PL324430A1 - Novel inhibitors of pharnesiltransferase, their production and pharmaceutic compositions containing them - Google Patents
Novel inhibitors of pharnesiltransferase, their production and pharmaceutic compositions containing themInfo
- Publication number
- PL324430A1 PL324430A1 PL96324430A PL32443096A PL324430A1 PL 324430 A1 PL324430 A1 PL 324430A1 PL 96324430 A PL96324430 A PL 96324430A PL 32443096 A PL32443096 A PL 32443096A PL 324430 A1 PL324430 A1 PL 324430A1
- Authority
- PL
- Poland
- Prior art keywords
- pharnesiltransferase
- production
- compositions containing
- novel inhibitors
- pharmaceutic compositions
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/72—4,7-Endo-alkylene-iso-indoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
- C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9508296A FR2736641B1 (en) | 1995-07-10 | 1995-07-10 | NOVEL FARNESYL TRANSFERASE INHIBITORS, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
| PCT/FR1996/001062 WO1997003050A1 (en) | 1995-07-10 | 1996-07-08 | 4,9-ethano-benzo(f)isoindole derivatives as farnesyl transferase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL324430A1 true PL324430A1 (en) | 1998-05-25 |
Family
ID=9480830
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL96324430A PL324430A1 (en) | 1995-07-10 | 1996-07-08 | Novel inhibitors of pharnesiltransferase, their production and pharmaceutic compositions containing them |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US5936097A (en) |
| EP (1) | EP0839133B1 (en) |
| JP (1) | JPH11511123A (en) |
| KR (1) | KR19990028856A (en) |
| CN (1) | CN1096448C (en) |
| AR (1) | AR003143A1 (en) |
| AT (1) | ATE185341T1 (en) |
| AU (1) | AU712194B2 (en) |
| BR (1) | BR9609440A (en) |
| CA (1) | CA2224414A1 (en) |
| CO (1) | CO4700457A1 (en) |
| CZ (1) | CZ291620B6 (en) |
| DE (1) | DE69604588T2 (en) |
| DK (1) | DK0839133T3 (en) |
| EA (1) | EA000797B1 (en) |
| ES (1) | ES2139373T3 (en) |
| FR (1) | FR2736641B1 (en) |
| GR (1) | GR3031409T3 (en) |
| IL (1) | IL122812A (en) |
| MA (1) | MA23929A1 (en) |
| MX (1) | MX9800262A (en) |
| MY (1) | MY114792A (en) |
| NO (1) | NO309565B1 (en) |
| NZ (1) | NZ313211A (en) |
| PE (1) | PE11898A1 (en) |
| PL (1) | PL324430A1 (en) |
| SK (1) | SK282250B6 (en) |
| TN (1) | TNSN96098A1 (en) |
| TW (1) | TW438792B (en) |
| UY (1) | UY24276A1 (en) |
| WO (1) | WO1997003050A1 (en) |
| ZA (1) | ZA965868B (en) |
Families Citing this family (74)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2757855B1 (en) * | 1996-12-30 | 1999-01-29 | Rhone Poulenc Rorer Sa | NOVEL FARNESYL TRANSFERASE INHIBITORS, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
| US6013662A (en) | 1996-12-30 | 2000-01-11 | Rhone-Poulenc Rorer S.A. | Farnesyl transferase inhibitors, their preparation, the pharmaceutical compositions which contain them and their use in the preparation of medicaments |
| US6124465A (en) * | 1997-11-25 | 2000-09-26 | Rhone-Poulenc S.A. | Farnesyl transferase inhibitors, their preparation, the pharmaceutical compositions which contain them and their use in the preparation of medicaments |
| AU1767599A (en) * | 1997-12-23 | 1999-07-19 | Aventis Pharma S.A. | Novel farnesyl transferase inhibitors, preparation, pharmaceutical compositions containing them and use for preparing medicines |
