PL3186395T3 - Wszczepienie komórek macierzystych z kombinacją środka, który celuje w komórki macierzyste i modulowanie sygnałowania immunoregulatorowego - Google Patents

Wszczepienie komórek macierzystych z kombinacją środka, który celuje w komórki macierzyste i modulowanie sygnałowania immunoregulatorowego

Info

Publication number
PL3186395T3
PL3186395T3 PL15835482T PL15835482T PL3186395T3 PL 3186395 T3 PL3186395 T3 PL 3186395T3 PL 15835482 T PL15835482 T PL 15835482T PL 15835482 T PL15835482 T PL 15835482T PL 3186395 T3 PL3186395 T3 PL 3186395T3
Authority
PL
Poland
Prior art keywords
stem cells
engraftment
modulation
agent
combination
Prior art date
Application number
PL15835482T
Other languages
English (en)
Other versions
PL3186395T5 (pl
Inventor
Judith A. Shizuru
Kipp Andrew WEISKOPF
Aaron Michael RING
Akanksha CHHABRA
Peter SCHNORR
Irving L. Weissman
Original Assignee
The Board Of Trustees Of The Leland Stanford Junior University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=55400510&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL3186395(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by The Board Of Trustees Of The Leland Stanford Junior University filed Critical The Board Of Trustees Of The Leland Stanford Junior University
Publication of PL3186395T3 publication Critical patent/PL3186395T3/pl
Publication of PL3186395T5 publication Critical patent/PL3186395T5/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1793—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/74—Inducing cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Developmental Biology & Embryology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Transplantation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Oncology (AREA)
PL15835482.9T 2014-08-26 2015-08-26 Wszczepienie komórek macierzystych z kombinacją środka, który celuje w komórki macierzyste i modulowanie sygnałowania immunoregulatorowego PL3186395T5 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462041989P 2014-08-26 2014-08-26
PCT/US2015/046976 WO2016033201A1 (en) 2014-08-26 2015-08-26 Engraftment of stem cells with a combination of an agent that targets stem cells and modulation of immunoregulatory signaling
EP15835482.9A EP3186395B2 (en) 2014-08-26 2015-08-26 Engraftment of stem cells with a combination of an agent that targets stem cells and modulation of immunoregulatory signaling

Publications (2)

Publication Number Publication Date
PL3186395T3 true PL3186395T3 (pl) 2020-02-28
PL3186395T5 PL3186395T5 (pl) 2023-06-12

Family

ID=55400510

Family Applications (2)

Application Number Title Priority Date Filing Date
PL19198976.3T PL3656869T5 (pl) 2014-08-26 2015-08-26 Wszczepienie komórek macierzystych z kombinacją środka, który celuje w komórki macierzyste i modulowanie sygnałowania immunoregulatorowego
PL15835482.9T PL3186395T5 (pl) 2014-08-26 2015-08-26 Wszczepienie komórek macierzystych z kombinacją środka, który celuje w komórki macierzyste i modulowanie sygnałowania immunoregulatorowego

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PL19198976.3T PL3656869T5 (pl) 2014-08-26 2015-08-26 Wszczepienie komórek macierzystych z kombinacją środka, który celuje w komórki macierzyste i modulowanie sygnałowania immunoregulatorowego

Country Status (14)

