PL3224255T3 - Związki n-((het)arylometylo)heteroarylokarboksyamidów jako inhibitory kalikreiny osoczowej - Google Patents

Związki n-((het)arylometylo)heteroarylokarboksyamidów jako inhibitory kalikreiny osoczowej

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Publication number
PL3224255T3
PL3224255T3 PL15804209T PL15804209T PL3224255T3 PL 3224255 T3 PL3224255 T3 PL 3224255T3 PL 15804209 T PL15804209 T PL 15804209T PL 15804209 T PL15804209 T PL 15804209T PL 3224255 T3 PL3224255 T3 PL 3224255T3
Authority
PL
Poland
Prior art keywords
arylmethyl
het
heteroaryl
plasma kallikrein
kallikrein inhibitors
Prior art date
Application number
PL15804209T
Other languages
English (en)
Inventor
David Michael Evans
Rebecca Louise DAVIE
Hannah Joy EDWARDS
Simon Teanby Hodgson
Original Assignee
Kalvista Pharmaceuticals Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kalvista Pharmaceuticals Limited filed Critical Kalvista Pharmaceuticals Limited
Publication of PL3224255T3 publication Critical patent/PL3224255T3/pl

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
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    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
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  • Pharmacology & Pharmacy (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
PL15804209T 2014-11-27 2015-11-26 Związki n-((het)arylometylo)heteroarylokarboksyamidów jako inhibitory kalikreiny osoczowej PL3224255T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1421085.0A GB201421085D0 (en) 2014-11-27 2014-11-27 New enzyme inhibitors
EP15804209.3A EP3224255B1 (en) 2014-11-27 2015-11-26 N-((het)arylmethyl)-heteroaryl-carboxamides compounds as plasma kallikrein inhibitors
PCT/GB2015/053613 WO2016083818A1 (en) 2014-11-27 2015-11-26 N-((het)arylmethyl)-heteroaryl-carboxamides compounds as plasma kallikrein inhibitors

Publications (1)

Publication Number Publication Date
PL3224255T3 true PL3224255T3 (pl) 2022-04-11

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Application Number Title Priority Date Filing Date
PL15804209T PL3224255T3 (pl) 2014-11-27 2015-11-26 Związki n-((het)arylometylo)heteroarylokarboksyamidów jako inhibitory kalikreiny osoczowej

Country Status (13)

Country Link
US (1) US10781181B2 (pl)
EP (1) EP3224255B1 (pl)
JP (1) JP6753849B2 (pl)
AR (1) AR102851A1 (pl)
CA (1) CA2967737C (pl)
ES (1) ES2908585T3 (pl)
GB (1) GB201421085D0 (pl)
HU (1) HUE057585T2 (pl)
PL (1) PL3224255T3 (pl)
PT (1) PT3224255T (pl)
SI (1) SI3224255T1 (pl)
TW (1) TW201629034A (pl)
WO (1) WO2016083818A1 (pl)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI636047B (zh) 2013-08-14 2018-09-21 英商卡爾維斯塔製藥有限公司 雜環衍生物
GB201421085D0 (en) 2014-11-27 2015-01-14 Kalvista Pharmaceuticals Ltd New enzyme inhibitors
GB201421083D0 (en) 2014-11-27 2015-01-14 Kalvista Pharmaceuticals Ltd Enzyme inhibitors
RS60600B1 (sr) 2016-05-31 2020-08-31 Kalvista Pharmaceuticals Ltd Derivati pirazola kao inhibitori kalikreina plazme
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