| FR2772764B1 (en) * | 1997-12-23 | 2000-01-14 | Rhone Poulenc Rorer Sa | NOVEL FARNESYLE TRANSFERASE INHIBITORS, THEIR PREPARATION, THE PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND THEIR USE IN THE PREPARATION OF MEDICAMENTS |
| FR2787327B1 (en) * | 1998-12-21 | 2003-01-17 | Aventis Pharma Sa | COMPOSITIONS CONTAINING FARNESYL TRANSFERASE INHIBITORS |
| FR2796641B1 (en) | 1999-07-22 | 2001-09-21 | Aventis Pharma Sa | NOVEL PROCESS FOR THE PREPARATION OF BENZOPERHYDROISOINDOLE COMPOUNDS |
| US20020177575A1 (en) * | 2001-05-04 | 2002-11-28 | Ward Wakeland | Identification of farnesyl-protein transferase as a target for systemic lupus erythematosus therapies |
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| US20110218176A1 (en) | 2006-11-01 | 2011-09-08 | Barbara Brooke Jennings-Spring | Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development |
| EA016079B1 (en) | 2007-01-10 | 2012-01-30 | Институто Ди Ричерке Ди Биолоджиа Молеколаре П. Анджелетти Спа | Amide substituted indazoles as poly(adp-ribose)polymerase (parp) inhibitors |
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| AU2008269154B2 (en) | 2007-06-27 | 2014-06-12 | Merck Sharp & Dohme Llc | 4-carboxybenzylamino derivatives as histone deacetylase inhibitors |
| US7932036B1 (en) | 2008-03-12 | 2011-04-26 | Veridex, Llc | Methods of determining acute myeloid leukemia response to treatment with farnesyltransferase |
| WO2010114780A1 (en) | 2009-04-01 | 2010-10-07 | Merck Sharp & Dohme Corp. | Inhibitors of akt activity |
| EP2440058A4 (en) | 2009-06-12 | 2012-11-21 | Dana Farber Cancer Inst Inc | FOUNDED HETEROCYCLIC COMPOUNDS AND USES THEREOF |
| JP5099731B1 (en) | 2009-10-14 | 2012-12-19 | メルク・シャープ・アンド・ドーム・コーポレーション | Substituted piperidines that increase p53 activity and uses thereof |
| EP2937345B1 (en) | 2009-12-29 | 2018-03-21 | Dana-Farber Cancer Institute, Inc. | Type ii raf kinase inhibitors |
| BR112012023021A2 (en) | 2010-03-16 | 2016-05-31 | Dana Farber Cancer Inst Inc | indazole compounds and their uses |
| EP2584903B1 (en) | 2010-06-24 | 2018-10-24 | Merck Sharp & Dohme Corp. | Novel heterocyclic compounds as erk inhibitors |
| CA2806112C (en) | 2010-07-28 | 2023-03-21 | Veridex, Llc | Methods of determining acute myeloid leukemia response to treatment with farnesyltransferase inhibitors |
| AU2011285909B2 (en) | 2010-08-02 | 2016-11-10 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of catenin (cadherin-associated protein), beta 1 (CTNNB1) gene expression using short interfering nucleic acid (siNA) |
| EP2606134B1 (en) | 2010-08-17 | 2019-04-10 | Sirna Therapeutics, Inc. | RNA INTERFERENCE MEDIATED INHIBITION OF HEPATITIS B VIRUS (HBV) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
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| EP2613782B1 (en) | 2010-09-01 | 2016-11-02 | Merck Sharp & Dohme Corp. | Indazole derivatives useful as erk inhibitors |
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| EP3766975A1 (en) | 2010-10-29 | 2021-01-20 | Sirna Therapeutics, Inc. | Rna interference mediated inhibition of gene expression using short interfering nucleic acid (sina) |
| EP2654748B1 (en) | 2010-12-21 | 2016-07-27 | Merck Sharp & Dohme Corp. | Indazole derivatives useful as erk inhibitors |
| EP2699567A1 (en) | 2011-04-21 | 2014-02-26 | Merck Sharp & Dohme Corp. | Insulin-like growth factor-1 receptor inhibitors |
