PL3233863T3 - Związki heteroarylowe ze skondensowanymi pierścieniami i ich zastosowanie jako inhibitorów trk - Google Patents

Związki heteroarylowe ze skondensowanymi pierścieniami i ich zastosowanie jako inhibitorów trk

Info

Publication number
PL3233863T3
PL3233863T3 PL15869420.8T PL15869420T PL3233863T3 PL 3233863 T3 PL3233863 T3 PL 3233863T3 PL 15869420 T PL15869420 T PL 15869420T PL 3233863 T3 PL3233863 T3 PL 3233863T3
Authority
PL
Poland
Prior art keywords
fused ring
ring heteroaryl
heteroaryl compounds
trk inhibitors
trk
Prior art date
Application number
PL15869420.8T
Other languages
English (en)
Inventor
Moonsoo Kim
Chaewoon LEE
Gilnam Lee
Cheolhwan YOON
Jeongbeob Seo
Jay Hak Kim
Minwoo Lee
Hankyul JEONG
Hyang Choi
Myung Eun Jung
Ki Nam Lee
Hyun Jung Kim
Hye Kyoung Kim
Jae Il Lee
Misoon KIM
Soongyu Choi
Original Assignee
Cmg Pharmaceutical Co., Ltd.
Handok Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cmg Pharmaceutical Co., Ltd., Handok Inc. filed Critical Cmg Pharmaceutical Co., Ltd.
Publication of PL3233863T3 publication Critical patent/PL3233863T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
PL15869420.8T 2014-12-15 2015-12-14 Związki heteroarylowe ze skondensowanymi pierścieniami i ich zastosowanie jako inhibitorów trk PL3233863T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462092193P 2014-12-15 2014-12-15
PCT/IB2015/002521 WO2016097869A1 (en) 2014-12-15 2015-12-14 Fused ring heteroaryl compounds and their use as trk inhibitors

Publications (1)

Publication Number Publication Date
PL3233863T3 true PL3233863T3 (pl) 2024-11-12

Family

ID=56110505

Family Applications (1)

Application Number Title Priority Date Filing Date
PL15869420.8T PL3233863T3 (pl) 2014-12-15 2015-12-14 Związki heteroarylowe ze skondensowanymi pierścieniami i ich zastosowanie jako inhibitorów trk

Country Status (17)

