PL324258A1 - Diglycosiled 1,2-dioles mimetisingly acting on sialed lewis x and sialed lewis a - Google Patents
Diglycosiled 1,2-dioles mimetisingly acting on sialed lewis x and sialed lewis aInfo
- Publication number
- PL324258A1 PL324258A1 PL96324258A PL32425896A PL324258A1 PL 324258 A1 PL324258 A1 PL 324258A1 PL 96324258 A PL96324258 A PL 96324258A PL 32425896 A PL32425896 A PL 32425896A PL 324258 A1 PL324258 A1 PL 324258A1
- Authority
- PL
- Poland
- Prior art keywords
- sialed
- lewis
- mimetisingly
- diglycosiled
- dioles
- Prior art date
Links
- 125000000424 1,2-diol group Chemical group 0.000 title 1
- CMQZRJBJDCVIEY-JEOLMMCMSA-N alpha-L-Fucp-(1->3)-[beta-D-Galp-(1->4)]-beta-D-GlcpNAc-(1->3)-beta-D-Galp-(1->4)-D-Glcp Chemical compound O[C@H]1[C@H](O)[C@H](O)[C@H](C)O[C@H]1O[C@H]1[C@H](O[C@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)[C@@H](CO)O[C@@H](O[C@@H]2[C@H]([C@H](O[C@@H]3[C@H](OC(O)[C@H](O)[C@H]3O)CO)O[C@H](CO)[C@@H]2O)O)[C@@H]1NC(C)=O CMQZRJBJDCVIEY-JEOLMMCMSA-N 0.000 title 1
- DUKURNFHYQXCJG-JEOLMMCMSA-N alpha-L-Fucp-(1->4)-[beta-D-Galp-(1->3)]-beta-D-GlcpNAc-(1->3)-beta-D-Galp-(1->4)-D-Glcp Chemical compound O[C@H]1[C@H](O)[C@H](O)[C@H](C)O[C@H]1O[C@H]1[C@H](O[C@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)[C@@H](NC(C)=O)[C@H](O[C@@H]2[C@H]([C@H](O[C@@H]3[C@H](OC(O)[C@H](O)[C@H]3O)CO)O[C@H](CO)[C@@H]2O)O)O[C@@H]1CO DUKURNFHYQXCJG-JEOLMMCMSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/207—Cyclohexane rings not substituted by nitrogen atoms, e.g. kasugamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Cosmetics (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH191495 | 1995-06-29 | ||
| PCT/EP1996/002785 WO1997001569A1 (en) | 1995-06-29 | 1996-06-26 | Diglycosylated 1,2-diols as mimetics of sialyl-lewis x and sialyl-lewis a |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL324258A1 true PL324258A1 (en) | 1998-05-11 |
Family
ID=4221546
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL96324258A PL324258A1 (en) | 1995-06-29 | 1996-06-26 | Diglycosiled 1,2-dioles mimetisingly acting on sialed lewis x and sialed lewis a |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP0836610A1 (no) |
| JP (1) | JPH11508548A (no) |
| KR (1) | KR19990028543A (no) |
| CN (1) | CN1196731A (no) |
| AU (1) | AU707474B2 (no) |
| BR (1) | BR9609285A (no) |
| CA (1) | CA2224346A1 (no) |
| CZ (1) | CZ419797A3 (no) |
| EA (1) | EA001356B1 (no) |
| HU (1) | HUP9801805A3 (no) |
| IL (1) | IL118740A0 (no) |
| MX (1) | MX9800218A (no) |
| NO (1) | NO976065L (no) |
| NZ (1) | NZ311686A (no) |
| PL (1) | PL324258A1 (no) |
| SI (1) | SI9620099A (no) |
| SK (1) | SK177897A3 (no) |
| TR (1) | TR199701728T1 (no) |
| WO (1) | WO1997001569A1 (no) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4564713B2 (ja) | 2000-11-01 | 2010-10-20 | ミレニアム・ファーマシューティカルズ・インコーポレイテッド | 窒素性複素環式化合物、ならびに窒素性複素環式化合物およびその中間体を作製するための方法 |