Country Link
US (4) US10406179B2 (pl)
EP (4) EP3186395B2 (pl)
CA (2) CA3229961A1 (pl)
CY (1) CY1123730T1 (pl)
DK (2) DK3186395T4 (pl)
ES (3) ES2763248T5 (pl)
FI (2) FI3186395T4 (pl)
HR (1) HRP20210057T4 (pl)
HU (2) HUE052725T2 (pl)
LT (1) LT3656869T (pl)
PL (2) PL3656869T5 (pl)
PT (2) PT3656869T (pl)
SI (1) SI3656869T2 (pl)
WO (1) WO2016033201A1 (pl)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT2804617T (lt) * 2012-01-17 2020-09-10 The Board Of Trustees Of The Leland Stanford Junior University Didelio giminingumo sirp-alfa reagentai
PL3656869T5 (pl) 2014-08-26 2025-06-09 The Board Of Trustees Of The Leland Stanford Junior University Wszczepienie komórek macierzystych z kombinacją środka, który celuje w komórki macierzyste i modulowanie sygnałowania immunoregulatorowego
US10550187B2 (en) * 2014-10-24 2020-02-04 Incept, Llc Extra luminal scaffold
IL287952B2 (en) 2015-04-06 2024-11-01 Harvard College Compositions and methods for non-myeloablative conditioning
HRP20211167T1 (hr) 2015-08-07 2021-10-15 ALX Oncology Inc. Konstrukcije koje imaju sirp-alfa domenu ili njihove varijante
SI3341015T2 (sl) 2015-08-26 2024-03-29 The Board Of Trustees Of The Leland Stanford, Junior University Izboljšana deplecija ciljanih celic z blokado CD47 in imunostimulatornim agonistom
JP7062647B2 (ja) * 2016-06-17 2022-05-06 マジェンタ セラピューティクス インコーポレイテッド Ｃｄ１１７＋細胞を枯渇させるための組成物及び方法
JOP20190009A1 (ar) 2016-09-21 2019-01-27 Alx Oncology Inc أجسام مضادة ضد بروتين ألفا منظم للإشارات وطرق استخدامها
WO2018134787A2 (en) 2017-01-20 2018-07-26 Magenta Therapeutics, Inc. Compositions and methods for the depletion of cd137+ cells
IL301075B2 (en) 2017-01-30 2024-05-01 Univ Leland Stanford Junior A genotoxic matching regimen for stem cell transplantation
WO2018165015A1 (en) 2017-03-09 2018-09-13 The Board Of Trustees Of The Leland Stanford Junior University Treatment of pediatric brain tumors with targeting of cd47 pathway
CA3071860A1 (en) 2017-08-02 2019-02-07 Phanes Therapeutics, Inc. Anti-cd47 antibodies and uses thereof
US20200308280A1 (en) * 2017-10-25 2020-10-01 Actinium Pharmaceuticals, Inc. Methods for cancer treatment using a radiolabeled anti-cd45 immunoglobulin and adoptive cell therapies
US11642379B2 (en) * 2017-12-08 2023-05-09 The Board Of Trustees Of The Leland Stanford Junior University Hematopoietic stem cell engraftment
CN112040979A (zh) 2018-03-21 2020-12-04 Alx肿瘤生物技术公司 针对信号调控蛋白α的抗体和使用方法
JP7642531B2 (ja) 2018-05-11 2025-03-10 ビーム セラピューティクス インク． プログラム可能塩基エディターシステムを用いて病原性アミノ酸を置換する方法
JP2021526525A (ja) * 2018-06-07 2021-10-07 マジェンタ セラピューティクス インコーポレイテッドＭａｇｅｎｔａ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． 抗体薬物コンジュゲート（ａｄｃｓ）を用いた治療方法
TW202028237A (zh) 2018-09-27 2020-08-01 美商西建公司 SIRPα結合蛋白及其使用方法
US11591390B2 (en) 2018-09-27 2023-02-28 Celgene Corporation SIRP-α binding proteins and methods of use thereof
US12331320B2 (en) 2018-10-10 2025-06-17 The Research Foundation For The State University Of New York Genome edited cancer cell vaccines
PE20211786A1 (es) 2018-11-26 2021-09-09 Forty Seven Inc Anticuerpos humanizados contra c-kit
AU2019390394C1 (en) 2018-11-28 2024-11-28 Forty Seven, LLC Genetically modified HSPCs resistant to ablation regime
EP3958879A4 (en) * 2019-04-25 2023-05-10 Actinium Pharmaceuticals, Inc. Compositions and methods of immunodepletion for the treatment of malignant and non-malignant hematological diseases
EP3976658A4 (en) * 2019-05-24 2023-06-07 Forty Seven, Inc. Regimes for co-administration of immunotherapeutic agents against c-kit and cd47
US11613564B2 (en) 2019-05-31 2023-03-28 ALX Oncology Inc. Methods of treating cancer
JP7713447B2 (ja) 2019-11-27 2025-07-25 エーエルエックス オンコロジー インコーポレイテッド がんを治療するための組み合わせ療法
US20240000847A1 (en) * 2020-11-06 2024-01-04 Bluebird Bio, Inc. Methods
US12098214B2 (en) 2021-05-13 2024-09-24 ALX Oncology Inc. Combination therapies for treating cancer
EP4479084A1 (en) 2022-02-14 2024-12-25 Sana Biotechnology, Inc. Methods of treating patients exhibiting a prior failed therapy with hypoimmunogenic cells
US20250171536A1 (en) * 2022-03-01 2025-05-29 CSL Innovation Pty Ltd Methods of Bone Marrow Conditioning
WO2023183313A1 (en) 2022-03-22 2023-09-28 Sana Biotechnology, Inc. Engineering cells with a transgene in b2m or ciita locus and associated compositions and methods
WO2023183555A1 (en) * 2022-03-25 2023-09-28 Memorial Sloan-Kettering Cancer Center Method of promoting thymic recovery by administering hematopoietic stem cells with low c-kit expression
WO2024040195A1 (en) 2022-08-17 2024-02-22 Capstan Therapeutics, Inc. Conditioning for in vivo immune cell engineering
CN121666232A (zh) 2023-05-31 2026-03-13 开普斯坦治疗公司 脂质纳米颗粒制剂和组合物
EP4516807A1 (en) 2023-08-28 2025-03-05 Consorcio Centro de Investigación Biomédica en Red Compositions for use in a method of providing improved hematopoietic stem cell engraftment
WO2025076113A1 (en) 2023-10-05 2025-04-10 Capstan Therapeutics, Inc. Ionizable cationic lipids with conserved spacing and lipid nanoparticles
US20250127728A1 (en) 2023-10-05 2025-04-24 Capstan Therapeutics, Inc. Constrained Ionizable Cationic Lipids and Lipid Nanoparticles
WO2025217452A1 (en) 2024-04-11 2025-10-16 Capstan Therapeutics, Inc. Constrained ionizable cationic lipids and lipid nanoparticles
WO2025217454A2 (en) 2024-04-11 2025-10-16 Capstan Therapeutics, Inc. Ionizable cationic lipids and lipid nanoparticles

