 (en) 2023-12-26
US10829423B2 (en) 2020-11-10
EP3157577B8 (en) 2020-12-23
EP3157577A1 (en) 2017-04-26
US20210139389A1 (en) 2021-05-13
DK3157577T3 (da) 2021-01-18
JP2017528512A (ja) 2017-09-28
EP3157577B1 (en) 2020-10-28
US20180215680A1 (en) 2018-08-02
JP6830435B2 (ja) 2021-02-17
ES2843625T3 (es) 2021-07-19
WO2015195042A1 (en) 2015-12-23
CN107073141A (zh) 2017-08-18
EP3157577A4 (en) 2018-03-07

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