Country Link
US (1) US9701681B2 (pl)
EP (2) EP3233863B1 (pl)
JP (1) JP6609631B2 (pl)
KR (2) KR20240055170A (pl)
CN (1) CN107207514B (pl)
AU (1) AU2015365587B2 (pl)
BR (1) BR112017012755B1 (pl)
CA (1) CA2971024C (pl)
DK (1) DK3233863T3 (pl)
ES (1) ES2983908T3 (pl)
FI (1) FI3233863T3 (pl)
HR (1) HRP20240937T1 (pl)
HU (1) HUE067779T2 (pl)
MX (1) MX383885B (pl)
PL (1) PL3233863T3 (pl)
RU (1) RU2708674C2 (pl)
WO (1) WO2016097869A1 (pl)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI2350075T1 (sl) 2008-09-22 2014-06-30 Array Biopharma, Inc. Substituirane imidazo (1,2b)piridazinske spojine kot Trk kinazni inhibitorji
CN102264736B (zh) 2008-10-22 2013-08-14 阵列生物制药公司 作为TRK激酶抑制剂的取代的吡唑并[1,5-a]嘧啶化合物
AR077468A1 (es) 2009-07-09 2011-08-31 Array Biopharma Inc Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa
BR122019024201B1 (pt) 2010-05-20 2021-08-03 Array Biopharma Inc Composto macrocíclico como inibidores de trk quinase, seu uso, e composição farmacêutica
WO2015112806A2 (en) 2014-01-24 2015-07-30 Tp Therapeutics, Inc. Diaryl macrocycles as modulators of protein kinases
TWI746426B (zh) 2014-11-16 2021-11-21 美商亞雷生物製藥股份有限公司 (S)-N-(5-((R)-2-(2,5-二氟苯基)-吡咯啶-1-基)-吡唑并[1,5-a]嘧啶-3-基)-3-羥基吡咯啶-1-甲醯胺硫酸氫鹽結晶型
RU2732405C2 (ru) 2015-07-02 2020-09-16 Тёрнинг Поинт Терапьютикс, Инк. Хиральные диарильные макроциклы в качестве модуляторов протеинкиназ
BR112018000297A2 (pt) 2015-07-06 2018-09-04 Tp Therapeutics Inc polimorfo de macrociclo de diarila
WO2017035354A1 (en) 2015-08-26 2017-03-02 Blueprint Medicines Corporation Compounds and compositions useful for treating disorders related to ntrk
EP3368039A1 (en) 2015-10-26 2018-09-05 The Regents of The University of Colorado, A Body Corporate Point mutations in trk inhibitor-resistant cancer and methods relating to the same
SG10201912607SA (en) 2015-11-19 2020-02-27 Blueprint Medicines Corp Compounds and compositions useful for treating disorders related to ntrk
UA125026C2 (uk) 2016-04-04 2021-12-29 Локсо Онколоджі, Інк. РІДКІ КОМПОЗИЦІЇ (S)-N-(5-((R)-2-(2,5-ДИФТОРФЕНІЛ)ПІРОЛІДИН-1-ІЛ)ПІРАЗОЛО[1,5-a]ПІРИМІДИН-3-ІЛ)-3-ГІДРОКСИПІРОЛІДИН-1-КАРБОКСАМІДУ
UA125025C2 (uk) 2016-04-04 2021-12-29 Локсо Онколоджі, Інк. Способи лікування дитячих ракових захворювань
MX392604B (es) 2016-05-18 2025-03-24 Array Biopharma Inc Procesos para la preparacion de (s)-n-(5-((r)-2-(2,5-difluorofenil)pirrolidin-1-il)-pirazolo[1,5-a]pirimidin-3-il)-3-hidroxipirrolidin-1-carboxamida y sales del mismo.
JOP20190092A1 (ar) * 2016-10-26 2019-04-25 Array Biopharma Inc عملية لتحضير مركبات بيرازولو[1، 5-a]بيريميدين وأملاح منها
AU2017348826B2 (en) * 2016-10-28 2021-12-02 Centaurus Biopharma Co., Ltd. Amino pyrazolopyrimidine compound used as neurotrophic factor tyrosine kinase receptor inhibitor
JP7153653B2 (ja) * 2017-02-14 2022-10-14 リサーチ トライアングル インスティテュート プロリン系神経ペプチドｆｆ受容体モジュレーター
JOP20190213A1 (ar) 2017-03-16 2019-09-16 Array Biopharma Inc مركبات حلقية ضخمة كمثبطات لكيناز ros1
US10738033B2 (en) 2017-05-31 2020-08-11 Nantbio, Inc. Trk inhibition
US10800760B2 (en) 2017-05-31 2020-10-13 Nantbio, Inc. Trk inhibition
CA3080157A1 (en) 2017-10-26 2019-05-02 Array Biopharma Inc. Formulations of a macrocyclic trk kinase inhibitor
IL275059B2 (en) * 2017-12-15 2023-11-01 Pyramid Biosciences Inc 5-(2-(5,2-difluorophenyl)pyrrolidin-1-yl)-3-(1H-pyrazol-1-yl)pyrazolo[5,1-A]pyrimidine derivatives and related compounds as TRK kinase inhibitors for cancer therapy
CN108218754B (zh) * 2018-01-23 2021-05-07 广东赛烽医药科技有限公司 一种2-(2,5-二氟苯基)吡咯烷的制备方法
WO2019165967A1 (zh) * 2018-02-28 2019-09-06 南京明德新药研发有限公司 吡唑并嘧啶衍生物及其用途
BR112020018444A2 (pt) * 2018-03-14 2020-12-29 Fochon Pharmaceuticals, Ltd. Compostos de (2-azabiciclo[3,1,0]hexan-2-il)pirazolo[1,5-a]pirimidina substituída e imidazo[1,2-b]piridazina como inibidores de trk cinases