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5686278A (en) * 1994-03-25 1997-11-11 Indiana University Foundation Methods for enhanced retrovirus-mediated gene transfer
EP0954585B1 (en) 1996-10-01 2009-11-25 Geron Corporation Human telomerase reverse transcriptase promoter
US5968829A (en) 1997-09-05 1999-10-19 Cytotherapeutics, Inc. Human CNS neural stem cells
US6638501B1 (en) 1997-09-29 2003-10-28 Neurospheres Holdings Ltd. Use of multipotent neural stem cell progeny to augment non-neural tissues
US5958767A (en) 1998-08-14 1999-09-28 The Children's Medical Center Corp. Engraftable human neural stem cells
US7468277B2 (en) 1999-12-23 2008-12-23 Cornell Research Foundation, Inc. Enriched preparation of human fetal multipotential neural stem cells
WO2004002425A2 (en) * 2002-06-28 2004-01-08 Bio Transplant, Inc. Process for promoting graft acceptance by depletion of hematopoietic stem cells
ES2348868T3 (es) * 2002-12-13 2010-12-16 Genetix Pharmaceuticals Inc. Vectores retrovirales terapeuticos para terapia genica.
US20090191202A1 (en) 2005-09-29 2009-07-30 Jamieson Catriona Helen M Methods for manipulating phagocytosis mediated by CD47
US8377448B2 (en) 2006-05-15 2013-02-19 The Board Of Trustees Of The Leland Standford Junior University CD47 related compositions and methods for treating immunological diseases and disorders
ES2642205T5 (en) 2006-11-03 2025-11-03 Univ Leland Stanford Junior Selective immunodepletion of endogenous stem cell niche for engraftment
ES2735144T5 (en) 2008-01-15 2026-01-02 Univ Leland Stanford Junior Methods for manipulating phagocytosis mediated by cd47
CA2771336C (en) * 2009-09-15 2019-11-26 The Board Of Trustees Of The Leland Stanford Junior University Synergistic anti-cd47 therapy for hematologic cancers
EP3181149A1 (en) 2010-05-14 2017-06-21 The Board Of Trustees Of The Leland Stanford Junior University Humanized and chimeric monoclonal antibodies to cd47
WO2013056352A1 (en) * 2011-10-19 2013-04-25 University Health Network Antibodies and antibody fragments targeting sirp-alpha and their use in treating hematologic cancers
LT2804617T (lt) 2012-01-17 2020-09-10 The Board Of Trustees Of The Leland Stanford Junior University Didelio giminingumo sirp-alfa reagentai
SG11201607143UA (en) * 2014-03-11 2016-09-29 Univ Leland Stanford Junior Anti sirp-alpha antibodies and bi-specific macrophage enhancing antibodies
PL3656869T5 (pl) 2014-08-26 2025-06-09 The Board Of Trustees Of The Leland Stanford Junior University Wszczepienie komórek macierzystych z kombinacją środka, który celuje w komórki macierzyste i modulowanie sygnałowania immunoregulatorowego
WO2016205042A1 (en) 2015-06-16 2016-12-22 The Board Of Trustees Of The Leland Stanford Junior University SIRPα AGONIST ANTIBODY