| WO2003097658A2 (en) | 2002-05-16 | 2003-11-27 | Glycomimetics, Inc. | Compounds and methods for inhibiting selectin-mediated function |
| EP1763533B1 (en) | 2003-11-19 | 2008-01-09 | GlycoMimetics, Inc. | Specific antagonist for both e- and p-selectins |
| EP1577289A1 (en) * | 2004-03-18 | 2005-09-21 | Revotar Biopharmaceuticals AG | Non-glycosylated/-glycosidic/-peptidic small molecule selectin inhibitors for the treament of inflammatory disorders |
| CN101291946B (zh) | 2005-08-09 | 2011-06-29 | 糖模拟物有限公司 | 对来自假单胞菌的pa-il凝集素、pa-iil凝集素或其两者的糖模拟物抑制剂 |
| PL2264043T3 (pl) | 2005-09-02 | 2018-04-30 | Glycomimetics, Inc. | Heterobifunkcyjne inhibitory pan-selektyny |
| EP1764096A1 (en) | 2005-09-20 | 2007-03-21 | Revotar Biopharmaceuticals AG | Novel phloroglucinol derivatives having selectin ligand activity |
| EP1764095A1 (en) | 2005-09-20 | 2007-03-21 | Revotar Biopharmaceuticals AG | Novel nitrocatechol derivatives having selectin ligand activity |
| EP1764093A1 (en) | 2005-09-20 | 2007-03-21 | Revotar Biopharmaceuticals AG | Novel aromatic compounds and their use in medical applications |
| EP2074132B1 (en) * | 2006-10-12 | 2013-05-15 | GlycoMimetics, Inc. | Glycomimetic replacements for hexoses and n-acetyl hexosamines |
| AU2008216794A1 (en) * | 2007-02-09 | 2008-08-21 | Glycomimetics, Inc. | Methods of use of glycomimetics with replacements for hexoses and N-acetyl hexosamines |
| WO2009126556A1 (en) | 2008-04-08 | 2009-10-15 | Glycomimetics, Inc. | Pan-selectin inhibitor with enhanced pharmacokinetic activity |
| US8921328B2 (en) | 2010-09-14 | 2014-12-30 | Glycomimetics, Inc. | E-selectin antagonists |
| KR102055958B1 (ko) | 2011-12-22 | 2019-12-13 | 글리코미메틱스, 인크. | E-셀렉틴 길항제 화합물, 조성물, 및 이용 방법 |
| US9867841B2 (en) | 2012-12-07 | 2018-01-16 | Glycomimetics, Inc. | Compounds, compositions and methods using E-selectin antagonists for mobilization of hematopoietic cells |
| JP6689854B2 (ja) | 2014-12-03 | 2020-04-28 | グリコミメティクス， インコーポレイテッド | Ｅ−セレクチンおよびｃｘｃｒ４ケモカイン受容体のヘテロ二官能性阻害剤 |
| JP2019502727A (ja) | 2016-01-22 | 2019-01-31 | グリコミメティクス， インコーポレイテッド | Ｐａ−ｉｌおよび／またはｐａ−ｉｉｌレクチンの糖模倣体阻害剤 |
| WO2017151708A1 (en) | 2016-03-02 | 2017-09-08 | Glycomimetics, Inc. | Methods for the treatment and/or prevention of cardiovescular disease by inhibition of e-selectin |
| US11433086B2 (en) | 2016-08-08 | 2022-09-06 | Glycomimetics, Inc. | Combination of T-cell checkpoint inhibitors with inhibitors of e-selectin or CXCR4, or with heterobifunctional inhibitors of both E-selectin and CXCR4 |
| AU2017341065B2 (en) | 2016-10-07 | 2023-04-06 | Crescent Biopharma, Inc. | Highly potent multimeric E-selectin antagonists |
| EP3596096A1 (en) | 2017-03-15 | 2020-01-22 | GlycoMimetics, Inc. | Galactopyranosyl-cyclohexyl derivatives as e-selectin antagonists |
| JP7275131B2 (ja) | 2017-11-30 | 2023-05-17 | グリコミメティクス， インコーポレイテッド | 骨髄浸潤リンパ球を動員する方法、およびその使用 |