EP3773725A1 (en) 2018-03-29 2021-02-17 Loxo Oncology Inc. Treatment of trk-associated cancers
CN108484361B (zh) * 2018-05-11 2022-09-30 弈柯莱生物科技(上海)股份有限公司 (s)-4-氯-1-(2,5)-二氟苯基丁-1-醇及其制备方法和应用
WO2019233461A1 (zh) * 2018-06-08 2019-12-12 江苏威凯尔医药科技有限公司 原肌球蛋白受体激酶抑制剂及其制备方法和应用
CN110577532B (zh) * 2018-06-08 2022-06-03 江苏威凯尔医药科技有限公司 原肌球蛋白受体激酶抑制剂及其制备方法和应用
CN110294761B (zh) * 2018-06-08 2020-09-08 南京雷正医药科技有限公司 作为Trk激酶抑制剂的取代的吡唑并[1,5-a]嘧啶化合物
GB201811825D0 (en) 2018-07-19 2018-09-05 Benevolentai Bio Ltd Organic compounds
CN108794370A (zh) * 2018-07-31 2018-11-13 上海弈柯莱生物医药科技有限公司 一种拉罗替尼中间体的制备方法
CN110857304B (zh) * 2018-08-24 2021-05-18 北京富龙康泰生物技术有限公司 Trk抑制剂、其制备方法和用途
CN109053525B (zh) * 2018-09-25 2020-05-05 成都福柯斯医药技术有限公司 一种(r)-2-(2-取代-5-氟苯)吡咯烷的制备方法
JP7619951B2 (ja) * 2018-10-15 2025-01-22 武田薬品工業株式会社 Ｔｙｋ２阻害剤およびその使用
CN111138333B (zh) * 2018-11-02 2023-05-23 上海复星星泰医药科技有限公司 一种(r)-2-(2,5-二氟苯基)-吡咯烷的制备方法
TW202033526A (zh) * 2018-12-07 2020-09-16 大陸商貝達藥業股份有限公司 用作酪胺酸激酶抑制劑的化合物、包含其的藥物組合物及其用途
CN111302995A (zh) * 2018-12-12 2020-06-19 上海复星星泰医药科技有限公司 一种2-(2,5-二氟苯基)-吡咯烷消旋体的制备方法
CN109593803A (zh) * 2018-12-24 2019-04-09 上海健康医学院 (r)-2-(2,5-二氟苯基)吡咯烷或其盐的制备方法
CN111362946A (zh) * 2018-12-25 2020-07-03 上海度德医药科技有限公司 一种药物化合物及其组合物和应用
WO2020187291A1 (zh) * 2019-03-19 2020-09-24 华中师范大学 吡唑并嘧啶化合物和药物组合物及其应用
BR112021022255A2 (pt) * 2019-05-08 2022-01-18 Tyk Medicines Inc Composto usado como inibidor de quinase e aplicação do mesmo
US20220289765A1 (en) * 2019-08-28 2022-09-15 Simcere Pharmaceutical Co., Ltd. Crystal of carcinogenic fused kinase inhibitor and applications thereof
CN114641478B (zh) * 2019-10-30 2024-07-02 南京再明医药有限公司 吡唑并嘧啶类化合物的制备方法及其中间体
CN112979654B (zh) * 2019-12-16 2024-03-19 赛诺哈勃药业（成都）有限公司 杂芳基稠环化合物、其制备方法及应用
IL294688A (en) 2020-01-22 2022-09-01 Benevolentai Bio Ltd Pharmaceutical compositions and their uses
CN111302997B (zh) * 2020-04-15 2022-03-29 江苏恒沛药物科技有限公司 “一锅法”制备拉罗替尼中间体的方法
IL296921B1 (en) 2020-04-15 2026-08-01 Pyramid Biosciences Inc Methods for preparing receptor tyrosine kinase inhibitors
CN111393347B (zh) * 2020-04-30 2020-11-17 安徽德信佳生物医药有限公司 一种拉洛替尼中间体的合成方法
WO2021249450A1 (zh) * 2020-06-11 2021-12-16 贝达药业股份有限公司 酪氨酸激酶抑制剂的盐型、晶型、药物组合物及其用途
CN114437075B (zh) * 2020-11-03 2026-01-30 上海瑶琪生物科技有限公司 用作ntrk激酶抑制剂的化合物及其应用
KR102541026B1 (ko) 2020-11-11 2023-06-12 주식회사 한독 Trk 억제제 화합물의 제조 방법
CN116102464B (zh) * 2021-11-10 2024-11-05 凯特立斯（深圳）科技有限公司 一种不对称氢化制备氨基醇的方法及其应用
CN119630660A (zh) * 2022-07-22 2025-03-14 深圳众格生物科技有限公司 一种抑制irak4活性的化合物及其应用
CN117624166A (zh) * 2022-08-09 2024-03-01 苏州朗睿生物医药有限公司 一种三氮唑衍生物及其制备方法和用途
WO2025107298A1 (zh) * 2023-11-24 2025-05-30 浙江同源康医药股份有限公司 晶体、药物组合物及其制备方法和应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2722418C (en) 2008-05-13 2013-09-17 Irm Llc Fused nitrogen containing heterocycles and compositions thereof as kinase inhibitors
CN102264736B (zh) * 2008-10-22 2013-08-14 阵列生物制药公司 作为TRK激酶抑制剂的取代的吡唑并[1,5-a]嘧啶化合物
BRPI0914404A2 (pt) * 2008-10-31 2019-03-06 Genentech Inc "compostos, composição farmacêutica e método para tratar ou atenuar a gravidade de uma doença ou condição responsiva à inibição da atividade jak quinase em um paciente"
AR077468A1 (es) * 2009-07-09 2011-08-31 Array Biopharma Inc Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa
US8865726B2 (en) * 2009-09-03 2014-10-21 Array Biopharma Inc. Substituted pyrazolo[1,5-a]pyrimidine compounds as mTOR inhibitors
BR122019024201B1 (pt) * 2010-05-20 2021-08-03 Array Biopharma Inc Composto macrocíclico como inibidores de trk quinase, seu uso, e composição farmacêutica
WO2012034095A1 (en) 2010-09-09 2012-03-15 Irm Llc Compounds and compositions as trk inhibitors
DK2834243T3 (en) * 2012-03-09 2018-07-23 Lexicon Pharmaceuticals Inc Pyrazole [1,5-a] pyrimidine-based compounds, compositions comprising them and methods for their use