Also Published As

Publication number Publication date
ES2763248T3 (es) 2020-05-27
EP3186395B1 (en) 2019-09-25
EP3822364B1 (en) 2023-05-10
FI3656869T4 (fi) 2025-06-04
HUE046387T2 (hu) 2020-03-30
ES2763248T5 (es) 2023-06-22
US11419897B2 (en) 2022-08-23
US12233093B2 (en) 2025-02-25
FI3186395T4 (fi) 2023-05-25
CY1123730T1 (el) 2022-05-27
EP3656869B2 (en) 2025-04-09
PL3656869T3 (pl) 2021-05-17
CA2958884A1 (en) 2016-03-03
HUE052725T2 (hu) 2021-05-28
EP4257145B1 (en) 2025-06-25
US20200129557A1 (en) 2020-04-30
EP3186395A4 (en) 2018-03-21
SI3656869T1 (sl) 2021-03-31
EP3822364A1 (en) 2021-05-19
CA2958884C (en) 2024-02-27
CA3229961A1 (en) 2016-03-03
DK3656869T4 (da) 2025-05-19
EP3656869B1 (en) 2020-11-11
DK3186395T4 (da) 2023-05-08
DK3656869T3 (da) 2021-01-04
PT3656869T (pt) 2021-01-13
EP3656869A8 (en) 2020-06-10
DK3186395T3 (da) 2019-11-25
ES2845898T5 (en) 2025-06-17
EP3186395B2 (en) 2023-03-29
ES2945588T3 (es) 2023-07-04
US10406179B2 (en) 2019-09-10
WO2016033201A1 (en) 2016-03-03
LT3656869T (lt) 2021-01-25
PL3656869T5 (pl) 2025-06-09
US20250249042A1 (en) 2025-08-07
HRP20210057T4 (hr) 2025-07-18
PT3186395T (pt) 2019-11-20
ES2845898T3 (es) 2021-07-28
EP4257145A3 (en) 2023-10-18
EP4257145A2 (en) 2023-10-11
US20170224737A1 (en) 2017-08-10
EP3186395A1 (en) 2017-07-05
EP3656869A1 (en) 2020-05-27
HRP20210057T1 (hr) 2021-03-05
US20220347224A1 (en) 2022-11-03
PL3186395T5 (pl) 2023-06-12
SI3656869T2 (sl) 2025-06-30

Similar Documents

Publication Publication Date Title
PL3186395T5 (pl) Wszczepienie komórek macierzystych z kombinacją środka, który celuje w komórki macierzyste i modulowanie sygnałowania immunoregulatorowego
HUS2400015I1 (hu) Komplement aktivitás modulálása
ZA201604795B (en) Catheter devices with valves and related methods
GB201418282D0 (en) Storage device and assembly
PL3066017T3 (pl) Zamknięcie metalowe z zaczepami do mocowania pod niskim naciskiem
ZA201700495B (en) Signaling of modulation configuration
SG11201702475VA (en) Methods and compositions for modulating th-gm cell function
ZA201605289B (en) Mushroom line b12998-s39 and methods and uses therefor
GB2531826B (en) Devices and methods for pulse-width modulation
GB2528698B (en) Location-specific messaging
PL3194199T3 (pl) Statek podwodny wyposażony w linie środków do magazynowania energii
GB201415002D0 (en) Cell modulation