| KR20200104889A (ko) | 2017-12-29 | 2020-09-04 | 글리코미메틱스, 인크. | E-셀렉틴 및 갈렉틴-3의 이종이기능성 억제제 |
| KR20200128025A (ko) | 2018-03-05 | 2020-11-11 | 글리코미메틱스, 인크. | 급성 골수성 백혈병 및 관련 병태의 치료 방법 |
| US11845771B2 (en) | 2018-12-27 | 2023-12-19 | Glycomimetics, Inc. | Heterobifunctional inhibitors of E-selectin and galectin-3 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5326752A (en) * | 1991-11-27 | 1994-07-05 | Glycomed Incorporated | Substituted lactose and lactosamine derivatives as cell adhesion inhibitors |
| WO1993023031A1 (en) * | 1992-05-08 | 1993-11-25 | The Biomembrane Institute | Multivalent mimetics and peptide mimetics for blocking carbohydrate-dependent cellular interaction and for eliciting anticarbohydrate t-cell response |
| CA2100412A1 (en) * | 1992-07-15 | 1994-01-16 | Yutaka Yamada | Glycolipid derivatives |
-
1996
- 1996-06-26 KR KR1019970709861A patent/KR19990028543A/ko not_active Withdrawn
- 1996-06-26 IL IL11874096A patent/IL118740A0/xx unknown
- 1996-06-26 HU HU9801805A patent/HUP9801805A3/hu unknown
- 1996-06-26 SI SI9620099A patent/SI9620099A/sl unknown
- 1996-06-26 EP EP96922034A patent/EP0836610A1/en not_active Ceased
- 1996-06-26 CA CA002224346A patent/CA2224346A1/en not_active Abandoned
- 1996-06-26 WO PCT/EP1996/002785 patent/WO1997001569A1/en not_active Ceased
- 1996-06-26 NZ NZ311686A patent/NZ311686A/xx unknown
- 1996-06-26 EA EA199800103A patent/EA001356B1/ru not_active IP Right Cessation
- 1996-06-26 CN CN96196452A patent/CN1196731A/zh active Pending
- 1996-06-26 PL PL96324258A patent/PL324258A1/xx unknown
- 1996-06-26 AU AU63053/96A patent/AU707474B2/en not_active Ceased
- 1996-06-26 BR BR9609285A patent/BR9609285A/pt not_active Application Discontinuation
- 1996-06-26 CZ CZ974197A patent/CZ419797A3/cs unknown
- 1996-06-26 JP JP9504171A patent/JPH11508548A/ja active Pending
- 1996-06-26 TR TR97/01728T patent/TR199701728T1/xx unknown
- 1996-06-26 SK SK1778-97A patent/SK177897A3/sk unknown
-
1997
- 1997-12-23 NO NO976065A patent/NO976065L/no not_active Application Discontinuation
-
1998
- 1998-01-07 MX MX9800218A patent/MX9800218A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU707474B2 (en) | 1999-07-08 |
| SI9620099A (sl) | 1998-08-31 |
| HUP9801805A3 (en) | 2002-01-28 |
| NO976065D0 (no) | 1997-12-23 |
| EP0836610A1 (en) | 1998-04-22 |
| CZ419797A3 (cs) | 1998-06-17 |
| CN1196731A (zh) | 1998-10-21 |
| MX9800218A (es) | 1998-07-31 |
| BR9609285A (pt) | 1999-05-11 |
| WO1997001569A1 (en) | 1997-01-16 |
| KR19990028543A (ko) | 1999-04-15 |
| IL118740A0 (en) | 1996-10-16 |
| JPH11508548A (ja) | 1999-07-27 |
| HUP9801805A2 (hu) | 1998-12-28 |
| EA001356B1 (ru) | 2001-02-26 |
| AU6305396A (en) | 1997-01-30 |
| SK177897A3 (en) | 1998-08-05 |
| CA2224346A1 (en) | 1997-01-16 |
| NO976065L (no) | 1998-02-17 |
| EA199800103A1 (ru) | 1998-08-27 |
| TR199701728T1 (xx) | 1998-03-21 |
| NZ311686A (en) | 2000-01-28 |
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