PL3231800T3 - Nowa pochodna 4-(arylo) -n-(2-alkoksytieno[3,2-b]pirazyn-3-ylo)-piperazyno-1-karboksyamidu oraz jej działanie antyproliferacyjne - Google Patents

Nowa pochodna 4-(arylo) -n-(2-alkoksytieno[3,2-b]pirazyn-3-ylo)-piperazyno-1-karboksyamidu oraz jej działanie antyproliferacyjne

Info

Publication number
PL3231800T3
PL3231800T3 PL15867145T PL15867145T PL3231800T3 PL 3231800 T3 PL3231800 T3 PL 3231800T3 PL 15867145 T PL15867145 T PL 15867145T PL 15867145 T PL15867145 T PL 15867145T PL 3231800 T3 PL3231800 T3 PL 3231800T3
Authority
PL
Poland
Prior art keywords
alkoxythieno
pyrazin
piperazine
aryl
novel
Prior art date
Application number
PL15867145T
Other languages
English (en)
Inventor
Young Dae Gong
Se Hun KWAK
Eun Sil Lee
Original Assignee
Lsk Nrdo Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lsk Nrdo Co., Ltd. filed Critical Lsk Nrdo Co., Ltd.
Publication of PL3231800T3 publication Critical patent/PL3231800T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epidemiology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
PL15867145T 2014-12-08 2015-12-03 Nowa pochodna 4-(arylo) -n-(2-alkoksytieno[3,2-b]pirazyn-3-ylo)-piperazyno-1-karboksyamidu oraz jej działanie antyproliferacyjne PL3231800T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR20140175121 2014-12-08
EP15867145.3A EP3231800B1 (en) 2014-12-08 2015-12-03 Novel 4-(aryl)-n-(2-alkoxythieno[3,2-b]pyrazin-3-yl)-piperazine-1-carboxamide derivative, and antiproliferative effect thereof
PCT/KR2015/013150 WO2016093554A2 (ko) 2014-12-08 2015-12-03 신규한 4-(아릴)-n-(2-알콕시티에노[3,2-b]피라진-3-일)-피페라진-1-카복스아미드 유도체 및 이의 항증식 효과

Publications (1)

Publication Number Publication Date
PL3231800T3 true PL3231800T3 (pl) 2020-04-30

Family

ID=56108326

Family Applications (1)

Application Number Title Priority Date Filing Date
PL15867145T PL3231800T3 (pl) 2014-12-08 2015-12-03 Nowa pochodna 4-(arylo) -n-(2-alkoksytieno[3,2-b]pirazyn-3-ylo)-piperazyno-1-karboksyamidu oraz jej działanie antyproliferacyjne

Country Status (7)

Country Link
US (1) US10059721B2 (pl)
EP (1) EP3231800B1 (pl)
JP (1) JP6349464B2 (pl)
KR (1) KR101727412B1 (pl)
HU (1) HUE046316T2 (pl)
PL (1) PL3231800T3 (pl)
WO (1) WO2016093554A2 (pl)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL3231800T3 (pl) * 2014-12-08 2020-04-30 Lsk Nrdo Co., Ltd. Nowa pochodna 4-(arylo) -n-(2-alkoksytieno[3,2-b]pirazyn-3-ylo)-piperazyno-1-karboksyamidu oraz jej działanie antyproliferacyjne
KR101872645B1 (ko) 2016-06-09 2018-08-03 동국대학교 산학협력단 신규한 4-(아릴)-N-(3-알콕시퓨로[2,3-b]피라진-2-일)-피페라진-1-카복스아미드 유도체 및 이의 항증식 효과
WO2017213452A1 (ko) * 2016-06-09 2017-12-14 동국대학교 산학협력단 신규한 4-(아릴)-n-(3-알콕시퓨로[2,3-b]피라진-2-일)-피페라진-1-카복스아미드 유도체 및 이의 항증식 효과
CN111606920A (zh) * 2020-05-29 2020-09-01 凯美克(上海)医药科技有限公司 一种7-溴噻吩并[2,3-b]吡嗪的合成方法
WO2024205336A1 (ko) * 2023-03-30 2024-10-03 에이치엘비생명과학알앤디 주식회사 튜블린 저해 활성을 갖는 약학적 조성물

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1424072A1 (en) * 1999-03-03 2004-06-02 Samjin Pharmaceutical Co., Ltd. N'-(pyridin-3-yl)-(4-phenylpiperazin-1-yl)-carboxyimidamide and -iminothiolate derivatives for the treatment of tumors
AU2003248052A1 (en) * 2002-07-12 2004-02-02 Yamanouchi Pharmaceutical Co., Ltd. N-phenyl-(2r,5s)dimethylpiperadine derivative
MX2007005863A (es) 2004-11-17 2007-10-19 Rexahn Pharmaceuticals Inc Derivados de 1-[(6,7-alcoxiquinoxalinil 6,7-sustituido) aminocarbonil]-4-(hetero)arilpiperazina.
US20060183758A1 (en) 2005-02-17 2006-08-17 Cb Research And Development, Inc. Method for synthesis of AZA-annelated pyrroles, thiophenes, and furans
US8669256B2 (en) 2010-05-28 2014-03-11 Merck Sharp & Dohme B.V. Substituted thieno[2,3-b]pyrazine compounds as modulators of B-Raf kinase activity
KR101470115B1 (ko) 2013-01-09 2014-12-05 동국대학교 산학협력단 2-(페닐에티닐)티에노[3,4-b]피라진 유도체 및 이를 포함하는 암의 예방 또는 치료용 약학적 조성물
PL3231800T3 (pl) * 2014-12-08 2020-04-30 Lsk Nrdo Co., Ltd. Nowa pochodna 4-(arylo) -n-(2-alkoksytieno[3,2-b]pirazyn-3-ylo)-piperazyno-1-karboksyamidu oraz jej działanie antyproliferacyjne

Also Published As

Publication number Publication date
US20170320890A1 (en) 2017-11-09
HUE046316T2 (hu) 2020-02-28
WO2016093554A3 (ko) 2016-10-27
EP3231800A2 (en) 2017-10-18
KR101727412B1 (ko) 2017-04-17
EP3231800B1 (en) 2019-08-14
US10059721B2 (en) 2018-08-28
EP3231800A4 (en) 2018-05-30
JP2018502070A (ja) 2018-01-25
WO2016093554A2 (ko) 2016-06-16
JP6349464B2 (ja) 2018-06-27
KR20160070005A (ko) 2016-06-17

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