Also Published As

Publication number Publication date
KR20240055170A (ko) 2024-04-26
KR20170095919A (ko) 2017-08-23
CN107207514B (zh) 2020-01-24
MX383885B (es) 2025-03-14
RU2708674C2 (ru) 2019-12-11
US9701681B2 (en) 2017-07-11
BR112017012755B1 (pt) 2023-11-14
DK3233863T3 (da) 2024-07-15
EP3233863A4 (en) 2018-06-06
EP3233863A1 (en) 2017-10-25
HRP20240937T1 (hr) 2024-10-25
WO2016097869A4 (en) 2016-08-04
EP3233863B1 (en) 2024-04-10
JP2017538766A (ja) 2017-12-28
KR102659741B1 (ko) 2024-04-23
JP6609631B2 (ja) 2019-11-20
WO2016097869A1 (en) 2016-06-23
FI3233863T3 (fi) 2024-07-10
EP4420732A3 (en) 2024-11-27
EP4420732A2 (en) 2024-08-28
CN107207514A (zh) 2017-09-26
CA2971024C (en) 2023-09-26
ES2983908T3 (es) 2024-10-28
MX2017007748A (es) 2018-01-30
AU2015365587B2 (en) 2020-07-23
BR112017012755A2 (pt) 2017-12-26
HUE067779T2 (hu) 2024-11-28
AU2015365587A1 (en) 2017-08-03
RU2017125025A (ru) 2019-01-17
US20160168156A1 (en) 2016-06-16
CA2971024A1 (en) 2016-06-23
RU2017125025A3 (pl) 2019-06-21

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