| WO2013063214A1 (en) | 2011-10-27 | 2013-05-02 | Merck Sharp & Dohme Corp. | Novel compounds that are erk inhibitors |
| WO2013074986A1 (en) | 2011-11-17 | 2013-05-23 | Dana-Farber Cancer Institute, Inc. | Inhibitors of c-jun-n-terminal kinase (jnk) |
| EP3358013B1 (en) | 2012-05-02 | 2020-06-24 | Sirna Therapeutics, Inc. | Short interfering nucleic acid (sina) compositions |
| KR20150060724A (en) | 2012-09-28 | 2015-06-03 | 머크 샤프 앤드 돔 코포레이션 | Novel compounds that are erk inhibitors |
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| US9758522B2 (en) | 2012-10-19 | 2017-09-12 | Dana-Farber Cancer Institute, Inc. | Hydrophobically tagged small molecules as inducers of protein degradation |
| DK2925888T3 (en) | 2012-11-28 | 2017-12-18 | Merck Sharp & Dohme | COMPOSITIONS AND METHODS OF CANCER TREATMENT |
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| US9540377B2 (en) | 2013-01-30 | 2017-01-10 | Merck Sharp & Dohme Corp. | 2,6,7,8 substituted purines as HDM2 inhibitors |
| WO2015034925A1 (en) | 2013-09-03 | 2015-03-12 | Moderna Therapeutics, Inc. | Circular polynucleotides |
| WO2015058126A1 (en) | 2013-10-18 | 2015-04-23 | Syros Pharmaceuticals, Inc. | Heteroaromatic compounds useful for the treatment of prolferative diseases |
| WO2015058140A1 (en) | 2013-10-18 | 2015-04-23 | Dana-Farber Cancer Institute, Inc. | Polycyclic inhibitors of cyclin-dependent kinase 7 (cdk7) |
| US10017477B2 (en) | 2014-04-23 | 2018-07-10 | Dana-Farber Cancer Institute, Inc. | Janus kinase inhibitors and uses thereof |
| WO2015164604A1 (en) | 2014-04-23 | 2015-10-29 | Dana-Farber Cancer Institute, Inc. | Hydrophobically tagged janus kinase inhibitors and uses thereof |
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| CN107427521B (en) | 2015-03-27 | 2021-08-03 | 达纳-法伯癌症研究所股份有限公司 | Inhibitors of cyclin-dependent kinases |
| EP3307728A4 (en) | 2015-06-12 | 2019-07-17 | Dana Farber Cancer Institute, Inc. | ASSOCIATION THERAPY USING TRANSCRIPTION INHIBITORS AND KINASE INHIBITORS |
| EA201890512A1 (en) | 2015-08-17 | 2018-09-28 | Кура Онколоджи, Инк. | METHODS OF TREATING PATIENTS WITH MALIGNANT TUMORS WITH THE USE OF PHARNESILTRANSFERASE INHIBITORS |
| JP7028766B2 (en) | 2015-09-09 | 2022-03-02 | ダナ－ファーバー キャンサー インスティテュート， インコーポレイテッド | Inhibitor of cyclin-dependent kinase |
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| WO2018071283A1 (en) | 2016-10-12 | 2018-04-19 | Merck Sharp & Dohme Corp. | Kdm5 inhibitors |
| RS61745B1 (en) | 2016-11-03 | 2021-05-31 | Kura Oncology Inc | Farnesyltransferase inhibitors for use in treating cancer |
| WO2018190719A2 (en) | 2017-04-13 | 2018-10-18 | Aduro Biotech Holdings, Europe B.V. | Anti-sirp alpha antibodies |
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| EP3833668B1 (en) | 2018-08-07 | 2025-03-19 | Merck Sharp & Dohme LLC | Prmt5 inhibitors |
| WO2020033285A1 (en) | 2018-08-07 | 2020-02-13 | Merck Sharp & Dohme Corp. | Prmt5 inhibitors |
| BR112021002267A8 (en) | 2018-08-07 | 2023-02-07 | Merck Sharp & Dohme | PRMT5 INHIBITORS |
| EP3833667B1 (en) | 2018-08-07 | 2024-03-13 | Merck Sharp & Dohme LLC | Prmt5 inhibitors |
| WO2020140098A1 (en) | 2018-12-28 | 2020-07-02 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinase 7 and uses thereof |
| US20220143006A1 (en) | 2019-03-15 | 2022-05-12 | Kura Oncology, Inc. | Methods of treating cancer with farnesyltransferase inhibitors |
| EP4076460B1 (en) | 2019-12-17 | 2026-01-21 | Merck Sharp & Dohme LLC | 1,4-dihydro-2h-spiro[isoquinoline-3,4'-piperidine derivatives as prmt5 inhibitors for the treatment of cancer |
| BR112022012015A2 (en) | 2019-12-17 | 2022-08-30 | Merck Sharp & Dohme Llc | PRMT5 INHIBITORS |
| EP4303246A1 (en) | 2022-07-04 | 2024-01-10 | Covestro Deutschland AG | Polyisocyanate mixture |
| JP2026509792A (en) | 2023-03-02 | 2026-03-25 | カルツィムン ビオテック ゲゼルシャフト ミット ベシュレンクテル ハフツング | Means and methods for diagnosing cancer and/or acute inflammatory diseases |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2492372A1 (en) * | 1980-10-21 | 1982-04-23 | Cird | 1,8-DIHYDROXY-9-ANTHRONES SUBSTITUTED IN POSITION 10 AND THEIR USE IN HUMAN OR VETERINARY MEDICINE AND IN COSMETICS |
| WO1995012612A1 (en) * | 1993-11-05 | 1995-05-11 | Warner-Lambert Company | Substituted di- and tripeptide inhibitors of protein:farnesyl transferase |
-
1995
- 1995-07-10 FR FR9508296A patent/FR2736641B1/en not_active Expired - Fee Related
-
1996
- 1996-07-03 MA MA24302A patent/MA23929A1/en unknown
- 1996-07-04 PE PE1996000510A patent/PE11898A1/en not_active Application Discontinuation
- 1996-07-05 TW TW085108158A patent/TW438792B/en not_active IP Right Cessation
- 1996-07-08 NZ NZ313211A patent/NZ313211A/en unknown
- 1996-07-08 DK DK96924952T patent/DK0839133T3/en active
- 1996-07-08 AT AT96924952T patent/ATE185341T1/en not_active IP Right Cessation
- 1996-07-08 PL PL96324430A patent/PL324430A1/en unknown
- 1996-07-08 UY UY24276A patent/UY24276A1/en not_active IP Right Cessation
- 1996-07-08 CZ CZ199854A patent/CZ291620B6/en not_active IP Right Cessation
- 1996-07-08 CN CN96195415A patent/CN1096448C/en not_active Expired - Fee Related
- 1996-07-08 AU AU65224/96A patent/AU712194B2/en not_active Ceased
- 1996-07-08 US US08/981,840 patent/US5936097A/en not_active Expired - Fee Related
- 1996-07-08 IL IL12281296A patent/IL122812A/en not_active IP Right Cessation
- 1996-07-08 WO PCT/FR1996/001062 patent/WO1997003050A1/en not_active Ceased
- 1996-07-08 EP EP96924952A patent/EP0839133B1/en not_active Expired - Lifetime
- 1996-07-08 KR KR1019980700157A patent/KR19990028856A/en not_active Ceased
- 1996-07-08 DE DE69604588T patent/DE69604588T2/en not_active Expired - Fee Related
- 1996-07-08 MX MX9800262A patent/MX9800262A/en not_active IP Right Cessation
- 1996-07-08 JP JP9505557A patent/JPH11511123A/en active Pending
- 1996-07-08 SK SK26-98A patent/SK282250B6/en unknown
- 1996-07-08 EA EA199800118A patent/EA000797B1/en not_active IP Right Cessation
- 1996-07-08 ES ES96924952T patent/ES2139373T3/en not_active Expired - Lifetime
- 1996-07-08 BR BR9609440A patent/BR9609440A/en not_active Application Discontinuation
- 1996-07-08 CA CA002224414A patent/CA2224414A1/en not_active Abandoned
- 1996-07-09 TN TNTNSN96098A patent/TNSN96098A1/en unknown
- 1996-07-10 MY MYPI96002848A patent/MY114792A/en unknown
- 1996-07-10 CO CO96036152A patent/CO4700457A1/en unknown
- 1996-07-10 AR ARP960103511A patent/AR003143A1/en unknown
- 1996-07-10 ZA ZA965868A patent/ZA965868B/en unknown
-
1998
- 1998-01-09 NO NO980094A patent/NO309565B1/en unknown
-
1999
- 1999-10-07 GR GR990402001T patent/GR3031409T3/en unknown
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